Adolescent Depression and Suicide
December 18, 2022Michael Bloch, MD, MS - Associate Professor at the Child Study Center and Department of Psychiatry at Yale University
Youngsun Cho, MD/Ph.D. - Assistant Professor at the Child Study Center and Department of Psychiatry at Yale University
Meeting the Complexities of Adolescent Mental Health -- November 5th, 2022
Information
- ID
- 9316
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- DCA Citation Guide
Transcript
- 00:00Next we're going to be talking about
- 00:03adolescent depression and suicide,
- 00:04and I think I've already,
- 00:08I already introduced myself before,
- 00:11but I'm delighted to do this
- 00:15presentation with Youngsun Cho,
- 00:17who's a wonderful child,
- 00:19child psychiatrist and expert in depression.
- 00:22She's also modest enough to put her
- 00:25name after mine, even though she
- 00:27put together like the whole talk.
- 00:28So she should probably be listed first
- 00:30on this and she should get the credit.
- 00:33But anyway, we're really lucky
- 00:36to have her talking today.
- 00:38And I think this is a really
- 00:40important topic and you can
- 00:41advance to the next slide.
- 00:45We have a bunch of
- 00:49disclosures I certainly get
- 00:51funds from various pharmaceutical
- 00:54companies looking at experimental
- 00:56treatments for depression, Tourettes,
- 00:59other conditions including OCD.
- 01:03Also, we get funding from the
- 01:05National Institute of Health.
- 01:06I don't think it's particularly
- 01:08germane to this presentation,
- 01:10but just wanted to make you aware of that.
- 01:14Next slide.
- 01:15So adolescent depression is a significant
- 01:19public health problem and it,
- 01:22and I think for a lot of you are probably
- 01:25where it's at a borderline crisis at
- 01:27this point. That nearly one in five
- 01:30people will experience a major depressive
- 01:33disorder during their adolescent years,
- 01:35and it's probably closer to one
- 01:38in four since COVID started.
- 01:40Suicide is the 2nd leading cause of death
- 01:44in adolescents in the United States.
- 01:47Not only is depression
- 01:50associated, teen depression associated
- 01:51with significant mortality,
- 01:53it's also associated with
- 01:55significant morbidity.
- 01:56There's an increased, teens who are
- 01:59depressed have increased social problems,
- 02:01they have problems in terms of
- 02:03their functioning in school,
- 02:04and it's associated with a variety
- 02:07of other things that affect behavior.
- 02:12So
- 02:13in terms of increased risk of substance use,
- 02:16pregnancy and so it's and then
- 02:20the other thing is that people,
- 02:23people who experience depression
- 02:26as teenagers
- 02:28are very likely to have another episode later on,
- 02:31and then there also probably has
- 02:33the worst prognosis in terms of
- 02:35their adulthood depression.
- 02:37OK.
- 02:40In terms of the actual suicide effects,
- 02:43these are from the CDC
- 02:44I didn't make them up, among high
- 02:47schoolers in the United States
- 02:5017% have considered suicide, attempting
- 02:53suicide in the last year,
- 02:5614% have had a suicide plan,
- 02:598% have actually attempted suicide,
- 03:01and 3% have made a suicide attempt
- 03:05that required medical attention.
- 03:08And then we, there are, we lose
- 03:12approximately 5500 adolescents
- 03:14per year who die by suicide and
- 03:17just thinking about the number
- 03:22my, my, my kids are slated to go to
- 03:24Hamden High School that has about 1100
- 03:27students and that's and it's a pretty
- 03:30big building and that's five Hamden
- 03:32high schools worth of kids every year
- 03:35that die by suicide in high school.
- 03:38Another way to think about these numbers
- 03:41is just, I think about them as a parent.
- 03:43So these are, this is a picture
- 03:46of my wife Angie,
- 03:47my daughter Rachel and my twin boys
- 03:50Sam and Paul.
- 03:52And so there's
- 03:53one year that all three of them are going
- 03:56to be going to high school together.
- 03:58Just one year.
- 04:01And during that year, there's a two out
- 04:07of five chance that one of my kids will
- 04:13have suicidal ideation.
- 04:16It's about one in three chance that one
- 04:19of them will have had a suicide plan.
- 04:22There's about a one in five chance that
- 04:25one of them will have attempted suicide.
- 04:28And there's about a one in ten
- 04:31chance, slightly less than, that one
- 04:33of them will have a suicide attempt
- 04:35that required medical attention and
- 04:37and that's really scary to me as
- 04:40a father. And then if you look at
- 04:42while my three kids are at high
- 04:44in high school,
- 04:45it's more likely than not that one of
- 04:47them will have a major depressive episode,
- 04:50and it's more likely than not that they
- 04:52will know of a classmate who dies by suicide.
- 04:55And I just think that's, it's
- 04:57just really staggering,
- 04:58the numbers.
- 05:03So I'm going to go ahead and
- 05:05talk a little bit about how
- 05:07depression presents in teenagers.
- 05:08So things to keep in mind is overall
- 05:12teenagers and people in general who
- 05:14have depression typically have what we
- 05:16call a persistent low mood or sadness.
- 05:18So this is sort of a, they report feeling
- 05:21sad or down for most of the day,
- 05:23many days of the week.
- 05:25In teenagers, irritability can
- 05:26also be a persistent feature,
- 05:28sometimes even more than the sad mood.
- 05:30So that's important to keep in mind that
- 05:32this seems to be a developmentally
- 05:33specific feature. So this occurs
- 05:35for at least two weeks at a time,
- 05:38plus the sort of official criteria
- 05:40asks that they have at least
- 05:42four of the following criteria,
- 05:44which we kind of keep track of
- 05:46with an acronym called SIGE CAPS.
- 05:48So the four criteria,
- 05:494 out of the following eight
- 05:51criteria are sleep changes,
- 05:53so this could be sleeping more
- 05:54or sleeping less than usual,
- 05:56a loss of interest or motivation,
- 05:58so this is the teenager who maybe like to
- 06:00go to art classes or like to play sports,
- 06:02but isn't showing that interest anymore,
- 06:05feelings of guilt,
- 06:06feeling like they don't have
- 06:08enough energy during the day,
- 06:09you know,
- 06:10seeming like they need to take naps or even
- 06:12taking naps and not feeling refreshed,
- 06:14having cognitive difficulties,
- 06:16so trouble concentrating,
- 06:18trouble remembering things which in turn
- 06:20can obviously affect the school performance.
- 06:23Appetite changes can also be seen as well.
- 06:26So either an increased appetite or
- 06:28decreased appetite. Sometimes
- 06:30kids can show what we call a
- 06:33psychomotor agitation or slowing.
- 06:35So changes in how their motor movements
- 06:37are, either moving faster or slower.
- 06:40And finally a component that's a
- 06:41large part of today's talk as well
- 06:43is suicidal thoughts and behaviors
- 06:45can accompany depression.
