Francis Lee
Biography
Research & Publications
Patient Care
News
Locations
Appointments
Biography
Affiliation: Professor with Tenure, Unmodified Title; Wayne O. Southwick Professor; Orthopedic Surgeon and Scientist, Department of Orthopedic Surgery, School of Medicine, Yale University (2016-Present); Professor in Pathology, Secondary Appointment, Yale University (2017-Present); Professor in Biomedical Engineering, Secondary Appointment (2019-Present); Professor, Graduate School of Art and Science, Yale University (2019-Present); Professor with Tenure and Robert Carroll & Jane Chace Carroll Professor, Columbia University, New York (2012-2016); Orthopaedic Attending & Chief of Orthopaedic Oncology, New York Presbyterian Hospital, Columbia University Medical Center, New York (1999-2016)- Clinical Practice Locations: Greenwich Hospital, Stamford Office, and Yale New Haven Hospital System
- Clinical Expertise: Sarcomas, Complex Musculoskeletal Reconstruction in Adults and Children; Musculoskeletal Bone and Soft Tissue Tumors (Benign Tumors and Cancers) & Complex Limb Reconstruction in Adults and Children; Pathological Fractures, Minimally Invasive Surgery for Metastatic Cancers to Bone (Breast, Prostate, Thyroid and Others); Failed Knee & Hip Implants; Osteomyelitis; Pediatric Orthopedics; Osteoid Osteoma, Enchodroma, Osteochondroma, Metabolic and Genetic Bone Diseases, Spine Tumors
- Research Interest: NIH R01-funded research programs in metastatic cancer-induced bone loss, fracture healing, regenerative orthopedics, and bone infection. Our lab is located in Tompkin 5 Orthopedic Research Laboratories.
- Administration: Vice Chair of Academic, Scientific, and Research Affairs (2016-2018; Interim; 2020-Present); Yale School of Medicine Admissions Committee; Yale University Saybrook College Advisor
- Education: American Board of Orthopaedic Surgery Written Question Task Force, Orthopaedic Research Society Mentorship Committee, New York Orthopaedic Pathology Review Course
- External Activities: NIH Skeletal Biology, Structure, and Regeneration (SBSR) Study Section Chair (2018-2020); Musculoskeletal Tumor Society Research Committee Chair (2017-2020); American Academy of Orthopaedic Surgeons Research Development Committee Chair (2019-2022); Orthopaedic Research and Education Foundation (OREF) Research Grant Committee Vice Chair (2019-2020); OREF Research Grant Chair & OREF Board of Directors (2020-2023)
- Current Research Programs & Grants:
- NIH/NIAMS R01 AR 073607 (2019-2024; PI: Francis Y. Lee, M.D.): PTH to rescue impaired fracture healing.
- NIH/NIAMS R01 (2015-2022; PI: Francis Y. Lee, M.D.): Infection and bone destruction; Eradication of bone destruction
- NIH/NCI R01 (2015-2022; PI: Francis Y. Lee, M.D.): Interactions between metastatic cancers and bone; Bone loss
- NIH/NIAMS R01 (2009-2019; PI: Francis Y. Lee, M.D.): Inflammation and bone loss; Osteoclastogenesis
- NIH/NIBIB R01 (Completed; 2007-2018; PI: Francis Y. Lee, M.D.): Biomaterials interface biology
- Musculoskeletal Transplantation Foundation (2013-2018): Enhanced Allograft Incorporation with Growth Factors
- NIAMS Mentored K08 Award (2017-2022; Mentor for PI Dr. David Koveacevic): Shoulder Inflammation
- Department of Defense (Completed; 2010-2015; PI: Francis Y. Lee, M.D.): 3D printed scaffolds for bone and cartilage defects
- External Scholarly Activities: Musculoskeletal Tumor Society Executive Committee member and Research Committee Chair (2017-2020); National Institute of Health Skeletal Biology, Structure and Regeneration(SBSR) Study Section Permanent Member (2015-2020) and Study Section Chair (2018-2020); Musculoskeletal Tumor Society (MSTS) Research Committee Chair (2018-2020); AAOS Tumor Program Committee (2016-2019); AAOS Research Development Committee Chair (2019-2022); Orthopaedic Research and Education Foundation (OREF) Research Grant Committee Vice Chair (2018-2020); Orthopaedic Research Society/International Society for Fracture Repair (ISFR) Board Member (2019-2021); Orthopaedic Research and Education Foundation (OREF) Research Grant Committee Chair (2020-Present); American Bone and Joint Surgery Member (2020-Present); AAOS Kappa Delta Award & OREF Clinical Research Award Selection Task Force Co-Chair
- Interactions with Undergraduate Students, YSM Medical Students, M.D.-Thesis Medical Students, M.D.-Ph.D. Candidate, Graduate Students, and Post-doctoral Fellows: Please send inquiries to francis.lee@yale.edu for research and clinical opportunities. Summer Research Fellow and One-Year YSM-sponsored Fellowships are provided.
