2017
Oxytocin response to youth–mother interactions in clinically anxious youth is associated with separation anxiety and dyadic behavior
Lebowitz ER, Silverman WK, Martino AM, Zagoory‐Sharon O, Feldman R, Leckman JF. Oxytocin response to youth–mother interactions in clinically anxious youth is associated with separation anxiety and dyadic behavior. Depression And Anxiety 2017, 34: 127-136. PMID: 28052452, PMCID: PMC5503301, DOI: 10.1002/da.22585.Peer-Reviewed Original ResearchConceptsSeparation anxiety disorderAnxious youthAnxiety disordersSeparation anxietySalivary oxytocinAffective touchDSM-5 anxiety disordersYouth anxiety symptomsOT responseParticular anxiety disordersAttachment figuresReliable codersMaternal sensitivityDyadic behaviorsChildren's ratingsMaternal intrusivenessAttachment behaviorAnxiety symptomsAnxiety regulationSocial supportPossible intervention strategiesSignificant distressHigher youthYouthIntervention strategies
2016
Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism
Gordon I, Jack A, Pretzsch CM, Vander Wyk B, Leckman JF, Feldman R, Pelphrey KA. Intranasal Oxytocin Enhances Connectivity in the Neural Circuitry Supporting Social Motivation and Social Perception in Children with Autism. Scientific Reports 2016, 6: 35054. PMID: 27845765, PMCID: PMC5109935, DOI: 10.1038/srep35054.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderIntranasal oxytocinSocial motivationSocial perceptionSocial-emotional informationFunctional magnetic resonance imagingPlacebo-controlled crossover designBiological motionSocial stimuliAngry voicesSocial deficitsSpectrum disorderOT administrationMesolimbic reward pathwayBehavioral treatmentBrain rewardReduced connectivityBrain regionsReward pathwayCortical sitesRewardPerceptionMotivationOxytocinBrain sitesCross-generational influences on childhood anxiety disorders: pathways and mechanisms
Lebowitz ER, Leckman JF, Silverman WK, Feldman R. Cross-generational influences on childhood anxiety disorders: pathways and mechanisms. Journal Of Neural Transmission 2016, 123: 1053-1067. PMID: 27145763, PMCID: PMC5007197, DOI: 10.1007/s00702-016-1565-y.Peer-Reviewed Original ResearchConceptsAnxiety disordersChild anxiety treatment outcomeChild anxiety disordersChildhood anxiety disordersParent-based interventionsAnxiety treatment outcomesCross-generational influencesSocial referencingFamily accommodationChild anxietyParenting stylesVicarious learningOxytocinergic systemChildren's symptomsBehavioral systemsParental responsesParental anxietyMaternal anxietyAnxietyExistence of linksSevere distressDisordersPrenatal environmentTreatment outcomesResearch
2015
Salivary oxytocin in clinically anxious youth: Associations with separation anxiety and family accommodation
Lebowitz ER, Leckman JF, Feldman R, Zagoory-Sharon O, McDonald N, Silverman WK. Salivary oxytocin in clinically anxious youth: Associations with separation anxiety and family accommodation. Psychoneuroendocrinology 2015, 65: 35-43. PMID: 26716876, PMCID: PMC4895196, DOI: 10.1016/j.psyneuen.2015.12.007.Peer-Reviewed Original ResearchConceptsSalivary OT levelsFamily accommodationSeparation anxiety disorderYouth anxietyAnxiety disordersAnxious youthInterpersonal behaviorSeparation anxietyOT levelsDSM-5 anxiety disordersSeparation anxiety symptomsTreatment of anxietyNeuropeptide oxytocinSalivary OTClinical anxietyMaternal ratingsSalivary oxytocinAnxiety symptomsOxytocinergic systemRegulation of anxietyAnxious behaviorOwn behaviorAnxiety assessmentAnxietyParental involvementOxytocin-augmented labor and risk for autism in males
Weisman O, Agerbo E, Carter CS, Harris JC, Uldbjerg N, Henriksen TB, Thygesen M, Mortensen PB, Leckman JF, Dalsgaard S. Oxytocin-augmented labor and risk for autism in males. Behavioural Brain Research 2015, 284: 207-212. PMID: 25707712, DOI: 10.1016/j.bbr.2015.02.028.Peer-Reviewed Original ResearchConceptsSynthetic oxytocinInfant developmentICD-10 DCRSingleton live birthsAugmentation of laborAutistic disorderDose-dependent effectAugment laborMaternal exposureLive birthsModest associationEpidemiological analysisAdverse effectsOxytocinPlausible associationRiskMalesInconsistent findingsDisordersFuture studiesBirthAssociationAutismFindingsAugmentation
