2004
Altered Interhemispheric Connectivity in Individuals With Tourettes Disorder
Plessen KJ, Wentzel-Larsen T, Hugdahl K, Feineigle P, Klein J, Staib LH, Leckman JF, Bansal R, Peterson BS. Altered Interhemispheric Connectivity in Individuals With Tourettes Disorder. American Journal Of Psychiatry 2004, 161: 2028-2037. PMID: 15514403, DOI: 10.1176/appi.ajp.161.11.2028.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAttention Deficit Disorder with HyperactivityCase-Control StudiesCerebral CortexComorbidityCorpus CallosumCross-Sectional StudiesFunctional LateralityHumansMagnetic Resonance ImagingMaleNeuronal PlasticityObsessive-Compulsive DisorderPrefrontal CortexSeverity of Illness IndexTourette SyndromeConceptsCorpus callosum sizeCallosum sizeTourette's disorderCorpus callosumCerebral hemispheresComparison subjectsCross-sectional case-control studyMidsagittal corpus callosum areaCorpus callosum areaCase-control studyEffects of medicationAge 30 yearsCortical inhibitory interneuronsHigh-resolution magnetic resonanceHealthy comparison subjectsMajor commissureComorbid illnessesTic symptomsOrbitofrontal cortical volumeCortical volumeInhibitory interneuronsInterhemispheric connectivityInhibitory inputsTic severityPrior evidence
1995
[123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder
Malison RT, McDougle CJ, van Dyck CH, Scahill L, Baldwin RM, Seibyl JP, Price LH, Leckman JF, Innis RB. [123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder. American Journal Of Psychiatry 1995, 152: 1359-1361. PMID: 7653693, DOI: 10.1176/ajp.152.9.1359.Peer-Reviewed Original ResearchConceptsTourette's disorderComparison subjectsDisorder patientsGender-matched healthy comparison subjectsStriatal dopamine transporter bindingStriatal dopamine transporter densityCIT SPECT imagingDopamine transporter levelsDopamine transporter densityDopamine transporter bindingPresynaptic dopamine functionTourette's disorder patientsPost-mortem findingsHealthy comparison subjectsSingle photon emissionBeta-carbomethoxy-3 betaAdult patientsCIT bindingPost-mortem resultsTransporter bindingDopamine functionTransporter densityTransporter levelsSPECT imagingDisordersA family study of obsessive-compulsive disorder
Pauls DL, Alsobrook JP, Goodman W, Rasmussen S, Leckman JF. A family study of obsessive-compulsive disorder. American Journal Of Psychiatry 1995, 152: 76-84. PMID: 7802125, DOI: 10.1176/ajp.152.1.76.Peer-Reviewed Original ResearchConceptsFirst-degree relativesObsessive-compulsive disorderComparison subjectsSubthreshold obsessive-compulsive disorderAvailable first-degree relativesGilles de la Tourette's syndromeRelatives of probandsLa Tourette's syndromeFamily studiesBest-estimate diagnosesRate of ticsTic disordersFamily historyHigh riskTourette syndromeChronic ticsFemale probandsEarly onsetFamilial typeDisordersUnaffected subjectsProbandsSyndromeStructured interviewsSubjects