2024
Social Anxiety Reduces Visual Attention to the Eyes of Emotional Faces in Autistic Youth
Franke C, Griffin J, Naples A, Wolf J, McPartland J. Social Anxiety Reduces Visual Attention to the Eyes of Emotional Faces in Autistic Youth. Journal Of Autism And Developmental Disorders 2024, 1-13. PMID: 39556296, DOI: 10.1007/s10803-024-06636-4.Peer-Reviewed Original ResearchNon-autistic participantsSocial attentionSocial anxietyEye contactAutistic youthEyes of emotional facesSA characteristicsEye trackingReduced eye contactSelf-reported SAReduced visual attentionNon-autistic childrenEmotional facesAutistic participantsPsychiatric characteristicsNon-autistic youthAutistic individualsEmotional expressionVisual attentionEye regionBehavioral featuresSocial interactionAutismParticipantsCo-occurrence11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults
Matuskey D, Yang Y, Naganawa M, Koohsari S, Toyonaga T, Gravel P, Pittman B, Torres K, Pisani L, Finn C, Cramer-Benjamin S, Herman N, Rosenthal L, Franke C, Walicki B, Esterlis I, Skosnik P, Radhakrishnan R, Wolf J, Nabulsi N, Ropchan J, Huang Y, Carson R, Naples A, McPartland J. 11C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults. Molecular Psychiatry 2024, 1-7. PMID: 39367053, DOI: 10.1038/s41380-024-02776-2.Peer-Reviewed Original ResearchPositron emission tomographySynaptic densityAutistic adultsBrain regionsAutistic featuresClinical phenotype of autismNon-autistic participantsPhenotype of autismNon-autistic individualsRelationship to clinical characteristicsSynaptic vesicle glycoprotein 2AAssociated with clinical measuresPost-mortem studiesPositron emission tomography scanPrefrontal cortexClinician ratingsAutism groupNeural basisBrain areasNeural processesBetween-group differencesVolumetric differencesBinding potentialDensity of synapsesAutismClinician-caregiver informant discrepancy is associated with sex, diagnosis age, and intervention use among autistic children.
Azu M, Han G, Wolf J, Naples A, Chawarska K, Dawson G, Bernier R, Jeste S, Dziura J, Webb S, Sugar C, Shic F, McPartland J. Clinician-caregiver informant discrepancy is associated with sex, diagnosis age, and intervention use among autistic children. Autism 2024, 13623613241279999. PMID: 39344965, DOI: 10.1177/13623613241279999.Peer-Reviewed Original ResearchAutism-related behaviorsAutism featuresClinician ratingsParent ratingsInformant discrepanciesCaregiver ratingsCaregiver reportsAutism diagnosisAutistic childrenChild sexAutismCaregiver perceptionsIntervention useClinicians' perceptionsAssociated with sexCaregiversChildrenDiagnosis ageCliniciansOlder ageInterventionPerceptionGirlsSexAgeCentral and peripheral physiological responses to decision making in hoarding disorder
Levy H, Naples A, Collett S, McPartland J, Tolin D. Central and peripheral physiological responses to decision making in hoarding disorder. International Journal Of Psychophysiology 2024, 205: 112437. PMID: 39265723, PMCID: PMC11502253, DOI: 10.1016/j.ijpsycho.2024.112437.Peer-Reviewed Original ResearchError-related negativityHoarding disorderControl participantsAlpha asymmetryPsychophysiological responsesIncreased frontal negativityGo/No-Go taskHealthy control participantsDecision-making taskPeripheral nervous system activityResponse to decisionsAnxiety disordersFrontal negativityNeurobiological modelsGo taskNeutral taskPsychiatric diagnosisExcessive clutterPsychophysiological measuresPersonal possessionsExaggerated activationDisordersNull resultsNervous system activityTaskSpatiotemporal Eye Movement Dynamics Reveal Altered Face Prioritization in Early Visual Processing Among Autistic Children