- 06:48The key point here also I think just
- 06:51like Wendy had mentioned in her talk,
- 06:53is just to understand how different
- 06:55depression can be for different kids.
- 06:57So as I had said,
- 06:58you need 4 out of these eight,
- 07:00but it doesn't say which
- 07:01four you have to have.
- 07:02And so kids can have any number of
- 07:05combination of symptoms and it's important
- 07:07to understand what aspects of depression
- 07:10really impact their ability to function.
- 07:12So the risk factors for
- 07:14adolescent depression?
- 07:15There are a number of them.
- 07:16So family history.
- 07:17So having family members with a history
- 07:20of depression or other mood disorders
- 07:22puts teenagers at risk for having depression.
- 07:24Teenage depression occurs more often
- 07:26in female teenagers,
- 07:27about two to three times
- 07:29more often than in males.
- 07:30A history of early life stress or adversity.
- 07:34Poverty is a risk factor
- 07:36for teenage depression,
- 07:37a history of or current trauma,
- 07:39as well as well as peer
- 07:41conflicts such as bullying.
- 07:42Which we know is, has become a
- 07:44large problem in recent years.
- 07:46Stresses at home.
- 07:47Familial conflicts or stress can be a
- 07:50risk factor for adolescent depression,
- 07:52minority stress,
- 07:53or the stress of feeling like
- 07:55the stress that people who identify as
- 07:57minorities in society may experience
- 07:58is also a risk factor as well
- 08:01as having a disability.
- 08:03And just to sort of put this in context
- 08:05with when the pandemic is started at,
- 08:07the information from the
- 08:09CDC suggests that in 2021,
- 08:11since the pandemic started,
- 08:1455% of high schoolers have reported receiving
- 08:17emotional abuse from an adult in the home,
- 08:1911% of experienced physical
- 08:21abuse from an adult in the home,
- 08:23and 29% of had a parent or adult
- 08:25in the home lose a job.
- 08:26So these are all stressors
- 08:28that have been exacerbated,
- 08:30likely since the pandemic has
- 08:31started and are contributing to the
- 08:33increase in the rise in depression
- 08:35and other psychiatric illnesses.
- 08:38So the talks all today are
- 08:40focused on the adolescent years.
- 08:41And so it's a period that I
- 08:43think is really interesting to
- 08:44all of us who are talking here.
- 08:45And so I think it's important to
- 08:47sort of step back a little bit
- 08:49and think about what is special
- 08:50about the adolescent years.
- 08:51So it's a time of rapid physical,
- 08:53emotional, social and cognitive growth.
- 08:55And for everyone who works in
- 08:57the schools or sees teenagers,
- 08:58you all know this.
- 09:00And the developmental changes
- 09:01that are occurring in the brain
- 09:04parallel this growth that's
- 09:05happening that we can all observe
- 09:08and continues into young adulthood.
- 09:10The growth is, you know,
- 09:12purposeful and intentional,
- 09:13and it allows the teenagers to
- 09:16start to explore their identity.
- 09:18And ideally,
- 09:19this developmental stage transitions
- 09:21them to successfully to adulthood
- 09:23and that would be the sort of ideal
- 09:26outcome for adolescence is this
- 09:29successful transition to adulthood.
- 09:31So just to talk briefly about the
- 09:33brain changes during adolescence,
- 09:34the brain undergoes quite a bit
- 09:36of change during childhood,
- 09:37adolescence and even into
- 09:39the early adulthood years.
- 09:40And particular areas that people have
- 09:43really focused on are, is the cortex.
- 09:46So the cortex is sort of this outer
- 09:48layer of the brain and is really
- 09:50responsible for helping us think, process,
- 09:53executive function, do a lot of things.
- 09:55And what people have noticed is that it is
- 09:58typically normal for the cortex to thin
- 10:01throughout childhood,
- 10:02adolescence and early adulthood probably
- 10:04related to pruning and other processes,
- 10:07especially in the prefrontal and
- 10:08parietal cortices. And again,
- 10:10these are areas that help us remember,
- 10:12think, plan and organize.
- 10:16And so this, these changes sort of
- 10:17go all the way through childhood,
- 10:19through early adulthood.
- 10:20And the picture on here is showing
- 10:23the changes from five years all
- 10:24the way to 20 years.
- 10:26The warm colors in red are areas
- 10:28where the cortex is thicker.
- 10:29And as it turns cooler colors
- 10:31as time goes on,
- 10:32it means that the cortex
- 10:34is thinning with time.
- 10:36So just to kind of illustrate
- 10:38this with the video is this sort
- 10:40of dynamic changes in the brain.
- 10:41Again,
- 10:42this is sort of illustrated from
- 10:43five years throughout 20 years old.
- 10:49So, Umm, the functional sort of changes
- 10:52here in adolescents with depression,
- 10:54areas that are in the brain that
- 10:56are associated with receiving rewards.
- 10:59So this idea of feeling pleasure when
- 11:01there are rewards given, these areas
- 11:03actually show decreased neural signals
- 11:05in adolescents with depression when
- 11:07they're anticipating rewards compared
- 11:08to teenagers who don't have depression.
- 11:11Suggesting again that this idea of not
- 11:14being motivated, having anhedonia may
- 11:16be linked to sort of neural changes
- 11:18in the brain in these reward areas.
- 11:21Additionally, when people look at an
- 11:23area of the brain called the amygdala,
- 11:25which is responsible for helping
- 11:27us emotionally process event and
- 11:29seeing what's emotionally important,
- 11:31adolescents with depression actually
- 11:32have higher neural signals in this
- 11:35region when they look at fearful or
- 11:37very emotional faces compared to
- 11:39teenagers who don't have depression.
- 11:41And this sort of suggests that these
- 11:44emotional expressions and peers or
- 11:45in other people are quite salient and
- 11:47quite sort of important to adolescent
- 11:50depression,
- 11:50maybe even more so in teenagers
- 11:52who don't have depression.
- 11:57So, so I think one thing
- 12:00that's really important about
- 12:02adolescent depression is that we
- 12:03have very good treatments for it,
- 12:05we have good treatments,
- 12:06we have effective treatments for, very good
- 12:08is probably an overstatement,
- 12:10but there have been studies
- 12:12that have looked at treatments
- 12:14for adolescent depression.
- 12:16This is a randomized controlled
- 12:19study of 440 adolescents that were
- 12:21randomized to either medication,
- 12:23therapy, the combination of
- 12:25both or placebo for 12 weeks.
- 12:27And the big take home point of
- 12:29this is both the medications
- 12:32and therapy are effective
- 12:33and the combination is
- 12:34probably better than either one alone.
- 12:36And then,
- 12:39A majority of kids with depression who
- 12:41were given evidence based treatment get
- 12:44significantly better with treatment,
- 12:45and fairly quickly. Next slide.
