2025
Chapter 53 Tourette syndrome
Abdallah S, Fasching L, Brady M, Bloch M, Lombroso P, Vaccarino F, Fernandez T. Chapter 53 Tourette syndrome. 2025, 951-962. DOI: 10.1016/b978-0-443-19176-3.00044-3.Peer-Reviewed Original ResearchTourette syndromeCortico-striatal-thalamo-cortical circuitryStriatal volume lossAdult TS patientsNeuroimaging studiesNeuropsychiatric disordersDopaminergic receptorsVocal ticsStriatal interneuronsClasses of striatal interneuronsBasal gangliaMetabolic hypofunctionEnvironmental risk factorsTS patientsAmeliorate symptomsGenetic contributionMolecular abnormalitiesPharmacological strategiesCircuitryAffecting 1Animal modelsRisk factorsInterneuronal circuitryVolume lossAbnormalities
2020
Empiric Recurrence Risk Estimates for Chronic Tic Disorders: Implications for Genetic Counseling
Heiman GA, Rispoli J, Seymour C, Leckman JF, King RA, Fernandez TV. Empiric Recurrence Risk Estimates for Chronic Tic Disorders: Implications for Genetic Counseling. Frontiers In Neurology 2020, 11: 770. PMID: 32849224, PMCID: PMC7432137, DOI: 10.3389/fneur.2020.00770.Peer-Reviewed Original ResearchChronic tic disorderRecurrence risk estimatesTic disordersRecurrence riskTourette's disorderRisk estimatesNeuropsychiatric disordersPopulation-based family studyGenetic counselingFirst-degree relativesQuality of lifeFamily studiesVocal ticsPopulation prevalenceFamilial recurrence riskSuch counselingGenetic testingDisordersRiskCounselingEmpiric recurrence riskGenetic variantsRange of risksHeterogeneous genetic architectureComorbidities
2015
Tourette Syndrome: Bridging the Gap between Genetics and Biology
Richer P, Fernandez TV. Tourette Syndrome: Bridging the Gap between Genetics and Biology. Complex Psychiatry 2015, 1: 156-164. PMID: 26509143, PMCID: PMC4617782, DOI: 10.1159/000439085.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGenetic studiesNeuropsychiatric disordersGenetic complexityInvolvement of dopaminergicPrecise therapeutic targetsChildhood neuropsychiatric disordersAttention deficit hyperactivity disorderGenetic overlapGenetic alterationsBiologyDeficit hyperactivity disorderHistaminergic pathwayObsessive-compulsive disorderHigh comorbidityVocal ticsCurrent treatmentTherapeutic targetTourette syndromePhenotypeHyperactivity disorderImproved treatmentDisordersDiseaseTreatmentGenetics