Griffin J, Naples A, Bernier R, Chawarska K, Dawson G, Dziura J, Faja S, Jeste S, Kleinhans N, Sugar C, Webb S, Shic F, McPartland J, Trials A. Spatiotemporal Eye Movement Dynamics Reveal Altered Face Prioritization in Early Visual Processing Among Autistic Children. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39237004, DOI: 10.1016/j.bpsc.2024.08.017.Peer-Reviewed Original ResearchReduced social attentionEye movement patternsSocial attentionVisual processingLongitudinal time pointsClinical features of autismContext of social perceptionAutism symptom severityFeatures of autismEarly visual processingWell-characterized sampleFace regionSymptom severityNeurotypical childrenAdaptive functioningExploratory patternsSocial difficultiesSocial perceptionAutismAutistic ChildrenFace informationTime pointsAssociated with clinical featuresFace recognitionDecreased likelihoodParsing evoked and induced gamma response differences in Autism: A visual evoked potential study
Dickinson A, Ryan D, McNaughton G, Levin A, Naples A, Borland H, Bernier R, Chawarska K, Dawson G, Dziura J, Faja S, Kleinhans N, Sugar C, Senturk D, Shic F, Webb S, McPartland J, Jeste S, Trials F. Parsing evoked and induced gamma response differences in Autism: A visual evoked potential study. Clinical Neurophysiology 2024, 165: 55-63. PMID: 38959536, DOI: 10.1016/j.clinph.2024.05.015.Peer-Reviewed Original ResearchVisual evoked potentialsMeasurement of visual evoked potentialsGamma powerVisual evoked potential studiesABC-CTGamma responseAutism Biomarkers ConsortiumAbsence of significant group differencesChildren aged 6Group differencesNon-phase-lockedEvoked potentialsVEP componentsVEP dataAged 6Biomarkers ConsortiumNeural circuit dynamicsGamma activitySignificant group differencesIndividual markersTargeted approachWavelet-based time-frequency analysisInduced responsesChildrenInduced gammaModeling intra‐individual inter‐trial EEG response variability in autism
Dong M, Telesca D, Guindani M, Sugar C, Webb S, Jeste S, Dickinson A, Levin A, Shic F, Naples A, Faja S, Dawson G, McPartland J, Şentürk D. Modeling intra‐individual inter‐trial EEG response variability in autism. Statistics In Medicine 2024, 43: 3239-3263. PMID: 38822707, DOI: 10.1002/sim.10131.Peer-Reviewed Original ResearchThe relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives
Arutiunian V, Santhosh M, Neuhaus E, Borland H, Tompkins C, Bernier R, Bookheimer S, Dapretto M, Gupta A, Jack A, Jeste S, McPartland J, Naples A, Van Horn J, Pelphrey K, Webb S. The relationship between gamma-band neural oscillations and language skills in youth with Autism Spectrum Disorder and their first-degree relatives. Molecular Autism 2024, 15: 19. PMID: 38711098, PMCID: PMC11075235, DOI: 10.1186/s13229-024-00598-1.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderElevated gamma powerLow language skillsGamma powerResponses to speech stimuliLanguage skillsLanguage functionFirst-degree relativesSpectrum disorderClinical Evaluation of Language FundamentalsCo-occurring language impairmentSpeech stimuliCortical gamma-band oscillationsHigh gamma powerSex-balanced sampleGamma-band oscillationsSample of participantsNonverbal IQLanguage impairmentASD participantsTD controlsNeural profilesAutism phenotypeTD groupLanguage Fundamentals
2023
Constrained Multivariate Functional Principal Components Analysis for Novel Outcomes in Eye-Tracking Experiments
Kwan B, Sugar C, Qian Q, Shic F, Naples A, Johnson S, Webb S, Jeste S, Faja S, Levin A, Dawson G, McPartland J, Şentürk D. Constrained Multivariate Functional Principal Components Analysis for Novel Outcomes in Eye-Tracking Experiments. Statistics In Biosciences 2023, 1-26. DOI: 10.1007/s12561-023-09399-1.Peer-Reviewed Original ResearchFrontal EEG alpha asymmetry in youth with autism: Sex differences and social–emotional correlates
