2023
The association of epigenetic age acceleration and depressive and anxiety symptom severity among children recently exposed to substantiated maltreatment
Zhang Z, Moeckel C, Mustafa M, Pham H, Olson A, Mehta D, Dorn L, Engeland C, Shenk C. The association of epigenetic age acceleration and depressive and anxiety symptom severity among children recently exposed to substantiated maltreatment. Journal Of Psychiatric Research 2023, 165: 7-13. PMID: 37441927, PMCID: PMC10529086, DOI: 10.1016/j.jpsychires.2023.07.007.Peer-Reviewed Original ResearchConceptsEpigenetic age accelerationSymptom severityAnxiety symptom severitySevere depressiveGreater riskAnxiety disordersStress-sensitive biomarkersAnxiety symptomsMajor risk factorAge accelerationYears of ageMultiple psychiatric disordersChild maltreatmentHorvath clockPediatric populationRisk factorsSubstantiated child maltreatmentPsychiatric disordersPromising biomarkerPredictive valueDiagnostic thresholdDepressiveChildren 8Transitory symptomsSymptoms
2021
Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging
McGill MG, Pokhvisneva I, Clappison AS, McEwen LM, Beijers R, Tollenaar MS, Pham H, Kee MZL, Garg E, de Mendonça Filho EJ, Karnani N, Silveira PP, Kobor MS, de Weerth C, Meaney MJ, O'Donnell KJ. Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging. Biological Psychiatry 2021, 91: 303-312. PMID: 34756561, DOI: 10.1016/j.biopsych.2021.07.025.Peer-Reviewed Original ResearchConceptsPrenatal maternal anxietyFetal originEpigenetic age accelerationMaternal anxietyAge accelerationPrenatal anxietyMental healthPrenatal maternal mental healthMaternal mental healthYears of ageGenetic risk factorsMonths of ageMental health supportMaternal prenatal anxietyRisk factorsLongitudinal cohortPrenatal adversityPregnant individualsLarge effect sizesLongitudinal assessmentHealth supportEffective mental health supportCohortPrenatal environmentLate childhood