2013
Oxytocin enhances brain function in children with autism
Gordon I, Vander Wyk B, Bennett RH, Cordeaux C, Lucas MV, Eilbott JA, Zagoory-Sharon O, Leckman JF, Feldman R, Pelphrey KA. Oxytocin enhances brain function in children with autism. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 20953-20958. PMID: 24297883, PMCID: PMC3876263, DOI: 10.1073/pnas.1312857110.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSuperior temporal sulcusTemporal sulcusOrbitofrontal cortexLeft superior temporal sulcusMiddle frontal gyrusMedial prefrontal cortexRight orbitofrontal cortexSocial attunementSocial judgmentsMeaningful stimuliFrontal gyrusSpectrum disorderBrain activityPrefrontal cortexRight amygdalaSocial functioningFunctional MRIPremotor cortexHedonic evaluationBrain functionJudgmentsCortexChildrenOxytocinChapter Nine Neuroendocrine Aspects of Tourette Syndrome
Martino D, Macerollo A, Leckman JF. Chapter Nine Neuroendocrine Aspects of Tourette Syndrome. International Review Of Neurobiology 2013, 112: 239-279. PMID: 24295624, DOI: 10.1016/b978-0-12-411546-0.00009-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleHumansMaleNeurosecretory SystemsOxytocinSex CharacteristicsTourette SyndromeConceptsTourette syndromeObsessive-compulsive disorderStereotyped behaviorSubgroup of womenAction of testosteroneAnecdotal clinical evidenceDiurnal cortisol rhythmInjection of oxytocinStress steroid hormonesPreliminary evidenceAcute stress responseClinical evidenceAdrenal axisEstrogen levelsExogenous androgensGonadal hormonesCortisol rhythmNormal restorationAnimal modelsAndrogenic steroidsNeuroendocrine aspectsPatientsGender distributionBaseline activityNatural history
2012
Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity
Schneiderman I, Zagoory-Sharon O, Leckman JF, Feldman R. Oxytocin during the initial stages of romantic attachment: Relations to couples’ interactive reciprocity. Psychoneuroendocrinology 2012, 37: 1277-1285. PMID: 22281209, PMCID: PMC3936960, DOI: 10.1016/j.psyneuen.2011.12.021.Peer-Reviewed Original ResearchConceptsRomantic attachmentRomantic relationshipsNew loversRole of oxytocinParent-infant bondingBio-behavioral mechanismsHuman imaging studiesPositive affectAffectionate touchDyadic interactionsOxytocinergic systemBrain areasEmotional distressThree monthsDyadic statesImaging studiesRelationship durationOT levelsAdult HealthYoung adultsHigh individual stabilitySocial focusPlasma oxytocinOxytocinMonths
2011
Variations in Maternal Behavior—Oxytocin and Reward Pathways—Peripheral Measures Matter?!
Leckman JF. Variations in Maternal Behavior—Oxytocin and Reward Pathways—Peripheral Measures Matter?! Neuropsychopharmacology 2011, 36: 2587-2588. PMID: 22071897, PMCID: PMC3230502, DOI: 10.1038/npp.2011.201.Peer-Reviewed Original ResearchOxytocin and social motivation
Gordon I, Martin C, Feldman R, Leckman JF. Oxytocin and social motivation. Developmental Cognitive Neuroscience 2011, 1: 471-493. PMID: 21984889, PMCID: PMC3185363, DOI: 10.1016/j.dcn.2011.07.007.Peer-Reviewed Original ResearchConceptsSocial motivationCourse of developmentBiobehavioral systemsRole of oxytocinSocial creaturesSocial partnersSensory inputKey unresolved questionGonadal axisGastrointestinal tractStress response axisMotivationOTR expressionOxytocinReceptor systemBrainSalienceReproductive organsResponse axisDetection pathwaySystem functionExternal environmentPeripheral componentsUnresolved questionsHumans
2010
Oxytocin, cortisol, and triadic family interactions
Gordon I, Zagoory-Sharon O, Leckman JF, Feldman R. Oxytocin, cortisol, and triadic family interactions. Physiology & Behavior 2010, 101: 679-684. PMID: 20723553, DOI: 10.1016/j.physbeh.2010.08.008.Peer-Reviewed Original ResearchProlactin, Oxytocin, and the development of paternal behavior across the first six months of fatherhood
