The association of epigenetic age acceleration and depressive and anxiety symptom severity among children recently exposed to substantiated maltreatment
Zhang Z, Moeckel C, Mustafa M, Pham H, Olson A, Mehta D, Dorn L, Engeland C, Shenk C. The association of epigenetic age acceleration and depressive and anxiety symptom severity among children recently exposed to substantiated maltreatment. Journal Of Psychiatric Research 2023, 165: 7-13. PMID: 37441927, PMCID: PMC10529086, DOI: 10.1016/j.jpsychires.2023.07.007.Peer-Reviewed Original ResearchConceptsEpigenetic age accelerationSymptom severityAnxiety symptom severitySevere depressiveGreater riskAnxiety disordersStress-sensitive biomarkersAnxiety symptomsMajor risk factorAge accelerationYears of ageMultiple psychiatric disordersChild maltreatmentHorvath clockPediatric populationRisk factorsSubstantiated child maltreatmentPsychiatric disordersPromising biomarkerPredictive valueDiagnostic thresholdDepressiveChildren 8Transitory symptomsSymptoms