Yale Pediatric Pathology

Pediatric Pathology

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The pediatric pathology service specializes in the evaluation of tissue specimen from patients of pediatric age (0-18 years) and from perinatal specimens including evaluation of fetal malformations and placentas.  Pediatric pathology is a pathology subspecialty requiring a specific board certification. We participate in national and international meetings and society  focusing in the advance in the field of pediatric and perinatal pathology

Pediatric Pathology Service

We diagnose solid tumors specific of infancy (small blue round cell tumor) and pediatric age, evaluate liver biopsies for cholestatic disease of infancy and pediatric liver transplants.  We specialize in the evaluation of gastro-intestinal biopsies of pediatric patients with particular interest in Hirschsprung  disease, eosinophilic esophagitis, celiac disease and pediatric idiopathic inflammatory bowel disease. The use of advanced techniques: immunohistochemistry, FISH, molecular genetics complement our evaluation of complex tumor cases and rare tumors.
The perinatal part of the service provides evaluation of placentas in addition to evaluation of fetal malformations collaborating with a very active maternal fetal medicine and genetic service here at Yale.

Services and Expertise
In addition to providing diagnostic service to the diverse subspecialties of Yale Children Hospital  we review specimens from surrounding hospitals including Bridgeport Hospital, Greenwich Hospital, and the Saint Raphael campus.

Yale Pediatric Pathology


Bio Profile

Raffaella Morotti, MD


Professor of Pathology

Associate Director, Autopsy Service

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Our main focus is on clinical oriented research with collaboration with the pediatric gastrointestinal and liver service. An additional  focus of academic  research is in relation to intestinal transplantation.

Publications :
  • Histopathology of duodenal mucosal lesions in pediatric patients with inflammatory bowel disease: statistical analysis to identify distinctive features. Hardee S, Alper A, Pashankar DS, Morotti RA. Pediatr Dev Pathol. 2014 Nov-Dec;17(6):450-4. doi: 10.2350/14-07-1529-OA.1. Epub 2014 Sep 10.PMID:25207874
  • Eosinophilic gastritis in children: clinicopathological correlation, disease course, and response to therapy. Ko HM, Morotti RA, Yershov O, Chehade M. Am J Gastroenterol. 2014 Aug;109(8):1277-85. doi: 10.1038/ajg.2014.166. Epub 2014 Jun 24. PMID:24957155
  • Pediatric Cholestatic Disorders: Approach to Pathologic Diagnosis. Morotti RA, Jain D. Surg Pathol Clin. 2013 Jun;6(2):205-25. doi: 10.1016/j.path.2013.03.001. Epub 2013 May 4.
  • Progressive familial intrahepatic cholestasis (PFIC) type 1, 2, and 3: a review of the liver pathology findings. Morotti RA, Suchy FJ, Magid MS. Semin Liver Dis. 2011 Feb;31(1):3-10. doi: 10.1055/s-0031-1272831. Epub 2011 Feb 22. Review.
  • Extracorporeal Hypothermic Perfusion Device for Intestinal Graft Preservation to Decrease Ischemic Injury During Transportation. Muñoz-Abraham AS, Patrón-Lozano R, Narayan RR, Judeeba SS, Alkukhun A, Alfadda TI, Belter JT, Mulligan DC, Morotti R, Zinter JP, Geibel JP, Rodríguez-Dávalos MI.J Gastrointest Surg. 2016 Feb;20(2):313-21
  • An immunohistochemical algorithm to facilitate diagnosis and subtyping of rhabdomyosarcoma: the Children's Oncology Group experience. Morotti RA, Nicol KK, Parham DM, Teot LA, Moore J, Hayes J, Meyer W, Qualman SJ; Children's Oncology Group. Am J Surg Pathol. 2006 Aug;30(8):962-8
The pediatric pathology service is engaged in educational efforts with
- Yale School of Medicine: course developer for Pediatric and Perinatal pathology
- Residency Programs (Pathology, Pediatric)