2023
Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome
Morand-Beaulieu S, Crowley M, Grantz H, Leckman J, Sukhodolsky D. Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome. Psychological Medicine 2023, 53: 7857-7864. PMID: 37485677, PMCID: PMC10755221, DOI: 10.1017/s0033291723001940.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBehavior TherapyChildHumansSeverity of Illness IndexTic DisordersTicsTourette SyndromeConceptsVoluntary tic suppressionTic suppressionVocal tic severityFunctional connectivityTic severityTourette syndromeRight superior frontal gyrusFirst-line treatmentBehavior therapyComprehensive Behavioral InterventionSuperior frontal gyrusRight angular gyrusVocal ticsFunctional brain networksBehavioral interventionsUsual control conditionFrontal gyrusBaselineAngular gyrusSeverityBrain networksSyndromeChildrenTherapyGyrus
2022
Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome
Morand-Beaulieu S, Crowley MJ, Grantz H, Leckman JF, Scahill L, Sukhodolsky DG. Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome. Clinical Neurophysiology 2022, 142: 75-85. PMID: 35987093, DOI: 10.1016/j.clinph.2022.07.500.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersChildElectroencephalographyHumansSeverity of Illness IndexTic DisordersTicsTourette SyndromeConceptsClinical Global Impressions-Improvement scaleYale Global Tic Severity ScaleComprehensive Behavioral InterventionGo/NoGo taskTourette syndromeTreatment outcomesEEG coherenceTic severityNoGo taskBehavioral interventionsFirst-line treatmentTic Severity ScaleClinical outcomesMotor areaSeverity ScaleAlpha frequency bandBlinded evaluatorsTic controlMotor responseEEG biomarkersOutcomesSyndromeBrain mechanismsSeverityIntervention
2019
Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome
Sukhodolsky DG, Walsh C, Koller WN, Eilbott J, Rance M, Fulbright RK, Zhao Z, Bloch MH, King R, Leckman JF, Scheinost D, Pittman B, Hampson M. Randomized, Sham-Controlled Trial of Real-Time Functional Magnetic Resonance Imaging Neurofeedback for Tics in Adolescents With Tourette Syndrome. Biological Psychiatry 2019, 87: 1063-1070. PMID: 31668476, PMCID: PMC7015800, DOI: 10.1016/j.biopsych.2019.07.035.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCross-Over StudiesHumansMagnetic Resonance ImagingNeurofeedbackSeverity of Illness IndexTicsTourette SyndromeConceptsSupplementary motor areaYale Global Tic Severity ScaleFunctional magnetic resonanceTic Severity ScaleReal-time functional magnetic resonanceTourette syndromeSeverity ScaleYale Global Tic Severity Scale-Total Tic ScoreTotal tic scorePrimary outcome measureSham control conditionReduction of ticsMagnetic resonanceSecondary outcomesSessions of neurofeedbackCrossover studyTic symptomsTic scoreOutcome measuresMotor areaSecondary measuresTic severityReal neurofeedbackEnd pointNeurofeedback intervention
2017
Extended-Release Guanfacine Does Not Show a Large Effect on Tic Severity in Children with Chronic Tic Disorders
Murphy TK, Fernandez TV, Coffey BJ, Rahman O, Gavaletz A, Hanks CE, Tillberg CS, Gomez LI, Sukhodolsky DG, Katsovich L, Scahill L. Extended-Release Guanfacine Does Not Show a Large Effect on Tic Severity in Children with Chronic Tic Disorders. Journal Of Child And Adolescent Psychopharmacology 2017, 27: 762-770. PMID: 28723227, DOI: 10.1089/cap.2017.0024.Peer-Reviewed Original ResearchConceptsExtended-release guanfacineLack of efficacyChronic tic disorderGuanfacine groupPlacebo groupYGTSS total scoreAdverse eventsTotal scoreTic disordersYale Global Tic Severity Scale total scoreClinical Global Impressions-Improvement scaleCommon adverse eventsPlacebo-controlled trialKey secondary outcomesPrimary outcome measureLarger efficacy trialScale total scoreDry mouthSecondary outcomesPreliminary efficacyWeek 8Efficacy trialsOutcome measuresTic severityTourette's disorder
2014
Examination of Aggression and Self-injury in Children with Autism Spectrum Disorders and Serious Behavioral Problems
