2024
Evaluation of Immunoglobulin A Enzyme Immunoassays to Detect Primary Respiratory Syncytial Virus Infection in Infants and Young Children
Sankaranarayanan R, Ha B, Sun H, Liu K, Jadhao S, Hussaini L, McCracken C, Gibson T, Yildirim I, Yi J, Stephens K, Korski C, Kao C, Rostad C, Anderson E, Anderson L. Evaluation of Immunoglobulin A Enzyme Immunoassays to Detect Primary Respiratory Syncytial Virus Infection in Infants and Young Children. The Journal Of Infectious Diseases 2024, jiae514. PMID: 39575588, DOI: 10.1093/infdis/jiae514.Peer-Reviewed Original ResearchRespiratory syncytial virus infectionRespiratory syncytial virusIgA enzyme immunoassayRespiratory syncytial virus seasonDocumented RSV infectionPlasma specimensEnzyme immunoassayRSV infectionRSV-FRespiratory syncytial virus antibodiesGroup DRespiratory syncytial virus FCord blood specimensGroup C specimensAcute lower respiratory infectionGroup B specimensPresence of maternal antibodiesLower respiratory infectionsImmunoglobulin G antibodiesRSV antibodiesNegative control groupSyncytial virusAntibody enzyme immunoassayRespiratory infectionsGroup B
2020
The burden of respiratory syncytial virus infections among children with sickle cell disease
Rostad CA, Maillis AN, Lai K, Bakshi N, Jerris RC, Lane PA, Yee ME, Yildirim I. The burden of respiratory syncytial virus infections among children with sickle cell disease. Pediatric Blood & Cancer 2020, 68: e28759. PMID: 33034160, PMCID: PMC8246443, DOI: 10.1002/pbc.28759.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusSickle cell diseaseRespiratory viral panelRSV-positive casesRSV infectionAnnual incidenceHospitalization ratesCell diseaseBurden of RSVPediatric lower respiratory tract infectionsLaboratory-confirmed RSV infectionRespiratory syncytial virus infectionRSV-related hospitalization rateLower respiratory tract infectionsRSV positive testRSV-negative childrenRSV-negative patientsAcute chest syndromeSyncytial virus infectionRespiratory tract infectionsAverage annual incidenceMultivariate logistic regressionConfidence intervalsCase-control studyOutcome of children
2019
Assessment and Validation of Syndromic Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis.
Lalani K, Yildirim I, Phadke VK, Bednarczyk RA, Omer SB. Assessment and Validation of Syndromic Case Definitions for Respiratory Syncytial Virus Infections in Young Infants: A Latent Class Analysis. The Pediatric Infectious Disease Journal 2019, 38: 1177-1182. PMID: 31568250, DOI: 10.1097/inf.0000000000002468.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusSyndromic case definitionsCase definitionYoung infantsWorld Health OrganizationRSV infectionLatent class analysisPredictive valueLaboratory-confirmed RSV infectionRespiratory syncytial virus infectionSyncytial virus infectionAcute respiratory infectionsHigh positive predictive valueRoutine clinical careStandardized case definitionsHigh-resource settingsAppropriate case definitionsHigh-income settingsNegative predictive valueMonths of agePositive predictive valueRespiratory infectionsVaccine evaluationClinical featuresPediatric morbidity2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF)
Anderson E, Hussaini L, Bristow L, Tippett A, Gibson T, Hart M, Salazar L, Gaffney M, Benyeogor I, Cheng A, Drobeniuc A, Traenkner J, Fayad D, Washington W, Emerson L, Schwartz N, Greaves K, Todd S, Stanley C, Bechnak A, Chaaya R, Al-Husien Z, Deović R, Winston J, Ahmed D, Li W, Le K, Singh A, Spencer J, Muchinsky A, Zaks K, Nesheim W, Stephens K, Swerdlow D, Hubler R, Agosti Y, Munye M, Jadhao S, Ha B, McCracken C, Kraft C, Rostad C, Kao C, Lopman B, Yildirim I, Anderson L, Rouphael N, Rouphael N. 2314. Burden of Respiratory Syncytial Virus (RSV) Infection Among Hospitalized Older Adults and Those with Underlying Chronic Obstructive Pulmonary Disease (COPD) or Congestive Heart Failure (CHF). Open Forum Infectious Diseases 2019, 6: s793-s794. PMCID: PMC6810302, DOI: 10.1093/ofid/ofz360.1992.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseCongestive heart failureAcute respiratory infectionsRespiratory viral panelYears of ageHealthy controlsRespiratory syncytial virus infectionOlder adultsRSV antibody titersSyncytial virus infectionObstructive pulmonary diseaseRespiratory syncytial virusFour-fold riseConvalescent serologyClinical characteristicsHeart failurePulmonary diseaseRespiratory infectionsAsymptomatic adultsEligible adultsProspective surveillanceSyncytial virusViral panelAntibody titersOropharyngeal swabs
2018
Assessment and Validation of Syndromic Case definitions for Respiratory Syncytial Virus Testing in a Low Resource Population
Omer SB, Bednarczyk R, Kazi M, Guterman LB, Aziz F, Allen KE, Yildirim I, Ali SA. Assessment and Validation of Syndromic Case definitions for Respiratory Syncytial Virus Testing in a Low Resource Population. The Pediatric Infectious Disease Journal 2018, Publish Ahead of Print: &na;. PMID: 30074977, PMCID: PMC6437080, DOI: 10.1097/inf.0000000000002159.Peer-Reviewed Original ResearchConceptsCommunity-based surveillanceCase definitionRespiratory syncytial virus testingRespiratory syncytial virus infectionSyncytial virus infectionLow-resource populationsStandardized case definitionsSyndromic case definitionsResource-limited settingsVaccine evaluationVirus infectionVirus testingYoung infantsVirus control strategiesModest specificitySurveillanceCyanosisWheezeApneaInfantsInfection