- Mentoring and Supporting Junior Faculty, Fellows, and Residents: Assisting Career Development Awards or Grants. Academic Promotion Guidance; Primary Mentorship for NIAMS K08 Career Development Award for an Orthopaedic Surgeon at Yale Orthopaedics & Rehabilitation (2017-2022); Mentorship for OREF Residents & Faculty Award
- Yale University (2016 - Present): Yale University Saybrook College Fellow; Medical School Admissions Committee; Biological and Biomedical Science Program; Faculty, Yale university Art and Science Graduate School
- Columbia University, New York, and New York Presbyterian Hospital (1999 - 2016): Professor of Orthopaedic Surgery with Tenure (2012-2016), Robert Carroll and Jane Chace Carroll Professor (2014-2016), Associate Professor with Tenure (2009-2012), Associate Professor (2005-2009), Assistant Professor (1999-2005); Orthopedic Surgeon, New York Presbyterian Hospital, New York; Columbia University Senate Budget Review Committee (2011-2015)
Education & Training
- MBAYale School of Management, Honorary MBA (2019)
- Honorary Executive MBAYale School of Management (2018)
- Non Degree ProgramHospital for Sick Chidren, Pediatric Orthopaedics Fellowship (1999)
- Clinical Orthopedic FellowshipHospital for Sick Children, University of Toronto (1999)
- Non Degree ProgramMassachusetts General Hospital & Boston Children’s Hospital, Orthopaedic Oncology Fellowship (1998)
- Clinical Orthopedic FellowshipHarvard Medical School (Mass General Hospital & Boston Children's Hospital) (1998)
- Non Degree ProgramRutgers Medical School, Orthopaedic Surgery Residency (1997)
- Orthopaedic ResidencyRutgers New Jersey Medical School (1997)
- Non Degree ProgramMount Sinai Hospital, Bone Research Fellowship (1996)
- Orthopedic Research FellowshipMount Sinai School of Medicine (1996)
- PhDSeoul National University College of Medicine, Orthopedic Basic Science (1992)
- Orthopaedic ResidencySeoul National University Hospital (1992)
- Non Degree ProgramSeoul National University Hospital, Orthopaedic Surgery Residency (1992)
- MDSeoul National University College of Medicine, Doctor of Medicine (1986)
- Premed & Doctor of MedicineSeoul National University College of Medicine (1986)
- Undergraduate StudentUniversity of Maryland at U.S. 8th Army, Seoul, Korea (1982)
Activities
- 2022 Annual Meeting of American Academy of Orthopaedic SurgeonsChicago, United States 2022Talk 1: "Rocket Fuel for the Young Academic Orthopaedic Surgeon - The National Institutes of Health K Award" Talk 2. 2. MRSA infection impairs long bone fracture healing by sustained inflammation and cytokine dysfunction. Talk 3. 3. Fracture Microenvironment Characterization in the Setting of Local Breast Cancer Metastases and Rescue of Fracture Healing Through Inhibition of ERK1/2 Signaling Talk 4. 4. A prospective cohort study on pain and ambulatory functional outcomes of AORIF (Ablation-Osteoplasty-Reinforcement-Internal Fixation) for peri-articular lesions in weight bearing bone. Talk 5. 5. Stabilization of Osteolytic Lesions in Pelvis, Femoral Head, and Femoral Neck with Ablation-Osteoplasty-Reinforcement-Internal Fixation.
