2021
Control of exploration, motor coordination and amphetamine sensitization by cannabinoid CB1 receptors expressed in medium spiny neurons
Bonm AV, Elezgarai I, Gremel CM, Viray K, Bamford NS, Palmiter RD, Grandes P, Lovinger DM, Stella N. Control of exploration, motor coordination and amphetamine sensitization by cannabinoid CB1 receptors expressed in medium spiny neurons. European Journal Of Neuroscience 2021, 54: 4934-4952. PMID: 34216157, PMCID: PMC9377695, DOI: 10.1111/ejn.15381.Peer-Reviewed Original ResearchConceptsMedium spiny neuronsR KO miceAmphetamine sensitizationKO miceMotor coordinationSpiny neuronsImpaired motor coordinationInvolvement of CBCannabinoid 1 receptorCannabinoid CB1 receptorsCB1 receptorsNeuronal subpopulationsCannabimimetic responsesInhibitory neuronsSpontaneous locomotionR activationR expressionMiceMouse linesKnockout backgroundNeuronsSpecific CBNew functional roleSensitizationDifferent behavioral responses
2019
Dopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson’s Disease
McKinley JW, Shi Z, Kawikova I, Hur M, Bamford IJ, Sudarsana Devi SP, Vahedipour A, Darvas M, Bamford NS. Dopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson’s Disease. Neuron 2019, 103: 1056-1072.e6. PMID: 31324539, PMCID: PMC7102938, DOI: 10.1016/j.neuron.2019.06.013.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAmphetamineAnimalsCholinergic NeuronsCyclic AMP-Dependent Protein KinasesDisease Models, AnimalDopamineDopamine AgentsDopamine Plasma Membrane Transport ProteinsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsInterneuronsMiceNeostriatumParkinson DiseasePatch-Clamp TechniquesReceptors, Dopamine D1Receptors, Dopamine D2Transcription, GeneticConceptsParkinson's diseaseDA deficiencyACh availabilityD1-type DA receptorsHyperpolarization-activated cation channelsRelease of acetylcholineStriatal acetylcholineDA receptorsStriatal interneuronsMotor deficitsDopamine deficiencyDA releasePharmacological treatmentResidual axonsStriatal synapsesMotor functionInterneuron functionAcetylcholineCognitive functionHCN channelsDiseaseCation channelsDopamineSpike timingDeficiencyCorticostriatal plasticity in the nucleus accumbens core
Bamford NS, Wang W. Corticostriatal plasticity in the nucleus accumbens core. Journal Of Neuroscience Research 2019, 97: 1559-1578. PMID: 31298422, PMCID: PMC6801067, DOI: 10.1002/jnr.24494.Peer-Reviewed Original ResearchConceptsPrefrontal cortical projectionsCortical projectionsNAc coreDrug reinstatementSaline-treated miceSpiny projection neuronsMotor learningNew therapeutic targetsNucleus accumbens coreUse of amphetaminesStriatal glutamateGlutamate releaseCortical stimulationPresynaptic depressionProjection neuronsStriatal circuitryD1 receptorsDrug challengeLocomotor sensitizationMale miceCorticostriatal plasticityGlutamatergic boutonsDopamine releaseNucleus accumbensParadoxical excitationThe Striatum’s Role in Executing Rational and Irrational Economic Behaviors
Bamford IJ, Bamford NS. The Striatum’s Role in Executing Rational and Irrational Economic Behaviors. The Neuroscientist 2019, 25: 475-490. PMID: 30678530, PMCID: PMC6656632, DOI: 10.1177/1073858418824256.Peer-Reviewed Original ResearchConceptsIrrational economic behaviorExecutive functionStriatum's roleMotor learningMotor movementsSensory stimulationExcitatory glutamatergic activityBehavioral economicsHabit formationNovel stimulationNeural pathwaysReflexive actionDecision makingReflexive movementsRational behaviorEconomic behaviorRational responseRewardDopamine releaseBehaviorStriatumGlutamatergic activityLearningCortexThalamus
2018
