Micha Sam Brickman Raredon, MD, PhD

Assistant Professor of Anesthesiology

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Appointments

Anesthesiology

Primary

Contact Info

michasam.raredon@yale.edu

Vascular Biology and Therapeutics Program

10 Amistad Street, Rm. 301A

New Haven, Connecticut 06519

United States

About

Titles

Assistant Professor of Anesthesiology

Biography

Dr. Micha Sam Brickman Raredon is an Assistant Professor in the Department of Anesthesiology at the Yale School of Medicine. The Raredon Laboratory studies regenerative tissue biology, with a particular focus on cell-to-cell communication networks, and builds primary-source software to explore and analyze these complex data, including NICHES and Connectome. Dr. Raredon's laboratory seeks to reverse-engineer regenerative therapeutics through the close study of spatial tissue systems biology.

Dr. Raredon completed his MD/PhD training at Yale in the laboratory of Dr. Laura Niklason (Biomedical Engineering). In 2022 he founded his lab as an independent group leader and in 2024 was promoted to Assistant Professor within the Research Section of the Department of Anesthesiology. The Raredon Laboratory is affiliated with the Vascular Biology and Therapeutics Program, the Program in Translational Biomedicine, and the Yale Biomedical Imaging Institute.

Dr. Raredon received a master's degree in Materials Science and Engineering at the Massachusetts Institute of Technology, where he received the Draper Fellowship to develop vascular tissue micro-fabrication techniques in the laboratories of Dr. Linda Griffith (Bioengineering), Dr. Paula Hammond (Chemical Engineering), and Dr. Jeffrey Borenstein (Draper Labs). He completed his undergraduate work in Biomedical Engineering and the History of Art at Yale University and the University of Cambridge.

Dr. Raredon plays the cello and enjoys finding time to be outdoors and near water as much as possible.

Last Updated on May 12, 2026.

Appointments

Anesthesiology
Assistant Professor
Primary
Anesthesiology

Anesthesiology
Human and Translational Immunology Program
Janeway Society
Molecular Medicine, Pharmacology, and Physiology
Program in Translational Biomedicine (PTB)
Vascular Biology and Therapeutics Program
Yale Biomedical Imaging Institute
Yale Combined Program in the Biological and Biomedical Sciences (BBS)

Education & Training

Independent Group Leader, T32 Fellowship: Yale School of Medicine (2024)

MD: Yale School of Medicine (2022)

PhD: Yale School of Engineering and Applied Science, Biomedical Engineering (2021)

MS: Yale School of Engineering and Applied Science, Biomedical Engineering (2020)

MPhil: Yale School of Engineering and Applied Science, Biomedical Engineering (2020)

MS: Massachusetts Institute of Technology, Materials Science and Engineering (2014)

BS: Yale University, Biomedical Engineering & History of Art (2011)

Research

Overview

Dr. Raredon's research group focuses on the mechanisms governing the behavior of complex multicellular systems and in leveraging these principles to influence living tissues for regenerative medicine. Our work combines systems biology, stem-cell engineering, materials science, surgical research, and biological engineering. The team is particularly invested in controlling the self-organization of perfusable vascular networks and tissue architecture, and in devising principles of microvascular construction and control that can be applied across organ types. We are a clinically-integrated laboratory with two broadly interconnected goals: the modeling of network-level mechanisms of tissue morphogenesis and cellular phenotype regulation, and the application of those models to the design and fabrication of translational therapeutics.

Medical Research Interests

Angiogenesis; CCN Intercellular Signaling Proteins; Computational Biology; Epigenomics; Gene Regulatory Networks; Graph Neural Networks; Guided Tissue Regeneration; Hippo Signaling Pathway; Intercellular Signaling Peptides and Proteins; Intracellular Signaling Peptides and Proteins; Lung Diseases; Machine Learning; Morphogenesis; Proteomics; Regeneration; RNAi Therapeutics; Single-Cell Analysis; Spatial Analysis; Systems Biology; Tissue Engineering

ORCID
0000-0003-1441-6122
Raredon Laboratory
View Lab Website

Research at a Glance

Yale Co-Authors

Frequent collaborators of Micha Sam Brickman Raredon's published research.