- 12:51In terms of the guidelines,
- 12:53the US and the UK differ slightly
- 12:56in terms of treatment guidelines. For
- 12:59for mild depression both in the UK and
- 13:03the US they recommend psychotherapy
- 13:06alone and then for moderate and severe
- 13:09depression it differs a little bit.
- 13:11In the US it's evidence based
- 13:14psychotherapy and/or medication,
- 13:16particularly fluoxetine which is a
- 13:18selective serotonin reuptake inhibitor.
- 13:20And in the UK it's evidence based
- 13:24therapy plus or minus fluoxetine.
- 13:27So I would say personally I'm
- 13:29much more of a Tory in terms of the
- 13:31guidelines and that I think you should
- 13:33be whenever possible you should be
- 13:35offering these kids evidence based
- 13:37psychotherapy and the medication
- 13:39is an add-on that you're often
- 13:42choosing to use in,
- 13:44in terms of adding it to the
- 13:46therapy when it's available.
- 13:48The big advantage of therapy
- 13:50versus medication
- 13:51it's probably not on the efficacy part of it,
- 13:55but in the fact that the lessons you can
- 13:58learn from therapy can be more durable.
- 14:00When I give the kid a medication,
- 14:01if they stop taking the medicine,
- 14:03it's probably not going to work anymore,
- 14:05whereas the lessons from the therapy or often
- 14:09maintained also, therapy has less side effects.
- 14:13In terms of therapies for
- 14:15adolescent depression,
- 14:15we have cognitive behavioral therapy which
- 14:18Wendy talked about a bunch of for
- 14:20anxiety
- 14:21but in depression,
- 14:22it focuses more on understanding
- 14:24thoughts and behaviors and identifying
- 14:27maladaptive thought patterns and behaviors.
- 14:30And the other therapy that's commonly used
- 14:33in adolescence is interpersonal therapy,
- 14:36which focuses on relationships and
- 14:38developing effective strategies for
- 14:41dealing with relationship problems.
- 14:43Again,
- 14:44both are generally evidence
- 14:45based and time limited.
- 14:50In terms of medications,
- 14:51there are a lot of medications
- 14:53we have for depression,
- 14:55but fairly few of them actually have
- 14:57a strong evidence based in kids.
- 14:59We particularly use this selective
- 15:02serotonin reuptake inhibitor.
- 15:03So Fluoxetine and Escitalopram are the only
- 15:07SSRI's that are FDA approved for children.
- 15:10They're probably a bunch of other
- 15:12medications work similarly,
- 15:13but we certainly don't have the
- 15:15same evidence base in terms
- 15:17of trials in kids that
- 15:19we have in adults.
- 15:22Just the main class of medication we're
- 15:25using in kids is called selective
- 15:27serotonin reuptake inhibitors.
- 15:29They're about 6 different
- 15:33SSRI's and they all work by increasing
- 15:36serotonin at the level of the synapse
- 15:39and really preventing the reuptake
- 15:41of serotonin from the synapse.
- 15:46And just to say that SSRI's,
- 15:49these medicines, are quite
- 15:50effective in kids and they're not
- 15:53only effective for depression.
- 15:54So oftentimes and if anything,
- 15:56they probably work better and obsessive
- 15:59compulsive disorder or anxiety than
- 16:01they actually work in depression.
- 16:03So a lot of kids benefit and so
- 16:06the number needed to treat is the
- 16:08number of kids you need to treat
- 16:10with the medication for one to
- 16:11respond who wouldn't have responded
- 16:13on placebo as you can see it's
- 16:14the number needed to treat is
- 16:16as low as three.
- 16:17So you need to treat three kids with
- 16:20an SSRI for one who would not have
- 16:23responded on placebo and they
- 16:25are quite effective for anxiety,
- 16:27OCD and depression.
- 16:30And one of the big challenges in using
- 16:34these medicines is that even though you
- 16:37often see the incremental benefits of
- 16:40the medicine fairly early on and actually
- 16:44the greatest improvement compared to
- 16:46placebo occurs early on in treatment,
- 16:49they actually generally takes a while for
- 16:51the full benefits of the medicine to accrue.
- 16:53So you typically see the full
- 16:55benefits of the medicine after two
- 16:58to three months in depression.
- 16:59And even later in anxiety or OCD.
- 17:05And then on the other hand,
- 17:07there are a lot of side effects associated
- 17:10with SSRI's and antidepressants.
- 17:11I should say that they're fairly well
- 17:14tolerated medicines on the whole.
- 17:16That being said, they can they can have
- 17:19a lot of side effects and generally
- 17:21you see the side effects early and
- 17:23the full benefits much later on.
- 17:24So you really need to give the
- 17:26kids a chance to respond to the
- 17:28medicine and give it time.
- 17:30So again, it's not,
- 17:33it's very hard for parents or
- 17:35doctors for families to make decisions
- 17:37about these medicines after a week
- 17:40or two when you're generally seeing
- 17:45mostly the the the side effects and then
- 17:47you get more of the benefits later on.
- 17:54And then the other big thing to
- 17:57think about when you're prescribing
- 17:59the medicine in kids and using the
- 18:02medicines is just a black box warning
- 18:04on suicidal, suicidality in kids.
- 18:06So there have been,
- 18:08Umm, in the in meta analysis of these
- 18:12randomized control trials comparing the
- 18:15antidepressants and compared to placebo,
- 18:19there's a small but statistically
- 18:23significant increase in spontaneously
- 18:26reported suicidal ideation
- 18:29and actions when kids are randomized to
- 18:32active medicine compared to placebo.
- 18:35The risk difference is about 1%.
- 18:39So that means if you treat 100 pediatric
- 18:43patients with antidepressant medications,
- 18:46one to two of them may experience short term
- 18:50increases in suicidal thinking or behavior.
- 18:52That being said,
- 18:53in these trials it's important
- 18:55to note when they actually look
- 18:57at the depression scales and ask
- 18:59every patient about the individual
- 19:01suicidal ideation,
- 19:03there was no signal in the
- 19:05medications compared to placebo.
- 19:07So it's still controversial whether
- 19:09these medicines are actually really
- 19:12increasing suicidal ideation.
- 19:16And it's important to keep
- 19:18the risks in context.
- 19:19So whereas I presented the number
- 19:22needed to treat before that you need to,
- 19:24you know, you have to treat three
- 19:26kids with an SSRI for one to benefit
- 19:30who would not have benefited on
- 19:32placebo, the number needed to harm the
- 19:34number of patients you need to treat
- 19:36for one of them to have treatment
- 19:38emergent suicidal ideation compared
- 19:41to placebo is much higher. So that,
- 19:45so thats's on the order of 110 to 200
- 19:47in terms of the number needed to harm.
- 19:49So kids are, you know,
- 19:5210 or 11 more times more likely
- 19:54to benefit in depression from
- 19:57these medicines than to experience
- 19:59short-term suicidal ideation and
- 20:02it's probably closer to
- 20:0440 or 50 times is likely in
- 20:06OCD or anxiety disorder.
