About
Titles
Associate Research Scientist
Co-chair Pediatric Protocol Review Committee, Yale Center for Clinical Investigation (YCCI); Faculty At Large, Educational Policy and Curriculum Committee Members
Biography
Dr. Landeros-Weisenberger graduated medicine from La Salle University in Mexico City, Mexico; and did her training in Psychiatry at the Hospital Español and the Universidad Nacional Autónoma de México (UNAM) in the same city. After graduating, she came to Yale University through the American Psychiatric Association (APA) Minority Training grant (PMRTP) to do her research fellowship under the mentorship of Dr. James F. Leckman at the Yale Child Study Center; focusing on novel evidence-based psychotherapeutic interventions for mental disorders across the lifespan. She has expertise in assessment of mood disorders, Tourette syndrome, obsessive compulsive disorder, trichotillomania and anxiety disorders, among others. She also has expertise conducting and implementing clinical trials in these same conditions both with industry and NIH. She enjoys teaching medical students in these disorders and training them in evidence-based techniques. She currently serves as a Co-chair of the Pediatric Protocol Review Committee (PPRC); is a member of the Yale Human Investigation Committee 4-B and an elected voting member for the EPCC. She is a mother of three and is constantly searching for the ever-elusive work-life balance.
Appointments
Child Study Center
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Associate
- Yale University (2012)
- Postdoctoral Research Fellow
- Yale University (2009)
- Psychiatry
- UNAM (2006)
- MD
- Facultad Mexicana de Medicina La Salle University (1999)
Board Certifications
Psychiatry
- Certification Organization
- Mexico Board
Research
Publications
2025
Associations between childhood interactions with people of Black race/ethnicity and racial implicit association tasks in psychiatric providers in the United States – a cross‐sectional study
Avila‐Quintero V, Malison K, Wilkerson M, Flores J, Taylor J, Landeros‐Weisenberger A, Bloch M, Tobón A. Associations between childhood interactions with people of Black race/ethnicity and racial implicit association tasks in psychiatric providers in the United States – a cross‐sectional study. Child And Adolescent Mental Health 2025, 30: 256-264. PMID: 40574470, DOI: 10.1111/camh.70001.Peer-Reviewed Original ResearchConceptsBlack race/ethnicityCross-sectional studySelf-reported amountPsychiatric providersD scoreLogistic regression modelsPsychiatric careRacial disparitiesRace/ethnicityChildhood interactionsAssociation scoreProvidersPsychiatric diagnosisMedical practiceRegression modelsEarly-lifeImplicit Association TaskClinical settingClinical contextChildhoodAssociationIAT taskWhite facesAssociation taskUnited States
2024
Systematic Review and Meta-Analysis: Placebo Response in Randomized Controlled Trials of Tourette’s Disorder Medications
Macul Ferreira de Barros P, Farhat L, Behling E, Nasir M, Landeros-Weisenberger A, Bloch M. Systematic Review and Meta-Analysis: Placebo Response in Randomized Controlled Trials of Tourette’s Disorder Medications. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 64: 577-592. PMID: 39505141, DOI: 10.1016/j.jaac.2024.10.011.Peer-Reviewed Original ResearchConceptsDrug-placebo differencesMagnitude of placebo responseTourette's disorderPaper self-identifiesPlacebo responseRandomized Controlled TrialsDrug responseChronic tic disorderAssociated with greater improvementStandardized mean changePlacebo armPlacebo-controlled randomized controlled trialsPharmacological interventionsMeta-analysisAssociated with larger improvementsStudy-level factorsClinical trialsPharmacological randomized controlled trialsDrug placeboPlacebo-controlled clinical trialPsychiatric conditionsControlled TrialsTic disordersTourette syndromeTourettePharmacological Interventions for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents with Tourette Disorder: A Systematic Review and Network Meta-Analysis
