2024
Post-traumatic stress disorder symptoms following exposure to acute psychological trauma in children aged 8–16 years in South Africa: protocol for the Sinethemba longitudinal study
Sharp T, Chideya Y, Giuliani A, Hunt X, Tomlinson M, Seedat S, Creswell C, Fearon P, Hamilton-Giachritsis C, Hiller R, Meiser-Stedman R, Du Toit S, Stewart J, Halligan S. Post-traumatic stress disorder symptoms following exposure to acute psychological trauma in children aged 8–16 years in South Africa: protocol for the Sinethemba longitudinal study. BMJ Open 2024, 14: e085129. PMID: 38991675, DOI: 10.1136/bmjopen-2024-085129.Peer-Reviewed Original ResearchConceptsMental health outcomesPost-traumatic stress disorderChildren aged 8Caregiver supportHealth outcomesAssociation of psychosocial factorsAdverse mental health outcomesAged 8Traumatic eventsChildren’s post-traumatic stress disorderDepartment of HealthMiddle-income countriesTrauma-related mental healthPsychological risk factorsHigh-income countriesStress disorder symptomsFollow-up assessmentPost-traumatic stress disorder symptomsCape TownMotor vehicle accidentsHealthcare clinicsPsychosocial factorsMental healthPsychological recoveryEthical approvalCommentary: Health anxiety in youth during ‘COVID’ – some thoughts prompted by Rask et al. (2024)
Sonuga‐Barke E, Fearon P. Commentary: Health anxiety in youth during ‘COVID’ – some thoughts prompted by Rask et al. (2024). Journal Of Child Psychology And Psychiatry 2024, 65: 431-434. PMID: 38415840, DOI: 10.1111/jcpp.13973.Peer-Reviewed Original ResearchTrial protocol for the Building Resilience through Socio-Emotional Training (ReSET) programme: a cluster randomised controlled trial of a new transdiagnostic preventative intervention for adolescents
Viding E, Lloyd A, Law R, Martin P, Lucas L, Wu T, Steinbeis N, Midgley N, Veenstra R, Smith J, Ly L, Bird G, Murphy J, Plans D, Munafo M, Penton-Voak I, Deighton J, Richards K, Richards M, Fearon P. Trial protocol for the Building Resilience through Socio-Emotional Training (ReSET) programme: a cluster randomised controlled trial of a new transdiagnostic preventative intervention for adolescents. Trials 2024, 25: 143. PMID: 38395922, PMCID: PMC10885387, DOI: 10.1186/s13063-024-07931-2.Peer-Reviewed Original ResearchConceptsMental health problemsPost-interventionPreventive interventionsCluster randomised controlled trialPrevent mental health problemsHealth problemsRates of mental health disordersCluster-randomised designCommunication skills trainingTransdiagnostic preventive interventionMental health disordersSchool year levelRandomised controlled trialsSubgroup of participantsDiscussionThis projectScalable interventionsEmotional processingFollow-upMental wellbeingWeekly sessionsFocus groupsHealth disordersGroup-basedAssessed pre-Individual sessions
2022
A modified video-feedback intervention for carers of foster children aged 6 years and under with reactive attachment disorder: a feasibility study and pilot RCT
Oliveira P, Stevens E, Barge L, Comyn J, Langley K, Ramchandani P, Wright B, Woolgar M, Kennedy E, Byford S, Shearer J, Scott S, Barlow J, Glaser D, Senior R, Fonagy P, Fearon P. A modified video-feedback intervention for carers of foster children aged 6 years and under with reactive attachment disorder: a feasibility study and pilot RCT. Health Technology Assessment 2022, 26: 1-106. PMID: 35959710, PMCID: PMC9421559, DOI: 10.3310/sliz1119.Peer-Reviewed Original ResearchConceptsVideo-feedback InterventionCase seriesMAIN OUTCOMEReactive attachment disorderNIHR Journals Library websiteHealth Technology Assessment programmeNew interventionsAdolescent mental health servicesFuture full-scale trialFurther project informationSmall case seriesTreatment manualWide inclusion criteriaTechnology Assessment programmeMental health servicesTarget sample sizeEffective treatment approachEvidence-based interventionsAttachment disorderLarge-scale trialsHealth service practitionersMental health professionalsTreatment completenessUsual carePilot RCTHeritability of Psychological Traits and Developmental Milestones in Infancy