Carroll D, Hallett V, McDougle CJ, Aman MG, McCracken JT, Tierney E, Arnold LE, Sukhodolsky DG, Lecavalier L, Handen BL, Swiezy N, Johnson C, Bearss K, Vitiello B, Scahill L. Examination of Aggression and Self-injury in Children with Autism Spectrum Disorders and Serious Behavioral Problems. Child And Adolescent Psychiatric Clinics Of North America 2014, 23: 57-72. PMID: 24231167, PMCID: PMC4212264, DOI: 10.1016/j.chc.2013.08.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionAnalysis of VarianceAntipsychotic AgentsChildChild Development Disorders, PervasiveChild, PreschoolChi-Square DistributionDouble-Blind MethodFemaleHumansIntelligence TestsMaleOutcome Assessment, Health CarePsychiatric Status Rating ScalesRandomized Controlled Trials as TopicRisperidoneSelf-Injurious BehaviorSeverity of Illness IndexConceptsAutism spectrum disorderSubtypes of aggressionSelf-injurious behaviorSpectrum disorderUnderstanding of aggressionSerious behavioral problemsParent interviewsBehavioral problemsSelf-InjuryAggressionStudy findingsChildrenRisperidone trialsChildren 2DisordersIndividualized treatmentPositive responseSubtypesFurther studiesBiological mechanismsHigh rateInterviewsFindingsNarrativesBehavior
2012
Randomized Trial of Behavior Therapy for Adults With Tourette Syndrome
Wilhelm S, Peterson AL, Piacentini J, Woods DW, Deckersbach T, Sukhodolsky DG, Chang S, Liu H, Dziura J, Walkup JT, Scahill L. Randomized Trial of Behavior Therapy for Adults With Tourette Syndrome. JAMA Psychiatry 2012, 69: 795-803. PMID: 22868933, PMCID: PMC3772729, DOI: 10.1001/archgenpsychiatry.2011.1528.Peer-Reviewed Original ResearchMeSH KeywordsAdultBehavior TherapyFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesSelf ReportSeverity of Illness IndexTicsTourette SyndromeTreatment OutcomeConceptsClinical Global Impressions-Improvement scaleYale Global Tic Severity ScaleComprehensive Behavioral InterventionTic Severity ScaleTourette syndromeBehavior therapySeverity ScaleBehavioral interventionsOutpatient research clinicTotal tic scoreLeast moderate severityChronic tic disorderGreater mean decreaseMonthly booster sessionsAdult patientsSupportive treatmentModerate severityTic scoreTic disordersPositive respondersResearch clinicBooster sessionsMean decreasePosttreatment evaluationPatients
2010
Neuropsychological Functioning in Children With Tourette Syndrome With and Without Attention-Deficit/Hyperactivity Disorder
Sukhodolsky DG, Landeros-Weisenberger A, Scahill L, Leckman JF, Schultz RT. Neuropsychological Functioning in Children With Tourette Syndrome With and Without Attention-Deficit/Hyperactivity Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2010, 49: 1155-1164.e1. PMID: 20970703, PMCID: PMC2965169, DOI: 10.1016/j.jaac.2010.08.008.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderConnors' Continuous Performance TestVisual-Motor Integration TestVisual-motor integrationContinuous Performance TestNeuropsychological functioningResponse inhibitionHyperactivity disorderCo-occurring attention-deficit/hyperactivity disorderStroop Color-Word Interference TestColor-Word Interference TestBeery Visual-Motor Integration TestAdequate control conditionsSample of childrenFine motor coordinationTourette syndromeNeuropsychological measuresPurdue Pegboard TestHealthy community control subjectsSubtle deficitsNeurobiological mechanismsNeuropsychological deficitsInterference testControl conditionPegboard Test
2008
ADHD Symptoms and Associated Psychopathology in a Community Sample of Adolescents From the European North of Russia
Ruchkin V, Lorberg B, Koposov R, Schwab-Stone M, Sukhodolsky DG. ADHD Symptoms and Associated Psychopathology in a Community Sample of Adolescents From the European North of Russia. Journal Of Attention Disorders 2008, 12: 54-63. PMID: 17712166, DOI: 10.1177/1087054707305169.Peer-Reviewed Original Research
2006
Randomized Trial of Parent Management Training in Children With Tic Disorders and Disruptive Behavior
