2020
Early Intervention for Psychosis in the United States: Tailoring Services to Improve Care for Women
Ferrara M, Srihari VH. Early Intervention for Psychosis in the United States: Tailoring Services to Improve Care for Women. Psychiatric Services 2020, 72: 5-6. PMID: 32966169, DOI: 10.1176/appi.ps.202000205.Peer-Reviewed Original ResearchEarly Intervention, EducationalEarly Medical InterventionFemaleHumansPsychotic DisordersUnited StatesAnalysis of Early Intervention Services on Adult Judicial Outcomes
Pollard JM, Ferrara M, Lin IH, Kucukgoncu S, Wasser T, Li F, Srihari VH. Analysis of Early Intervention Services on Adult Judicial Outcomes. JAMA Psychiatry 2020, 77: 871-872. PMID: 32320010, PMCID: PMC7177643, DOI: 10.1001/jamapsychiatry.2020.0448.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultConnecticutCrimeCriminalsEarly Medical InterventionFemaleFollow-Up StudiesHumansMaleOutcome Assessment, Health CarePsychotic DisordersYoung Adult
2019
Parsing the impact of early detection on duration of untreated psychosis (DUP): Applying quantile regression to data from the Scandinavian TIPS study
Ferrara M, Guloksuz S, Li F, Burke S, Tek C, Friis S, Ten Velden Hegelstad W, Joa I, Johannessen JO, Melle I, Simonsen E, Srihari VH. Parsing the impact of early detection on duration of untreated psychosis (DUP): Applying quantile regression to data from the Scandinavian TIPS study. Schizophrenia Research 2019, 210: 128-134. PMID: 31204063, DOI: 10.1016/j.schres.2019.05.035.Peer-Reviewed Original ResearchMeSH KeywordsAdultEarly DiagnosisEarly Medical InterventionFemaleHumansMaleNorwayProspective StudiesPsychotic DisordersSchizophreniaSex FactorsTime-to-TreatmentYoung AdultEarly intervention service for first episode psychosis in Modena, Northern Italy: The first hundred cases
Ferrara M, Tedeschini E, Baccari F, Musella V, Vacca F, Mazzi F, Ferri M, Srihari V, Starace F, Group F. Early intervention service for first episode psychosis in Modena, Northern Italy: The first hundred cases. Early Intervention In Psychiatry 2019, 13: 1011-1017. PMID: 30672134, DOI: 10.1111/eip.12788.Peer-Reviewed Original ResearchConceptsEarly intervention servicesClinical improvementMedian ageIntervention servicesCommunity mental health centerCommunity outpatient servicesPsychiatric hospital unitMeaningful clinical improvementFirst-episode psychosisModel of careNon-affective psychosisNation Outcome ScalesMental health centersHigher median ageEarly detection effortsRefinement of treatmentMain referralsPharmacological consultationYounger patientsUntreated psychosisOutcome ScaleGeneral practitionersEpisode psychosisHealth centersOutpatient services
2018
An Economic Evaluation of Coordinated Specialty Care (CSC) Services for First-Episode Psychosis in the U.S. Public Sector.
Murphy SM, Kucukgoncu S, Bao Y, Li F, Tek C, Breitborde NJK, Guloksuz S, Phutane VH, Ozkan B, Pollard JM, Cahill JD, Woods SW, Cole RA, Schoenbaum M, Srihari VH. An Economic Evaluation of Coordinated Specialty Care (CSC) Services for First-Episode Psychosis in the U.S. Public Sector. The Journal Of Mental Health Policy And Economics 2018, 21: 123-130. PMID: 30530872, PMCID: PMC6314808.Peer-Reviewed Original ResearchConceptsSpecialty care servicesPatient costsEarly intervention servicesUsual treatmentSchizophrenia spectrum disordersMonth 12Economic evaluationCare servicesSTEP participantsCommunity mental health centerThird-party payer perspectiveIntervention servicesFirst-episode servicesMonths post randomizationHealthcare service utilizationMental health centersU.S. public sectorTeam-based careCost-offset analysisEligible patientsThird-party payersAntipsychotic exposureED visitsMonth 6Episode psychosisComparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression
Correll CU, Galling B, Pawar A, Krivko A, Bonetto C, Ruggeri M, Craig TJ, Nordentoft M, Srihari VH, Guloksuz S, Hui CLM, Chen EYH, Valencia M, Juarez F, Robinson DG, Schooler NR, Brunette MF, Mueser KT, Rosenheck RA, Marcy P, Addington J, Estroff SE, Robinson J, Penn D, Severe JB, Kane JM. Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression. JAMA Psychiatry 2018, 75: 555-565. PMID: 29800949, PMCID: PMC6137532, DOI: 10.1001/jamapsychiatry.2018.0623.Peer-Reviewed Original ResearchConceptsEarly phase psychosisEarly intervention servicesCause treatment discontinuationSchizophrenia spectrum disordersSymptom severityTreatment discontinuationPsychiatric hospitalizationSystematic reviewIntervention servicesMonths of treatmentEnd of treatmentFirst-episode psychosisTotal symptom severitySystematic literature searchMeta-regression analysisPositive symptom severityCoprimary outcomesPrespecified subgroupsLanguage restrictionsNegative symptom severityClinical trialsTreatment periodMAIN OUTCOMESpectrum disorderPRISMA guidelines
2016
Early Intervention for Psychotic Disorders: Building Population Health Systems
Srihari VH, Jani A, Gray M. Early Intervention for Psychotic Disorders: Building Population Health Systems. JAMA Psychiatry 2016, 73: 1-3. PMID: 26747524, DOI: 10.1001/jamapsychiatry.2015.2821.Peer-Reviewed Original Research
2015
First-Episode Services for Psychotic Disorders in the U.S. Public Sector: A Pragmatic Randomized Controlled Trial
Srihari VH, Tek C, Kucukgoncu S, Phutane VH, Breitborde NJ, Pollard J, Ozkan B, Saksa J, Walsh BC, Woods SW. First-Episode Services for Psychotic Disorders in the U.S. Public Sector: A Pragmatic Randomized Controlled Trial. Psychiatric Services 2015, 66: 705-712. PMID: 25639994, PMCID: PMC4490067, DOI: 10.1176/appi.ps.201400236.Peer-Reviewed Original ResearchConceptsUsual treatmentSTEP participantsCommunity mental health centerFirst-episode servicesFirst-episode psychosisMental health centersSerious mental illnessInpatient psychiatric unitAntipsychotic exposureAdditional patientsIllness onsetHospital utilizationHealth centersInpatient utilizationPsychiatric hospitalizationMAIN OUTCOMEPsychotic illnessPsychiatric unitPsychotic disordersHospitalizationEarly interventionMental illnessSpecialized treatmentPatientsTranslational research