Yale Hematopathology

Hematopathology

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The Hematopathology Service specializes in the evaluation of lymph nodes, bone marrow, blood, spleen, and hematolymphoid tissues in other organs. The faculty are board-certified in this specialty, with expertise in both anatomic and clinical pathology aspects of hematopathology. The Hematopathology team renders diagnoses on 3300 primary diagnostic specimens each year and an additional 1000 consultation specimens. As a tertiary referral center, many of these cases are malignant in nature, including but not limited to aggressive and indolent lymphomas, chronic myeloid neoplasms, acute leukemias, and plasma cell neoplasms. Challenging cases are discussed in detail among the expert hematopathologists at the weekly consensus conference.The faculty are involved nationally and internationally in professional societies and organizations to advance their field. The program offers a highly competitive fellowship in Hematopathology to two trainees each year. These are one-year fellowships (joint between anatomic and clinical pathology) that can be extended for approved research.
Services and Expertise
In addition to providing diagnostic service to Yale’s Smilow Cancer Center, we are the primary Hematopathology specialists for surrounding hospitals, including Bridgeport Hospital, Greenwich Hospital, Milford Hospital, Griffin Hospital, and the Saint Raphael Campus of Yale New Haven. Furthermore, we serve as the physicians for Precipio Laboratories, which receives consultative diagnostic specimens from around the country.

Hematopathology Pathology Service

Bone Marrows & Lymph Nodes: As the diagnostic service that supports a very active bone marrow transplant service, our average turnaround time for rush biopsies is less than 24 hours. Urgent results incorporating aspirate morphology, histology, flow cytometry, immunohistochemistry, FISH/cytogenetic, and molecular results, as necessary, are called in immediately to submitting physicians. 
 
- Tissue consultations: Our group receives external slide consultations from across the nation as well as from international sites for both primary diagnoses and  second opinions. To submit slides and tissue blocks, please send to:

Yale School of Medicine 
Department of Pathology
200 South Frontage Road, Room EP2-631
New Haven, CT 06510
Attention: Hematopathology
203.785.2788

We work closely with our colleagues in the Clinical Hematology Laboratory and Cytogenetics Laboratory to correlate results from advanced technologies, including next-generation sequencing and array comparative genomic hybridization. For more information about these and other resources:
https://medicine.yale.edu/labmed/sections/hematology/
https://medicine.yale.edu/lab/cytogenetics/

Services and Expertise
In addition to providing diagnostic service to Yale’s Smilow Cancer Center, we are the primary Hematopathology specialists for surrounding hospitals, including Bridgeport Hospital, Greenwich Hospital, Milford Hospital, Griffin Hospital, and the Saint Raphael Campus of Yale New Haven. Furthermore, we serve as the physicians for Precipio Laboratories, which receives consultative diagnostic specimens from around the country.

