2012
Overinhibition of corticostriatal activity following prenatal cocaine exposure
Wang W, Nitulescu I, Lewis JS, Lemos JC, Bamford IJ, Posielski NM, Storey GP, Phillips PE, Bamford NS. Overinhibition of corticostriatal activity following prenatal cocaine exposure. Annals Of Neurology 2012, 73: 355-369. PMID: 23225132, PMCID: PMC3766752, DOI: 10.1002/ana.23805.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnesthetics, LocalAnimalsBiophysicsCerebral CortexCocaineCorpus StriatumDopamineDopamine AgentsDopamine Uptake InhibitorsDrug InteractionsElectric StimulationEmbryo, MammalianExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsExploratory BehaviorFemaleGABA AgentsGreen Fluorescent ProteinsHindlimb SuspensionIn Vitro TechniquesInterneuronsLidocaineMaleMiceMice, Inbred C57BLMice, TransgenicNerve Tissue ProteinsNeural InhibitionNeuronal PlasticityPatch-Clamp TechniquesPregnancyPrenatal Exposure Delayed EffectsQuinoxalinesQuinpiroleReceptors, GABA-ARotarod Performance TestSodium Channel BlockersStatistics, NonparametricTetrodotoxinConceptsPrenatal cocaine exposureCocaine exposureCorticostriatal activityTonic GABA currentsGABAA receptor antagonistBasal ganglia functionDopamine-dependent behaviorsCorticostriatal terminalsGABA interneuronsCorticostriatal synapsesDopamine-dependent plasticityGABAergic mechanismsGlutamate releaseGABAB receptorsMotor abnormalitiesGanglia functionTonic inhibitionReceptor antagonistStriatal synapsesAdolescent miceGABAergic signalingGABA currentsClinical studiesD2 receptorsPolysubstance abuse
2004
Dopamine Modulates Release from Corticostriatal Terminals
Bamford NS, Robinson S, Palmiter RD, Joyce JA, Moore C, Meshul CK. Dopamine Modulates Release from Corticostriatal Terminals. Journal Of Neuroscience 2004, 24: 9541-9552. PMID: 15509741, PMCID: PMC6730145, DOI: 10.1523/jneurosci.2891-04.2004.Peer-Reviewed Original ResearchConceptsCorticostriatal terminalsMedium spiny neuronsD2 receptorsDD miceSpiny neuronsD2-like receptor agonist quinpiroleExtracellular striatal glutamateFM1-43 destainingNormal striatal functionReserpine-treated miceCortical glutamatergic neuronsReceptor agonist quinpiroleActivity-dependent releaseMidbrain dopamine neuronsFM1-43Styryl dye FM1-43Aberrant cytoarchitectureGlutamate densityStriatal stimulationStriatal glutamateDopamine depletionAgonist quinpiroleControl miceDopamine deficiencyGlutamatergic neuronsHeterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals
Bamford NS, Zhang H, Schmitz Y, Wu NP, Cepeda C, Levine MS, Schmauss C, Zakharenko SS, Zablow L, Sulzer D. Heterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals. Neuron 2004, 42: 653-663. PMID: 15157425, DOI: 10.1016/s0896-6273(04)00265-x.Peer-Reviewed Original ResearchMeSH KeywordsAfferent PathwaysAmphetamineAnimalsCalcium SignalingCerebral CortexDopamineElectric StimulationExcitatory Postsynaptic PotentialsExocytosisFeedbackGlutamic AcidMiceMice, Inbred C57BLMice, KnockoutNeostriatumNeural InhibitionPresynaptic TerminalsPyridinium CompoundsQuaternary Ammonium CompoundsReceptors, Dopamine D2Substantia NigraSynaptic TransmissionSynaptic VesiclesConceptsMedium spiny neuronsCorticostriatal terminalsDirect presynaptic effectIndividual presynaptic terminalsStriatal dopamine releaseEffects of dopamineHigh-frequency stimulationVoluntary motor movementDrugs of abuseCorticostriatal afferentsMSN excitabilityPresynaptic effectsCorticostriatal inputsCorticostriatal synapsesActivity of subsetsInhibitory modulationSpiny neuronsD2 receptorsDopamine releaseFrequency stimulationDopamine inputPresynaptic terminalsElectrical stimulationHeterosynaptic inhibitionSynaptic connections