2021
Clinical Epidemiology and Outcomes of Pediatric Musculoskeletal Infections
Yi J, Wood JB, Creech CB, Williams D, Jimenez-Truque N, Yildirim I, Sederdahl B, Daugherty M, Hussaini L, Munye M, Tomashek KM, Focht C, Watson N, Anderson EJ, Thomsen I. Clinical Epidemiology and Outcomes of Pediatric Musculoskeletal Infections. The Journal Of Pediatrics 2021, 234: 236-244.e2. PMID: 33771580, PMCID: PMC8238832, DOI: 10.1016/j.jpeds.2021.03.028.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdministration, OralAdolescentAnti-Bacterial AgentsArthritis, InfectiousChildChild, PreschoolCombined Modality TherapyFemaleGram-Negative Bacterial InfectionsGram-Positive Bacterial InfectionsHumansInfantLogistic ModelsMaleMethicillin-Resistant Staphylococcus aureusOrthopedic ProceduresOsteomyelitisRetrospective StudiesStaphylococcal InfectionsTreatment OutcomeUnited StatesConceptsOsteomyelitis/septic arthritisAcute hematogenous osteomyelitisMethicillin-resistant S aureusSeptic arthritisHematogenous osteomyelitisTreatment failureS aureusOral therapyAntibiotic therapyMusculoskeletal infectionsHigher oddsPediatric musculoskeletal infectionsLonger hospital stayOral antibiotic therapyRetrospective cohort studyTreatment-related complicationsTreatment-associated complicationsHospital stayPediatric infectionsCohort studyParenteral therapyTreatment complicationsIntensive careRecurrent infectionsWorse outcomes
2019
Effect of Concomitant Antibiotic and Vaccine Administration on Serologic Responses to Rotavirus Vaccine
Anderson EJ, Lopman B, Yi J, Libster R, Creech CB, El-Khorazaty J, Baqar S, Yildirim I, Kao C, Rouphael N, Shane AL, Edwards K. Effect of Concomitant Antibiotic and Vaccine Administration on Serologic Responses to Rotavirus Vaccine. Journal Of The Pediatric Infectious Diseases Society 2019, 9: 479-482. PMID: 31237948, PMCID: PMC7495907, DOI: 10.1093/jpids/piz044.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnti-Bacterial AgentsChildFemaleHumansImmunoglobulin AMaleRotavirus InfectionsRotavirus VaccinesChest Wall Swelling in a Child With Pneumonia
McAteer J, Wang LA, Chan A, Raabe VN, Kamat P, Freeman A, Yildirim I. Chest Wall Swelling in a Child With Pneumonia. Clinical Pediatrics 2019, 58: 1462-1465. PMID: 31165640, DOI: 10.1177/0009922819853004.Peer-Reviewed Original Research
2012
Evolving Picture of Invasive Pneumococcal Disease in Massachusetts Children
Yildirim I, Stevenson A, Hsu KK, Pelton SI. Evolving Picture of Invasive Pneumococcal Disease in Massachusetts Children. The Pediatric Infectious Disease Journal 2012, 31: 1016-1021. PMID: 22673142, DOI: 10.1097/inf.0b013e3182615615.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Bacterial AgentsChildChild, PreschoolCluster AnalysisFemaleHeptavalent Pneumococcal Conjugate VaccineHumansIncidenceInfantMaleMassachusettsMeningitis, PneumococcalMicrobial Sensitivity TestsMultilocus Sequence TypingPneumococcal VaccinesProspective StudiesSepsisSerotypingStreptococcus pneumoniaeConceptsInvasive pneumococcal diseasePneumococcal conjugate vaccine serotypesPneumococcal conjugate vaccineIPD incidence ratesMassachusetts childrenPCV7 eraIPD casesPneumococcal diseaseConjugate vaccineVaccine serotypesSerotype 19AIncidence rateCases of IPDChildhood invasive pneumococcal diseaseHeptavalent pneumococcal conjugate vaccinePopulation-based surveillanceOverall IPD incidence ratesCeftriaxone-resistant isolatesYears of ageAntimicrobial susceptibility testingBacteremic pneumoniaPCV7 serotypesMultilocus sequence typingNonvaccine serotypesClinical presentation
2010
A Case Report of Thrombocytopenia‐associated Multiple Organ Failure Secondary to Salmonella enterica Serotype Typhi Infection in a Pediatric Patient: Successful Treatment With Plasma Exchange
Yildirim I, Ceyhan M, Bayrakci B, Uysal M, Kuskonmaz B, Ozaltin F. A Case Report of Thrombocytopenia‐associated Multiple Organ Failure Secondary to Salmonella enterica Serotype Typhi Infection in a Pediatric Patient: Successful Treatment With Plasma Exchange. Therapeutic Apheresis And Dialysis 2010, 14: 226-229. PMID: 20438547, DOI: 10.1111/j.1744-9987.2009.00714.x.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsChildHumansMaleMultiple Organ FailurePlasma ExchangeSalmonella typhiSepsisThrombocytopeniaTreatment OutcomeTyphoid FeverConceptsSalmonella enterica serotype Typhi infectionMultiple organ failureS. typhi infectionTyphi infectionOrgan failurePlasma exchangeAggressive antimicrobial therapyPlasma exchange therapyLife-saving interventionsConventional supportive measuresSevere sepsisExchange therapyPediatric patientsCase reportAntimicrobial therapySuccessful treatmentSupportive measuresMortality rateAntimicrobial treatmentPatientsThrombocytopeniaInfectionTherapyHigher proportionTreatment
