2023
Bulimia symptoms and anger and aggression among adolescents
Koposov R, Stickley A, Sukhodolsky D, Ruchkin V. Bulimia symptoms and anger and aggression among adolescents. BMC Public Health 2023, 23: 833. PMID: 37147644, PMCID: PMC10161674, DOI: 10.1186/s12889-023-15664-1.Peer-Reviewed Original ResearchConceptsAnger ruminationBulimia symptomsBN symptomsEating Disorder Diagnostic ScaleState-Trait Anger Expression InventoryAggressive behaviorTrait Anger Expression InventoryDisorder Diagnostic ScaleSelf-report scalesAnger Rumination ScaleCommunity-based adolescentsAnger Expression InventoryBulimia nervosa diagnosisTrait Anger ScaleSocial aggressionPhysical aggressionRumination ScaleHigh angerAngerAnger ScaleRuminationAggression scoresDiagnostic ScaleAggressionAdolescents
2022
Posttraumatic Stress and Perceived Interpersonal Provocation in Adolescents
Saunderson JM, Stickley A, Sturidsson K, Koposov R, Sukhodolsky DG, Ruchkin V. Posttraumatic Stress and Perceived Interpersonal Provocation in Adolescents. Journal Of Interpersonal Violence 2022, 38: 3191-3214. PMID: 35613735, PMCID: PMC9850389, DOI: 10.1177/08862605221104525.Peer-Reviewed Original ResearchConceptsPosttraumatic stress symptomsPosttraumatic stressStress symptomsProvocation scenariosPosttraumatic symptomsAggressive responsesPhysical aggressionAttribution of intentionalityInterpersonal provocationPeer provocationHostile intentionsChoice of responseAggressive reactionsAdolescent boysAggressive situationsConflict situationsOpposite patternHigh levelsAdolescentsAggressive behaviorAggressionGirlsDaily lifeBoysDifferent patterns
2021
Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior
Sukhodolsky DG, Ibrahim K, Kalvin CB, Jordan RP, Eilbott J, Hampson M. Increased amygdala and decreased frontolimbic r esting- s tate functional connectivity in children with aggressive behavior. Social Cognitive And Affective Neuroscience 2021, 17: 634-644. PMID: 34850939, PMCID: PMC9250305, DOI: 10.1093/scan/nsab128.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulateFunctional connectivityAnterior cingulateDorsolateral prefrontal cortical regionsResting-state brain connectivityAggressive behaviorResting-state functional connectivityIntrinsic connectivity distributionAmygdala-prefrontal circuitryAnterior cingulate cortexIntrinsic functional connectivityPrefrontal cortical regionsHealthy controlsAmygdala connectivityGreater severityVentromedial prefrontal cortexCingulate cortexFunctional MRI dataCortical regionsMedial prefrontalMaladaptive aggressionPrefrontal cortexBrain connectivitySeverity of aggressionTreatment-seeking childrenLarge-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling
Ibrahim K, Noble S, He G, Lacadie C, Crowley MJ, McCarthy G, Scheinost D, Sukhodolsky DG. Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling. Molecular Psychiatry 2021, 27: 985-999. PMID: 34690348, PMCID: PMC9035467, DOI: 10.1038/s41380-021-01317-5.Peer-Reviewed Original ResearchConceptsLarge-scale functional networksChildhood aggressionSeverity of aggressionIndividual differencesBrain networksAdolescent Brain Cognitive Development (ABCD) studyConnectome-based predictive modelingReactive-Proactive Aggression QuestionnaireEmotion perception taskLarge-scale functional brain networksAssociation of connectivityFunctional networksCognitive Development StudyAggressive behaviorFunctional brain networksIndependent samplesCognitive controlEmotion regulationEmotion processingPerception taskCalm facesMaladaptive aggressionPsychiatric disordersTransdiagnostic sampleFrontoparietal network
2020
Sex differences in medial prefrontal and parietal cortex structure in children with disruptive behavior