Yale Hematopathology

Director

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Mina LuQing Xu, MD

Director of Hematopathology

Associate Professor of Pathology

Director of Hematopathology

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Pathologists

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Demetrios Braddock, MD, PhD

Associate Professor of Pathology

Medical Director, Precipio Diagnostics

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Stanley David Hudnall, MD

Professor of Pathology and of Laboratory Medicine

Director of Pathology Education, Yale Department of Pathology

Medical Director, Precipio Diagnostics, LLC

Former Director of Hematopathology, Yale Department of Pathology

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Alexa Siddon, MD

Assistant Professor of Laboratory Medicine

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Our academic interests are diverse and composed of a balance of clinical, basic science, and translational efforts. Drs. Braddock and Katz lead bench research laboratories. The Katz laboratory is interested in mechanisms of cancer cell death; both intrinsically as regulated by the BCL-2 family of proteins and extrinsically as instigated by the immune system through Chimeric Antigen Receptor (CAR)- T cells. https://medicine.yale.edu/lab/katz/.  The Braddock laboratory studies ENPP enzymology. They developed a curative biologic therapeutic for a lethal orphan disease called ‘Generalized Arterial Calcification of Infancy’, which they are translating into patients while continuing to investigate diseases of aberrant mineralization. https://medicine.yale.edu/lab/braddock/. Faculty engage in a wide range of clinical and translational research, including lymphoma and leukemia microenvironment and the development of companion diagnostics (Xu), pathobiology of Hodgkin and the role of HHV-6 in human disease (Hudnall), and molecular genetics of hematopoietic neoplasms (Siddon, Much, Perincheri).
Publications :
  • Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG.  The BCL-2 Family Member BOK Promotes Apoptosis in Response to Endoplasmic Reticulum Stress.  Proc Natl Acad Sci USA 2015, 112(23):7201-6.  PMID: 26015568.
  • Gross A, Katz SG.  Non-Apoptotic Functions of BCL-2 Family Proteins.  Cell Death Differ 2017 Feb 24. PMID: 28234359.
  • Albright, R.A., Stabach, P., Cao, W., Kavanagh, D., Mullen, I., Braddock, A.A., Covo M.S., Tehan, M., Yang, G., Cheng, Z., Bouchard, K., Zhao-Xue, Y., Thorn, S., Wang, X., Sinusas, A.J., Shiloach, J., Zubal, G., Joseph A. Madri, J.A., De La Cruz, E.M., and Braddock, D.T., “ENPP1-Fc Fusion Protein Prevents Mortality and Vascular Calcifications in Rodent Model of Generalized Calcification of Infancy.” (2015), Nature Communications, Dec 1;6:10006. PMID: 26624227
  • Albright RA, Ornstein DL, Cao W, Chang WC, Robert D, Tehan M, Hoyer D, Liu L, Stabach P, Yang G, De La Cruz EM, Braddock DT. Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. J Biol Chem. 2014 Feb 7;289(6):3294-306. PMID: 24338010
  • Hudnall SD, Meng H, Lozovatsky L, Li P, Strout M, Kleinstein SH. Recurrent genetic defects in classical Hodgkin lymphoma cell lines. Leuk Lymphoma. 2016 Dec;57(12):2890-2900. PMID: 27121023
  • Johnson S, Mathews S, Hudnall SD. Human herpesvirus 6 lymphadenitis in drug rash with eosinophilia and systemic symptoms syndrome: a lymphoma mimic. Histopathology. 2017 Jun;70(7):1166-1170. PMID: 28008656
  • Xu ML, Acevedo-Gadea C, Seropian S, Katz SG. Expression of CD30 as a biomarker to predict response to brentuximab vedotin. Histopathology. 2016 Jul;69(1):155-8. PMID: 26648051
  • Baraban EG, Hu S, Hui P, Podoltsev N, Cooper D, Xu ML. Tissue-based chimerism analysis enhances detection of donor derived neoplasia in allogeneic stem cell transplant patients. Bone Marrow Transplantation. 2017;52(4):634-637. PMID: 27991892
  • Siddon AJ, Tormey CA. Successful Use of Four Factor-Prothrombin Complex Concentrate for Congenital Factor X Deficiency in the Setting of Neurosurgery. Lab Med. 2016 Aug;47(3):e35-7. PMID: 27378481
  • Abi Raad R, Tormey CA, Siddon AJ. Transfusion medicine illustrated. Catastrophic basilar artery leukostasis in the setting of acute myeloid leukemia. Transfusion. 2014 Apr;54(4):970. PMID: 24724788
  • Perincheri S, Hui P. KRAS mutation testing in clinical practice. Expert Rev Mol Diagn. 2015 Mar;15(3):375-84. PMID: 25487540
  • Much M, Buza N, Hui P. Tissue identity testing of cancer by short tandem repeat polymorphism: pitfalls of interpretation in the presence of microsatellite instability. Hum Pathol. 2014 Mar;45(3):549-55. PMID: 24444463

Faculty in the Hematopathology Division are engaged in and lead educational efforts within: 

  • Yale School of Medicine: course developers, lecturers and lab leaders in Genes & Development Hematology Module
  • Residency and Fellowship Programs: AP/CP lecturers and instructors in practical microscopy sessions in Hematopathology
  • Graduate Program: lecturer in Path 650b (Cellular and molecular biology of cancer), lecturer and lab leader in Genes & Development, module directors in Path 690 (Molecular mechanisms of disease; Hematology and orphan disease modules), and course co-director of Path 682b (Cancer Clinical Translation Workshop)
  • Yale College: director, lecturer in MCDB 315 (Pathobiology)