Stephanie Wemm, PhD
Associate Research Scientist, PsychiatryCards
About
Research
Publications
2025
W139 Guanfacine Reduces Drug Craving, Stress and Increases the Number of Abstinence Days in Women With Polysubstance Use Disorder (PSUD): A Pilot 2-Site Clinical Study
Wemm S, Fogelman N, Sullivan L, Vacey E, Bera S, Hermes G, Swain J, Fox H, Sinha R. W139 Guanfacine Reduces Drug Craving, Stress and Increases the Number of Abstinence Days in Women With Polysubstance Use Disorder (PSUD): A Pilot 2-Site Clinical Study. Drug And Alcohol Dependence 2025, 267: 112081. DOI: 10.1016/j.drugalcdep.2024.112081.Peer-Reviewed Original ResearchM125 Guanfacine Improves Stroop Performance That in Turn Moderates Drug Treatment Effect on Cumulative Abstinence in Women With Polysubstance Use Disorder
Fogelman N, McGowan C, Wemm S, Tate M, Hermes G, Sinha R, Wemm S. M125 Guanfacine Improves Stroop Performance That in Turn Moderates Drug Treatment Effect on Cumulative Abstinence in Women With Polysubstance Use Disorder. Drug And Alcohol Dependence 2025, 267: 111719. DOI: 10.1016/j.drugalcdep.2024.111719.Peer-Reviewed Original ResearchW33 Real-World Cue Reactivity and Subjective Stress Independently Predict Cannabis Craving in Individuals With CUD
Conway R, Pearlman M, Sinha R, Wemm S, Conway R. W33 Real-World Cue Reactivity and Subjective Stress Independently Predict Cannabis Craving in Individuals With CUD. Drug And Alcohol Dependence 2025, 267: 111975. DOI: 10.1016/j.drugalcdep.2024.111975.Peer-Reviewed Original ResearchPositive affect amplifies integration within episodic memories in the laboratory and the real world.
Pratt J, Wemm S, Harris B, Huang Y, Sinha R, Goldfarb E. Positive affect amplifies integration within episodic memories in the laboratory and the real world. Learning & Memory 2025, 32: a053971. PMID: 39870487, PMCID: PMC11801478, DOI: 10.1101/lm.053971.124.Peer-Reviewed Original ResearchConceptsPositive eventsReal worldEpisodic memoryEmotional eventsConsistent with past findingsTime of retrievalImpact of emotionsParticipants' emotional responsesMemory accuracyAssess memoryPositive affectExperiment 1Experiment 2Memory integrationEmotional responsesEmotional statesMemoryMemory structureNegative experiencesMemory featuresLaboratory environmentAccuracySmartphonePregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder
Gao H, Sinha R, Wemm S, Milivojevic V. Pregnenolone effects on parasympathetic response to stress and alcohol cue provocation in treatment‐seeking individuals with alcohol use disorder. Alcohol Clinical And Experimental Research 2025, 49: 619-628. PMID: 39779217, PMCID: PMC11928267, DOI: 10.1111/acer.15529.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment-seeking individualsAlcohol cuesAlcohol cravingResponse to stressPregnenolone groupUse disorderResponse to alcohol cuesGroup x condition interactionHigher alcohol cravingLinear mixed-effects modelsHeart rate variabilityHeart rate variability indicesAutonomic nervous system dysregulationChronic alcohol consumptionRandomized to placeboAutonomic nervous system responsesNervous system dysregulationCravingAlcohol's impactCondition interactionAssociated with autonomic nervous system dysregulationNervous system responsesAutonomic responsesEnhanced autonomic functionStress and Addictive Disorders: Drug- and Stressor-related Effects on Stress Biological and Psychological Response
Wemm S, Pearlman M, Sinha R. Stress and Addictive Disorders: Drug- and Stressor-related Effects on Stress Biological and Psychological Response. 2025, 145-162. DOI: 10.4135/9781529673913.n10.Peer-Reviewed Original Research
2024
S143 Traumatic Events, Chronic Pain, and Multiple Substance Use in Women With Poly-Substance Use Disorder
Fogelman N, Tate M, Wemm S, Vacey E, Bera S, Hermes G, Swain J, Fox H, Sinha R. S143 Traumatic Events, Chronic Pain, and Multiple Substance Use in Women With Poly-Substance Use Disorder. Drug And Alcohol Dependence 2024, 260: 110254. DOI: 10.1016/j.drugalcdep.2023.110254.Peer-Reviewed Original ResearchM68 Individuals With Cannabis Use Disorder Display Altered Parasympathetic HRV During Waking and Sleeping Hours Relative to Light Cannabis Users
Pearlman M, Wemm S, Pearlman M, Liston J, Sinha R. M68 Individuals With Cannabis Use Disorder Display Altered Parasympathetic HRV During Waking and Sleeping Hours Relative to Light Cannabis Users. Drug And Alcohol Dependence 2024, 260: 110348. DOI: 10.1016/j.drugalcdep.2023.110348.Peer-Reviewed Original ResearchThe effects of simultaneous alcohol and cannabis use on subjective drug effects: A narrative review across methodologies
Bedillion M, Claus E, Wemm S, Fox H, Ansell E. The effects of simultaneous alcohol and cannabis use on subjective drug effects: A narrative review across methodologies. Alcohol Clinical And Experimental Research 2024, 48: 988-999. PMID: 38641546, PMCID: PMC11238947, DOI: 10.1111/acer.15322.Peer-Reviewed Original ResearchSAM useDrug effectsNaturalistic studySimultaneous alcoholSubstance useCombined effects of alcoholSubstance use disordersEffects of alcoholSubstance use historyFrequent substance useIndividual's subjective experienceReport drinking alcoholCannabis useNaturalistic settingsImpaired cognitionCannabisNarrative reviewYoung adultsDrinking alcoholSubjective experienceRecall biasUse historyIdentifying individualsAlcoholDisordersSubstance use patterns, quantities, and associated risk factors in women with polysubstance misuse
Fogelman N, Tate M, Wemm S, Sullivan L, Hart R, Vacey E, Fox H, Sinha R. Substance use patterns, quantities, and associated risk factors in women with polysubstance misuse. Addiction Biology 2024, 29: 10.1111/adb.13390. PMID: 38619491, PMCID: PMC11017971, DOI: 10.1111/adb.13390.Peer-Reviewed Original ResearchConceptsPolysubstance useDepressive symptomsSubstance use patternsDrug cravingRisk factorsPatterns of polysubstance useSingle substance useAssociated with polysubstance usePlacebo-controlled studyHigher cravingGuanfacine treatmentCross-sectional observational studyPolysubstance use patternsCraving managementLife eventsCravingPolysubstance misuseSubstance useOpioid amountsPain ratingsStress/traumaObservational studyAnxietyPainPolysubstance
Clinical Trials
Current Trials
Investigating real-world stress-related mechanisms in heavy cannabis users
HIC ID2000034321RolePrincipal InvestigatorPrimary Completion Date12/31/2024Recruiting Participants
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Yale School of Medicine
2 Church St South Suite 209
New Haven, CT 06519
United States