- 2022 Orthopaedic Research Society Meeting Research Presentations & Grant Writing Workshop FacultyTampa, United States 20221. Synovial Lactate And Inflammation Accumulated In A Murine Model Of Septic Arthritis Caused By Methicillin-resistant Staphylococcus Aureus (mrsa) Infection. 2. Excessive Transforming Growth Factor-β Expressions In The Fracture
- 2021 EMSOS Meeting PresentationsVirtual Meeting, EMSOS, Graz, Austria 2021Talk 1: Functional Ambulation and Pain Outcomes of Same-Day Percutaneous Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF) Reconstruction of Massive Periacetabular Osteolytic Defects and Pathological Fractures; Talk 2: Surgical Anatomy, Techniques and Biomechanical Analysis of Aorif Percutaneous Stabilization of Periacetabular Osteolytic Lesions and Biomechanical Analysis; Talk 3: Aggressive Osteolytic Breast Cancer Inflammatory Tumor Microenvironment in the Skeletal Compartment
- 2021 ORS Clinician Scholar Career Development ProgramChicago, United States 2021Faculty & Mentor
- 2021 American Academy of Orthopaedic SurgeonsSan Diego, United States 2021Paper Presentations
- Kelly Visiting Professorship, Mayo ClinicRochester, United States 2020Grand Round and Research Seminar, Mayo Orthopaedics, Nov 30, 2020
- OREF Key Note Speaker at HSSKeynote Speech 2020OREF North East Regional Resident Research Symposium
- Visiting ProfessorProvidence, United States 2019
- International Society of Limb SalvageAthens, Greece 2019Introductory Lecture-17. Metastasis Session. Ambulatory Minimally invasive percutaneous Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF) for osteolytic skeletal metastasis.
- Visiting Professor at Baylor School of Medicine, M.D. Anderson., and University of TexasHouston, United States 2019Grand Round Speaker, Baylor College of Medicine/M.D. Anderson Cancer Center/U Texas Houston, May, 2019
- Speaker, Faculty, ModeratorLas Vegas, United States 2019American Academy of Orthopaedic Surgeons Tumor Session Moderator; Presentation of 2 Papers; Metastatic Cancer Symposium Moderator, Organizer, Speaker
- Key Note SpeakerFarmington, United States 2019U Conn Musculoskeletal Institute Research Day
- Visiting Professor, University of California San FranciscoSan Francisco, United States 2018Grand Round
- AAOS/OREF/ORS Clinician Scholar ProgramRosemont, United States 2017AAOS/OREF/ORS Clinician Scholar Program
- LectureSeoul, South Korea 2017Musculoskeletal Infection
- Musculoskeletal Tumor SocietyDenver, United States 2017Precision Medicine Prediction Of Skeletal Metastasis: Big Clinical And Gene Profiling Data Analysis
- Musculoskeletal Tumor SocietyDenver, United States 2017
- Metastatic Breast Cancer Cells Destroy Bone by Inhibiting Ossification and Promoting Osteolytic Cytokine Production: A New MechanismKanazawa, Japan 2017
- Intracellular Staphylococcus Aureus Are Resistant to AntibioticsSan Diego, United States 2017
- Mechanical Integrity of Unseeded, BMP-2 And Canine BMSC Seeded HA-PCL Scaffolds Compared to Allografts in Critical Size Defects in a Canine ModelSan Diego, United States 2017
- Osteosarcoma Compartment Stiffness Affects Growth RateSan Diego, United States 2017
- Trametinib Protects Bone from MRSA Induced Bone ErosionSan Diego, United States 2017
