2024
A Phase 1, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Safety and Immunogenicity of HEV-239 (Hecolin) Vaccine in Healthy US Adults
Kao C, Rostad C, Nolan L, Peters E, Kleinhenz J, Sherman J, Tippett A, Shih J, Yildirim I, Agbakoba V, Beresnev T, Ballou C, Kamidani S, Karmali V, Natrajan M, Scherer E, Rouphael N, Anderson E. A Phase 1, Double-Blinded, Placebo-Controlled Clinical Trial to Evaluate the Safety and Immunogenicity of HEV-239 (Hecolin) Vaccine in Healthy US Adults. The Journal Of Infectious Diseases 2024, 230: 1093-1101. PMID: 38536442, PMCID: PMC11565884, DOI: 10.1093/infdis/jiae148.Peer-Reviewed Original ResearchHealthy US adultsDouble-blindThird dosePlacebo-Controlled Clinical TrialSystemic reactionsHepatitis E virus vaccineUS adultsHepatitis E vaccinePlacebo groupPlacebo-controlledAdverse eventsE vaccineSecond doseClinical trialsDay 1Immune responseDosePhase 1ImmunogenicityMonthsSafety studiesVaccineInfant mortalityTrialsAdults
2020
Plasmablast, Memory B Cell, CD4+ T Cell, and Circulating Follicular Helper T Cell Responses to a Non-Replicating Modified Vaccinia Ankara Vaccine
Anderson EJ, Lai L, Wrammert J, Kabbani S, Xu Y, Priyamvada L, Hill H, Goll JB, Jensen TL, Kao C, Yildirim I, Rouphael N, Jackson L, Mulligan MJ. Plasmablast, Memory B Cell, CD4+ T Cell, and Circulating Follicular Helper T Cell Responses to a Non-Replicating Modified Vaccinia Ankara Vaccine. Vaccines 2020, 8: 69. PMID: 32041104, PMCID: PMC7158692, DOI: 10.3390/vaccines8010069.Peer-Reviewed Original ResearchMemory B cellsPlaque reduction neutralization testVaccinia Ankara vaccineCD4 T cellsT cellsB cellsDay 1Follicular helper T cell responsesIgG-secreting B cellsModified Vaccinia Ankara VaccineFollicular helper T cellsHelper T cell responsesVaccinia-specific antibodiesT cell responsesHelper T cellsReduction neutralization testEnzyme-linked immunosorbentSecond vaccineEvaluable specimensInjection recipientsPRNT titersDay 29Neutralization testPlasmablastsNovel vaccines