- 20:11So how do I discuss the black
- 20:13box warning with families and
- 20:14what would be my take home point
- 20:18for sort of school personnel
- 20:20in thinking about medications?
- 20:22The first one is SSRI's and
- 20:24antidepressants are the most effective
- 20:26pharmacological treatment we have
- 20:28for pediatric depression and a bunch
- 20:31of other associated conditions,
- 20:34OCD anxiety. That there's some signal
- 20:38of an increased risk of self reported
- 20:41suicidal ideation over the short term
- 20:44so the FDA put a warning
- 20:45on these medications.
- 20:46That being said, there's no evidence of
- 20:48any association
- 20:50between these medicines and
- 20:52attempted or completed suicide.
- 20:55And suicidality and suicidal ideation is
- 20:58really common in pediatric depression.
- 21:00So it's more likely when these
- 21:02things are reported by kids that
- 21:04they're coincidental and not
- 21:06caused by the medicine.
- 21:08And then again, we,
- 21:09the majority of kids that I see
- 21:12and treat for depression have
- 21:14some degree of suicidal ideation.
- 21:16It's more a matter of degree
- 21:18than presence or not.
- 21:20And then, if anything,
- 21:22the epidemiologic data
- 21:23so the data from looking at
- 21:26prescribing these medicines over
- 21:28the long term, suggests that SSRI's
- 21:30are effective in treating depression
- 21:33and may actually protect against
- 21:35attempted and completed suicides.
- 21:38And so,
- 21:38so then people always ask why
- 21:40is the warning there?
- 21:41So the first things I'm not sure I
- 21:44necessarily agree with the warning
- 21:45being put on the medicine in the 1st
- 21:47place because I think the evidence
- 21:49is still pretty scant for a warning.
- 21:51But the FDA noticed the potential
- 21:53increased risk associated with
- 21:55these medications and they want
- 21:57the kids to be monitored closely
- 21:59when they start medications.
- 22:00And I think I entirely agree with
- 22:04the the end of the warning result,
- 22:07which is that kids should be monitored
- 22:08closely when they're starting medication,
- 22:10because it's a point at which
- 22:12kids are particularly at high
- 22:14risk of having adverse events.
- 22:19So we're going to switch and
- 22:21just kind of transitioned into
- 22:23talking a little bit about
- 22:25adolescent suicide as well.
- 22:26So as people on this call are probably aware,
- 22:29suicide is the second and third
- 22:31leading cause of death in pre teens,
- 22:33adolescents and young adults.
- 22:34So this is a table from the CDC,
- 22:37sort of outlying causes
- 22:38of death for age groups.
- 22:40And in red at the top here are 10 to
- 22:4214 year olds and 15 to 24 year olds.
- 22:45And here's the rank order of
- 22:47causes of death in this group.
- 22:49And you can see the second leading
- 22:51cause of death in the 10 to 14 year
- 22:54olds is suicide with 581 deaths
- 22:56in that year and 15 to 24 year olds,
- 22:59it's the third leading cause of suicide,
- 23:02with about 6000 deaths that year.
- 23:05Other top causes are unintentional injuries,
- 23:08homicides and then malignant neoplasms,
- 23:10in the top three for these age groups.
- 23:14So kind of characterizing
- 23:16what a suicide attempt is,
- 23:18there are lots of ways
- 23:20in which this happen,
- 23:21but the thing that's in common for
- 23:23all of these sort of events is it's
- 23:25really considered any act that's
- 23:27linked to an intention to die,
- 23:29even if this intention is
- 23:31reported as small or minor.
- 23:32So even if, you know,
- 23:33you ask a child,
- 23:34did any part of you want to die
- 23:36when you did that particular event
- 23:38and they say maybe just a little,
- 23:40that is still considered a suicide attempt
- 23:43and that's something to pay attention to.
- 23:46So in the United States,
- 23:48let's go over a little bit about
- 23:50the adolescent suicide rate.
- 23:51So I think Michael went over some
- 23:52some of the data and we'll just
- 23:54sort of repeat some of this,
- 23:55but data from the year 2019 said that
- 23:5819% of high schoolers had seriously
- 24:01considered suicide in the prior year
- 24:02from when the data was collected,
- 24:05many more in females than in males.
- 24:0816% of high schoolers have made
- 24:10a plan in the prior year as it's,
- 24:13a suicide plan in the prior year,
- 24:14again higher in females than in males.
- 24:17And 9% of high schoolers are, almost
- 24:19one in 10 high schoolers, actually
- 24:21attempted suicide in the prior year.
- 24:24So here's a graph from the CDC that
- 24:26sort of looks at this and looks
- 24:29at the total attempted suicides
- 24:31during that 2018 to 2019 period,
- 24:33which is about 9% or one in 10.
- 24:36Breaking it down by male and female here,
- 24:39so about 7% of males,
- 24:4211% of females. And by race here,
- 24:44so 8% for those who identify as White,
- 24:48almost 12% for those who identify
- 24:50as Black and almost 9% for those
- 24:53who identify as Hispanic.
- 24:55Other groups that are not represented
- 24:57on this graph that also have a
- 25:00suicide rates that are worth noting.
- 25:0219% of LGBTQ plus identifying 13 to
- 25:0417 year olds have attempted suicide,
- 25:07so this is not suicidal ideation,
- 25:09this is attempted suicide comparing
- 25:11that to 9% of high schoolers in general.
- 25:16Other racial groups that have
- 25:18more limited analysis and require
- 25:20more research, Native American
- 25:21youth have a suicide rate attempt
- 25:24that's about three times higher
- 25:25than the national average,
- 25:27Native Hawaiian youth data from
- 25:292000 have about a 13% attempt rate,
- 25:31and the Asian American youth have
- 25:33an 8% suicide attempt rate and a
- 25:3624% rate of suicidal ideation.
- 25:38So these rates are quite high in
- 25:40aggregate across all high schoolers
- 25:42and teenagers and are quite
- 25:44alarming both in terms of
- 25:46the ideation and the actual attempts.
- 25:50The past few years have been very
- 25:52difficult for a lot of people,
- 25:54for teenagers and their families,
- 25:55for schools, for clinicians.
- 25:56And this is just some of the data that
- 25:59looks at the emergency room visits
- 26:01for suicide attempts and showing
- 26:03the increase since the pandemic.
- 26:05So the sort of take home here,
- 26:07I've labeled the graphs,
- 26:08the top one is females,
- 26:10the bottom one is males,
- 26:12and these different lines
- 26:13represent the different years.
- 26:15And so here's 2019 the dotted
- 26:17line at the bottom for both
- 26:19graphs. 2020 shows the jump
- 26:22both for males and females.
- 26:24This is probably around the
- 26:26start of the pandemic or so,
- 26:27and this increase just
- 26:29continues in 2021 here.
