Yale Thoracic Pathology

Thoracic Pathology

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The Yale Thoracic Pathology Service specializes in analysis of tissue obtained from the thorax, including lungs, trachea, and chest wall, for evaluation for neoplastic (e.g. lung cancer, mesothelioma, other tumors) conditions as well as specific non-neoplastic conditions (inflammatory lung disease, including specific infections and fibrotic (scarring) diseases of the lung). The Service includes evaluation of prognostic features relative to tumor immunotherapy (PD-L1 expression levels).

Pediatric Thoracic Service

The Yale Thoracic Pathology Service specializes in analysis of tissue obtained from the thorax, including lungs, trachea, and chest wall, for evaluation for neoplastic (e.g. lung cancer, mesothelioma, other tumors) conditions as well as specific non-neoplastic conditions (inflammatory lung disease, including specific infections and fibrotic (scarring) diseases of the lung). The Service includes evaluation of prognostic features relative to tumor immunotherapy (PD-L1 expression levels).
Diseases and conditions include but are not limited to: lung cancer, interstitial lung disease, lung fibrosis, occupational lung disease, chronic extrinsic hypersensitivity pneumonitis, early lung cancer, screening detected cancers,  small cell carcinoma, neuroendocrine carcinoma, adenocarcinoma, bronchial biopsies, thoracoscopic biopsies, mesothelioma, thymoma, sarcoidosis, emphysema, asthma, airways diseases, immunohistochemistry.

Services and Expertise

Diseases and conditions include but are not limited to: lung cancer, interstitial lung disease, lung fibrosis, occupational lung disease, chronic extrinsic hypersensitivity pneumonitis, early lung cancer, screening detected cancers,  small cell carcinoma, neuroendocrine carcinoma, adenocarcinoma, bronchial biopsies, thoracoscopic biopsies, mesothelioma, thymoma, sarcoidosis, emphysema, asthma, airways diseases, immunohistochemistry.

Yale Thoracic Pathology

Director

Bio Profile

Robert Homer, MD, PhD

Directory, Thoracic Pathology

Professor of Pathology

Director, Thoracic Pathology

Director of Medical Studies

Director, Medical Student Course Module

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Pathologists

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Guoping Cai, MD

Associate Professor of Pathology

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Paul Jay Cohen, MD

Assistant Professor of Pathology

Chair, Bridgeport Hospital Pathology

Site Director, Yale Pathology Residency Program at Bridgeport Hospital

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Bio Profile

John Sinard, MD, PhD

Professor of Pathology and of Ophthalmology and Visual Science

Vice Chair Pathology

Director, Anatomic Pathology

Medical Director, Pathology Informatics

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Xuchen Zhang, MD, PhD

Associate Professor of Pathology

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Dr Homers and Zhang have had a long-standing interest in interstitial lung disease and animal models of lung disease.  Dr Cai works on translational research including molecular markers of lung cancer.

Current projects:

  • Molecular profiling of fibrotic lung disease in context of morphologic analysis (with Naftali Kaminski)
  • Diagnostic criteria for neuroendocrine tumors of the lung
  • Analysis of genetically engineered mouse models of lung cancer (with Katie Politi)
  • Immune profiling of lung cancer (Kurt Schalper)
  • Adequacy of cytology specimens for molecular analysis (Cai)
  • Adequacy of cryobiopsies for evaluation of interstitial lung disease (Homer)

Publications :
  • Vukmirovic M, Herazo-Maya JD, Blackmon J, Skodric-Trifunovic V, Jovanovic D, Pavlovic S, et al. Identification and validation of differentially expressed transcripts by rna-sequencing of formalin-fixed, paraffin-embedded (FFPE) lung tissue from patients with idiopathic pulmonary fibrosis. BMC Pulm Med 2017, Jan 12;17(1):15.
  • Rimm DL, Han G, Taube JM, Yi ES, Bridge JA, Flieder DB, et al. A prospective, multi-institutional, pathologist-based assessment of 4 immunohistochemistry assays for PD-L1 expression in non-small cell lung cancer. JAMA Oncol 2017, Mar 9.
  • Homer R, Lederer DJ. Diagnosing idiopathic pulmonary fibrosis without a lung biopsy: Honeycombing not required. Thorax 2017, May;72(5):391-2.
  • Ryu C, Homer RJ, Herzog EL. The airway in idiopathic pulmonary fibrosis: Protecting the lung or promoting disease? Am J Respir Crit Care Med 2016, May 15;193(10):1081-2.
  • Ramaswamy A, Homer R, Killam J, Pisani MA, Murphy TE, Araujo K, Puchalski J. Comparison of transbronchial and cryobiopsies in evaluation of diffuse parenchymal lung disease. J Bronchology Interv Pulmonol 2016, Jan;23(1):14-21.

Training for the Pathology Residency Program