Farhat L, Behling E, Landeros-Weisenberger A, de Barros P, Polanczyk G, Cortese S, Bloch M. Pharmacological Interventions for Attention-Deficit/Hyperactivity Disorder in Children and Adolescents with Tourette Disorder: A Systematic Review and Network Meta-Analysis. Journal Of Child And Adolescent Psychopharmacology 2024, 34: 373-382. PMID: 39320340, PMCID: PMC11807863, DOI: 10.1089/cap.2024.0049.Peer-Reviewed Original ResearchConceptsADHD symptomsAttention-deficit/hyperactivity disorderTic severityTourette's disorderAttention-deficit/hyperactivityRandomized Controlled TrialsA2 agonistPharmacological interventionsADHD symptom severityIncreased tic severityPersistent tic disordersNetwork Meta-AnalysisStandardized mean differencePairs of medicationsEfficacy of pharmacological interventionsWorsen ticsRandom-effects network meta-analysisSymptom severityTic disordersADHDMeta-analysisNetwork meta-analysis frameworkCertainty of evidenceDisordersNetwork meta-analysesRacial Implicit Associations in Child Psychiatry
Malison K, Avila-Quintero V, Al-Mateen C, Flores J, Landeros-Weisenberger A, Njoroge W, Novins D, Robles-Ramamurthy B, Taylor J, Bloch M, Tobón A. Racial Implicit Associations in Child Psychiatry. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 64: 734-744. PMID: 38823476, DOI: 10.1016/j.jaac.2024.04.013.Peer-Reviewed Original ResearchImplicit Association TestRace Implicit Association TestRecruitment of human participantsExternalizing behavior problemsPaper self-identifiesImplicit associationsChildren faceBehavior problemsChild psychiatryAbstractText Label="DIVERSITY &Negatively valenced wordsExternal wordHuman participantsValenced wordsExternalizing disordersParticipating psychiatristsPsychiatric cliniciansNegative valenceNegative wordsPsychiatristsAssociation TestPsychiatryInvestigate psychiatristsReduce racial inequalityDemographic predictorsAn evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis
Ramakrishnan D, Farhat L, Vattimo E, Levine J, Johnson J, Artukoglu B, Landeros-Weisenberger A, Zangen A, Pelissolo A, de B Pereira C, Rück C, Costa D, Mataix-Cols D, Shannahoff-Khalsa D, Tolin D, Zarean E, Meyer E, Hawken E, Storch E, Andersson E, Miguel E, Maina G, Leckman J, Sarris J, March J, Diniz J, Kobak K, Mallet L, Vulink N, Amiaz R, Fernandes R, Shavitt R, Wilhelm S, Golshan S, Tezenas du Montcel S, Erzegovesi S, Baruah U, Greenberg W, Kobayashi Y, Bloch M. An evaluation of treatment response and remission definitions in adult obsessive-compulsive disorder: A systematic review and individual-patient data meta-analysis. Journal Of Psychiatric Research 2024, 173: 387-397. PMID: 38598877, DOI: 10.1016/j.jpsychires.2024.03.044.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderYale-Brown Obsessive-Compulsive ScaleCGI-IRandomized-controlled trialsAdult obsessive-compulsive disorderClinical Global Impression ImprovementObsessive-Compulsive ScaleTreatment responseIndividual Participant Data Meta-AnalysisPosttreatment scoresIndividual-patient data meta-analysisEvaluation of treatment responseMeta-analysis of randomized-controlled trialsFirst-line therapyCGIIndividual participant dataMeta-analysisNovel treatment modalitiesExpert consensusSystematic reviewDisordersData Meta-AnalysisPosttreatmentRemission definitionsImpressive improvement
2022
Characterization of human basal ganglia organoids
Brady M, Mariani J, Koca Y, Szekely A, King R, Bloch M, Landeros-Weisenberger A, Leckman J, Vaccarino F. Characterization of human basal ganglia organoids. Molecular Psychiatry 2022, 27: 4823-4823. PMID: 36536052, DOI: 10.1038/s41380-022-01914-y.Peer-Reviewed Original ResearchComparative efficacy, tolerability, and acceptability of pharmacological interventions for the treatment of children, adolescents, and young adults with Tourette's syndrome: a systematic review and network meta-analysis
