2023
Aberrant Hierarchical Prediction Errors Are Associated With Transition to Psychosis: A Computational Single-Trial Analysis of the Mismatch Negativity
Hauke D, Charlton C, Schmidt A, Griffiths J, Woods S, Ford J, Srihari V, Roth V, Diaconescu A, Mathalon D. Aberrant Hierarchical Prediction Errors Are Associated With Transition to Psychosis: A Computational Single-Trial Analysis of the Mismatch Negativity. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 8: 1176-1185. PMID: 37536567, DOI: 10.1016/j.bpsc.2023.07.011.Peer-Reviewed Original ResearchConceptsPrecision-weighted prediction errorsHealthy control participantsCourse of schizophreniaCHR-P individualsLower-level precision-weighted prediction errorsControl participantsLow-level sensoryPredictive coding accountMismatch negativity paradigmHierarchical Gaussian FilterPrediction errorEarly psychosisSingle-trial analysisClinical high riskDouble deviantsMismatch negativityComputational mechanismsElectroencephalography amplitudeFuture psychosisComputational modelSchizophreniaPsychosisIndividualsParticipantsSensor space
2022
Brain–phenotype models fail for individuals who defy sample stereotypes
Greene AS, Shen X, Noble S, Horien C, Hahn CA, Arora J, Tokoglu F, Spann MN, Carrión CI, Barron DS, Sanacora G, Srihari VH, Woods SW, Scheinost D, Constable RT. Brain–phenotype models fail for individuals who defy sample stereotypes. Nature 2022, 609: 109-118. PMID: 36002572, PMCID: PMC9433326, DOI: 10.1038/s41586-022-05118-w.Peer-Reviewed Original ResearchConceptsBrain-phenotype relationshipsBrain functional organizationCognitive constructsIndividual differencesNeurocognitive measuresBrain activityNeurocognitive scoresStereotypical profileNeural targetsClinical interventionsNeural circuitsFunctional organizationIndividualsSuch relationshipsData-driven approachRelationshipStereotypes
2012
Self-determination and first-episode psychosis: Associations with symptomatology, social and vocational functioning, and quality of life
Breitborde NJ, Kleinlein P, Srihari VH. Self-determination and first-episode psychosis: Associations with symptomatology, social and vocational functioning, and quality of life. Schizophrenia Research 2012, 137: 132-136. PMID: 22445463, PMCID: PMC3351585, DOI: 10.1016/j.schres.2012.02.026.Peer-Reviewed Original ResearchConceptsSelf-determination theoryBasic psychological needsNeed satisfactionPsychological needsFirst-episode psychosisNeed of relatednessSample of individualsEarly intervention servicesVocational functioningLess satisfactionIntervention servicesSatisfactionCurrent studyPsychosisIndividualsModest associationBeingQuality of lifeFunctioningMotivationSymptomatologyAssociationNeedDomainRelatedness
2009
Review of the operational definition for first‐episode psychosis
Breitborde NJ, Srihari VH, Woods SW. Review of the operational definition for first‐episode psychosis. Early Intervention In Psychiatry 2009, 3: 259-265. PMID: 22642728, PMCID: PMC4451818, DOI: 10.1111/j.1751-7893.2009.00148.x.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisDuration of psychosisEarly psychosis patientsAntipsychotic medication useFirst treatment contactRecent-onset psychosisMedication usePsychosis patientsTreatment contactPsychotic illnessClinical servicesPsychosisIllnessResearch settingsDurationOperational definitionTreatmentReviewPatientsSelective reviewIndividuals