Scahill L, Sukhodolsky DG, Bearss K, Findley D, Hamrin V, Carroll DH, Rains AL. Randomized Trial of Parent Management Training in Children With Tic Disorders and Disruptive Behavior. Journal Of Child Neurology 2006, 21: 650-656. PMID: 16970865, DOI: 10.1177/08830738060210080201.Peer-Reviewed Original ResearchConceptsTic disordersParent management trainingUsual groupClinical Global ImpressionShort-term efficacyRating Scale scoresShort-term improvementDisruptive behaviorRandomized trialsStable medicationBehavior rating scale scoresGlobal ImpressionParent management training programsClinical trialsImprovement ScaleScale scoreStructured parent training programTraining programTreatment assignmentParent training programTraining groupDisruptive behavior problemsDisordersClinical samplesSevere levelsFine‐motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome
Bloch MH, Sukhodolsky DG, Leckman JF, Schultz RT. Fine‐motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome. Journal Of Child Psychology And Psychiatry 2006, 47: 551-559. PMID: 16712631, DOI: 10.1111/j.1469-7610.2005.01561.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBasal GangliaChildFemaleFunctional LateralityHand StrengthHumansMaleMotor Skills DisordersNeuropsychological TestsObsessive-Compulsive DisorderPredictive Value of TestsPsychologyPsychomotor PerformanceSeverity of Illness IndexSocial BehaviorSurveys and QuestionnairesTourette SyndromeConceptsGlobal psychosocial functioningPurdue Pegboard TestFine motor skill deficitsTourette syndromeTic severityPegboard TestPsychosocial functioningTic symptomsTS patientsNeuropsychological testsStudy of TSBasal ganglia dysfunctionVisual-Motor Integration TestBeery Visual-Motor Integration TestLogistic regression analysisOrdinal logistic regression analysisFine motor coordinationMotor skill deficitsNeuropsychological testing batteryGanglia dysfunctionVisual-motor integrationClinical evaluationClinical assessmentClinical measuresNeuropsychological testingDepressive Symptoms and Associated Psychopathology in Urban Adolescents
Ruchkin V, Sukhodolsky DG, Vermeiren R, Koposov RA, Schwab-Stone M. Depressive Symptoms and Associated Psychopathology in Urban Adolescents. The Journal Of Nervous And Mental Disease 2006, 194: 106-113. PMID: 16477188, DOI: 10.1097/01.nmd.0000198142.26754.18.Peer-Reviewed Original ResearchAdolescentAntisocial Personality DisorderBelgiumComorbidityCross-Cultural ComparisonDepressive DisorderFemaleHealth StatusHealth SurveysHumansMaleMental DisordersPersonality InventoryPrevalencePsychology, AdolescentRisk-TakingRussiaSeverity of Illness IndexSex FactorsSurveys and QuestionnairesUnited StatesUrban Population
2005
Characterizing Aggressive and Noncompliant Behaviors in a Children’s Psychiatric Inpatient Setting
Sukhodolsky DG, Cardona L, Martin A. Characterizing Aggressive and Noncompliant Behaviors in a Children’s Psychiatric Inpatient Setting. Child Psychiatry & Human Development 2005, 36: 177-193. PMID: 16228146, DOI: 10.1007/s10578-005-3494-0.Peer-Reviewed Original Research
1997
The association between adaptive and cognitive deficits in geriatric chronic schizophrenic patients
Harvey P, Sukhodolsky D, Parrella M, White L, Davidson M. The association between adaptive and cognitive deficits in geriatric chronic schizophrenic patients. Schizophrenia Research 1997, 27: 211-218. PMID: 9416650, DOI: 10.1016/s0920-9964(97)00068-6.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAge of OnsetAgedAged, 80 and overCognition DisordersComorbidityDisruptive, Impulse Control, and Conduct DisordersFemaleGeriatric AssessmentHumansMaleNeuropsychological TestsPsychiatric Status Rating ScalesPsychological TestsSchizophreniaSchizophrenic PsychologySelf CareSeverity of Illness IndexSocial AdjustmentConceptsUndercontrolled behaviorCognitive impairmentSocial skills deficitsChronic schizophreniaCognitive measuresCognitive batteryAdaptive functioningSkill deficitsCognitive deficitsAdaptive functionMagnitude of correlationsNegative symptomsStructured scaleDeficitsImpairmentChronic schizophrenic patientsSchizophrenic patientsSchizophreniaCertain aspectsFunctioningBehavior