Ibrahim K, Kalvin C, Li F, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Sex differences in medial prefrontal and parietal cortex structure in children with disruptive behavior. Developmental Cognitive Neuroscience 2020, 47: 100884. PMID: 33254067, PMCID: PMC7704291, DOI: 10.1016/j.dcn.2020.100884.Peer-Reviewed Original ResearchConceptsDisruptive behavior disordersGray matter volumeCortical thicknessMatter volumeSex differencesDisruptive behavior severityCross-sectional studySex-specific associationsDisruptive behaviorLeft ventromedial prefrontal cortexWhole-brain analysisSurface-based morphometryStructural MRI dataHealthy controlsSex-specific differencesNeural biomarkersTarget-based treatmentVentromedial prefrontal cortexMedial prefrontalBehavior disorderPrefrontal cortexBrain structuresSupramarginal gyrusRespective controlsVmPFC volumeTantrum Tool: Development and Open Pilot Study of Online Parent Training for Irritability and Disruptive Behavior
Diaz-Stransky A, Rowley S, Zecher E, Grodberg D, Sukhodolsky DG. Tantrum Tool: Development and Open Pilot Study of Online Parent Training for Irritability and Disruptive Behavior. Journal Of Child And Adolescent Psychopharmacology 2020, 30: 558-566. PMID: 33035067, PMCID: PMC7699014, DOI: 10.1089/cap.2020.0089.Peer-Reviewed Original ResearchConceptsOpen pilot studyAffective Reactivity IndexOpen trialPilot studyFirst-line treatmentSecondary outcome measuresDisruptive Behavior Rating ScaleYoung childrenDisruptive behaviorSignificant reductionDisruptive behavior disordersClinical effectsParent management training interventionOutcome measuresEffective treatmentTreatment retentionBehavior disorderClinical settingParent management trainingPrimary caregiversMeaningful reductionRating ScaleIrritability scoresLimited service availabilityParent training programDevelopmental Course and Risk Factors of Physical Aggression in Late Adolescence
Henriksen M, Skrove M, Hoftun GB, Sund ER, Lydersen S, Tseng WL, Sukhodolsky DG. Developmental Course and Risk Factors of Physical Aggression in Late Adolescence. Child Psychiatry & Human Development 2020, 52: 628-639. PMID: 32852728, PMCID: PMC8238740, DOI: 10.1007/s10578-020-01049-7.Peer-Reviewed Original ResearchConceptsRisk factorsMale genderAggressive behaviorLate adolescenceHeavy drinkingEarly adolescenceStudy sampleLongitudinal studyPhysical aggressionAdolescencePhysical aggressive behaviorAdolescentsNorwegian adolescentsPhysical fightsAttention problemsYoung adolescentsDrinkingDevelopmental courseGenderSmokingFactorsStudyAssessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index
Kalvin CB, Gladstone TR, Jordan R, Rowley S, Marsh CL, Ibrahim K, Sukhodolsky DG. Assessing Irritability in Children with Autism Spectrum Disorder Using the Affective Reactivity Index. Journal Of Autism And Developmental Disorders 2020, 51: 1496-1507. PMID: 32734421, PMCID: PMC7855357, DOI: 10.1007/s10803-020-04627-9.Peer-Reviewed Original ResearchThe Role of Gender in the Associations Among Posttraumatic Stress Symptoms, Anger, and Aggression in Russian Adolescents
Isaksson J, Sukhodolsky DG, Koposov R, Stickley A, Ruchkin V. The Role of Gender in the Associations Among Posttraumatic Stress Symptoms, Anger, and Aggression in Russian Adolescents. Journal Of Traumatic Stress 2020, 33: 552-563. PMID: 32384585, DOI: 10.1002/jts.22502.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderPTSD symptomsAnger ruminationSocial aggressionRussian adolescentsPosttraumatic stress symptomsAggressive behaviorFull path analysisMeasures of angerClinical levelSelf-reported dataInteraction effectsCognitive componentsRole of genderVerbal aggressionStress disorderStress symptomsAngerPath analysisAggressionAdolescentsRuminationDepressive symptomsBoysVeteran population
2019
Discrepancies between parent and child ratings of anxiety in children with autism spectrum disorder
Kalvin CB, Marsh CL, Ibrahim K, Gladstone TR, Woodward D, Grantz H, Ventola P, Sukhodolsky DG. Discrepancies between parent and child ratings of anxiety in children with autism spectrum disorder. Autism Research 2019, 13: 93-103. PMID: 31643143, PMCID: PMC7062240, DOI: 10.1002/aur.2220.Peer-Reviewed Original ResearchAnxiety in 3- to 7-year-old children with autism spectrum disorder seeking treatment for disruptive behavior
