2024
Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors
Dixon R, Malave L, Thompson R, Wu S, Li Y, Sadik N, Anacker C. Sex-specific and developmental effects of early life adversity on stress reactivity are rescued by postnatal knockdown of 5-HT1A autoreceptors. Neuropsychopharmacology 2024, 1-12. PMID: 39396089, DOI: 10.1038/s41386-024-01999-9.Peer-Reviewed Original ResearchEffects of early life adversityEarly life adversityVentral dentate gyrusAcute swim stressCorticotropin-releasing factorStress reactivityParaventricular nucleusSwim stressLife adversityNeuronal activityModel of early life adversityEarly life adversity effectsIn adulthoodIncreased passive copingSex-specific impairmentsFemale miceSerotonin-1ASerotonin systemNeurobiological mechanismsStress vulnerabilityIncreased microglia activationLimited beddingPassive copingAutoreceptorsCorticosterone levels
2023
Impact of Stress Exposure on Mental and Physical Health across the Life Span: Molecular mechanisms, Neurobiological abnormalities, and Novel Pathways for Intervention
Cattaneo A, Anacker C, Daskalakis N, Riva M. Impact of Stress Exposure on Mental and Physical Health across the Life Span: Molecular mechanisms, Neurobiological abnormalities, and Novel Pathways for Intervention. Psychoneuroendocrinology 2023, 153: 106142. DOI: 10.1016/j.psyneuen.2023.106142.Peer-Reviewed Original ResearchStress exposureEffects of stress exposureImpact of stress exposureSensorimotor gating deficitsChildhood trauma survivorsNegative outcomesPhysical healthEarly life adversityNegative effects of stressExposure to adversityExposure to stressEffects of stressGating deficitsNeurobiological abnormalitiesNeurobiological mechanismsLife stressLife adversityTrauma survivorsSerotonin signalingAffective behaviorNeurodevelopmental windowBrain functionAt adulthoodPhysical diseaseMouse hippocampus