Dopamine’s Effects on Corticostriatal Synapses during Reward-Based Behaviors
Bamford NS, Wightman RM, Sulzer D. Dopamine’s Effects on Corticostriatal Synapses during Reward-Based Behaviors. Neuron 2018, 97: 494-510. PMID: 29420932, PMCID: PMC5808590, DOI: 10.1016/j.neuron.2018.01.006.Peer-Reviewed Original ResearchConceptsVariety of neurotransmittersPresynaptic filterCorticostriatal synapsesExcitatory inputsDopamine effectsExcitatory synapsesSynaptic pathwaysDopamine neurotransmissionLocal releaseSynapsesOperant responseCoordinated activationActivationResponseStriatumNeurotransmissionNeuron outputNeurotransmitters
2016
Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice1,2,3
Storey GP, Gonzalez-Fernandez G, Bamford IJ, Hur M, McKinley JW, Heimbigner L, Minasyan A, Walwyn WM, Bamford NS. Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice1,2,3. ENeuro 2016, 3: eneuro.0095-15.2015. PMID: 26866057, PMCID: PMC4745180, DOI: 10.1523/eneuro.0095-15.2015.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAlpha7 Nicotinic Acetylcholine ReceptorAmphetamineAnimalsCentral Nervous System StimulantsCholinergic NeuronsConditioning, OperantCorpus StriatumDrug-Seeking BehaviorFemaleMaleMiceMice, Inbred C57BLMotor ActivityMotor CortexNeural PathwaysNeuronal PlasticityNicotineNicotinic AgonistsReceptors, NicotinicRewardSelf AdministrationConceptsCorticostriatal activityAmphetamine challengeGlutamate releaseLocomotor sensitizationDirect pathway medium spiny neuronsAmphetamine-induced locomotor sensitizationActive cholinergic interneuronsAmphetamine-seeking behaviorSubsequent drug challengeMedium spiny neuronsActivity ex vivoNicotinic acetylcholine receptorsDrug-seeking behaviorPeriod of abstinenceSelf-administer amphetamineDrugs of abuseSelf-administering miceDrug-taking behaviorDwelling catheterAmphetamine withdrawalCholinergic interneuronsGlutamatergic activityPresynaptic depressionPotentiating responseSpiny neurons
2015
Dopamine-dependent corticostriatal synaptic filtering regulates sensorimotor behavior
Wong MY, Borgkvist A, Choi SJ, Mosharov EV, Bamford NS, Sulzer D. Dopamine-dependent corticostriatal synaptic filtering regulates sensorimotor behavior. Neuroscience 2015, 290: 594-607. PMID: 25637802, PMCID: PMC4494866, DOI: 10.1016/j.neuroscience.2015.01.022.Peer-Reviewed Original ResearchConceptsReceptor agonistD2-like receptor agonistDopamine D2-like receptor agonistsSensorimotor responsesNigrostriatal dopamine axonsD2 receptor activationD2 receptor agonistCB1 receptor antagonistLeft dorsal striatumSensorimotor behaviorSynaptic filteringCB1 endocannabinoid receptorLesioned miceCorticostriatal terminalsCorticostriatal synapsesSensorimotor deficitsReplacement therapyD2 agonistMetabotropic glutamateReceptor antagonistCB1 receptorsEndocannabinoid receptorsSynaptic activityControl disordersCorticostriatal activity
2013
Acetylcholine Encodes Long-Lasting Presynaptic Plasticity at Glutamatergic Synapses in the Dorsal Striatum after Repeated Amphetamine Exposure
Wang W, Darvas M, Storey GP, Bamford IJ, Gibbs JT, Palmiter RD, Bamford NS. Acetylcholine Encodes Long-Lasting Presynaptic Plasticity at Glutamatergic Synapses in the Dorsal Striatum after Repeated Amphetamine Exposure. Journal Of Neuroscience 2013, 33: 10405-10426. PMID: 23785153, PMCID: PMC3685836, DOI: 10.1523/jneurosci.0014-13.2013.