Farhat L, Behling E, Landeros-Weisenberger A, Levine J, Macul Ferreira de Barros P, Wang Z, Bloch M. Comparative efficacy, tolerability, and acceptability of pharmacological interventions for the treatment of children, adolescents, and young adults with Tourette's syndrome: a systematic review and network meta-analysis. The Lancet Child & Adolescent Health 2022, 7: 112-126. PMID: 36528030, DOI: 10.1016/s2352-4642(22)00316-9.Peer-Reviewed Original ResearchConceptsAntipsychotic drugsTourette syndromeComorbid attention-deficit hyperactivity disorderSecond-generation antipsychotic drugsModerate certainty of evidenceAttention-deficit hyperactivity disorderCertainty of evidenceNetwork Meta-AnalysisPharmacological interventionsSeverity of tic symptomsObsessive-compulsive disorderIndividual medicationsRandomised controlled trialsFirst-generationDiscontinuation due to adverse eventsSecond-generationAntipsychotic medicationControlled TrialsModerate certaintyHyperactivity disorderMeta-analysisTic symptomsChoice of medicationMedication categoriesTouretteMispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids
Brady M, Mariani J, Koca Y, Szekely A, King R, Bloch M, Landeros-Weisenberger A, Leckman J, Vaccarino F. Mispatterning and interneuron deficit in Tourette Syndrome basal ganglia organoids. Molecular Psychiatry 2022, 27: 5007-5019. PMID: 36447010, PMCID: PMC9949887, DOI: 10.1038/s41380-022-01880-5.Peer-Reviewed Original ResearchConceptsTourette syndromeInterneuron deficitsGABAergic interneuronsHealthy controlsNeurodevelopmental underpinningsNeuropathological deficitsBG circuitryNeuropsychiatric disordersDecreased differentiationT patientsInterneuronsAltered expressionPotential mechanismsCilia disruptionSonic hedgehogOrganoidsStem cellsTS individualsPluripotent stem cellsGli transcription factorsDeficitsOrganoid differentiationEarly stagesCholinergicPatientsEfficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial
Dwyer J, Landeros-Weisenberger A, Johnson J, Londono Tobon A, Flores J, Nasir M, Couloures K, Sanacora G, Bloch M. Efficacy of Intravenous Ketamine in Adolescent Treatment-Resistant Depression: A Randomized Midazolam-Controlled Trial. FOCUS The Journal Of Lifelong Learning In Psychiatry 2022, 20: 241-251. PMID: 37153136, PMCID: PMC10153503, DOI: 10.1176/appi.focus.22020004.Peer-Reviewed Original ResearchTreatment-resistant depressionDepression Rating ScaleIntravenous ketamineClinical trialsAdolescent treatment-resistant depressionAdult treatment-resistant depressionPlacebo-controlled clinical trialSignificant short-term efficacySerious adverse eventsPrimary outcome measureSingle intravenous infusionChildren's Depression Rating ScaleCrossover clinical trialShort-term efficacyMajor depressive disorderSingle ketamine infusionSymptoms 24 hoursLater time pointsKetamine’s safetyAdverse eventsAntidepressant medicationKetamine infusionPediatric populationSignificant morbidityIntravenous infusionComprehensive Assessment Strategies
King R, Landeros-Weisenberger A. Comprehensive Assessment Strategies. 2022, 335-342. DOI: 10.1093/med/9780197543214.003.0020.Peer-Reviewed Original Research
Clinical Trials
Current Trials
The D1AMOND long-term safety extension study of ecopipam tablets in children, adolescents, and adults with Tourette’s Disorder
HIC ID2000035226RoleSub InvestigatorPrimary Completion Date12/31/2026Recruiting ParticipantsPET and MRI in OCD and/or Tic disorders
HIC ID2000021811RoleSub InvestigatorPrimary Completion Date11/30/2018Recruiting ParticipantsStem Cell Study in Tourette's Disorder
HIC ID1104008337RoleSub InvestigatorPrimary Completion Date11/30/2023Recruiting ParticipantsBrain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)
HIC ID0407026910RoleSub InvestigatorPrimary Completion Date06/30/2022Recruiting ParticipantsGenderBothAge16 years - 24 years
Academic Achievements & Community Involvement
News & Links
News
- September 16, 2024
New Clinical Framework Addresses Racism, Enhances Mental Health Care
- April 23, 2024Source: The UpTic Podcast
Research-based Treatment of Tics, OCD, and Depression
- October 03, 2023
Over 150 Attend Yale Child Study Center In-house Open House
- May 04, 2023
April 2023 YCSC Faculty Development Fund Awardees Announced
Get In Touch
Contacts
Child Study Center
350 George St.
New Haven, CT 06511
United States