- 26:31So for 12 to 17 year old teenagers,
- 26:33the emergency room visits for
- 26:36suicide attempts actually increased
- 26:37twofold in the winter of 2021
- 26:39compared to the winter of 2019.
- 26:42Again largely driven by increases in
- 26:45presentations from female teenagers.
- 26:48So risk factors for suicide,
- 26:50So it is
- 26:51pretty impossible for us to predict
- 26:53who actually dies from suicide.
- 26:56Unfortunately we do not have great
- 26:58models in a being able to identify people
- 27:01who will actually complete a suicide
- 27:03but we do know some risk factors
- 27:06for those for suicide,
- 27:08and these include having prior
- 27:10suicide attempts puts someone
- 27:12at greater risk for suicide,
- 27:14having psychiatric illness,
- 27:15a recent inpatient psychiatric
- 27:17hospitalization, which I'll talk a
- 27:19little bit more about in a minute,
- 27:21living in middle or low income countries,
- 27:23so this is sort of looking at
- 27:25suicide as a global phenomenon,
- 27:26account for about 75% of suicides worldwide.
- 27:30So it's not just a phenomenon that
- 27:32happens in developed countries.
- 27:34A family history of suicide,
- 27:36again,
- 27:37minority stress or having stress
- 27:39that's related to identifying as
- 27:41a minority in the social sphere,
- 27:43having this disability,
- 27:45impulsive personality traits.
- 27:46So there's a sort of an idea of
- 27:49impulsivity sort of being associated
- 27:50with suicide and sort of not taking
- 27:53the time to sort of think through what
- 27:55the the full effects of a suicide are.
- 27:57So having impulsive personality traits
- 27:59does put someone at risk for this. The
- 28:02way someone may approach life events.
- 28:05So a tendency towards cognitive
- 28:06rigidity or what we would call black
- 28:08or white thinking or all or none type
- 28:11thinking is also a risk factor for suicide.
- 28:13And any type of interpersonal loss.
- 28:16So for teenagers,
- 28:17obviously this is very a very important one:
- 28:19loss of friendships,
- 28:20bullying,
- 28:20peer rejection or even the death
- 28:23of friends or loved ones.
- 28:26So a little bit more about suicide
- 28:28rates and how high they are following
- 28:30psychiatric hospitalization.
- 28:31I think it's important to draw
- 28:33attention to this because this is sort
- 28:35of a clear marker in which we can
- 28:37sort of pay attention to teenagers.
- 28:39So it's a clear and objective marker of
- 28:41when people are hospitalized and when
- 28:43they're released from the hospital.
- 28:45So in the three months in which a
- 28:47teenager is released from the hospital,
- 28:49the rate of suicide is 100 times
- 28:51higher than the global rate of suicide
- 28:54and suicidal thoughts and behaviors
- 28:55resulting in hospitalization occur at
- 28:57200 times higher than the global rate.
- 29:00About 24%, or about one in four of
- 29:04all suicides that occur are attributed
- 29:07to having occurred within one year
- 29:10of hospitalization.
- 29:11And attending a mental health follow
- 29:13up after hospitalization reduces the
- 29:15risk of a subsequent suicide by about 75%.
- 29:18So that care that's arranged after
- 29:20the hospitalization and following
- 29:22up to make sure that care has been
- 29:25attended to is really important
- 29:27for reducing suicide risk.
- 29:28So this monitoring suicide risk
- 29:30is very critical in this post
- 29:32hospitalization period for teenagers.
- 29:36And while this talk focuses on depression,
- 29:39it's also important to note that
- 29:40teenagers who have other psychiatric
- 29:42illnesses are also associated with
- 29:43an increased risk for suicide.
- 29:45So these include illnesses like
- 29:48schizophrenia, substance use disorders,
- 29:51ADHD, bipolar disorder,
- 29:54PTSD, and others.
- 29:55It's also important to note that
- 29:57suicide can also occur in the absence
- 29:59of any diagnosed psychiatric illness.
- 30:01So while we are really focusing on
- 30:03teenagers who have psychiatric illnesses or
- 30:05have been diagnosed or suspected to have
- 30:07psychiatric illness,
- 30:08it's important to note that it can also
- 30:12occur for teenagers who don't have
- 30:14any diagnosed psychiatric illnesses.
- 30:16So some of the warning signs for suicide
- 30:19include talking about not wanting to live,
- 30:22talking about having no reason to live,
- 30:24starting to isolate or being
- 30:26more irritable with more mood swings,
- 30:28talking about feeling like a burden to
- 30:31others, talking about feeling trapped,
- 30:33like there's no way to escape whatever
- 30:36they're going through,
- 30:37observing that they're increasing
- 30:39substance or alcohol use,
- 30:41observing that they're researching
- 30:43methods for suicide or trying to obtain
- 30:46a gun is another clear warning sign and
- 30:49finally giving away personal items.
- 30:51So this is sort of a tweet that I
- 30:53thought was kind of illustrative of
- 30:55someone who was going through some
- 30:57suicidal ideation and thoughts and behaviors.
- 31:00So this was posted publicly by
- 31:02someone named Harry Miller,
- 31:04who's a football player at Ohio
- 31:06State and a junior in college.
- 31:07And one of the things,
- 31:09some of the statements that I'll just
- 31:11sort of highlight here is he says
- 31:12that "prior to the season last year,
- 31:14he had told his coach of his
- 31:16intention to kill himself."
- 31:17And he sort of goes on to
- 31:19elaborate that at that time,
- 31:20one of the reasons he had been
- 31:22thinking was he'd "rather be dead
- 31:23than a coward."
- 31:24"I'd rather be nothing at all than having
- 31:26to explain everything that was wrong."
- 31:28And he was already being "planning
- 31:30on being reduced to initials on the
- 31:32sticker on the back of a helmet."
- 31:33He had "seen people seek help before,"
- 31:36"had seen the old age-old adage" of how
- 31:38his "generation was softening by the 2nd."
- 31:40But he says that his "skin was tough"
- 31:42but "not tougher than the sharp
- 31:44metal of his box cutter."
- 31:46And he said that he saw that it was
- 31:47"easy for people to dismiss others by
- 31:49talking about how they were just a
- 31:51dumb college kid who didn't know anything."
- 31:52And he talks about how he has
- 31:54so many strengths.
- 31:55He's college student, he's a football player.
- 31:57He has a 4.0 GPA and everything.
- 32:00And but yet how difficult it is still
- 32:03for him even with all these sort of
- 32:05positive things going on in his life.
- 32:07Any he sort of ends here by saying
- 32:09"a person like me,
- 32:10who supposedly has the entire
- 32:11world in front of them,
- 32:13can be fully prepared to
- 32:14give up the world entire.
- 32:15This is not an issue reserved for
- 32:17the far and away it is in our homes.
- 32:19It is in our conversations.