Neuhaus E, Santhosh M, Kresse A, Aylward E, Bernier R, Bookheimer S, Jeste S, Jack A, McPartland J, Naples A, Van Horn J, Pelphrey K, Webb S, Network A. Frontal EEG alpha asymmetry in youth with autism: Sex differences and social–emotional correlates. Autism Research 2023, 16: 2364-2377. PMID: 37776030, PMCID: PMC10840952, DOI: 10.1002/aur.3032.Peer-Reviewed Original ResearchConceptsAutistic youthFrontal alpha powerMaternal depression historyIndividual differencesExternalizing behaviorsAlpha powerFrontal EEG alpha asymmetrySocial-emotional correlatesDepression historyEEG alpha asymmetryMental health behaviorsModel of riskAffective styleAutism featuresInternalizing symptomsASD diagnosisAlpha asymmetryAutistic femalesBehavioral indicesLevels of analysisAutistic malesEEG markersGroup differencesParticipant groupsASDThe Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC‐CT) feasibility study
Shic F, Barney E, Naples A, Dommer K, Chang S, Li B, McAllister T, Atyabi A, Wang Q, Bernier R, Dawson G, Dziura J, Faja S, Jeste S, Murias M, Johnson S, Sabatos‐DeVito M, Helleman G, Senturk D, Sugar C, Webb S, McPartland J, Chawarska K, Trials T. The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC‐CT) feasibility study. Autism Research 2023, 16: 2150-2159. PMID: 37749934, PMCID: PMC11003770, DOI: 10.1002/aur.3026.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial attention taskSchool-aged childrenAttention taskASD groupSpectrum disorderEye-tracking taskTotal T-scoreAttentional patternsAutism spectrumTD groupPresentation timeTrial feasibility studyGroup differencesPercent of timeOlder childrenTaskComparison groupToddlersT-scoreChildrenChildren 4Outcome variablesFaceCondition effectsDevelopment of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children
Finn C, Han G, Naples A, Wolf J, McPartland J. Development of peak alpha frequency reflects a distinct trajectory of neural maturation in autistic children. Autism Research 2023, 16: 2077-2089. PMID: 37638733, DOI: 10.1002/aur.3017.Peer-Reviewed Original ResearchConceptsPeak alpha frequencyAutism spectrum disorderCognitive abilitiesAutistic childrenNonverbal IQNeural maturationSpectrum disorderTypical age-related increaseAlpha frequencyDifferent developmental trajectoriesDistinct trajectoriesSample of childrenCurrent study clarifiesDiagnostic groupsNeurotypical childrenNeurotypical controlsBehavioral measuresDevelopmental trajectoriesDiagnostic statusAge-related increaseFunction of ageIQEffect of ageBivariate relationsPrevious findingsEvaluation of clinical assessments of social abilities for use in autism clinical trials by the autism biomarkers consortium for clinical trials
Faja S, Sabatos‐DeVito M, Sridhar A, Kuhn J, Nikolaeva J, Sugar C, Webb S, Bernier R, Sikich L, Hellemann G, Senturk D, Naples A, Shic F, Levin A, Seow H, Dziura J, Jeste S, Chawarska K, Nelson C, Dawson G, McPartland J, Trials A. Evaluation of clinical assessments of social abilities for use in autism clinical trials by the autism biomarkers consortium for clinical trials. Autism Research 2023, 16: 981-996. PMID: 36929131, PMCID: PMC10192100, DOI: 10.1002/aur.2905.Peer-Reviewed Original Research
2022
Exploring communicative competence in autistic children who are minimally verbal: The Low Verbal Investigatory Survey for Autism (LVIS)
Naples A, Tenenbaum E, Jones R, Righi G, Sheinkopf S, Eigsti I. Exploring communicative competence in autistic children who are minimally verbal: The Low Verbal Investigatory Survey for Autism (LVIS). Autism 2022, 27: 1391-1406. PMID: 36373838, PMCID: PMC10183057, DOI: 10.1177/13623613221136657.Peer-Reviewed Original ResearchConceptsVerbal autistic childrenAutistic childrenCommunication skillsMeasures of languageParent-report measuresChildren's communication skillsSymptoms of autismLack of wordsVerbal childrenAutism symptomatologyCognitive abilitiesLanguage abilityCommunicative abilitiesVerbal languageCommunicative competenceHelpful interventionsAlternative formsLanguageAutismChildrenClinical implicationsWordsSkillsCommunicationAbilityNeural correlates of eye contact and social function in autism spectrum disorder
