Featured Publications
Relationship between the use of nonpharmaceutical interventions and COVID-19 vaccination among U.S. child care providers: A prospective cohort study
Patel KM, Shafiq M, Malik AA, Cobanoglu A, Klotz M, Eric Humphries J, Lee A, Murray T, Wilkinson D, Yildirim I, Elharake JA, Diaz R, Rojas R, Kuperwajs Cohen A, Omer SB, Gilliam WS. Relationship between the use of nonpharmaceutical interventions and COVID-19 vaccination among U.S. child care providers: A prospective cohort study. Vaccine 2022, 40: 4098-4104. PMID: 35660329, PMCID: PMC9135692, DOI: 10.1016/j.vaccine.2022.05.064.Peer-Reviewed Original ResearchConceptsCOVID-19 vaccinationProspective cohort studyCare providersNonpharmaceutical interventionsChild care providersCohort studyLikelihood of vaccinationPreventative health behaviorsVaccinationHealth behaviorsCare programMandatory vaccinationSignificant associationVaccine mandatesDistrict of ColumbiaLarge healthInterventionPandemic controlCOVID-19Child care programsProvidersEmail surveyNonadherenceMeasures
2022
Association of Child Masking With COVID-19–Related Closures in US Childcare Programs
Murray TS, Malik AA, Shafiq M, Lee A, Harris C, Klotz M, Humphries JE, Patel KM, Wilkinson D, Yildirim I, Elharake JA, Diaz R, Reyes C, Omer SB, Gilliam WS. Association of Child Masking With COVID-19–Related Closures in US Childcare Programs. JAMA Network Open 2022, 5: e2141227. PMID: 35084484, PMCID: PMC8796014, DOI: 10.1001/jamanetworkopen.2021.41227.Peer-Reviewed Original ResearchConceptsCOVID-19 casesLower riskImportant public health policy implicationsCOVID-19-related closuresPublic health policy implicationsChildren 2 yearsElectronic survey studyCenter-based childcare programsHealth policy implicationsSARS-CoV-2Survey studyChildcare professionalsMAIN OUTCOMEProgram closureHealth policyStudy periodRobust SEsBaselineChildcare programsCOVID-19Young childrenChildcare settingsChildrenPhysical distancingAssociation
2021
Respiratory Syncytial Virus–Associated Mortality Among Young Infants in Karachi, Pakistan: A Prospective Postmortem Surveillance Study
Kazi AM, Aguolu OG, Mughis W, Ahsan N, Jamal S, Khan A, Qureshi HM, Yildirim I, Malik FA, Omer SB. Respiratory Syncytial Virus–Associated Mortality Among Young Infants in Karachi, Pakistan: A Prospective Postmortem Surveillance Study. Clinical Infectious Diseases 2021, 73: s203-s209. PMID: 34472574, PMCID: PMC8411247, DOI: 10.1093/cid/ciab488.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusRespiratory symptomsInfant deathRSV seasonalityRole of RSVYoung infantsPresence of RSVMultivariable logistic regression analysisMaternal immunization strategiesSignificant mortality burdenVaccine-hesitant populationYoung infant deathsMultivariable logistic regressionCold-like symptomsSignificant predictorsLogistic regression analysisPostneonatal ageRSV mortalityRSV seasonMaternal immunizationInfant morbidityNasopharyngeal specimensNasopharyngeal swabsSyncytial virusRespiratory illness
2020
The burden of respiratory syncytial virus infections among children with sickle cell disease
Rostad CA, Maillis AN, Lai K, Bakshi N, Jerris RC, Lane PA, Yee ME, Yildirim I. The burden of respiratory syncytial virus infections among children with sickle cell disease. Pediatric Blood & Cancer 2020, 68: e28759. PMID: 33034160, PMCID: PMC8246443, DOI: 10.1002/pbc.28759.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusSickle cell diseaseRespiratory viral panelRSV-positive casesRSV infectionAnnual incidenceHospitalization ratesCell diseaseBurden of RSVPediatric lower respiratory tract infectionsLaboratory-confirmed RSV infectionRespiratory syncytial virus infectionRSV-related hospitalization rateLower respiratory tract infectionsRSV positive testRSV-negative childrenRSV-negative patientsAcute chest syndromeSyncytial virus infectionRespiratory tract infectionsAverage annual incidenceMultivariate logistic regressionConfidence intervalsCase-control studyOutcome of childrenInfluenza vaccine effectiveness and disease burden in children and adolescents with sickle cell disease: 2012‐2017
