2023
Incidence of cytomegalovirus DNAemia in pediatric kidney, liver, and heart transplant recipients: Efficacy and risk factors associated with failure of weight‐based dosed valganciclovir prophylaxis
Liverman R, Serluco A, Nance G, George R, Rodriguez D, Deshpande S, Mao C, Garro R, Yildirim I. Incidence of cytomegalovirus DNAemia in pediatric kidney, liver, and heart transplant recipients: Efficacy and risk factors associated with failure of weight‐based dosed valganciclovir prophylaxis. Pediatric Transplantation 2023, 27: e14493. PMID: 36945819, DOI: 10.1111/petr.14493.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsPediatric solid organ transplant recipientsCytomegalovirus DNAemiaValganciclovir prophylaxisDose reductionRisk factorsTransplant recipientsImpact of dose adjustmentsRisk factors associated with failureFactors associated with failureOrgan transplant recipientsHeart transplant recipientsIndependent risk factorRetrospective cohort studyAssociated with morbidityCMV DNAemiaCytomegalovirus eventsValganciclovir dosingImmunosuppressive therapyDose adjustmentYounger age groupsDNAemiaValganciclovirRisk stratificationAdverse events
2022
Vaccination in pediatric solid organ transplant: A primer for the immunizing clinician
Chen JK, Cheng J, Liverman R, Serluco A, Corbo H, Yildirim I. Vaccination in pediatric solid organ transplant: A primer for the immunizing clinician. Clinical Transplantation 2022, 36: e14577. PMID: 34997642, DOI: 10.1111/ctr.14577.Peer-Reviewed Original ResearchConceptsVaccine-preventable illnessesPediatric solid organ transplant recipientsSolid organ transplant recipientsPediatric solid organ transplantCorrect immunization schedulesPrevention's Advisory CommitteeOrgan transplant recipientsSolid organ transplantsInfectious Diseases SocietyTime of transplantTransplant recipientsDiseases SocietyVaccine recommendationsIncomplete immunizationImmunization scheduleAntibody titersInadequate responseOrgan transplantsElevated riskPreventable illnessMultiple guidelinesVaccine managementRapid catchDisease controlAmerican Society
2021
#77: Impact of Targeted Tacrolimus Levels on BK Polyomavirus DNAemia Among Pediatric Kidney Transplant Recipients
Yildirim I, Liverman R, Serluco S, George R, Garro R, Winterberg P. #77: Impact of Targeted Tacrolimus Levels on BK Polyomavirus DNAemia Among Pediatric Kidney Transplant Recipients. Journal Of The Pediatric Infectious Diseases Society 2021, 10: s4-s4. DOI: 10.1093/jpids/piaa170.011.Peer-Reviewed Original ResearchPost-intervention cohortKidney transplant recipientsTacrolimus levelsTransplant recipientsKidney transplantPediatric kidney transplant recipientsPre-intervention cohortTacrolimus target levelsQuality improvement studyAllograft dysfunctionBK viremiaGraft lossImmunosuppression reductionUncontrolled viremiaBK nephropathyInfectious complicationsKidney transplantationMedian ageSerious complicationsMedian timeBK polyomavirusIncidence rateDNAemiaTrough targetsProspective monitoring
2020
Brincidofovir for the treatment of human adenovirus infection in pediatric solid organ transplant recipients: A case series
Londeree J, Winterberg PD, Garro R, George RP, Shin S, Liverman R, Serluco A, Romero R, Yildirim I. Brincidofovir for the treatment of human adenovirus infection in pediatric solid organ transplant recipients: A case series. Pediatric Transplantation 2020, 24: e13769. PMID: 32558134, DOI: 10.1111/petr.13769.Peer-Reviewed Original ResearchConceptsPediatric SOT recipientsSOT recipientsCase seriesSevere diseasePediatric solid organ transplant recipientsSolid organ transplant recipientsType of allograftMainstay of treatmentOrgan transplant recipientsSeverity of diseaseHuman adenovirus infectionHAdV diseaseHAdV viremiaPediatric recipientsTransplant recipientsHAdV infectionDisease courseAntiviral therapySignificant morbidityDisease presentationUS FDAAdenovirus infectionBrincidofovirDiseaseRecipients
