2025
Chapter 52 Obsessive–compulsive disorder
Abdallah S, Olfson E, Fernandez T. Chapter 52 Obsessive–compulsive disorder. 2025, 937-950. DOI: 10.1016/b978-0-443-19176-3.00011-x.Peer-Reviewed Original ResearchObsessive-compulsive disorderObsessive-compulsive disorder etiologiesCognitive behavioral therapySerotonin reuptake inhibitorsReuptake inhibitorsBehavioral therapyMedication augmentationNeuroanatomical alterationsNeurochemical imbalanceMedication trialsGenetic influencesImprove treatment outcomesEvidence-based therapeutic strategiesTreatment outcomesRobust clinical trialsDisordersClinical manifestationsTreatment optionsClinical trialsTherapeutic strategiesSerotoninMultifactorial naturePharmacotherapyNeuromodulationTrials
2024
The genetics of trichotillomania and excoriation disorder: A systematic review
Reid M, Lin A, Farhat L, Fernandez T, Olfson E. The genetics of trichotillomania and excoriation disorder: A systematic review. Comprehensive Psychiatry 2024, 133: 152506. PMID: 38833896, PMCID: PMC11513794, DOI: 10.1016/j.comppsych.2024.152506.Peer-Reviewed Original ResearchSystematic reviewGenome-wide researchGenome-wide associationDNA sequencing studiesDiscovery of risk genesWeb of ScienceGenetic factorsObsessive-compulsive disorderGenetic epidemiologyGenetic risk factorsSequencing studiesRisk genesGeneral populationMolecular geneticsExcoriation disorderRisk factorsGeneticsFirst-line medicationPsychiatric disordersObsessive-compulsive related disordersObsessive-compulsive disorder spectrumBody-focused repetitive behaviorsDevelopment of trichotillomaniaPsycINFOGenome
2023
Characteristics of trichotillomania and excoriation disorder across the lifespan
Lin A, Farhat L, Flores J, Levine J, Fernandez T, Bloch M, Olfson E. Characteristics of trichotillomania and excoriation disorder across the lifespan. Psychiatry Research 2023, 322: 115120. PMID: 36842397, PMCID: PMC10023474, DOI: 10.1016/j.psychres.2023.115120.Peer-Reviewed Original ResearchConceptsExcoriation disorderClinical characteristicsSkin-picking severityAttention-deficit/hyperactivity disorderCo-occurring conditionsBody-focused repetitive behaviorsObsessive-compulsive disorderSeverity scoreCurrent symptomsSignificant positive correlationTrichotillomaniaHyperactivity disorderDisordersSelf-reported anxietyAge 4High rateSubtypesSelf-report measuresSeverityCross-sectional survey responsesRepetitive behaviorsAdulthoodPositive correlation
2018
Chapter 49 Genetic susceptibility in obsessive-compulsive disorder
Fernandez TV, Leckman JF, Pittenger C. Chapter 49 Genetic susceptibility in obsessive-compulsive disorder. Handbook Of Clinical Neurology 2018, 148: 767-781. PMID: 29478613, DOI: 10.1016/b978-0-444-64076-5.00049-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObsessive-compulsive disorderPotential novel therapeutic avenuesNovel therapeutic avenuesSpecific risk allelesUnderlying pathophysiologyLarge cohortLifelong disabilityImmune pathwaysTherapeutic avenuesNew treatmentsGenetic susceptibilityRisk allelesCandidate gene association studiesMouse knockout modelsGenetic findingsGene association studiesKnockout modelsOCD pathologyRisk variantsNotable inroadsGenetic variantsDisordersVulnerable pathwaysSubstantial genetic contributionRepetitive behaviors
2016
Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder
Fernandez TV, Leckman JF. Prenatal and Perinatal Risk Factors and the Promise of Birth Cohort Studies: Origins of Obsessive-Compulsive Disorder. JAMA Psychiatry 2016, 73: 1117-1118. PMID: 27706471, PMCID: PMC5180419, DOI: 10.1001/jamapsychiatry.2016.2092.Peer-Reviewed Original ResearchConceptsPerinatal risk factorsBirth cohort studyCohort studyObsessive-compulsive disorderRisk factorsPre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder
Abdulkadir M, Tischfield JA, King RA, Fernandez TV, Brown LW, Cheon KA, Coffey BJ, de Bruijn SF, Elzerman L, Garcia-Delgar B, Gilbert DL, Grice DE, Hagstrøm J, Hedderly T, Heyman I, Hong HJ, Huyser C, Ibanez-Gomez L, Kim YK, Kim YS, Koh YJ, Kook S, Kuperman S, Lamerz A, Leventhal B, Ludolph AG, Madruga-Garrido M, Maras A, Messchendorp MD, Mir P, Morer A, Münchau A, Murphy TL, Openneer TJ, Plessen KJ, Rath JJ, Roessner V, Fründt O, Shin EY, Sival DA, Song DH, Song J, Stolte AM, Tübing J, van den Ban E, Visscher F, Wanderer S, Woods M, Zinner SH, State MW, Heiman GA, Hoekstra PJ, Dietrich A. Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder. Journal Of Psychiatric Research 2016, 82: 126-135. PMID: 27494079, PMCID: PMC5026935, DOI: 10.1016/j.jpsychires.2016.07.017.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAttention Deficit Disorder with HyperactivityCase-Control StudiesChildChild, PreschoolEuropeFemaleHumansMaleMiddle AgedObsessive-Compulsive DisorderParent-Child RelationsPregnancyPregnancy ComplicationsPsychiatric Status Rating ScalesRepublic of KoreaRetrospective StudiesSeverity of Illness IndexSex FactorsTic DisordersTourette SyndromeUnited StatesYoung AdultConceptsCo-occurring obsessive-compulsive disorderChronic tic disorderAttention-deficit/hyperactivity disorderObsessive-compulsive disorderPerinatal complicationsTic disordersTourette syndromeUnaffected family controlsHyperactivity disorderNeonatal complicationsDelivery complicationsPremature birthClinical expressionMorning sicknessMedical attentionComplicationsSymptom severityPropensity scoreFirst weekDisordersEarly exposureADHD severitySeverityCollaborative Genetics StudySyndrome
2015
Tourette Syndrome: Bridging the Gap between Genetics and Biology
Richer P, Fernandez TV. Tourette Syndrome: Bridging the Gap between Genetics and Biology. Complex Psychiatry 2015, 1: 156-164. PMID: 26509143, PMCID: PMC4617782, DOI: 10.1159/000439085.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGenetic studiesNeuropsychiatric disordersGenetic complexityInvolvement of dopaminergicPrecise therapeutic targetsChildhood neuropsychiatric disordersAttention deficit hyperactivity disorderGenetic overlapGenetic alterationsBiologyDeficit hyperactivity disorderHistaminergic pathwayObsessive-compulsive disorderHigh comorbidityVocal ticsCurrent treatmentTherapeutic targetTourette syndromePhenotypeHyperactivity disorderImproved treatmentDisordersDiseaseTreatmentGenetics