Evaluation of Immunoglobulin A Enzyme Immunoassays to Detect Primary Respiratory Syncytial Virus Infection in Infants and Young Children
Sankaranarayanan R, Ha B, Sun H, Liu K, Jadhao S, Hussaini L, McCracken C, Gibson T, Yildirim I, Yi J, Stephens K, Korski C, Kao C, Rostad C, Anderson E, Anderson L. Evaluation of Immunoglobulin A Enzyme Immunoassays to Detect Primary Respiratory Syncytial Virus Infection in Infants and Young Children. The Journal Of Infectious Diseases 2024, jiae514. PMID: 39575588, DOI: 10.1093/infdis/jiae514.Peer-Reviewed Original ResearchRespiratory syncytial virus infectionRespiratory syncytial virusIgA enzyme immunoassayRespiratory syncytial virus seasonDocumented RSV infectionPlasma specimensEnzyme immunoassayRSV infectionRSV-FRespiratory syncytial virus antibodiesGroup DRespiratory syncytial virus FCord blood specimensGroup C specimensAcute lower respiratory infectionGroup B specimensPresence of maternal antibodiesLower respiratory infectionsImmunoglobulin G antibodiesRSV antibodiesNegative control groupSyncytial virusAntibody enzyme immunoassayRespiratory infectionsGroup BDevelopment and comparison of immunologic assays to detect primary RSV infections in infants
Anderson L, Jadhao S, Hussaini L, Ha B, McCracken C, Gibson T, Yildirim I, Yi J, Stephens K, Korski C, Kao C, Sun H, Lee C, Jaunarajs A, Rostad C, Anderson E. Development and comparison of immunologic assays to detect primary RSV infections in infants. Frontiers In Immunology 2024, 14: 1332772. PMID: 38283339, PMCID: PMC10811012, DOI: 10.3389/fimmu.2023.1332772.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusIgG enzyme immunoassayNeutralizing antibody assaysELISPOT assayAntibody assayRSV antibodiesEnzyme immunoassayRSV infectionSubgroup ARespiratory syncytial virus seasonDocumented RSV infectionPrimary RSV infectionEffective respiratory syncytial virusVaccine clinical trialsEvidence of past infectionEpidemiological studiesRed cell lysisYoung childrenMaternal microchimerismPBMC specimensPregnant womenIFN-gSyncytial virusAntibody enzyme immunoassayELISPOT