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAdrenergic Uptake InhibitorsAmphetamineAnimalsCholine O-AcetyltransferaseDependovirusElectrophysiological PhenomenaExcitatory Postsynaptic PotentialsGenetic VectorsGlutamic AcidInterneuronsLocomotionMaleMaze LearningMiceMice, Inbred C57BLMice, KnockoutMotor ActivityNeostriatumNeuronal PlasticityPostural BalanceReceptors, Dopamine D1Receptors, Dopamine D2Receptors, PresynapticSynapsesConceptsGlutamate releaseCorticostriatal activityDirect pathway medium spiny neuronsMedium spiny neuronsCorticostriatal terminalsAcetylcholine releaseAmphetamine treatmentAmphetamine challengePresynaptic depressionAmphetamine exposurePresynaptic potentiationChronic decreaseSpiny neuronsDrug challengeLocomotor sensitizationGlutamatergic synapsesBrain slicesCorticostriatal signalingParkinson's diseaseDorsal striatumLocomotor responseDopamine regulationDrug dependenceStriatal activityActive interneurons
2012
Overinhibition of corticostriatal activity following prenatal cocaine exposure
Wang W, Nitulescu I, Lewis JS, Lemos JC, Bamford IJ, Posielski NM, Storey GP, Phillips PE, Bamford NS. Overinhibition of corticostriatal activity following prenatal cocaine exposure. Annals Of Neurology 2012, 73: 355-369. PMID: 23225132, PMCID: PMC3766752, DOI: 10.1002/ana.23805.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnesthetics, LocalAnimalsBiophysicsCerebral CortexCocaineCorpus StriatumDopamineDopamine AgentsDopamine Uptake InhibitorsDrug InteractionsElectric StimulationEmbryo, MammalianExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsExploratory BehaviorFemaleGABA AgentsGreen Fluorescent ProteinsHindlimb SuspensionIn Vitro TechniquesInterneuronsLidocaineMaleMiceMice, Inbred C57BLMice, TransgenicNerve Tissue ProteinsNeural InhibitionNeuronal PlasticityPatch-Clamp TechniquesPregnancyPrenatal Exposure Delayed EffectsQuinoxalinesQuinpiroleReceptors, GABA-ARotarod Performance TestSodium Channel BlockersStatistics, NonparametricTetrodotoxinConceptsPrenatal cocaine exposureCocaine exposureCorticostriatal activityTonic GABA currentsGABAA receptor antagonistBasal ganglia functionDopamine-dependent behaviorsCorticostriatal terminalsGABA interneuronsCorticostriatal synapsesDopamine-dependent plasticityGABAergic mechanismsGlutamate releaseGABAB receptorsMotor abnormalitiesGanglia functionTonic inhibitionReceptor antagonistStriatal synapsesAdolescent miceGABAergic signalingGABA currentsClinical studiesD2 receptorsPolysubstance abuseLack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
Quintana A, Sanz E, Wang W, Storey GP, Güler AD, Wanat MJ, Roller BA, La Torre A, Amieux PS, McKnight GS, Bamford NS, Palmiter RD. Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors. Nature Neuroscience 2012, 15: 1547-1555. PMID: 23064379, PMCID: PMC3483418, DOI: 10.1038/nn.3239.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAvoidance LearningBenzylaminesBiophysicsCells, CulturedChromonesCorpus StriatumCuesElectric StimulationEmbryo, MammalianExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsFemaleGABA AntagonistsGamma-Aminobutyric AcidGene Expression ProfilingGreen Fluorescent ProteinsIn Vitro TechniquesMaleMaze LearningMiceMice, Inbred C57BLMice, TransgenicMotor ActivityMutationNeuronsOligonucleotide Array Sequence AnalysisPhosphinic AcidsReceptors, AMPAReceptors, GABA-BReceptors, G-Protein-CoupledRotarod Performance TestConceptsMedium spiny neuronsMedium spiny neuron activityStriatal medium spiny neuronsOrphan G protein-coupled receptorPoor motor coordinationG protein-coupled receptorsProtein-coupled receptorsSpiny neuronsMotor coordinationGPR88Neuron activityFiring rateReduced inhibitionHyperactivityMiceNeuronsReceptorsRegulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core
