Deficient Activity in the Neural Systems That Mediate Self-regulatory Control in Bulimia Nervosa
Marsh R, Steinglass J, Gerber A, O’Leary K, Wang Z, Murphy D, Walsh B, Peterson B. Deficient Activity in the Neural Systems That Mediate Self-regulatory Control in Bulimia Nervosa. JAMA Psychiatry 2009, 66: 51-63. PMID: 19124688, PMCID: PMC2759684, DOI: 10.1001/archgenpsychiatry.2008.504.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainBulimia NervosaCaudate NucleusCorpus StriatumDiscrimination, PsychologicalDominance, CerebralFemaleFrontal LobeGyrus CinguliHumansImage Processing, Computer-AssistedImpulsive BehaviorInternal-External ControlMagnetic Resonance ImagingNerve NetOrientationOxygenPattern Recognition, VisualPrefrontal CortexPsychomotor PerformanceReference ValuesConceptsAnterior cingulate cortexBulimia nervosaHealthy controlsCingulate cortexFrontostriatal circuitsMain outcome measuresBlood oxygenation level-dependent (BOLD) responseDorsal anterior cingulate cortexAnterior cingulate cortex activityHealthy control participantsSimon Spatial Incompatibility taskTask-related activationCingulate cortex activityLevel-dependent responsesBilateral inferior frontal gyrusFunctional magnetic resonanceSelf-regulatory controlNeural systemsGeneral linear modelingInferior frontal gyrusFunctional abnormalitiesOutcome measuresCaudate nucleusSevere symptomsPatients