Austerberry C, Mateen M, Fearon P, Ronald A. Heritability of Psychological Traits and Developmental Milestones in Infancy. JAMA Network Open 2022, 5: e2227887. PMID: 35994288, PMCID: PMC9396365, DOI: 10.1001/jamanetworkopen.2022.27887.Peer-Reviewed Original ResearchAdolescent development of multiscale structural wiring and functional interactions in the human connectome
Park B, Paquola C, Bethlehem R, Benkarim O, Consortium N, Mišić B, Smallwood J, Bullmore E, Bernhardt B, Bullmore E, Dolan R, Goodyer I, Fonagy P, Jones P, Moutoussis M, Hauser T, Neufeld S, Romero-Garcia R, St Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Kiddle B, Polek E, Fearon P, Suckling J, van Harmelen A, Kievit R, Chamberlain S. Adolescent development of multiscale structural wiring and functional interactions in the human connectome. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2116673119. PMID: 35776541, PMCID: PMC9271154, DOI: 10.1073/pnas.2116673119.Peer-Reviewed Original ResearchConceptsAdolescent developmentFunctional brain network developmentResting-state functional MRI measuresAccelerated longitudinal cohortBrain network developmentDefault mode networkFunctional MRI measuresStructural wiringHuman brain structureStructure-function couplingAge-related changesMode networkSame participantsHuman connectomeCortical wiringBrain structuresLongitudinal analysisCross-sectional analysisLongitudinal changesFunctional hierarchyMRI featuresLongitudinal cohortMRI measuresWhite matterFunctional interactionDevelopmental pathways from toddler difficult temperament to child generalized psychopathology and adult functioning
Wu T, Meehan A, Rijlaarsdam J, Maughan B, Fearon P, Barker E. Developmental pathways from toddler difficult temperament to child generalized psychopathology and adult functioning. Journal Of Affective Disorders 2022, 301: 14-22. PMID: 34990631, DOI: 10.1016/j.jad.2022.01.012.Peer-Reviewed Original ResearchConceptsEarly difficult temperamentLate childhood/early adolescenceChildhood/early adolescenceDifficult temperamentMental health symptomsPositive parentingEarly adolescenceChild mental health symptomsDepressive symptomsLater mental health difficultiesRisk community sampleLow-risk community sampleChild mental health problemsImpaired psychosocial functioningMother-child dyadsMental health difficultiesOwn depressive symptomsChild difficult temperamentMental health problemsNegative parentingChildhood/adolescenceGeneral psychopathology factorGeneralized psychopathologyPsychosocial functioningAdult functioning
2021
Editorial: ‘The giant’s shoulders’: understanding Michael Rutter’s impact on science and society
Sonuga‐Barke E, Fearon P, Scott S. Editorial: ‘The giant’s shoulders’: understanding Michael Rutter’s impact on science and society. Journal Of Child Psychology And Psychiatry 2021, 63: 1-3. PMID: 34957560, DOI: 10.1111/jcpp.13558.Peer-Reviewed Original ResearchEditorial: Do lockdowns scar? Three putative mechanisms through which COVID‐19 mitigation policies could cause long‐term harm to young people's mental health
Sonuga‐Barke E, Fearon P. Editorial: Do lockdowns scar? Three putative mechanisms through which COVID‐19 mitigation policies could cause long‐term harm to young people's mental health. Journal Of Child Psychology And Psychiatry 2021, 62: 1375-1378. PMID: 34806768, PMCID: PMC9011706, DOI: 10.1111/jcpp.13537.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildCicatrixCommunicable Disease ControlCOVID-19HumansMental HealthPolicySARS-CoV-2ConceptsYoung people's mental healthPeople's mental healthMental healthLong-term effectsPutative mechanismsHigh-risk settingsParent mental healthPre-existing conditionsUse of lockdownsLong-term harmCOVID-19 mitigation policiesNegative psychological impactParticular riskCOVID-19Social isolationPsychological impactVulnerable individualsHealthEarly predictionDirect effectSuch long-term effectsIndirect effectsLockdownHarmPersonsFirst 1,000 days: enough for mothers but not for children? Long‐term outcomes of an early intervention on maternal depressed mood and child cognitive development: follow‐up of a randomised controlled trial
