2012
Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders
Handen BL, Johnson CR, Butter EM, Lecavalier L, Scahill L, Aman MG, McDougle CJ, Arnold LE, Swiezy NB, Sukhodolsky DG, Mulick JA, White SW, Bearss K, Hollway JA, Stigler KA, Dziura J, Yu S, Sacco K, Vitiello B. Use of a Direct Observational Measure in a Trial of Risperidone and Parent Training in Children with Pervasive Developmental Disorders. Journal Of Developmental And Physical Disabilities 2012, 25: 355-371. PMID: 23730123, PMCID: PMC3665525, DOI: 10.1007/s10882-012-9316-y.Peer-Reviewed Original ResearchParent trainingPositive reinforcementChild's inappropriate behaviorParent-child interactionsAutism spectrum disorderDirect observational measuresTrial of risperidoneSerious behavior problemsPervasive developmental disorderAnalysis of covarianceClinician-based measuresParent behaviorSpectrum disorderObservational measuresAnalogue measuresBehavior problemsInappropriate behaviorDevelopmental disordersAnalog procedureParentsParental requestChildrenTreatment conditionsGreater useMeasures
2009
Medication and Parent Training in Children With Pervasive Developmental Disorders and Serious Behavior Problems: Results From a Randomized Clinical Trial
Aman MG, Mcdougle CJ, Scahill L, Handen B, Arnold LE, Johnson C, Stigler KA, Bearss K, Butter E, Swiezy NB, Sukhodolsky DD, Ramadan Y, Pozdol SL, Nikolov R, Lecavalier L, Kohn AE, Koenig K, Hollway JA, Korzekwa P, Gavaletz A, Mulick JA, Hall KL, Dziura J, Ritz L, Trollinger S, Yu S, Vitiello B, Wagner A, Network F. Medication and Parent Training in Children With Pervasive Developmental Disorders and Serious Behavior Problems: Results From a Randomized Clinical Trial. Journal Of The American Academy Of Child & Adolescent Psychiatry 2009, 48: 1143-1154. PMID: 19858761, PMCID: PMC3142923, DOI: 10.1097/chi.0b013e3181bfd669.Peer-Reviewed Original ResearchConceptsPervasive developmental disorderClinical trialsClinical Global Impressions-Improvement scoreAberrant Behavior Checklist IrritabilityParallel-group clinical trialParent trainingBehavioral problemsDevelopmental disordersRisperidone doseRisperidone monotherapyHyperactivity/noncompliance subscaleSevere behavioral problemsCOMB groupPT sessionsQuestionnaire scoresHSQ scoresMedicationsGreater reductionChildrenPrimary measureRisperidoneSignificant reductionStereotypic behaviorScoresDoseStandardised Observation Analogue Procedure (SOAP) for assessing parent and child behaviours in clinical trials
Johnson CR, Butter EM, Handen BL, Sukhodolsky DG, Mulick J, Lecavalier L, Aman MG, Arnold E, Scahill L, Swiezy N, Sacco K, Stigler KA, McDougle CJ. Standardised Observation Analogue Procedure (SOAP) for assessing parent and child behaviours in clinical trials. Journal Of Intellectual & Developmental Disability 2009, 34: 230-238. PMID: 19681003, PMCID: PMC2739602, DOI: 10.1080/13668250903074471.Peer-Reviewed Original ResearchConceptsPervasive developmental disorderInappropriate child behaviorChild behaviorParent ratingsStructured parent training programParent-child behaviorsPsychological intervention researchParent training programAnalog procedureField of autismMedium effect sizeObservations of behaviorChild noncomplianceObservational measuresDevelopmental disabilitiesIntervention researchDevelopmental disordersValid measureNoncompliant behaviorTraining programEffect sizeModerate positive correlationBaseline scoresInter-rater reliabilityChildren
2008
Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders
Scahill L, Aman MG, McDougle CJ, Arnold LE, McCracken JT, Handen B, Johnson C, Dziura J, Butter E, Sukhodolsky D, Swiezy N, Mulick J, Stigler K, Bearss K, Ritz L, Wagner A, Vitiello B. Trial Design Challenges When Combining Medication and Parent Training in Children with Pervasive Developmental Disorders. Journal Of Autism And Developmental Disorders 2008, 39: 720-729. PMID: 19096921, PMCID: PMC4807607, DOI: 10.1007/s10803-008-0675-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionBehavior TherapyChildChild Development Disorders, PervasiveCombined Modality TherapyDopamine AntagonistsFemaleHumansMaleOutpatientsParent-Child RelationsParentsPatient CompliancePersonality AssessmentPsychiatric Status Rating ScalesRisperidoneSelf-Injurious BehaviorTreatment OutcomeConceptsParent trainingAdaptive functioningPervasive developmental disorderMeasures of noncomplianceBehavioral interventionsSymptom reductionDevelopmental disordersTraining targetClinical treatment targetsTrial design challengesTreatment targetsFunctioningTrainingFunctional improvementLow doseTreatment groupsMedicationsClinical practiceTantrumsAggressionBeneficial effectsIrritabilityChildrenNoncomplianceDisorders
2007
Parent-Rated Anxiety Symptoms in Children with Pervasive Developmental Disorders: Frequency and Association with Core Autism Symptoms and Cognitive Functioning
Sukhodolsky DG, Scahill L, Gadow KD, Arnold LE, Aman MG, McDougle CJ, McCracken JT, Tierney E, Williams White S, Lecavalier L, Vitiello B. Parent-Rated Anxiety Symptoms in Children with Pervasive Developmental Disorders: Frequency and Association with Core Autism Symptoms and Cognitive Functioning. Research On Child And Adolescent Psychopathology 2007, 36: 117-128. PMID: 17674186, DOI: 10.1007/s10802-007-9165-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAggressionAntipsychotic AgentsAnxietyAsperger SyndromeAttention Deficit Disorder with HyperactivityAutistic DisorderCentral Nervous System StimulantsChildChild Development Disorders, PervasiveChild, PreschoolCognition DisordersComorbidityCross-Over StudiesDouble-Blind MethodFemaleHumansIntelligenceLanguage Development DisordersMaleMethylphenidatePersonality AssessmentRandomized Controlled Trials as TopicRisperidoneSocial BehaviorStereotyped BehaviorConceptsPervasive developmental disorderParent-rated anxiety symptomsAnxiety symptomsHigher IQCore symptomsDevelopmental disordersCore autism symptomsAdolescent Symptom InventoryFunctional language useMedication-free childrenSocial anxietyAutism symptomsCognitive functioningParent ratingsSocial reciprocityResultsForty-three percentProblem behaviorAnxiety disordersSymptom InventoryOverall impairmentAnxietyGreater impairmentLanguage useStereotyped behaviorIQDevelopment of a parent training program for children with pervasive developmental disorders
Johnson C, Handen B, Butter E, Wagner A, Mulick J, Sukhodolsky D, Williams S, Swiezy N, Arnold L, Aman M, Scahill L, Stigler K, McDougle C, Vitiello B, Smith T. Development of a parent training program for children with pervasive developmental disorders. Behavioral Interventions 2007, 22: 201-221. DOI: 10.1002/bin.237.Peer-Reviewed Original ResearchPervasive developmental disorderApplied behavior analysisBehavioral parent training programParent training programSingle-subject design methodologyAdaptive functioningChild functioningPsychosocial interventionsTreatment fidelityBehavioral interventionsTraining procedureDevelopmental disordersPT programImportant next stepTraining programPediatric psychopharmacologyFunctioningLarge sampleMultisite studyParentsBehavior analysisInterventionMeaningful outcomesChildrenPharmacological treatment