Kao CM, Lai K, McAteer JM, Elmontser M, Quincer EM, Yee MEM, Tippet A, Jerris RC, Lane PA, Anderson EJ, Bakshi N, Yildirim I. Influenza vaccine effectiveness and disease burden in children and adolescents with sickle cell disease: 2012‐2017. Pediatric Blood & Cancer 2020, 67: e28358. PMID: 32469138, PMCID: PMC8221251, DOI: 10.1002/pbc.28358.Peer-Reviewed Original ResearchConceptsInfluenza vaccine effectivenessSickle cell diseaseVaccine effectivenessYears of ageInfluenza infectionOdds ratioCell diseaseLaboratory-confirmed influenza infectionSeasonal influenza vaccine effectivenessTest-negative case-control study designAdjusted vaccine effectivenessAdjusted VE estimatesInfluenza-positive casesOverall vaccine effectivenessAcute chest syndromeBurden of influenzaPatients 6 monthsMulticenter prospective studyTest-negative controlsAnnual influenza vaccineCase-control study designConfidence intervalsLogistic regression modelsChest syndromeInfluenza season
2018
Assessment and Validation of Syndromic Case definitions for Respiratory Syncytial Virus Testing in a Low Resource Population
Omer SB, Bednarczyk R, Kazi M, Guterman LB, Aziz F, Allen KE, Yildirim I, Ali SA. Assessment and Validation of Syndromic Case definitions for Respiratory Syncytial Virus Testing in a Low Resource Population. The Pediatric Infectious Disease Journal 2018, Publish Ahead of Print: &na;. PMID: 30074977, PMCID: PMC6437080, DOI: 10.1097/inf.0000000000002159.Peer-Reviewed Original ResearchConceptsCommunity-based surveillanceCase definitionRespiratory syncytial virus testingRespiratory syncytial virus infectionSyncytial virus infectionLow-resource populationsStandardized case definitionsSyndromic case definitionsResource-limited settingsVaccine evaluationVirus infectionVirus testingYoung infantsVirus control strategiesModest specificitySurveillanceCyanosisWheezeApneaInfantsInfection
2012
Evolving Picture of Invasive Pneumococcal Disease in Massachusetts Children
Yildirim I, Stevenson A, Hsu KK, Pelton SI. Evolving Picture of Invasive Pneumococcal Disease in Massachusetts Children. The Pediatric Infectious Disease Journal 2012, 31: 1016-1021. PMID: 22673142, DOI: 10.1097/inf.0b013e3182615615.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Bacterial AgentsChildChild, PreschoolCluster AnalysisFemaleHeptavalent Pneumococcal Conjugate VaccineHumansIncidenceInfantMaleMassachusettsMeningitis, PneumococcalMicrobial Sensitivity TestsMultilocus Sequence TypingPneumococcal VaccinesProspective StudiesSepsisSerotypingStreptococcus pneumoniaeConceptsInvasive pneumococcal diseasePneumococcal conjugate vaccine serotypesPneumococcal conjugate vaccineIPD incidence ratesMassachusetts childrenPCV7 eraIPD casesPneumococcal diseaseConjugate vaccineVaccine serotypesSerotype 19AIncidence rateCases of IPDChildhood invasive pneumococcal diseaseHeptavalent pneumococcal conjugate vaccinePopulation-based surveillanceOverall IPD incidence ratesCeftriaxone-resistant isolatesYears of ageAntimicrobial susceptibility testingBacteremic pneumoniaPCV7 serotypesMultilocus sequence typingNonvaccine serotypesClinical presentation
2009
Multicenter Prospective Study on the Burden of Rotavirus Gastroenteritis in Turkey, 2005–2006: A Hospital-Based Study
Ceyhan M, Alhan E, Salman N, Kurugol Z, Yildirim I, Celik U, Keser M, Koturoglu G, Tezer H, Bulbul EK, Karabocuoglu M, Halicioglu O, Anis S, Pawinski R. Multicenter Prospective Study on the Burden of Rotavirus Gastroenteritis in Turkey, 2005–2006: A Hospital-Based Study. The Journal Of Infectious Diseases 2009, 200: s234-s238. PMID: 19817603, DOI: 10.1086/605056.Peer-Reviewed Original ResearchConceptsRotavirus gastroenteritisWorld Health Organization's generic protocolRotavirus-positive childrenPrevalence of rotavirusMulticenter prospective studyRotavirus vaccineProspective surveillanceProspective studyDisease burdenMortality rateGastroenteritisPrevalent strainsRotavirusIndividual centersChildrenBurdenMain causeHospitalizationHospitalInfantsVaccineYearsPrevalenceComparison of nasopharyngeal culture, polymerase chain reaction (PCR) and serological test for diagnosis of pertussis.