Sukhodolsky DG, Lecavalier L, Johnson C, Smith T, Swiezy N, Bearss K, Kalvin CB, Scahill L. Anxiety in 3- to 7-year-old children with autism spectrum disorder seeking treatment for disruptive behavior. Autism 2019, 24: 400-410. PMID: 31390873, PMCID: PMC6982590, DOI: 10.1177/1362361319866561.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderAnxiety symptomsDisruptive behaviorParent-completed rating scaleOppositional defiant behaviorYoung childrenEarly Childhood InventorySchool-aged childrenAnxiety severity scoresChild psychiatric symptomsParent trainingDefiant behaviorOppositional behaviorBehavioral problemsSocial withdrawalPreschool childrenAnxietyIQSocial disabilityPsychiatric symptomsChildrenRating ScalePercent of childrenSignificant symptomsAltered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality‐Controlled Diffusion Tensor Imaging Study
Lei J, Lecarie E, Jurayj J, Boland S, Sukhodolsky DG, Ventola P, Pelphrey KA, Jou RJ. Altered Neural Connectivity in Females, But Not Males with Autism: Preliminary Evidence for the Female Protective Effect from a Quality‐Controlled Diffusion Tensor Imaging Study. Autism Research 2019, 12: 1472-1483. PMID: 31347307, PMCID: PMC6851962, DOI: 10.1002/aur.2180.Peer-Reviewed Original ResearchEffects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD
Smith SD, Crowley MJ, Ferrey A, Ramsey K, Wexler BE, Leckman JF, Sukhodolsky DG. Effects of Integrated Brain, Body, and Social (IBBS) intervention on ERP measures of attentional control in children with ADHD. Psychiatry Research 2019, 278: 248-257. PMID: 31233935, PMCID: PMC6637759, DOI: 10.1016/j.psychres.2019.06.021.Peer-Reviewed Original ResearchConceptsBehavioral measuresAttentional controlIntegrated brainGo/No-Go taskGo-P3 latencySlower reaction timesSocial interventionsRobust treatment effectAttentional systemADHD groupERP measuresDifference waveP3 latencyBrain activityADHDTAU groupEEG proceduresHealthy controlsHC groupReaction timeReplication purposesERPTreatment effectsChildrenSecondary goalAnger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder
Ibrahim K, Kalvin C, Marsh CL, Anzano A, Gorynova L, Cimino K, Sukhodolsky DG. Anger Rumination is Associated with Restricted and Repetitive Behaviors in Children with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2019, 49: 3656-3668. PMID: 31144231, PMCID: PMC7035789, DOI: 10.1007/s10803-019-04085-y.Peer-Reviewed Original ResearchReduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior
Ibrahim K, Eilbott JA, Ventola P, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Reduced Amygdala–Prefrontal Functional Connectivity in Children With Autism Spectrum Disorder and Co-occurring Disruptive Behavior. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2019, 4: 1031-1041. PMID: 30979647, PMCID: PMC7173634, DOI: 10.1016/j.bpsc.2019.01.009.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderCallous-unemotional traitsAmygdala-vlPFC connectivityDisruptive behaviorAmygdala reactivityNeural mechanismsSpectrum disorderAmygdala-prefrontal functional connectivityEmotion perception taskFunctional magnetic resonance imagingVentrolateral prefrontal cortexUnderlying neural mechanismsDisruptive behavior disordersTask-specific changesRisk of aggressionEmotion dysregulationFearful facesCalm facesPerception taskFear processingAmygdala activityPsychophysiological interactionAmygdala connectivityExternalizing behaviorsAmygdala hyperactivity
2018
An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder
Lewis AS, van Schalkwyk GI, Lopez MO, Volkmar FR, Picciotto MR, Sukhodolsky DG. An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2018, 48: 2748-2757. PMID: 29536216, PMCID: PMC6394231, DOI: 10.1007/s10803-018-3536-7.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderTransdermal nicotineDouble-blind crossover trialAggressive behaviorPreliminary efficacyAggressive symptomsSleep ratingsAggressionSubscale changesNicotinic acetylcholine receptorsNAChR agonistsPrimary outcomeNicotine treatmentCrossover trialExploratory trialΑ7 nAChRsAcetylcholine receptorsNicotineAdultsDisordersPlaceboNAChRsFurther investigationTrials
