2018
Should I Stay or Should I Go? FMRI Study of Response Inhibition in Early Illness Schizophrenia and Risk for Psychosis
Fryer SL, Roach BJ, Ford JM, Donaldson KR, Calhoun VD, Pearlson GD, Kiehl KA, Srihari VH, McGlashan TH, Woods SW, Mathalon DH. Should I Stay or Should I Go? FMRI Study of Response Inhibition in Early Illness Schizophrenia and Risk for Psychosis. Schizophrenia Bulletin 2018, 45: 158-168. PMID: 29385625, PMCID: PMC6293268, DOI: 10.1093/schbul/sbx198.Peer-Reviewed Original ResearchConceptsEarly illness schizophrenia patientsClinical high riskESZ groupsBilateral dorsal anterior cingulateResponse inhibitionGo/NoGo task performanceEarly illness schizophreniaInhibitory control regionsVariable motor responseTask-based functional connectivityFunctional connectivity relationshipsDorsal anterior cingulateMedial prefrontal cortexDefault mode network regionsInferior frontal cortexRight inferior frontal regionsFunctional magnetic resonanceFrontal cortexHigh riskHealthy adolescentsSchizophrenia patientsAnterior cingulateControl groupInferior frontal regionsCHR group
2016
Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition
Starc M, Murray JD, Santamauro N, Savic A, Diehl C, Cho YT, Srihari V, Morgan PT, Krystal JH, Wang XJ, Repovs G, Anticevic A. Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition. Schizophrenia Research 2016, 181: 107-116. PMID: 27745755, PMCID: PMC5901719, DOI: 10.1016/j.schres.2016.10.011.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsSpatial WM taskSchizophrenia patientsSevere cognitive deficitsSpecific spatial locationsComputational modelContinuous response measuresWM precisionWM representationsSpatial WMWM taskDistractor distanceWM impairmentWM tracesNeural mechanismsCognitive deficitsMemory deficitsBehavioral consequencesDelay periodDelay durationCortical disinhibitionSpatial locationComparison subjectsMicrocircuit modelDistractibility
2015
Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients
Hay RA, Roach BJ, Srihari VH, Woods SW, Ford JM, Mathalon DH. Equivalent mismatch negativity deficits across deviant types in early illness schizophrenia-spectrum patients. Biological Psychology 2015, 105: 130-137. PMID: 25603283, PMCID: PMC4336819, DOI: 10.1016/j.biopsycho.2015.01.004.Peer-Reviewed Original ResearchConceptsSchizophrenia spectrum patientsHealthy controlsEarly schizophrenia patientsMMN amplitude reductionDuration of illnessCourse of schizophreniaMismatch negativityDeviant typesMismatch negativity deficitsClinical symptomsDifferent deviant typesNeurophysiological abnormalitiesAuditory deviantsSchizophrenia patientsPatientsAuditory deviance processingIllnessNeurophysiological mechanismsAmplitude reductionSignificant interactionMMN responsesDeviance processingSymptomsAbnormalitiesSchizophrenia
2013
Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity
Perez VB, Woods SW, Roach BJ, Ford JM, McGlashan TH, Srihari VH, Mathalon DH. Automatic Auditory Processing Deficits in Schizophrenia and Clinical High-Risk Patients: Forecasting Psychosis Risk with Mismatch Negativity. Biological Psychiatry 2013, 75: 459-469. PMID: 24050720, PMCID: PMC4028131, DOI: 10.1016/j.biopsych.2013.07.038.Peer-Reviewed Original ResearchConceptsCHR patientsHealthy control subjectsPsychosis onsetControl subjectsClinical high-risk patientsEarly illness schizophrenia patientsPsychosis riskClinical high-risk individualsHigh-risk patientsThird of patientsHigh-risk individualsCurrent clinical criteriaAuditory processing deficitsMismatch negativityNonclinical measuresAuditory devianceCox regressionClinical criteriaUnnecessary treatmentHigh riskCHR convertersPatientsPsychotic disordersSchizophrenia patientsPreventive interventionsDeficient Suppression of Default Mode Regions during Working Memory in Individuals with Early Psychosis and at Clinical High-Risk for Psychosis
Fryer SL, Woods SW, Kiehl KA, Calhoun VD, Pearlson GD, Roach BJ, Ford JM, Srihari VH, McGlashan TH, Mathalon DH. Deficient Suppression of Default Mode Regions during Working Memory in Individuals with Early Psychosis and at Clinical High-Risk for Psychosis. Frontiers In Psychiatry 2013, 4: 92. PMID: 24032017, PMCID: PMC3768116, DOI: 10.3389/fpsyt.2013.00092.Peer-Reviewed Original ResearchHealthy controlsDefault mode networkPsychosis onsetDMN regionsSeed-based connectivity analysisEarly schizophrenia patientsDMN suppressionClinical high riskLoad-dependent increaseMedial prefrontal cortexPosterior DMN nodesSuppression of activityPosterior parietal cortexResting-state fMRI dataDorsolateral prefrontal cortex activationDeficient suppressionESZ groupsESZ patientsPrefrontal cortex activationHigh riskEarly psychosisSchizophrenia patientsCHR individualsCortex activationLoad-dependent modulationChapter 10 Early auditory gamma-band responses in patients at clinical high risk for schizophrenia
Perez VB, Roach BJ, Woods SW, Srihari VH, McGlashan TH, Ford JM, Mathalon DH. Chapter 10 Early auditory gamma-band responses in patients at clinical high risk for schizophrenia. Supplements To Clinical Neurophysiology 2013, 62: 147-162. PMID: 24053038, PMCID: PMC4120874, DOI: 10.1016/b978-0-7020-5307-8.00010-7.Peer-Reviewed Original ResearchConceptsClinical high riskPhase-locking factorGamma-band responseAuditory gamma-band responsesCHR patientsHigh riskSchizophrenia patientsChronic schizophrenia patientsNMDA glutamate receptorsYounger schizophrenia patientsTransient gamma-band responseTrend-level reductionsNeurotransmission abnormalitiesGamma-band oscillationsYounger patientsIllness onsetProdromal symptomsPhase synchronyProdromal periodHealthy controlsPsychosis onsetPatientsPsychotic disordersCHR groupElectroencephalographic studies
2012
Error Monitoring Dysfunction Across the Illness Course of Schizophrenia
Perez VB, Ford JM, Roach BJ, Woods SW, McGlashan TH, Srihari VH, Loewy RL, Vinogradov S, Mathalon DH. Error Monitoring Dysfunction Across the Illness Course of Schizophrenia. Journal Of Psychopathology And Clinical Science 2012, 121: 372-387. PMID: 22060947, PMCID: PMC3358508, DOI: 10.1037/a0025487.Peer-Reviewed Original ResearchConceptsEarly illness schizophrenia patientsClinical high-risk patientsSchizophrenia patientsIllness courseAge-matched healthy controlsHigh-risk patientsAge-matched HCChronic schizophrenia patientsOnset of psychosisCorrect response negativityPE abnormalitiesRisk patientsCHR patientsClinical prodromeEvent-related potentialsIllness durationHealthy controlsIllness progressionPsychosis onsetPatientsAbnormalitiesIllnessResponse monitoringError-related negativityOnset