Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors
Dixon R, Malave L, Thompson R, Wu S, Li Y, Sadik N, Anacker C. Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors. Neuropsychopharmacology 2024, 1-12. PMID: 39396089, DOI: 10.1038/s41386-024-01999-9.Peer-Reviewed Original ResearchEffects of early life adversityEarly life adversityVentral dentate gyrusAcute swim stressCorticotropin-releasing factorStress reactivityParaventricular nucleusSwim stressLife adversityNeuronal activityModel of early life adversityEarly life adversity effectsIn adulthoodIncreased passive copingSex-specific impairmentsFemale miceSerotonin-1ASerotonin systemNeurobiological mechanismsStress vulnerabilityIncreased microglia activationLimited beddingPassive copingAutoreceptorsCorticosterone levelsSex Differences in Early Life Stress Effects on Fear Generalization are Mediated by Serotonergic Regulation of the Ventral Dentate Gyrus
Anacker C, Malave L, Dixon R. Sex Differences in Early Life Stress Effects on Fear Generalization are Mediated by Serotonergic Regulation of the Ventral Dentate Gyrus. Biological Psychiatry 2024, 95: s12-s13. DOI: 10.1016/j.biopsych.2024.02.036.Peer-Reviewed Original Research