Gordon I, Zagoory-Sharon O, Leckman JF, Feldman R. Prolactin, Oxytocin, and the development of paternal behavior across the first six months of fatherhood. Hormones And Behavior 2010, 58: 513-518. PMID: 20399783, PMCID: PMC3247300, DOI: 10.1016/j.yhbeh.2010.04.007.Peer-Reviewed Original ResearchOxytocin and the Development of Parenting in Humans
Gordon I, Zagoory-Sharon O, Leckman JF, Feldman R. Oxytocin and the Development of Parenting in Humans. Biological Psychiatry 2010, 68: 377-382. PMID: 20359699, PMCID: PMC3943240, DOI: 10.1016/j.biopsych.2010.02.005.Peer-Reviewed Original Research
2008
Oxytocin and cortisol in romantically unattached young adults: Associations with bonding and psychological distress
Gordon I, Zagoory‐Sharon O, Schneiderman I, Leckman JF, Weller A, Feldman R. Oxytocin and cortisol in romantically unattached young adults: Associations with bonding and psychological distress. Psychophysiology 2008, 45: 349-352. PMID: 18266803, DOI: 10.1111/j.1469-8986.2008.00649.x.Peer-Reviewed Original ResearchConceptsPsychological distressHuman social affiliationSelf-report measuresYoung adultsInvolvement of oxytocinAttachment anxietyAdult representationsSocial affiliationOwn parentsSalivary cortisolPlasma oxytocinOT levelsDistressDepressive symptomsAnxietyOxytocinParentsAdultsCognitionRegression analysisLife spanRepresentationAttachmentCortisolExtensive researchGenes Controlling Affiliative Behavior as Candidate Genes for Autism
Yrigollen CM, Han SS, Kochetkova A, Babitz T, Chang JT, Volkmar FR, Leckman JF, Grigorenko EL. Genes Controlling Affiliative Behavior as Candidate Genes for Autism. Biological Psychiatry 2008, 63: 911-916. PMID: 18207134, PMCID: PMC2386897, DOI: 10.1016/j.biopsych.2007.11.015.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAsperger SyndromeAutistic DisorderBehaviorChildDopamine beta-HydroxylaseFamily HealthFemaleGenetic LinkageGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansMaleOrganizational AffiliationOxytocinProlactinProto-Oncogene Proteins c-fosReceptors, OxytocinReceptors, ProlactinConceptsHeterogeneous genetic factorsAllelic associationCandidate genesAssociation analysisGenetic linkageManifestation of ASDGenesGenetic variantsAllelic variantsFBAT softwareGenetic factorsComplex etiologyIndependent replicationNeurodevelopmental disordersOXTR geneAffiliative behaviorMultiple facetsVariantsPRLRPhenotypeHypothesis
2002
Maternal behavior and developmental psychopathology
Leckman JF, Herman AE. Maternal behavior and developmental psychopathology. Biological Psychiatry 2002, 51: 27-43. PMID: 11801229, DOI: 10.1016/s0006-3223(01)01277-x.Peer-Reviewed Original ResearchConceptsMaternal behaviorNeuronal nitric oxide synthaseEstrogen alpha receptorsNitric oxide synthaseMouse strain backgroundDopamine beta hydroxylaseGene knockout dataAnimal model systemsGene knockout studiesGene knockout technologyPeer-reviewed journalsOxide synthaseAlpha receptorsBehavioral deficitsSearch of literatureBeta hydroxylaseDisease pathogenesisTranscription factorsMolecular basisGenetic factorsKnockout studiesSpecific genesKnockout dataKnockout technologyStrain background
1999
Oxytocin, vasopressin, and autism: is there a connection?
Insel T, O’Brien D, Leckman J. Oxytocin, vasopressin, and autism: is there a connection? Biological Psychiatry 1999, 45: 145-157. PMID: 9951561, DOI: 10.1016/s0006-3223(98)00142-5.Peer-Reviewed Original ResearchConceptsVasopressin neurotransmissionAvailable preclinical evidencePreclinical evidenceClinical studiesAnimal studiesRodent brainPeptide receptorFeatures of autismOxytocinVasopressinGenetic disordersCompulsive behaviorsNeurotransmissionNormal expressionDevelopmental disordersSocial impairmentReceptorsCommunication deficitsDisordersSpecies-typical social behaviorsNeurobiological approachAutismEvidenceUnique effectsExpression