The Yale Renal Pathology Service provides high quality electron micrographs/digital images for analysis of ultrastructural pathologic changes in organ tissue. We maintain the highest level of diagnostic accuracy coupled with rapid turnaround time for renal diseases, ciliary abnormalities, metabolic disorders, microbial identification, and tumor diagnosis. Diseases and conditions include but are not limited to: primary glomerular, tubulointerstitial, and vascular diseases of the kidney, renal genetic disease, lupus and systemic vasculitis, renal transplantation.
Although patients with all varieties of renal parenchymal disease have undergone renal biopsy, the biopsy is of greatest value in patients with large amounts of proteinuria, patients with systemic disease that involve the kidneys, certain patients with acute renal failure, and patients with an active urinary sediment. Important clinical information such as serum creatinine, serologic studies, and the degree of proteinuria are useful in assisting the interpretation of the renal biopsy. The renal biopsy provides significant information relative to the risk of progression by examining the degree of tubulointerstitial scarring. The potential to respond to therapy is generally based on the presence or absence of acute inflammatory changes in the glomerulus and in the tubulointerstitial compartment. Important clinical information such as serum creatinine, serological studies for hepatitis and lupus, and the degree of proteinuria are generally useful in assisting in the interpretation of the renal biopsy.
The technique of a renal biopsy has been improved so that complications are very uncommon. It is relatively rare to have a serious complication, although it is not uncommon to have blood in the urine following a biopsy.
Complete electron microscopy and renal biopsy consultation services are available to departments and physicians within YNHH, as well as outside hospitals and groups.