2023
Levodopa for Dystonia in Children: A Case Series and Review of the Literature
DeArias A, Bamford N. Levodopa for Dystonia in Children: A Case Series and Review of the Literature. Pediatric Neurology 2023, 152: 16-19. PMID: 38176223, DOI: 10.1016/j.pediatrneurol.2023.12.012.Peer-Reviewed Original ResearchMotor functionMarsden Dystonia Rating ScaleLimited effective treatment optionsDystonia Rating ScaleEffective treatment optionForms of dystoniaLong-term treatmentShort-term useDopa-responsive dystoniaCarbidopa-levodopaBurke-FahnRetrospective reviewCase seriesHyperkinetic movementsTreatment optionsUntoward effectsExamination notesDystoniaSignificant causeLevodopaRating ScaleTrial periodChildrenTreatmentReview
2020
Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice
Shi Z, Bamford IJ, McKinley JW, Devi SPS, Vahedipour A, Bamford NS. Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice. Brain Sciences 2020, 10: 903. PMID: 33255421, PMCID: PMC7760026, DOI: 10.3390/brainsci10120903.Peer-Reviewed Original ResearchL-DOPA-induced dyskinesiaL-DOPAStriatal acetylcholineDA deficiencyMovement disordersDA availabilityHypokinetic movement disordersStriatal cholinergic interneuronsHyperkinetic movement disordersDopa decarboxylase inhibitorElectrophysiological experimentsOpen field testingStriatal ChIsParkinsonian miceCholinergic interneuronsMotor dysfunctionTherapeutic optionsMotor hyperactivityParadoxical riseDA ratioMotor functionDecarboxylase inhibitorDopamine insufficiencyΒ-ARsΒ-AR
2019
Dopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson’s Disease
McKinley JW, Shi Z, Kawikova I, Hur M, Bamford IJ, Sudarsana Devi SP, Vahedipour A, Darvas M, Bamford NS. Dopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson’s Disease. Neuron 2019, 103: 1056-1072.e6. PMID: 31324539, PMCID: PMC7102938, DOI: 10.1016/j.neuron.2019.06.013.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAmphetamineAnimalsCholinergic NeuronsCyclic AMP-Dependent Protein KinasesDisease Models, AnimalDopamineDopamine AgentsDopamine Plasma Membrane Transport ProteinsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsInterneuronsMiceNeostriatumParkinson DiseasePatch-Clamp TechniquesReceptors, Dopamine D1Receptors, Dopamine D2Transcription, GeneticConceptsParkinson's diseaseDA deficiencyACh availabilityD1-type DA receptorsHyperpolarization-activated cation channelsRelease of acetylcholineStriatal acetylcholineDA receptorsStriatal interneuronsMotor deficitsDopamine deficiencyDA releasePharmacological treatmentResidual axonsStriatal synapsesMotor functionInterneuron functionAcetylcholineCognitive functionHCN channelsDiseaseCation channelsDopamineSpike timingDeficiency
2018
Loss of glutamate signaling from the thalamus to dorsal striatum impairs motor function and slows the execution of learned behaviors
Melief EJ, McKinley JW, Lam JY, Whiteley NM, Gibson AW, Neumaier JF, Henschen CW, Palmiter RD, Bamford NS, Darvas M. Loss of glutamate signaling from the thalamus to dorsal striatum impairs motor function and slows the execution of learned behaviors. Npj Parkinson's Disease 2018, 4: 23. PMID: 30083593, PMCID: PMC6072777, DOI: 10.1038/s41531-018-0060-6.Peer-Reviewed Original ResearchParkinson's diseaseCentral lateralDopamine neuronsMotor functionDorsal striatumMajor projection fieldBeam-walking testImpairs motor functionViral vector approachLewy body inclusionsMidbrain dopamine neuronsMotor coordination tasksMorris water mazeSlowness of thoughtLoss of glutamateTwo-way active avoidance taskGlutamatergic neuronsMotor abnormalitiesActive avoidance taskLox miceExcitatory inputsThalamic regionsWater mazeCognitive impairmentCell loss
2008
The Corticostriatal Pathway in Parkinson’s Disease
Bamford N, Cepeda C. The Corticostriatal Pathway in Parkinson’s Disease. Contemporary Neuroscience 2008, 87-104. DOI: 10.1007/978-1-60327-252-0_6.Peer-Reviewed Original ResearchParkinson's diseaseCortico-basal gangliaDopamine-deficient stateStriatal synaptic plasticityCorticostriatal synapseMotor dyskinesiasCorticostriatal pathwayMotor functionStriatal adaptationsAbnormal neurotransmissionSynaptic plasticityThalamocortical loopNeurodegenerative disordersDiseaseDopamine availabilityGangliaMotor movementsGoal-directed behaviorBradykinesiaDyskinesiaNeurotransmissionPathway