Wang W, Dever D, Lowe J, Storey GP, Bhansali A, Eck EK, Nitulescu I, Weimer J, Bamford NS. Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core. The Journal Of Physiology 2012, 590: 3743-3769. PMID: 22586226, PMCID: PMC3476631, DOI: 10.1113/jphysiol.2012.235200.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAmphetamineAnimalsDopamineEndocannabinoidsGreen Fluorescent ProteinsMaleMiceMice, TransgenicNucleus AccumbensOptical ImagingPrefrontal CortexPresynaptic TerminalsPyridinium CompoundsQuaternary Ammonium CompoundsReceptors, AMPAReceptors, Dopamine D1Receptors, GlutamateReceptors, N-Methyl-D-AspartateSynaptic TransmissionConceptsD2 receptor-expressing cellsReceptor-expressing cellsMedium spiny neuronsSpiny neuronsExcitatory inputsD2 receptor-expressing medium spiny neuronsReceptor-expressing medium spiny neuronsGroup 1 metabotropic glutamate receptorsActivation of NMDAReceptor null miceMetabotropic glutamate receptorsBacterial artificial chromosome transgenic miceDopamine D1 receptorsBasal ganglia pathwaysConvergence of excitatoryNucleus accumbens coreCortical terminalsGlutamate releaseGlutamatergic inputsStriatonigral pathwayInhibitory modulationGlutamatergic signalsD1 receptorsSlice preparationGlutamatergic synapses
2011
Attenuating GABAA Receptor Signaling in Dopamine Neurons Selectively Enhances Reward Learning and Alters Risk Preference in Mice
Parker JG, Wanat MJ, Soden ME, Ahmad K, Zweifel LS, Bamford NS, Palmiter RD. Attenuating GABAA Receptor Signaling in Dopamine Neurons Selectively Enhances Reward Learning and Alters Risk Preference in Mice. Journal Of Neuroscience 2011, 31: 17103-17112. PMID: 22114279, PMCID: PMC3235504, DOI: 10.1523/jneurosci.1715-11.2011.Peer-Reviewed Original ResearchConceptsDA neuronsDA neuron activityGABAA Receptor SignalingPhasic dopamine transmissionPhasic DA responsesAversive learningAppetitive learningGABAergic toneExcitatory afferentsMidbrain slicesDA releaseDopamine neuronsExcitatory driveDopamine transmissionNucleus accumbensDA responseElectrical stimulationNeuron activityDA signalingPsychiatric conditionsCompensatory upregulationMiceNeuronsReceptor signalingAppetitive taskBalanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization
Beutler LR, Wanat MJ, Quintana A, Sanz E, Bamford NS, Zweifel LS, Palmiter RD. Balanced NMDA receptor activity in dopamine D1 receptor (D1R)- and D2R-expressing medium spiny neurons is required for amphetamine sensitization. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 4206-4211. PMID: 21368124, PMCID: PMC3054029, DOI: 10.1073/pnas.1101424108.Peer-Reviewed Original ResearchConceptsDopamine D1 receptorsAMPH sensitizationNucleus accumbensBehavioral sensitizationDopamine neuronsD1 receptorsD1R neuronsVirus-mediated restorationMedium spiny neuronsNMDA receptor activityType glutamate receptorsEssential NR1 subunitNMDAR signalingSpiny neuronsAmphetamine sensitizationNeuron targetsD1R-MSNsGlutamate receptorsNMDARNR1 subunitReceptor activityBrain regionsNeuronsSensitizationAmphetamine
2009
Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease
Joshi PR, Wu NP, André VM, Cummings DM, Cepeda C, Joyce JA, Carroll JB, Leavitt BR, Hayden MR, Levine MS, Bamford NS. Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease. Journal Of Neuroscience 2009, 29: 2414-2427. PMID: 19244517, PMCID: PMC2670193, DOI: 10.1523/jneurosci.5687-08.2009.