Publications

2026

PathwayEmbed: a computational tool to quantify intracellular signaling transduction states from transcriptomic data
Huang Y, Gerecht S, Kyriakides T, Raredon M. PathwayEmbed: a computational tool to quantify intracellular signaling transduction states from transcriptomic data. Bioinformatics 2026, 42: btag346. PMID: 42209442, PMCID: PMC13292150, DOI: 10.1093/bioinformatics/btag346.
Peer-Reviewed Original Research
MeSH Keywords
Vascular Endothelial Growth Factor-D Improves Lung Vascular Integrity During Acute Lung Injury
Yoon Y, Sharma L, Tang W, Kirk S, Raredon M, Ahangari F, Khoury J, Qian H, Ke Y, Tulapurkar M, Liu R, Luan Y, Yuan Q, Chen L, Birukov K, Simons M, Wu D, Niklason L, Kaminski N, Yuan Y. Vascular Endothelial Growth Factor-D Improves Lung Vascular Integrity During Acute Lung Injury. Circulation Research 2026, 138: e326094. PMID: 41822962, PMCID: PMC13007730, DOI: 10.1161/circresaha.124.326094.
Peer-Reviewed Original Research
Pulmonary organoid models demonstrate compositionally driven epithelial plasticity and immune polarization
Edelstein S, Mizoguchi S, Gracia M, Wang N, Lee V, Obata T, Kim H, Haynes C, Danelski C, Tsuchiya T, Sauler M, Raredon M. Pulmonary organoid models demonstrate compositionally driven epithelial plasticity and immune polarization. IScience 2026, 29: 115030. PMID: 41940331, PMCID: PMC13049529, DOI: 10.1016/j.isci.2026.115030.
Peer-Reviewed Original Research
Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging
De Man R, Cai Z, Doddaballapur P, Guerrera N, Regan A, Lin L, Schwarz E, Justet A, Abu Hussein N, Di Palo J, Cavinato C, Raredon M, Heerdt P, Singh I, Yan X, Kang M, Bruns D, Lee P, Tellides G, Humphrey J, Kaminski N, Ramachandra A, Manning E. Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging. Aging Cell 2026, 25: e70383. PMID: 41589414, PMCID: PMC12836046, DOI: 10.1111/acel.70383.
Peer-Reviewed Original Research
MeSH Keywords
Epithelial Reprogramming and Transition during Pulmonary Bioengineering.
Mizoguchi S, Lee V, Kim H, Edelstein SE, Wang N, Gracia MT, Danelski C, Haynes C, Rivero R, Stitelman D, Obata T, Greaney AM, Tsuchiya T, Kyriakides TR, Kaminski N, Raredon MSB. Epithelial Reprogramming and Transition during Pulmonary Bioengineering. BioRxiv 2026 PMID: 41659587, DOI: 10.64898/2026.01.24.701406.
Peer-Reviewed Original Research
Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease
Zhang Y, Wei H, Nouws J, Jiang W, Brewster R, Nguyen J, Liang S, Pass S, Wang W, Collin F, Oill A, Kim S, Siller S, Liu J, Zhao A, Hansbro P, Dela Cruz C, Britto C, Gomez J, Cloonan S, Herzog E, Lam T, Banovich N, Raredon M, Zhang X, Mangiola S, Homer R, Kaminski N, McDonough J, Polverino F, Yan X, Sauler M. Aberrant cellular communities underlying disease heterogeneity in chronic obstructive pulmonary disease. Nature Genetics 2026, 58: 376-391. PMID: 41578022, PMCID: PMC12900648, DOI: 10.1038/s41588-025-02480-z.
Peer-Reviewed Original Research
MeSH Keywords
Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy
De Man R, McDonough J, Adams T, Nikola F, Rangel R, Anderson S, Manning E, Cala Garcia J, Moss B, Waich A, Poli F, Cardenas R, Coarfa C, Song Q, Bar-Joseph Z, Vanaudenaerde B, Wuyts W, Niklason L, Raredon M, Yan X, Rosas I, Kaminski N. Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy. Nature Communications 2026, 17: 2095. PMID: 41571679, PMCID: PMC12953888, DOI: 10.1038/s41467-026-68810-9.
Peer-Reviewed Original Research
MeSH Keywords

