Gastrointestinal and Liver Pathology

Diseases of the gastrointestinal tract constitute some of the most common human disorders. Almost everyone experiences some form of a GI ailment at least once during their lifetime. The common disorders include gastroesophageal reflux and Barrett’s esophagus, gastroenteritides including inflammatory bowel disease, gastritides including helicobacter gastritis, hepatitides including viral hepatitis B and C, fatty liver disease and pancreatitis. Cancer of large bowel constitutes one of the commonest malignancies in the developed counties and also remains one of the commonest causes for cancer-related mortality. Compared to colon cancers, cancers of the pancreas and liver are less common, but are amongst the most aggressive cancers with very poor prognosis. The team of Gastrointestinal Pathologists at Yale is dedicated to provide state of the art diagnostic services pertaining to these disorders. The team consists of highly qualified and experienced trained gastrointestinal pathologists who are outstanding clinicians dedicated to patient care. All our pathologists are fellowship-trained and experts in the field, with national and international recognition. Our faculty is committed to providing the best possible clinical care in a timely fashion and being at the forefront of academic medicine. All our pathologists are engaged in clinical and translational research related to gastrointestinal disorders that include liver tumors, pancreatic tumors, metabolic liver disease, Barrett’s esophagus, inflammatory bowel disease, motility disorders, gastrointestinal infections and colon cancer.

Services and Expertise

In the area of gastrointestinal pathology our faculty has a broad academic interest in the pathogenesis, diagnosis, therapeutic markers of neoplastic and pre-neoplastic lesions of luminal gastrointestinal tract, liver and pancreas. Our faculty is engaged in high quality clinical, translational and collaborative basic science research spanning wide spectrum of disorders. The broad clinical and translational areas where our faculty has either already published or currently working include Barrett’s esophagus, inflammatory bowel disease, hepatitis, colon cancer, liver tumors, pancreatitis, and pancreatic tumors. Major areas of ongoing research include pathologic and imaging correlations in liver cancer, phenotypic and genotypic correlation in liver tumors, adenocarcinomas of the gastroesophageal junction, intraductal pancreatic mucinous neoplasms, morphometric analysis of liver biopsies for sub-classification of cirrhosis and serrated polyps. Areas of collaborative basic science research where our faculty has been actively involved include graft vs. host disease and metabolic liver disorders.