Cengiz AB, Yildirim I, Ceyhan M, Seçmeer G, Gür D, Kara A. Comparison of nasopharyngeal culture, polymerase chain reaction (PCR) and serological test for diagnosis of pertussis. The Turkish Journal Of Pediatrics 2009, 51: 309-16. PMID: 19950836.Peer-Reviewed Original ResearchConceptsDiagnosis of pertussisFirst serum samplePolymerase chain reactionIgG antibodiesSerum samplesNasopharyngeal culturesPertussis toxinInitial examinationHacettepe University Ihsan Doğramaci Children's HospitalB. pertussisAnti-pertussis antibodiesSecond serum samplePCR-positive patientsB. pertussis antigensChain reactionTypes of antibodiesBordetella pertussis cultureAntibody positivityParoxysmal coughPertussis antigensVaccination historyAntibody levelsChildren's HospitalProspective studyInspiratory whoop
2008
A Prospective Study of Etiology of Childhood Acute Bacterial Meningitis, Turkey - Volume 14, Number 7—July 2008 - Emerging Infectious Diseases journal - CDC
Ceyhan M, Yildirim I, Balmer P, Borrow R, Dikici B, Turgut M, Kurt N, Aydogan A, Ecevit C, Anlar Y, Gulumser O, Tanir G, Salman N, Gurler N, Hatipoglu N, Hacimustafaoglu M, Celebi S, Coskun Y, Alhan E, Celik U, Camcioglu Y, Secmeer G, Gur D, Gray S. A Prospective Study of Etiology of Childhood Acute Bacterial Meningitis, Turkey - Volume 14, Number 7—July 2008 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2008, 14: 1089-1096. PMID: 18598630, PMCID: PMC2600347, DOI: 10.3201/eid1407.070938.Peer-Reviewed Original ResearchConceptsAcute bacterial meningitisBacterial meningitisSerogroup WCSF samplesChildhood acute bacterial meningitisHaemophilus influenzae type bInfectious Diseases journal - CDCEtiology of meningitisInfluenzae type bCerebrospinal fluid samplesPCR-positive samplesProspective studyBacterial etiologyMeningococcal diseaseVaccination policyCost of diseaseMeningitisS. pneumoniaeStreptococcus pneumoniaeClinical diagnosisEtiologyN. meningitidisNeisseria meningitidisDiseaseType BA prospective comparative study of the relationship between different types of ring and microbial hand colonization among pediatric intensive care unit nurses
Yildirim I, Ceyhan M, Cengiz AB, Bagdat A, Barin C, Kutluk T, Gur D. A prospective comparative study of the relationship between different types of ring and microbial hand colonization among pediatric intensive care unit nurses. International Journal Of Nursing Studies 2008, 45: 1572-1576. PMID: 18479684, DOI: 10.1016/j.ijnurstu.2008.02.010.Peer-Reviewed Original ResearchMeSH Keywords1-PropanolClinical Nursing ResearchColony Count, MicrobialCross InfectionDisinfectionGram-Negative BacteriaGram-Positive BacteriaHandHand DisinfectionHumansInfectious Disease Transmission, Professional-to-PatientIntensive Care Units, PediatricJewelryNursing Staff, HospitalProspective StudiesStatistics, NonparametricConceptsAlcohol-based hand disinfectionHand disinfectionPediatric intensive care unit nursesIntensive care unit nursesAlcohol-based hand disinfectantsPotential nosocomial pathogensIntensive care settingIntensive care unitProspective comparative studyCare unit nursesBacterial colonizationDirect patient careAlcohol-based rubsColony countsHand colonizationTotal bacterial colonizationCare unitPediatric hospitalUnit nursesHand culturesCare settingsHand contaminationHand disinfectantsSterile glovesNosocomial pathogenComparing body temperature measurements by mothers and physicians using mercury-in-glass, digital mercury and infrared tympanic membrane thermometers in healthy newborn babies.
Cultu O, Yildirim I, Ceyhan M, Korkmaz A, Yurdakök M, Karaağaoğlu E, Seçmeer G. Comparing body temperature measurements by mothers and physicians using mercury-in-glass, digital mercury and infrared tympanic membrane thermometers in healthy newborn babies. The Turkish Journal Of Pediatrics 2008, 50: 354-8. PMID: 19014049.Peer-Reviewed Original ResearchMeSH KeywordsBody TemperatureEducational StatusEquipment DesignFemaleHumansInfant, NewbornMaleMothersPhysiciansProspective StudiesThermometersConceptsNewborn babiesTympanic membrane thermometerEducational levelHealthy newborn babiesHealth care workersBody temperatureBody temperature changesHealthy newbornsProspective studyCare workersMedical carePediatriciansPrevious childIntraclass coefficientAbsolute differencePhysiciansTympanic thermometer measurementsMothersTympanic thermometerBody temperature measurementPresence of childrenBabiesDegrees CChildrenThermometer readings