2019
Cryptosporidiosis among solid organ transplant recipient attendees at a summer camp
McAteer J, Jernigan S, Mao C, Gonzalez MD, Watson RJ, Liverman R, Angelo M, M. H, Shane A, Yildirim I. Cryptosporidiosis among solid organ transplant recipient attendees at a summer camp. Pediatric Transplantation 2019, 24: e13649. PMID: 31885132, DOI: 10.1111/petr.13649.Peer-Reviewed Original ResearchConceptsTransplant recipientsSolid organ transplant recipientsKidney transplant recipientsRetrospective cohort studyOrgan transplant recipientsPediatric transplant recipientsOverall attack rateAcute rejection eventsLong-term interventionsImmunosuppressive therapySymptom durationCohort studyRisk factorsNotable burdenStool specimensCryptosporidiosis infectionEtiologic agentRejection eventsAttack rateFurther outbreaksInfectionRecipientsCryptosporidium hominisCryptosporidiosisOutbreakSirolimus‐associated pericardial effusion with cardiac tamponade and interstitial pneumonitis in a hematopoietic stem cell transplant recipient
Joo SJ, Yildirim I, Stenger EO, Anderson EJ. Sirolimus‐associated pericardial effusion with cardiac tamponade and interstitial pneumonitis in a hematopoietic stem cell transplant recipient. Pediatric Transplantation 2019, 23: e13425. PMID: 31012209, DOI: 10.1111/petr.13425.Peer-Reviewed Original ResearchConceptsHSCT patientsCardiac tamponadeInterstitial pneumonitisPericardial effusionAllogeneic hematopoietic stem cell transplant patientsHematopoietic stem cell transplant recipientsHematopoietic stem cell transplant patientsStem cell transplant patientsStem cell transplant recipientsAllogeneic HSCT patientsCell transplant recipientsLife-threatening complicationsCell transplant patientsTreatment of graftInvasive fungal infectionsGVHD prophylaxisHost diseaseTransplant patientsTransplant recipientsSirolimus useRapamycin inhibitorsPotent immunosuppressantPatientsFungal infectionsMammalian target
2018
Impact of Pharmacy-Initiated Interventions on Influenza Vaccination Rates in Pediatric Solid Organ Transplant Recipients
Gattis S, Yildirim I, Shane AL, Serluco S, McCracken C, Liverman R. Impact of Pharmacy-Initiated Interventions on Influenza Vaccination Rates in Pediatric Solid Organ Transplant Recipients. Journal Of The Pediatric Infectious Diseases Society 2018, 8: 525-530. PMID: 30307524, DOI: 10.1093/jpids/piy095.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsPediatric SOT recipientsInfluenza vaccination ratesOrgan transplant recipientsSOT recipientsTransplant recipientsInfluenza infectionVaccination ratesVaccination coveragePediatric solid organ transplant recipientsSubsequent graft dysfunctionHeart transplant recipientsInfluenza vaccination coveragePre-post study designNumber of patientsRate of vaccinationGraft dysfunctionInfluenza immunizationInfluenza vaccinationChart reviewPharmacy interventionsMedian timeVaccine coverageTransplant servicesInfluenza ratesNecrotizing fasciitis caused by Mucor indicus in a pediatric bone marrow transplant recipient
Bloch D, Gonzalez MD, Haight A, Abramowsky C, Yildirim I. Necrotizing fasciitis caused by Mucor indicus in a pediatric bone marrow transplant recipient. Pediatric Transplantation 2018, 22: e13294. PMID: 30246483, PMCID: PMC6460914, DOI: 10.1111/petr.13294.Peer-Reviewed Original ResearchConceptsPediatric bone marrow transplant recipientsBone marrow transplant recipientsMarrow transplant recipientsLiposomal amphotericin BSubcutaneous cellular tissueMultiple debridementsTransplant recipientsCase reportRare fungal organismRisk factorsAmphotericin BSusceptibility testingFasciitisFungal organismsAnaerobic bacteria