2012
Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors
Quintana A, Sanz E, Wang W, Storey GP, Güler AD, Wanat MJ, Roller BA, La Torre A, Amieux PS, McKnight GS, Bamford NS, Palmiter RD. Lack of GPR88 enhances medium spiny neuron activity and alters motor- and cue-dependent behaviors. Nature Neuroscience 2012, 15: 1547-1555. PMID: 23064379, PMCID: PMC3483418, DOI: 10.1038/nn.3239.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAvoidance LearningBenzylaminesBiophysicsCells, CulturedChromonesCorpus StriatumCuesElectric StimulationEmbryo, MammalianExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsFemaleGABA AntagonistsGamma-Aminobutyric AcidGene Expression ProfilingGreen Fluorescent ProteinsIn Vitro TechniquesMaleMaze LearningMiceMice, Inbred C57BLMice, TransgenicMotor ActivityMutationNeuronsOligonucleotide Array Sequence AnalysisPhosphinic AcidsReceptors, AMPAReceptors, GABA-BReceptors, G-Protein-CoupledRotarod Performance TestConceptsMedium spiny neuronsMedium spiny neuron activityStriatal medium spiny neuronsOrphan G protein-coupled receptorPoor motor coordinationG protein-coupled receptorsProtein-coupled receptorsSpiny neuronsMotor coordinationGPR88Neuron activityFiring rateReduced inhibitionHyperactivityMiceNeuronsReceptors
2006
362 ROLE OF ACETYLCHOLINE IN PSYCHOSTIMULANT ADDICTION.
Kumar T, Joyce J, Bamford N. 362 ROLE OF ACETYLCHOLINE IN PSYCHOSTIMULANT ADDICTION. Journal Of Investigative Medicine 2006, 54: s142. DOI: 10.2310/6650.2005.x0004.361.Peer-Reviewed Original ResearchMedium spiny neuronsWithdrawal day 1Nucleus accumbensCholinergic activationCholinergic interneuronsBasal gangliaSpiny neuronsDorsolateral striatumDay 1Striatal medium spiny neuronsAdult C57B1/6 miceCaudal nucleus accumbensChronic METH treatmentExcitatory glutamatergic projectionsWithdrawal day 10Striatal cholinergic interneuronsC-fosTreatment of miceC-Fos immunoreactivityRole of acetylcholineNumber of ChATImmediate early gene expressionChronic METHCortical terminalsGlutamate release