- Aggressive osteolytic breast cancer cells destroy bone by stealing calcium and making osteolytic cytokines: new mechanism and therapeutic targetSan Diego, United States 2017
- Local PTH treatment enhances intercalary allograft incorporationSan Diego, United States 2017
- The Hidden Enemy: MRSA-Osteoblast Interaction and Its Consequences in Tissue Destruction and RecurrenceOrlando, United States 2016
- Erk Mediates Aggressive Growth And Bone Destruction In Osteolytic Metastatic Breast Cancers To BoneOrlando, United States 2016
Honors & Recognition
Award | Awarding Organization | Date |
---|---|---|
Best Paper Award, 3rd Place | Musculoskeletal Tumor Society | 2021 |
Best Poster Award, 2nd Place; Osteolytic Metastatic Cancers | Musculoskeletal Tumor Society | 2016 |
Kappa Delta Ann Doner Vaughn Award (2016) | American Academy of Orthopedic Surgeons | 2016 |
Best Paper Award, Second Place | European Musculoskeletal Tumor Society | 2014 |
J. Neff Awad | Musculoskeletal Transplantation Foundation | 2014 |
Career Development Award | Orthopedic Research and Education Foundation | 2006 |
AAOS/OREF/ORS Clinician Scientist Traveling Fellowship Award | AAOS | 2005 |
AOA Resident Traveling Fellowship Award | American Orthopedic Association | 1996 |
Young Investigator Award | Internal Society for Fracture Repair | 1996 |
Professional Service
Organization | Role | Date |
---|---|---|
Association of Bone and Joint Surgeons | Member | 2020 - Present |
Orthopaedic Research and Education Foundation | OREF Grant Committee Vice Chair (2018-2019); Chair (2019-Present); OREF Executive Board Committee | 2019 - Present |
National Institute of Health Skeletal Biology, Structure, and Reconstruction (SBSR) Study Section | NIH SBSR Study Section Permanent Member 2015-2018; Study Section Chair 2018-2020 | 2017 - 2019 |
Musculoskeletal Tumor Society | Research Committee | 2015 - 2020 |
Department of Defense Orthopaedic Trauma PRMRP Study Section Chair | 2014 | |
American Academy of Orthopedic Surgeons | AAOS Tumor Program Committee | 2013 - 2019 |
American Academy of Orthopedic Surgeons, Orthopaedic Research Society, Orthopedic Research and Education Foundation | Clinician Scholar Development Program Chair | 2012 - 2014 |
American Academy of Orthopedic Surgeons, Orthopaedic Research Society, Orthopedic Research and Education Foundation | New Investigator Mentoring Workshop Chair | 2011 - 2015 |
American Board of Orthopedic Surgery | Orthopedic Surgery Board Written Question Writing | 2008 - 2019 |
NIH, NCI, 2013 NIAMS P50 and P30 Study Section Panel; NIH CSR MTE, SBDD, Skeletal Biology Structure Regeneration (Standing Member 2015-2019), SEP Panel Members; 2017 NIAMS Musculoskeletal Center P50 CORT Review Panel; 2017 NIAMS Musculoskeletal Clinical Research Center P30 Review Panel | NIH Study Section Panel Members (2007 - Present) ; NIH SBSR Study Section Chair 2018-2020 | 2007 - 2022 |
American Academy of Orthopedic Surgeons | Research Development Committee | 2006 - 2012 |
Departments & Organizations
- 3-D Patient-Specific Surgical Correction Program
- Cancer Signaling Networks
- Francis Lee Lab
- Molecular Medicine, Pharmacology, and Physiology
- Musculoskeletal Oncology
- Ortho Clinical Faculty
- Orthopaedics & Rehabilitation
- Pathology
- Pathology Research
- Sarcoma Program
- Yale Cancer Center
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Medicine