Tomlinson M, Skeen S, Melendez‐Torres G, Hunt X, Desmond C, Morgan B, Murray L, Cooper P, Rathod S, Marlow M, Fearon P. First 1,000 days: enough for mothers but not for children? Long‐term outcomes of an early intervention on maternal depressed mood and child cognitive development: follow‐up of a randomised controlled trial. Journal Of Child Psychology And Psychiatry 2021, 63: 261-272. PMID: 34227113, DOI: 10.1111/jcpp.13482.Peer-Reviewed Original ResearchConceptsChildren's cognitive developmentChild cognitive outcomesCognitive developmentCognitive outcomesMaternal moodMother-infant relationship qualityDepressed moodEarly interventionKaufman Assessment BatteryEarly mother-infant relationshipLong-term child outcomesCapacity of parentsYears of ageMother-infant relationshipMaternal depressed moodAttachment interventionsMaternal mental healthPsychological distressAssessment BatteryChild developmentChild outcomesRelationship qualityNull findingsMental healthMoodDevelopmental trajectories of autistic social traits in the general population
Pender R, Fearon P, St Pourcain B, Heron J, Mandy W. Developmental trajectories of autistic social traits in the general population. Psychological Medicine 2021, 53: 814-822. PMID: 34154678, DOI: 10.1017/s0033291721002166.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderGrowth mixture modellingAutistic traitsSocial difficultiesCommunication Disorders ChecklistTrajectory groupsMajority-male groupsSCDC scoresAutistic peopleASD diagnosisSpectrum disorderDevelopmental trajectoriesCommunication traitsExternalising difficultiesAvon Longitudinal StudyTrait continuumGeneral population sampleAge 7Social traitsMental healthLongitudinal studyAdolescenceExternal validityPersistent lowYoung peopleDecision-making ability, psychopathology, and brain connectivity
Moutoussis M, Garzón B, Neufeld S, Bach D, Rigoli F, Goodyer I, Bullmore E, Consortium N, Fonagy P, Jones P, Hauser T, Romero-Garcia R, St Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Fearon P, Suckling J, van Harmelen A, Kievit R, Guitart-Masip M, Dolan R. Decision-making ability, psychopathology, and brain connectivity. Neuron 2021, 109: 2025-2040.e7. PMID: 34019810, PMCID: PMC8221811, DOI: 10.1016/j.neuron.2021.04.019.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAffectAntisocial Personality DisorderAnxietyBrainCognitionDecision MakingDepressionDepressive Disorder, MajorFactor Analysis, StatisticalFemaleFunctional NeuroimagingHumansIntelligence TestsMagnetic Resonance ImagingMaleNeural PathwaysNeuropsychological TestsPsychosocial FunctioningSelf ConceptSocial InteractionYoung AdultConceptsDecision-making abilityFunctional connectivityResting-state functional connectivityGeneral social functioningDecision-making measuresPoor social functionCognitive constructsCognitive processesBrain signaturesSocial functioningThought patternsBrain connectivityMental healthMultiple domainsSocial functionIQBrain dataCommon factorsYoung peopleConstructsIndividuals 18Neural networkConnectivityAbilityPsychopathologyAn expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization
Park B, Bethlehem R, Paquola C, Larivière S, Rodríguez-Cruces R, de Wael R, Bullmore E, Dolan R, Goodyer I, Fonagy P, Jones P, Moutoussis M, Hauser T, Neufeld S, Romero-Garcia R, St Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Kiddle B, Polek E, Fearon P, Suckling J, van Harmelen A, Kievit R, Chamberlain S, Bullmore E, Bernhardt B. An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization. ELife 2021, 10: e64694. PMID: 33787489, PMCID: PMC8087442, DOI: 10.7554/elife.64694.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent BehaviorAdolescent DevelopmentAdultAge FactorsBrainCognitionConnectomeFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalHumansLongitudinal StudiesMagnetic Resonance ImagingMaleModels, NeurologicalNerve Tissue ProteinsNeural PathwaysNeurogenesisTranscriptomeYoung AdultConceptsTransmodal regionsHigher-order association networksStructural connectome organizationMeasures of intelligenceLarge longitudinal sampleAdolescent developmentCognitive outcomesConnectome developmentBrain networksLongitudinal sampleStatistical learningConnectome organizationYoung adulthoodModule connectivityConnectivity patternsStructural connectomeEmpirical gapMaturational changesAdolescencePrenatal attachment: using measurement invariance to test the validity of comparisons across eight culturally diverse countries
Foley S, Hughes C, Murray A, Baban A, Fernando A, Madrid B, Osafo J, Sikander S, Abbasi F, Walker S, Luong-Thanh B, Vo T, Tomlinson M, Fearon P, Ward C, Valdebenito S, Eisner M. Prenatal attachment: using measurement invariance to test the validity of comparisons across eight culturally diverse countries. Archives Of Women's Mental Health 2021, 24: 619-625. PMID: 33559754, PMCID: PMC8266779, DOI: 10.1007/s00737-021-01105-8.Peer-Reviewed Original ResearchConceptsMaternal-fetal attachmentMiddle-income countriesHigh-income countriesExpectant mothersProspective birth cohort studyBirth cohort studyFirst-time mothersPrenatal Attachment InventoryCohort studyThird trimesterPregnant womenMaternal healthFirst infantMaternal behaviorGroup comparisonsMean levelsMothersInfantsSingle latent factorFuture studiesPlace childrenChildrenChild outcomesSimilar informationPAI
2020
Antisocial cognition as a mediator of the peer influence effect and peer selection effect in antisocial adolescents
Brewer A, Saunders R, Fearon P, Fonagy P, Cottrell D, Kraam A, Pilling S, Simes E, Anokhina A, Butler S. Antisocial cognition as a mediator of the peer influence effect and peer selection effect in antisocial adolescents. European Child & Adolescent Psychiatry 2020, 31: 177-187. PMID: 33330952, PMCID: PMC8816781, DOI: 10.1007/s00787-020-01695-1.Peer-Reviewed Original ResearchConceptsPeer selection effectsDelinquent peer associationPeer conflictAntisocial behaviorPeer influenceSerious antisocial behaviorPeer associationAntisocial cognitionSelf-reported antisocial behaviorPeer influence effectsAntisocial adolescentsBritish adolescentsInfluence effectsPredictive relationshipAdolescentsCognitionCriminological literatureBeliefsAttitudesSelection effectsTotal effectCausal mechanismsConflictBehaviorFindingsEmotion regulation in adolescents: Influences of internal representations of relationships – An ERP study
Desatnik A, Bel-Bahar T, Taylor L, Nolte T, Crowley MJ, Fonagy P, Fearon P. Emotion regulation in adolescents: Influences of internal representations of relationships – An ERP study. International Journal Of Psychophysiology 2020, 160: 1-9. PMID: 33278467, DOI: 10.1016/j.ijpsycho.2020.11.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildEmotional RegulationEmotionsEvoked PotentialsHumansIndividualityObject AttachmentConceptsLate positive potentialEmotion regulationIndividual differencesInternal representationEmotion regulation strategiesExperience of emotionEvent Related PotentialsSample of adolescentsExpressive suppressionSocial cognitionERP studyNeural correlatesRegulation strategiesER taskEmotional responsesDevelopmental variablesRelated potentialsObject relationsIndividual's abilityAdolescentsEmotionsPositive potentialsClinical implicationsCognitionFirst studyPTSD symptoms and cortisol stress reactivity in adolescence: Findings from a high adversity cohort in South Africa