2017
Extended-Release Guanfacine Does Not Show a Large Effect on Tic Severity in Children with Chronic Tic Disorders
Murphy TK, Fernandez TV, Coffey BJ, Rahman O, Gavaletz A, Hanks CE, Tillberg CS, Gomez LI, Sukhodolsky DG, Katsovich L, Scahill L. Extended-Release Guanfacine Does Not Show a Large Effect on Tic Severity in Children with Chronic Tic Disorders. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 762-770. PMID: 28723227, DOI: 10.1089/cap.2017.0024.Peer-Reviewed Original ResearchConceptsExtended-release guanfacineLack of efficacyChronic tic disorderGuanfacine groupPlacebo groupYGTSS total scoreAdverse eventsTotal scoreTic disordersYale Global Tic Severity Scale total scoreClinical Global Impressions-Improvement scaleCommon adverse eventsPlacebo-controlled trialKey secondary outcomesPrimary outcome measureLarger efficacy trialScale total scoreDry mouthSecondary outcomesPreliminary efficacyWeek 8Efficacy trialsOutcome measuresTic severityTourette's disorderModerators and predictors of response to behavior therapy for tics in Tourette syndrome
Sukhodolsky DG, Woods DW, Piacentini J, Wilhelm S, Peterson AL, Katsovich L, Dziura J, Walkup JT, Scahill L. Moderators and predictors of response to behavior therapy for tics in Tourette syndrome. Neurology 2017, 88: 1029-1036. PMID: 28202705, PMCID: PMC5384839, DOI: 10.1212/wnl.0000000000003710.Peer-Reviewed Original ResearchConceptsPredictors of responseChronic tic disorderTic reductionTic disordersPsychiatric disordersYale Global Tic Severity Scale-Total Tic ScoreTic severityTourette syndromeClinical Global Impressions-Improvement scoreCo-occurring psychiatric disordersAnxiety disordersSubgroup of patientsTotal tic scoreMain outcome measuresPredictors of outcomeBehavior therapyComprehensive Behavioral InterventionAttention-deficit/hyperactivity disorderPremonitory urge severityReduction of ticsCo-occurring attention-deficit/hyperactivity disorderGreater tic severityTIC characteristicsTic improvementClinical characteristics
2016
Moderators of Parent Training for Disruptive Behaviors in Young Children with Autism Spectrum Disorder
Lecavalier L, Smith T, Johnson C, Bearss K, Swiezy N, Aman MG, Sukhodolsky DG, Deng Y, Dziura J, Scahill L. Moderators of Parent Training for Disruptive Behaviors in Young Children with Autism Spectrum Disorder. Research On Child And Adolescent Psychopathology 2016, 45: 1235-1245. PMID: 27917460, PMCID: PMC5459681, DOI: 10.1007/s10802-016-0233-x.Peer-Reviewed Original ResearchConceptsHome Situations QuestionnaireAutism spectrum disorderParent education programAttention deficit hyperactivity disorderParent trainingAberrant Behavior Checklist-Irritability subscaleSpectrum disorderClinical Global Impressions-Improvement scaleDisruptive behaviorOppositional defiant disorder symptomsASD symptom severityLow anxiety groupDeficit hyperactivity disorderYoung childrenADHD groupASD severityHyperactivity disorderAnxiety groupDisorder symptomsPotential moderatorsSituations QuestionnaireNoncompliant behaviorAge 3ModeratorSymptom severityBrain responses to biological motion predict treatment outcome in young children with autism
Yang D, Pelphrey KA, Sukhodolsky DG, Crowley MJ, Dayan E, Dvornek NC, Venkataraman A, Duncan J, Staib L, Ventola P. Brain responses to biological motion predict treatment outcome in young children with autism. Translational Psychiatry 2016, 6: e948-e948. PMID: 27845779, PMCID: PMC5314125, DOI: 10.1038/tp.2016.213.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderYoung childrenSocial information processingMultivariate pattern analysisMotivation/rewardBiological motionCore deficitComplex neurodevelopmental disorderBrain responsesResponse treatmentSpectrum disorderNeurobiological markersNeural predictorsInformation processingBehavioral interventionsIndividual childrenNeurodevelopmental disordersCurrent findingsNeural circuitsBehavioral deficitsEarly childhoodChildrenUnsuccessful interventionsNeurobiomarkersPattern analysis