Hirsch J, Zhang X, Noah J, Dravida S, Naples A, Tiede M, Wolf J, McPartland J. Neural correlates of eye contact and social function in autism spectrum disorder. PLOS ONE 2022, 17: e0265798. PMID: 36350848, PMCID: PMC9645655, DOI: 10.1371/journal.pone.0265798.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderDorsal parietal regionsNeural correlatesEye contactLive eyesNeural responsesSpectrum disorderAutism Diagnostic Observation ScheduleUnderlying neural correlatesSocial Responsiveness ScaleGold standard measureCentral diagnostic criterionDiagnostic criteriaDiagnostic biomarkersSRS-2ADOS-2Responsiveness ScaleObservation ScheduleParietal regionsPupillometry dataNeural systemsEyesNatural interactionDisordersCorrelatesPredictability modulates neural response to eye contact in ASD
Naples AJ, Foss-Feig JH, Wolf JM, Srihari VH, McPartland JC. Predictability modulates neural response to eye contact in ASD. Molecular Autism 2022, 13: 42. PMID: 36309762, PMCID: PMC9618208, DOI: 10.1186/s13229-022-00519-0.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderEvent-related potentialsNeural responsesAdult participantsAmplitude of N170Perception of gazeP300 event-related potentialExperiment twoN170 responseAnxiety symptomologyCognitive abilitiesNeural basisExperiment oneNeural processingASD sampleSpectrum disorderInterpersonal interactionsN170P300 responseAutistic womenEye contactEye trackingSocial interactionSocial contextSocial worldA Functional Model for Studying Common Trends Across Trial Time in Eye Tracking Experiments
Dong M, Telesca D, Sugar C, Shic F, Naples A, Johnson S, Li B, Atyabi A, Xie M, Webb S, Jeste S, Faja S, Levin A, Dawson G, McPartland J, Şentürk D. A Functional Model for Studying Common Trends Across Trial Time in Eye Tracking Experiments. Statistics In Biosciences 2022, 15: 261-287. PMID: 37077750, PMCID: PMC10112660, DOI: 10.1007/s12561-022-09354-6.Peer-Reviewed Original ResearchAttention Allocation During Exploration of Visual Arrays in ASD: Results from the ABC-CT Feasibility Study
Tsang T, Naples AJ, Barney EC, Xie M, Bernier R, Dawson G, Dziura J, Faja S, Jeste SS, McPartland JC, Nelson CA, Murias M, Seow H, Sugar C, Webb SJ, Shic F, Johnson SP. Attention Allocation During Exploration of Visual Arrays in ASD: Results from the ABC-CT Feasibility Study. Journal Of Autism And Developmental Disorders 2022, 53: 3220-3229. PMID: 35657448, PMCID: PMC10980886, DOI: 10.1007/s10803-022-05569-0.Peer-Reviewed Original ResearchConceptsExploration paradigmNonsocial stimuliAttention allocationASD groupSocial stimuliTD childrenVisual arrayCognitive skillsObject arraysTypical developmentASDVisual explorationObjective measuresStimuliParadigmChildrenFaceSalienceSkillsRecent workLess timeAttentionMeasuresQuantifying featuresObjects
2021
Electrophysiological Studies of Reception of Facial Communication in Autism Spectrum Disorder and Schizophrenia
Levy E, Isenstein E, Foss-Feig J, Srihari V, Anticevic A, Naples A, McPartland J. Electrophysiological Studies of Reception of Facial Communication in Autism Spectrum Disorder and Schizophrenia. Review Journal Of Autism And Developmental Disorders 2021, 9: 521-554. PMID: 36568688, PMCID: PMC9783109, DOI: 10.1007/s40489-021-00260-z.Peer-Reviewed Original ResearchAutism spectrum disorderEvent-related potentialsSchizophrenia spectrum disordersSpectrum disorderFacial communicationResearch Domain Criteria frameworkSocial cognitionHeterogeneous clinical populationN170 latencySocial perceptionTransdiagnostic researchClinical populationsNeural activitySZ populationInconsistent findingsNeurodevelopmental disordersN170Criteria frameworkResearch findingsAreas of overlapDisordersN250CognitionElectrophysiological studiesPerceptionHyperlexia
Naples A, McPartland J. Hyperlexia. 2021, 2372-2375. DOI: 10.1007/978-3-319-91280-6_734.Chapters