2008
A Chryseobacterium meningosepticum outbreak observed in 3 clusters involving both neonatal and non-neonatal pediatric patients
Ceyhan M, Yıldırım I, Tekelı A, Yurdakok M, Us E, Altun B, Kutluk T, Cengiz AB, Gurbuz V, Barın C, Bagdat A, Cetınkaya D, Gur D, Tuncel O. A Chryseobacterium meningosepticum outbreak observed in 3 clusters involving both neonatal and non-neonatal pediatric patients. American Journal Of Infection Control 2008, 36: 453-457. PMID: 18675153, DOI: 10.1016/j.ajic.2007.09.008.Peer-Reviewed Original ResearchMeSH KeywordsAnti-Bacterial AgentsChryseobacteriumCluster AnalysisCross InfectionDisease OutbreaksDNA FingerprintingDNA, BacterialEnvironmental MicrobiologyFemaleFlavobacteriaceae InfectionsGenotypeHandHealth PersonnelHospital UnitsHumansInfantInfant, NewbornMaleMicrobial Sensitivity TestsRandom Amplified Polymorphic DNA TechniqueTurkeyConceptsNon-neonatal pediatric patientsHealth care workers' handsNeonatal intensive care unitTertiary health centerEnterobacterial repetitive intergenic consensus sequence polymerase chain reactionIntensive care unitInfection control measuresMeningosepticum infectionOlder patientsPediatric patientsPremature infantsCare unitPediatric wardPolymerase chain reactionHand culturesHealth centersIndex patientsNosocomial infectionsAmbu bagPatientsEtiologic agentAntimicrobial treatmentPowdered infant formulaOutbreak investigationInfant formulaComparison of the effect of benzathine penicillin G, clarithromycin, cefprozil and amoxicillin/clavulanate on the bacteriological response and throat flora in group A beta hemolytic streptococcal tonsillopharyngitis.
Yildirim I, Ceyhan M, Gür D, Kaymakoğlu I. Comparison of the effect of benzathine penicillin G, clarithromycin, cefprozil and amoxicillin/clavulanate on the bacteriological response and throat flora in group A beta hemolytic streptococcal tonsillopharyngitis. The Turkish Journal Of Pediatrics 2008, 50: 120-5. PMID: 18664074.Peer-Reviewed Original ResearchConceptsAlpha-hemolytic streptococciBeta-lactamase productionBeta-hemolytic streptococcal tonsillopharyngitisBenzathine penicillin GStreptococcal tonsillopharyngitisInhibitory effectBacteriological cure rateEffect of clarithromycinAmoxicillin/clavulanatePenicillin GYears of ageProminent inhibitory effectAnaerobic bacteriaBacteriological responseCefprozil groupClarithromycin groupGABHS eradicationGABHS tonsillopharyngitisOral clarithromycinPharyngeal microfloraAmoxicillin/Lactamase productionThroat swabsCure rateThroat floraPIPERACILLIN/TAZOBACTAM PLUS AMIKACIN VERSUS CARBAPENEM MONOTHERAPY AS EMPIRICAL TREATMENT OF FEBRILE NEUTROPENIA IN CHILDHOOD HEMATOLOGICAL MALIGNANCIES
Yildirim I, Aytac S, Ceyhan M, Cetin M, Tuncer M, Cengiz AB, Secmeer G, Yetgin S. PIPERACILLIN/TAZOBACTAM PLUS AMIKACIN VERSUS CARBAPENEM MONOTHERAPY AS EMPIRICAL TREATMENT OF FEBRILE NEUTROPENIA IN CHILDHOOD HEMATOLOGICAL MALIGNANCIES. Pediatric Hematology And Oncology 2008, 25: 291-299. PMID: 18484473, DOI: 10.1080/08880010802016847.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmikacinAnti-Bacterial AgentsBacteriaBacterial InfectionsCarbapenemsChildChild, PreschoolDrug Therapy, CombinationEnzyme InhibitorsFemaleHumansLeukemia, Myeloid, AcuteMaleNeutropeniaPenicillanic AcidPiperacillinPiperacillin, Tazobactam Drug CombinationPrecursor Cell Lymphoblastic Leukemia-LymphomaConceptsFebrile neutropenic episodesDuration of feverPiperacillin/tazobactamCarbapenem monotherapyNeutropenic episodesHematological malignanciesFebrile neutropeniaEmpirical treatmentInitial empirical regimenInfection-related mortalityPediatric hematological malignanciesChildhood hematological malignanciesAcute lymphoblastic leukemiaAcute myeloblastic leukemiaAmikacin combinationEmpirical regimenPTA groupCarbapenem groupLymphoblastic leukemiaTreatment modificationAntimicrobial therapyClinical trialsTreatment successAdditional antibioticsCommon cause