- 32:20It is in the people that we love."
- 32:22So I think this is a really eloquent
- 32:25and poignant sort of way of expressing
- 32:27sort of how he's feeling and also
- 32:30drawing attention to sort of how,
- 32:32how universal this can be and how
- 32:34easy it might be to miss some of
- 32:36the suicidal thoughts and kids
- 32:38and teenagers and young adults.
- 32:40So switching to sort of some
- 32:43protective factors for suicide.
- 32:44So some protective factors that
- 32:46teenagers have reported include
- 32:48feeling supported by family,
- 32:49friends and school.
- 32:50So this is their community -- do
- 32:52they feel a sense of belonging,
- 32:54that they feel supported by their community?
- 32:56Are they future oriented?
- 32:57What do they want to be when they get older?
- 32:59Are they looking forward to that
- 33:01activity at school or with their friends?
- 33:04Do they have strong relationships
- 33:05with their family and friends?
- 33:07Are they engaged in mental healthcare?
- 33:11Other protective factors include cultural,
- 33:13religious or moral objections to suicide,
- 33:16as well as reducing the access
- 33:18to lethal means.
- 33:19So this is really an important,
- 33:21again sort of action that can
- 33:22be taken to lock up weapons,
- 33:24pills and sharps in the home.
- 33:27So along those lines of of
- 33:28locking up sort of means,
- 33:30if we look at the suicide
- 33:32methods in adolescents,
- 33:33firearms are actually the most common
- 33:35method of suicide for adolescent boys.
- 33:37And asphyxiation,
- 33:38which is sort of defined
- 33:39as hanging or suffocation,
- 33:41is the most common method of
- 33:43suicide for adolescent girls.
- 33:44So if we look at the data here,
- 33:46this is collected I think by the CDC
- 33:50between 1999 and 2020, on the left
- 33:52here for male adolescence and the
- 33:55blue triangles are the deaths
- 33:57from firearms here the orange are
- 34:00the deaths from asphyxiation and the
- 34:03green squares are other means of death.
- 34:06And so highest in males,
- 34:07about 60, 60 to 50% from firearm
- 34:11deaths. In females,
- 34:13it's consistently asphyxiation
- 34:14is the method of suicide death,
- 34:17about 60% throughout the years,
- 34:19and that's consistent.
- 34:21So again,
- 34:22reducing sort of means to suicide
- 34:24is a really,
- 34:25really important step for reducing
- 34:27the risk for suicide.
- 34:29The other important point is to not
- 34:30be afraid to talk about suicide.
- 34:32There is absolutely no evidence
- 34:34that talking about suicide leads to
- 34:36greater suicide attempts or suicides,
- 34:38ways in which this topic can be
- 34:40broached or questions like do you
- 34:42ever think that life is not worth living?
- 34:45Or do you ever wish you could go
- 34:46to sleep and not wake up again?
- 34:48And do you ever think about killing yourself?
- 34:50These are sort of ways
- 34:51progressively get a little bit more
- 34:53explicit about whether a teenager
- 34:54is actually thinking about suicide.
- 34:59And again reducing the
- 35:00access to means of suicide.
- 35:02So this is an explicit discussion with
- 35:04families about locking up all the sharps,
- 35:07medications and weapons.
- 35:08And I would say don't be
- 35:09afraid to ask for details.
- 35:11Where are they being kept?
- 35:12Where are the keys being kept?
- 35:14Who knows where things are and how
- 35:16does the child take their medication?
- 35:18Does someone give it to them?
- 35:20The same goes for discussing supervision
- 35:22of the teenagers. Who is watching them?
- 35:24So it's really important to know
- 35:26whether the teenagers at home alone
- 35:28or going out on their own and
- 35:30getting that that information
- 35:31from families and parents.
- 35:36The final sort of note here is to
- 35:38recognize that adolescents and
- 35:40people in general remain under
- 35:42treated for mental health issues.
- 35:44And so again our top focus is
- 35:46on a number of adolescent mental
- 35:48health issues throughout the day.
- 35:50And part of our hope is, you know,
- 35:52to bring attention to these issues
- 35:54and to improve treatments, access
- 35:56and awareness and just to look
- 35:58at some of these numbers here.
- 36:00So this is a graph again from the CDC.
- 36:02So this is split into sort of three
- 36:06areas. So on the left
- 36:07here is any mental health
- 36:09treatment that's received.
- 36:10Here are the percent of kids
- 36:12who took medication,
- 36:13and here are the percent of kids
- 36:15who receive counseling or therapy.
- 36:16And they've broken it down to age groups.
- 36:18So the darkest purple bar is
- 36:21between 5 and 17 year olds.
- 36:23The next lightest bar is 5 to 11 year olds,
- 36:27and the lightest bar is 12 to 17 year olds.
- 36:29So in the group that we're talking
- 36:31about today, the 12 to 17 year olds,
- 36:33about 16.8% of kids
- 36:35have received any mental health
- 36:37treatment in the past year.
- 36:39This is data from 2019,
- 36:41which is a fair number.
- 36:43However,
- 36:43when you look at this across
- 36:45some of the other statistics
- 36:46that we've given in the talk,
- 36:48you would note that this rate is even
- 36:51lower for racial minority groups,
- 36:54and that from the same year,
- 36:55data showed that 19% of high schoolers
- 36:58seriously considered suicide.
- 36:59So a higher percent of high schoolers
- 37:01actually seriously considered suicide
- 37:03than the percent of this group who
- 37:05actually received any mental health
- 37:06treatment in the prior 12 months.
- 37:15So I think Michael's going to talk
- 37:17a little bit about sort of things
- 37:19that we're kind of doing to try
- 37:21to help improve our understanding
- 37:22of depression and suicide here.
- 37:25So I think that in terms of the
- 37:28stuff we're working on at Yale and
- 37:32in the clinic we're looking
- 37:35to develop novel treatments to
- 37:37help kids who don't respond to
- 37:39the evidence based therapies and
- 37:41medications we have for depression
- 37:44and suicidal ideation.
- 37:45Another big part of our research
- 37:47program is looking at imaging studies.
- 37:52MRI studies or PET studies to
- 37:56better understand brain mechanisms
- 37:58behind adolescent depression and
- 38:01suicide so we can hopefully develop
- 38:04better treatments in the long run.
- 38:05And I think just highlighting
- 38:11one of the really important things in Youngsun's
- 38:14presentation is that even though I,
- 38:17I guess in my research and clinically I'm
- 38:20thinking about depression in individual
- 38:22adolescents and how to help them get better,
- 38:25a lot of the things that probably can reduce
- 38:30completed suicide at a public health level,
- 38:33really part of the decreasing
- 38:37the deaths due to suicide
- 38:39is going to be developing better
- 38:42treatments and helping individuals,
- 38:43but a big part of it is about
- 38:47population based stuff and
- 38:48environmental based stuff that is,
- 38:50that's also probably crucially
- 38:52important and maybe more important
- 38:54than than access to individual
- 38:57treatments. Means reductions in terms
- 39:00of reducing access to to firearms,
- 39:03reducing access to things that increase
- 39:07impulsivity and impulsive decisions
- 39:11like access to substances and alcohol,
- 39:15and then also the other big thing is just
- 39:18enhancing protective factors to making
- 39:21the school environment as protective and
- 39:24beneficial to adolescents as possible.