Zimmerman A, Halligan S, Skeen S, Morgan B, Fraser A, Fearon P, Tomlinson M. PTSD symptoms and cortisol stress reactivity in adolescence: Findings from a high adversity cohort in South Africa. Psychoneuroendocrinology 2020, 121: 104846. PMID: 32919210, DOI: 10.1016/j.psyneuen.2020.104846.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderCortisol stress reactivityTrier Social Stress TestPTSD symptomsTrauma exposureStress reactivityHPA axis stress reactivitySmall inverse associationHPA stress reactivitySex-specific associationsTotal cortisol outputElevated PTSD symptomsImpoverished South African communityMiddle-income countriesAdrenal axisInverse associationSocial Stress TestMiddle-income country contextCortisol responsePsychosocial stressCortisol outputCortisol increaseSalivary cortisolStress disorderSouth African communityChildhood socio‐economic disadvantage predicts reduced myelin growth across adolescence and young adulthood
Ziegler G, Moutoussis M, Hauser T, Fearon P, Bullmore E, Goodyer I, Fonagy P, Jones P, Lindenberger U, Dolan R. Childhood socio‐economic disadvantage predicts reduced myelin growth across adolescence and young adulthood. Human Brain Mapping 2020, 41: 3392-3402. PMID: 32432383, PMCID: PMC7375075, DOI: 10.1002/hbm.25024.Peer-Reviewed Original ResearchConceptsSocio-economic disadvantageMyelin growthEarly socioeconomic disadvantageYoung adulthoodBody mass indexChildhood socio-economic disadvantageLife stressorsYears of ageEarly life stressorsPotential translational implicationsEarly life disadvantageWhite matter regionsParental educationMass indexSubcortical nucleiBrain developmentAlcohol useMatter regionsTranslational implicationsSocioeconomic disadvantageAge 12Life disadvantagePositive parentingProtective mannerNormal trajectoryConservative and disruptive modes of adolescent change in human brain functional connectivity
Váša F, Romero-Garcia R, Kitzbichler M, Seidlitz J, Whitaker K, Vaghi M, Kundu P, Patel A, Fonagy P, Dolan R, Jones P, Goodyer I, Vértes P, Bullmore E, Bullmore E, Dolan R, Goodyer I, Fonagy P, Jones P, Moutoussis M, Hauser T, Neufeld S, Romero-Garcia R, St Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Fearon P, Suckling J, van Harmelen A, Kievit R. Conservative and disruptive modes of adolescent change in human brain functional connectivity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 3248-3253. PMID: 31992644, PMCID: PMC7022153, DOI: 10.1073/pnas.1906144117.Peer-Reviewed Original ResearchConceptsFunctional connectivityAdolescent changesFunctional MRIMaturational indexAutobiographical memory taskHuman brain organizationSubcortical regionsResting-state oscillationsHuman brain functional connectivityHuman brain functionBaseline functional connectivityCortical surface expansionBrain functional connectivitySocial cognitionMemory taskAge-related changesBrain organizationAssociation cortexHealthy adolescentsDevelopmental changesCortical regionsBrain functionConservative developmentAerobic glycolysisSubcortical areas
2019
Schizotypy-Related Magnetization of Cortex in Healthy Adolescence Is Colocated With Expression of Schizophrenia-Related Genes
Romero-Garcia R, Seidlitz J, Whitaker K, Morgan S, Fonagy P, Dolan R, Jones P, Goodyer I, Suckling J, Consortium N, Bullmore E, Dolan R, Goodyer I, Fonagy P, Jones P, Vaghi M, Moutoussis M, Hauser T, Neufeld S, Romero-Garcia R, St Clair M, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Fearon P, Suckling J, van Harmelen A, Kievit R, Vértes P, Vértes P, Bullmore E. Schizotypy-Related Magnetization of Cortex in Healthy Adolescence Is Colocated With Expression of Schizophrenia-Related Genes. Biological Psychiatry 2019, 88: 248-259. PMID: 32029217, PMCID: PMC7369635, DOI: 10.1016/j.biopsych.2019.12.005.Peer-Reviewed Original Research