2024
BK polyomavirus DNAemia, allograft rejection, and de novo donor‐specific antibodies after lowering target tacrolimus levels in pediatric kidney transplant recipients
Huang H, Xiang Y, George R, Winterberg P, Serluco A, Liverman R, Yildirim I, Garro R. BK polyomavirus DNAemia, allograft rejection, and de novo donor‐specific antibodies after lowering target tacrolimus levels in pediatric kidney transplant recipients. Pediatric Transplantation 2024, 28: e14791. PMID: 38808701, DOI: 10.1111/petr.14791.Peer-Reviewed Original ResearchConceptsDe novo donor-specific antibodiesTarget tacrolimus levelsDevelopment of de novo donor-specific antibodiesBiopsy-proven rejectionDonor-specific antibodiesMonths post-KTTacrolimus levelsTime of transplantationPediatric KT recipientsBK polyomavirusBKV-DNAemiaPost-KTPost-intervention cohortAllograft rejectionRecipient ageKT recipientsKidney transplantationPediatric kidney transplant recipientsLow tacrolimus levelsReduction of immunosuppressionKaplan-Meier survival analysisYounger recipient ageIndividualized immunosuppressive regimensKidney transplant recipientsRetrospective chart review
2021
#77: Impact of Targeted Tacrolimus Levels on BK Polyomavirus DNAemia Among Pediatric Kidney Transplant Recipients
Yildirim I, Liverman R, Serluco S, George R, Garro R, Winterberg P. #77: Impact of Targeted Tacrolimus Levels on BK Polyomavirus DNAemia Among Pediatric Kidney Transplant Recipients. Journal Of The Pediatric Infectious Diseases Society 2021, 10: s4-s4. DOI: 10.1093/jpids/piaa170.011.Peer-Reviewed Original ResearchPost-intervention cohortKidney transplant recipientsTacrolimus levelsTransplant recipientsKidney transplantPediatric kidney transplant recipientsPre-intervention cohortTacrolimus target levelsQuality improvement studyAllograft dysfunctionBK viremiaGraft lossImmunosuppression reductionUncontrolled viremiaBK nephropathyInfectious complicationsKidney transplantationMedian ageSerious complicationsMedian timeBK polyomavirusIncidence rateDNAemiaTrough targetsProspective monitoring