2025

TSP2 Deficiency Promotes Fibroblast Proliferation and Migration With Enhanced WNT4/β‐Catenin/TGFb3
Huang Y, Xing H, Tian J, Zhang D, Zhang J, Pichurin J, Lu J, Raredon M, Kyriakides T. TSP2 Deficiency Promotes Fibroblast Proliferation and Migration With Enhanced WNT4/β‐Catenin/TGFb3. The FASEB Journal 2025, 39: e71368. PMID: 41427771, DOI: 10.1096/fj.202501884r.
Peer-Reviewed Original Research
MeSH Keywords
Lung adenocarcinoma cells respond differently to mechanical stress in 3D versus 2D environments
Kitamura N, Iwatake M, Mizoguchi S, Ibrahim Wani S, Kobayashi K, Hasnain M, Nguyen V, Yokoyama R, Kitade N, Ojima T, Shimoyama K, Koba N, Hatta H, Raredon M, Hirabayashi K, Morinaga Y, Tsuchiya T. Lung adenocarcinoma cells respond differently to mechanical stress in 3D versus 2D environments. Communications Biology 2025, 8: 1819. PMID: 41381717, PMCID: PMC12749616, DOI: 10.1038/s42003-025-09179-1.
Peer-Reviewed Original Research
Altered Epithelial-Mesenchymal Progenitor States Lead to Matrix Deposition, Tissue Inflammation, and Transitional Epithelial State in Congenital Diaphragmatic Hernia
Rivero R, Edelstein S, Haynes C, Mizoguchi S, Wang N, Saltzman M, Stitelman D, Raredon M. Altered Epithelial-Mesenchymal Progenitor States Lead to Matrix Deposition, Tissue Inflammation, and Transitional Epithelial State in Congenital Diaphragmatic Hernia. Fetal And Pediatric Pathology 2025, 44: 551-572. PMID: 41246903, PMCID: PMC13014129, DOI: 10.1080/15513815.2025.2585371.
Peer-Reviewed Original Research
MeSH Keywords

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Academic Achievements & Community Involvement

Honors

honor
MD/PhD Thesis Prize
05/23/2022Yale School of Medicine AwardYale School of Medicine
Details
honor
Draper Fellowship
09/05/2012Other AwardDraper Laboratories
Details
honor
Distinction in Biomedical Engineering
05/05/2011Yale University AwardYale University
Details
honor
Distinction in History of Art
05/05/2011Yale University AwardYale University
Details
honor
Engineering Honors
05/01/2011National AwardTau Beta Pi
Details

View full list of honors

Get In Touch

Contacts

michasam.raredon@yale.edu

Mailing Address

Vascular Biology and Therapeutics Program

10 Amistad Street, Rm. 301A

New Haven, Connecticut 06519

United States

Administrative Support

Sara Lane
Senior Administrative Assistant

Events

Feb 20272Tuesday

Yale Only
12:00 PM1:00 PM
Christopher Lengner, PhD
PTB Translational Science Seminar Series
Christopher Kuo, MD (LA Children's Hospital) - Title TBA
Hope Memorial Building
ZOOM LINK PASSWORD AVAILABLE UPON REQUEST (TIANA.SMITH@YALE.EDU)
https://yale.zoom.us/j/92398341165?pwd=ASSfI5cnQRemFh7G12OO1143HmpDrg.1
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Appointments

Contact Info

Titles

Biography

Appointments

Anesthesiology

Other Departments & Organizations

Education & Training

Overview

Medical Research Interests

ORCID

Raredon Laboratory

Research at a Glance

Yale Co-Authors

Naftali Kaminski, MD

Allison M. Greaney, PhD

Jonas Christian Schupp, MD

Katherine Leiby

Taylor Adams

Laura Niklason, PhD, MD

Publications

2026

2025

Honors

MD/PhD Thesis Prize

Draper Fellowship

Distinction in Biomedical Engineering

Distinction in History of Art

Engineering Honors

Media

Bronchioalveolar junction

Contacts

Administrative Support

Events

PTB Translational Science Seminar Series