- 39:27And societally reducing poverty and
- 39:31other economic and social stresses will
- 39:33probably be the most effective things in
- 39:37reducing the actual completed suicide rate.
- 39:40So that there's these two dual purposes one
- 39:43involving screening and getting individuals
- 39:45to effective treatment
- 39:46but another big part of it is decisions
- 39:49we make as schools and as societies
- 39:51and as health systems in terms of
- 39:54what behaviors we try to promote.
- 39:57Now,
- 39:57I will throw it to Rebecca to
- 40:00help moderate the questions.
- 40:01And I guess I would apologize for
- 40:03not realizing that we can unmute
- 40:05the participants and they can
- 40:07actually ask questions.
- 40:08Love to hear your voices rather than.
- 40:12Thank you everyone.
- 40:14Excellent.
- 40:16And so what I will as Dr Bloch
- 40:18shared I will go ahead and unmute
- 40:19some of the folks who have asked some
- 40:22really great questions in the chat if
- 40:24you prefer just for me to ask the, our
- 40:26panelists directly just feel free to
- 40:27to let me know and happy to do so.
- 40:30So we're actually going to
- 40:33start with Kristin.
- 40:34So if everyone can bear with me, just getting
- 40:38a little familiar with the unmuting.
- 40:41So Kristin you should be able
- 40:43to ask your question directly.
- 40:45Hello, how is everyone?
- 40:49Doing well.
- 40:50OK, good.
- 40:52So I was wondering what
- 40:54biopsychosocial factors you
- 40:56think contribute to adolescent
- 40:58females being more at risk for
- 41:01depression and suicidal ideation?
- 41:05Youngsun, do you want to go first?
- 41:08I can go first. I mean I was going
- 41:11to say I think some of this is,
- 41:13is social related as you sort of posed
- 41:15and these sort of expectations and
- 41:17stresses that come with adolescence.
- 41:19There probably is a hormonal component,
- 41:21it's probably not just
- 41:23social and psychosocial.
- 41:24But you know, I think again with
- 41:26the preteen and teenage years,
- 41:28these peer relationships just become so,
- 41:30so important and that's normal, right.
- 41:32That's developmentally normal for
- 41:33for teenagers and part of their
- 41:35sort of pathway to independence.
- 41:37But I think the difficulties
- 41:39navigating this can certainly make
- 41:42the risk for depression go up and I
- 41:44think you know females navigate the
- 41:46the social relationships in a bit of a
- 41:48different way than males typically do.
- 41:50So I think that that's one probably
- 41:53risk factor for the females.
- 41:55I think there probably is a hormonal and
- 41:57biological component to that as well,
- 41:59but in terms of the psychosocial
- 42:01component there.
- 42:04And another thing that I always wondered I,
- 42:06it's hard to control for this and study,
- 42:08but I wonder how much it's their sort
- 42:10of, our societal expectations on males
- 42:13and not reporting depressive symptoms
- 42:16in the same degree as as females and
- 42:19that it's at some level they're sort of
- 42:21still the stereotype of the stoic male
- 42:23who's not allowed to talk about their
- 42:25feelings and how much that affects
- 42:28the numbers because I, on the other hand,
- 42:31if you're looking at completed suicides it's
- 42:33more males than females.
- 42:37We definitely see more females in clinic.
- 42:39Yeah. Thank you both.
- 42:45And next I'll, Kathryn I'll have
- 42:48you go ahead and ask your
- 42:50question about the language used.
- 42:52Sure. Hi. Thank you.
- 42:54I used to teach this,
- 42:56so I know the answer,
- 42:57but I was hoping you would share
- 42:59with everyone your preference for
- 43:00using the language "die by suicide"
- 43:02instead of "committed suicide."
- 43:04I hear "committed" a lot in the field.
- 43:07Yeah. No, that's a that's a really great,
- 43:09great question and I think
- 43:11the language does matter.
- 43:12It's, it's it is important you know
- 43:15and I think it probably will
- 43:17evolve as we keep thinking about it.
- 43:19But certainly the things to pay
- 43:21attention to with the language and
- 43:23there are media guidelines around this
- 43:25because of the sensationalism that
- 43:28can accompany suicides and the risk
- 43:30for what are called "copycats" or people
- 43:32who get sort of inspired by suicide.
- 43:35So there are media guidelines for instance on
- 43:37how to report suicides.
- 43:38And so you'll see headlines
- 43:40that say you know,
- 43:41so and so is dead at whatever age instead of,
- 43:44you know, suicide or died or you know took
- 43:46their life or other language such as that.
- 43:48And that's purposeful.
- 43:49And I think it's a similar thing when
- 43:52we are talking with each other as well.
- 43:54And so I do think, you know,
- 43:56you raise a really,
- 43:57really good point about being mindful
- 43:59about the language in which we use.
- 44:03I guess just the other thing to add about this
- 44:05I think on this issue, die by suicide
- 44:08is is definitely preferable language to me,
- 44:12but I think you know, I think
- 44:16something that really bothers me
- 44:18about being involved in this field
- 44:21and treating the children and
- 44:23experiencing their deaths with families
- 44:25is that I feel like as a society,
- 44:28we view the death by suicide as somehow
- 44:31different than a death by pediatric cancer.
- 44:34And in terms of the lot of the public
- 44:37health decisions we're making as a society,
- 44:39this is a, you know,
- 44:41basically the second leading
- 44:42cause of death in these kids.
- 44:44And it, it feels to me like,
- 44:46even as a mental health profession we have,
- 44:49we often aren't placing the
- 44:52proper importance and sort of
- 44:56severity on that and I think the
- 44:59language partially makes a difference.
- 45:00The other thing I really, sort of
- 45:03really, I've struggled with in just
- 45:05sort of talking to teenagers about
- 45:07this and doing these talks is
- 45:10that a lot of times in the media sort
- 45:13of you know the the cause of death
- 45:16gets sort of hidden or not mentioned
- 45:18because there's a worry about sort of
- 45:22a suicidal contagion and I think
- 45:24that's a realistic worry but I also think
- 45:27when we're not really talking
- 45:29about the severity of the problem
- 45:31it also is hard to shine light on it
- 45:33and that there's sort of a constant
- 45:35tension there that I I'm not sure
- 45:38I've entirely figured out how to
- 45:39be comfortable with and negotiate.
- 45:43Yeah, that's actually a really good point.