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgingAnalysis of VarianceAnimalsBiophysicsCadmiumCells, CulturedCerebral CortexChromosomes, Artificial, YeastCorpus StriatumDisease Models, AnimalDopamine AgentsDose-Response Relationship, DrugElectric StimulationExcitatory Amino Acid AgentsExcitatory Postsynaptic PotentialsHumansHuntington DiseaseIn Vitro TechniquesMembrane PotentialsMiceNeural PathwaysNeuronsPyridinium CompoundsQuaternary Ammonium CompoundsStatistics, NonparametricTime FactorsTrinucleotide Repeat ExpansionConceptsYAC128 mouse modelGlutamate releaseCorticostriatal pathwayHuntington's diseaseCorticostriatal activityMouse modelSynaptic currentsMedium spiny neuronsAge-dependent alterationsGenetic neurodegenerative disorderAge-dependent changesBehavioral phenotypesSpiny neuronsCortical neuronsDisease progressionReceptor modulationSynaptic dysregulationDegenerative changesBrain slicesCorticostriatal functionPresynaptic terminalsCognitive deficitsNeurodegenerative disordersDiseaseMonths
2008
Repeated Exposure to Methamphetamine Causes Long-Lasting Presynaptic Corticostriatal Depression that Is Renormalized with Drug Readministration
Bamford NS, Zhang H, Joyce JA, Scarlis CA, Hanan W, Wu NP, André VM, Cohen R, Cepeda C, Levine MS, Harleton E, Sulzer D. Repeated Exposure to Methamphetamine Causes Long-Lasting Presynaptic Corticostriatal Depression that Is Renormalized with Drug Readministration. Neuron 2008, 58: 89-103. PMID: 18400166, PMCID: PMC2394729, DOI: 10.1016/j.neuron.2008.01.033.Peer-Reviewed Original ResearchConceptsAddiction-associated behaviorsDrug-experienced animalsSynaptic dopamine releaseCholinergic receptor systemsDrug readministrationLasting depressionCorticostriatal terminalsPresynaptic depressionSynaptic basisSynaptic effectsDopamine releaseD1 dopamineDrug reinstatementSynaptic changesDrug cravingReceptor systemLong-term maintenanceDepressionHabit learningReadministrationMethamphetamineExposureRelapseLong-term changes
2004
Dopamine Modulates Release from Corticostriatal Terminals
Bamford NS, Robinson S, Palmiter RD, Joyce JA, Moore C, Meshul CK. Dopamine Modulates Release from Corticostriatal Terminals. Journal Of Neuroscience 2004, 24: 9541-9552. PMID: 15509741, PMCID: PMC6730145, DOI: 10.1523/jneurosci.2891-04.2004.Peer-Reviewed Original ResearchConceptsCorticostriatal terminalsMedium spiny neuronsD2 receptorsDD miceSpiny neuronsD2-like receptor agonist quinpiroleExtracellular striatal glutamateFM1-43 destainingNormal striatal functionReserpine-treated miceCortical glutamatergic neuronsReceptor agonist quinpiroleActivity-dependent releaseMidbrain dopamine neuronsFM1-43Styryl dye FM1-43Aberrant cytoarchitectureGlutamate densityStriatal stimulationStriatal glutamateDopamine depletionAgonist quinpiroleControl miceDopamine deficiencyGlutamatergic neuronsHeterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals
Bamford NS, Zhang H, Schmitz Y, Wu NP, Cepeda C, Levine MS, Schmauss C, Zakharenko SS, Zablow L, Sulzer D. Heterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals. Neuron 2004, 42: 653-663. PMID: 15157425, DOI: 10.1016/s0896-6273(04)00265-x.Peer-Reviewed Original ResearchMeSH KeywordsAfferent PathwaysAmphetamineAnimalsCalcium SignalingCerebral CortexDopamineElectric StimulationExcitatory Postsynaptic PotentialsExocytosisFeedbackGlutamic AcidMiceMice, Inbred C57BLMice, KnockoutNeostriatumNeural InhibitionPresynaptic TerminalsPyridinium CompoundsQuaternary Ammonium CompoundsReceptors, Dopamine D2Substantia NigraSynaptic TransmissionSynaptic VesiclesConceptsMedium spiny neuronsCorticostriatal terminalsDirect presynaptic effectIndividual presynaptic terminalsStriatal dopamine releaseEffects of dopamineHigh-frequency stimulationVoluntary motor movementDrugs of abuseCorticostriatal afferentsMSN excitabilityPresynaptic effectsCorticostriatal inputsCorticostriatal synapsesActivity of subsetsInhibitory modulationSpiny neuronsD2 receptorsDopamine releaseFrequency stimulationDopamine inputPresynaptic terminalsElectrical stimulationHeterosynaptic inhibitionSynaptic connections