2019
Prenatal nicotine sex-dependently alters adolescent dopamine system development
Dwyer JB, Cardenas A, Franke RM, Chen Y, Bai Y, Belluzzi JD, Lotfipour S, Leslie FM. Prenatal nicotine sex-dependently alters adolescent dopamine system development. Translational Psychiatry 2019, 9: 304. PMID: 31740669, PMCID: PMC6861272, DOI: 10.1038/s41398-019-0640-1.Peer-Reviewed Original ResearchConceptsDopamine systemStriatal dopamine transporter bindingNorepinephrine transporterCocaine-induced locomotor activityGestational day 4Role of D2Postnatal day 32Dopamine transporter bindingCatechol-O-methyl transferaseElectronic nicotine delivery systemsCocaine-induced behaviorsPublic health initiativesSex-independent effectsNicotine delivery systemsG protein couplingNaïve damsMaternal smokingNicotine patchClinical deficitsDopamine turnoverOsmotic minipumpsPlasma levelsNeurobehavioral deficitsPregnant damsReceptor expression
2011
Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats
Cao J, Dwyer JB, Mangold JE, Wang J, Wei J, Leslie FM, Li MD. Modulation of cell adhesion systems by prenatal nicotine exposure in limbic brain regions of adolescent female rats. The International Journal Of Neuropsychopharmacology 2011, 14: 157-174. PMID: 20196919, PMCID: PMC5575906, DOI: 10.1017/s1461145710000179.Peer-Reviewed Original ResearchConceptsGestational nicotine treatmentLimbic brain regionsCell adhesion moleculePsychiatric disordersBrain regionsPregnant Sprague-Dawley ratsGestational day 4Prenatal nicotine exposureNicotine replacement therapyPostnatal day 35Sprague-Dawley ratsMajor psychoactive componentAdolescent female ratsCentral nervous systemQuantitative RT-PCR techniqueRT-PCR techniqueMaternal smokingNicotine treatmentNicotine exposureReplacement therapyCaudate putamenFemale ratsPrenatal treatmentNeurotransmitter systemsNeurobehavioural deficits