- 45:44It does put the onus on the rest of
- 45:47the community. So parents, schools,
- 45:49teenagers themselves to start to have
- 45:52this conversation and which you know,
- 45:55can be a hard conversation to have for sure.
- 45:58But it is, it is something that
- 45:59is in the media that you know,
- 46:01teenagers are seeing and you know
- 46:03some of the celebrities or people
- 46:05that they follow maybe, you know,
- 46:07sort of affected by this as well.
- 46:12We had another
- 46:13question from Anonymous,
- 46:14so I'll ask this one of "what
- 46:16are the best short term in the
- 46:18moment interventions for suicide
- 46:19prevention and how should providers
- 46:21respond in the moment to a suicide
- 46:23threat that's been verbalized?"
- 46:28I can start, I think, you know, always
- 46:30probably acknowledging how hard it
- 46:32is for someone to probably say this.
- 46:34So being sort of, you know,
- 46:36thankful that that someone's
- 46:37actually sharing is it,
- 46:38it takes a lot for people to
- 46:39share this kind of information,
- 46:41so it sort of acknowledging that Umm.
- 46:44And I think so that's I think one thing
- 46:46that's really important and I and I
- 46:48do think it's important to do sort of
- 46:50the practical safety things you know,
- 46:52in this moment.
- 46:53"Are you safe right now?"
- 46:54"What are you thinking about right
- 46:56now?" Because it's it's really
- 46:58hard to guess as I have said,
- 47:00it's hard for us to know.
- 47:01There's an impulsivity factor
- 47:03that accompanies everything.
- 47:04So, you know,
- 47:05acknowledging how hard it is, talking about,
- 47:08you know, arranging for the safety in
- 47:10the moment is really important, Umm.
- 47:13And then for yourself sort of triaging
- 47:16how worried do you have to be
- 47:18and who do you notify next?
- 47:19Right. So you don't necessarily,
- 47:21depending on who you are,
- 47:22necessarily have to sit with
- 47:23this information alone.
- 47:24But you know,
- 47:25should we talk to the teenagers parent?
- 47:27Is there a clinician involved?
- 47:28Is there a someone else at the school
- 47:30that's involved that can be discussed
- 47:32with as
- 47:32well? And those are some of
- 47:34the other things I think that
- 47:35I would think about.
- 47:39And I just, so I think the big thing to
- 47:42just under score the need for immediate
- 47:44safety and to triage sort of the extent
- 47:47of how worried you are. I think another
- 47:50big thing is, and it's really hard
- 47:54to negotiate this again, is in terms
- 47:57of telling parents or referring
- 48:00kids to the emergency room
- 48:01if they're talking about suicidal ideation,
- 48:03it's a balance because I
- 48:05think in in the long run,
- 48:07at some level some of the time,
- 48:09they just need someone to talk to
- 48:12and if you're and if you're
- 48:14kind of comfortable talking about
- 48:17their experiences with them,
- 48:18often they don't need to go
- 48:20to the emergency room.
- 48:22Or something like that.
- 48:24And if you and that being
- 48:27comfortable and being able to sit
- 48:29with someone who's having those
- 48:31thoughts is important in their comfort
- 48:33level in coming back in the future.
- 48:35And so I think this is a constant
- 48:38tension between what to do.
- 48:39Obviously there are certain circumstances
- 48:40where you have to intervene and
- 48:42that's the most important thing,
- 48:44but it's always a double edged sword.
- 48:49Being mindful of time,
- 48:50I'm going to kind of synthesize a couple
- 48:52of the questions that we have left.
- 48:54One was from Patricia of "what are
- 48:56some of the novel ways that that the
- 48:58team has found to help?" that I imagine
- 49:01I know Dr. Bloch you started
- 49:02to hit on with some of the trials
- 49:03but for both of you to respond to.
- 49:06And then we also had a question
- 49:07related to that from Catherine
- 49:09of any specific evidence based
- 49:11treatment approaches that would be
- 49:13recommended over others for when
- 49:14there is the chronic suicidality.
- 49:19So I would say the first thing in terms
- 49:22of intervention is you know that one
- 49:25thing's helpful is really it's important
- 49:28to have a good therapeutic relationship
- 49:30and get these kids into any treatment.
- 49:32I think the biggest thing I see in
- 49:34sort of doing trials for treatment
- 49:36refractory depression is that the
- 49:39number of kids who've been in treatment
- 49:41for a fairly long period of time
- 49:43and have not really had any evidence
- 49:46based therapy and making sure that
- 49:48getting access to that's crucial and
- 49:51and I think that's the first part of it.
- 49:54I think cognitive behavioral therapy,
- 49:57DBT's are really good things,
- 50:00especially for kids with chronic
- 50:02suicide. We've been looking more at
- 50:05Ketamine and Esketamine.
- 50:07So these are new medications
- 50:10along that have an indication for
- 50:13treatment refractory depression in adults
- 50:15and also depression with the acute
- 50:18suicidal ideation and looking
- 50:19at whether they work in kids.
- 50:21And I think the real reason that we're
- 50:24interested in those interventions
- 50:25that at least in adults they show a
- 50:28larger benefit than a lot of the other
- 50:30second line treatments that we have
- 50:32available and that they work faster.
- 50:34So they may be particularly useful in
- 50:37these adolescents and patients when
- 50:40you look at just the practical fact
- 50:42of how big of a risk factor right
- 50:45when they start medication is,
- 50:47right when they get hospitalized
- 50:48or get released from the hospital,
- 50:50that's something that works better
- 50:52and faster would be something that
- 50:54would be really attractive.
- 50:58Rebecca, can I make one comment if I
- 51:00was just going to say one?
- 51:03First of all I just want to say
- 51:04this has been a really really
- 51:06interesting informative
- 51:07set of presentations. Thank you.
- 51:09And I just also wanted to just
- 51:11make a comment really quick is that
- 51:14I know we're focusing on adolescents,
- 51:17but in fact the rates have gone
- 51:19have been over the roof with the
- 51:22young, younger children for the
- 51:24first time in in my career.
- 51:27And in fact the NIMH sent out
- 51:30an announcement that they were
- 51:32interested in how can we assess?
- 51:35We need measures to develop,
- 51:38people to develop
- 51:39measures to assess suicide
- 51:41ideation in young children.
- 51:43And so I know the anxiety program shared
- 51:47with you information about our projects,
- 51:50but we now have a funded project to
- 51:53develop a suicide ideation assessment
- 51:57measure in children 8 to 12.
- 51:59You do not need to be depressed or
- 52:01suicidal we're just developing the measure.
- 52:04So I guess I wanted to share that
- 52:06information with you
- 52:07because
- 52:08it is happening in children 8
- 52:10years old and 9 years old,
- 52:12and this is a big public health emergency,
- 52:15so we're doing some work on that.
- 52:17So I wanted to let people know about the
- 52:20problem and also about our latest study on
- 52:23this. Thank you.