2024
Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project
Sajatovic M, Rej S, Almeida O, Altinbas K, Balanzá‐Martínez V, Barbosa I, Beunders A, Blumberg H, Briggs F, Dols A, Forester B, Forlenza O, Gildengers A, Jimenez E, Klaus F, Lafer B, Mulsant B, Mwangi B, Nunes P, Olagunju A, Oluwaniyi S, Orhan M, Patrick R, Radua J, Rajji T, Sarna K, Schouws S, Simhandl C, Sekhon H, Soares J, Sutherland A, Teixeira A, Tsai S, Vidal‐Rubio S, Vieta E, Yala J, Eyler L. Bipolar symptoms, somatic burden and functioning in older‐age bipolar disorder: A replication study from the global aging & geriatric experiments in bipolar disorder database (GAGE‐BD) project. International Journal Of Geriatric Psychiatry 2024, 39: e6057. PMID: 38511929, DOI: 10.1002/gps.6057.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar Disorder DatabaseSomatic burdenBipolar disorderGAGE-BDAssociated with worse functionSymptom severityBD symptomsAssociated with depression severityOlder-age bipolar disorderGlobal Aging & Geriatric ExperimentsManic symptom severityAssociated with poorer functioningGeriatric experiencesAssociation of depressionBipolar symptomsSevere maniaDepression severityDepressive symptomsLow functioningSomatic conditionsPoor functionWorse functionArchival datasetWave 2Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project
Chen P, Sajatovic M, Briggs F, Mulsant B, Dols A, Gildengers A, Yala J, Beunders A, Blumberg H, Rej S, Forlenza O, Jimenez E, Schouws S, Orhan M, Sutherland A, Vieta E, Tsai S, Sarna K, Eyler L, Investigators T. Sociodemographic and clinical characteristics of people with oldest older age bipolar disorder in a global sample: Results from the global aging and geriatric experiments in bipolar disorder project. International Journal Of Geriatric Psychiatry 2024, 39: e6073. PMID: 38393311, DOI: 10.1002/gps.6073.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar disorderGAGE-BDSeverity of manic symptomsRates of suicidal thoughtsLower depressive symptomsComorbid physical conditionsClinical characteristics of peopleGeriatric experiencesManic symptomsClinical characteristicsDepressive symptomsSuicidal thoughtsCharacteristics of peoplePhysical burdenDisordersGlobal ageMedical burdenAge categoriesLogistic regression modelsMultinomial logistic regression modelCross-sectional analysisYounger groupMusculoskeletal domainsSymptoms
2023
Sex Differences Among Older Adults With Bipolar Disorder: Results From the Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project
Blanken M, Oudega M, Almeida O, Schouws S, Orhan M, Beunders A, Klumpers U, Sonnenberg C, Blumberg H, Eyler L, Forester B, Forlenza O, Gildengers A, Mulsant B, Rajji T, Rej S, Sarna K, Sutherland A, Yala J, Vieta E, Tsai S, Briggs F, Sajatovic M, Dols A. Sex Differences Among Older Adults With Bipolar Disorder: Results From the Global Aging & Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project. American Journal Of Geriatric Psychiatry 2023, 32: 326-338. PMID: 37981507, DOI: 10.1016/j.jagp.2023.10.008.Peer-Reviewed Original ResearchOlder age bipolar disorderBipolar disorderPsychiatric hospitalizationMood symptomsSex differencesClinical sex differencesMore psychiatric hospitalizationsPhysical health comorbiditiesLifetime psychiatric comorbidityGlobal AGEingBipolar Disorder (STEP-BD) studySex-specific researchAdult bipolar disorderSubstance abuse disordersDepressive mood symptomsOld age womenClinical characteristicsHealth comorbiditiesSevere courseClinical presentationStudy cohortMale sexPsychiatric comorbidityFemale sexAge womenEssential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE‐BD group
Lavin P, Rej S, Olagunju A, Teixeira A, Dols A, Alda M, Almeida O, Altinbas K, Balanzá‐Martínez V, Barbosa I, Blumberg H, Briggs F, Calkin C, Cassidy K, Forester B, Forlenza O, Hajek T, Haarman B, Jimenez E, Lafer B, Mulsant B, Oluwaniyi S, Patrick R, Radua J, Schouws S, Sekhon H, Simhandl C, Soares J, Tsai S, Vieta E, Villa L, Sajatovic M, Eyler L. Essential data dimensions for prospective international data collection in older age bipolar disorder (OABD): Recommendations from the GAGE‐BD group. Bipolar Disorders 2023, 25: 554-563. PMID: 36843436, DOI: 10.1111/bdi.13312.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderBipolar disorderGeneral medical comorbidityGeriatric mental healthSubgroup of patientsInternational data collectionSubjective cognitive functionMedical comorbiditiesCurrent medicationsPsychiatric comorbidityFamily historyDelphi consensusPsychotic symptomsBD diagnosisClinical practiceSystematic reviewCognitive functionCore symptomsMental healthGlobal AGEingComorbiditiesDisordersSymptomsInitial recommendationsData collection
2022
Demographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD).
Chen P, Eyler LT, Gildengers A, Beunders AJ, Blumberg HP, Briggs FB, Dols A, Rej S, Forlenza OV, Jimenez E, Mulsant B, Schouws S, Orhan M, Sarna K, Sutherland AN, Vieta E, Tsai S, Yala J, Villa LM, Sajatovic M. Demographic and Clinical Characteristics of Antipsychotic Drug-Treated Older Adults with Bipolar Disorder from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE-BD). Psychopharmacology Bulletin 2022, 52: 8-33. PMID: 35721813, PMCID: PMC9172555.Peer-Reviewed Original ResearchConceptsOlder age bipolar disorderFirst-generation antipsychoticsAntipsychotic drugsBipolar disorderPsychiatric hospitalizationMean age 63.2 yearsGlobal AGEingClinical characteristicsFrequent hospitalizationsClinical variablesSevere illnessTreatment statusGreater burdenHospitalizationDisorder databaseOlder adultsCross-sectional dataLongitudinal outcomesDisordersPatientsGeneralized mixed modelMultivariate model resultsInternational studiesDrugsObservational analysisIllness Chronology, Brain Morphology and Mixed Symptom Presentations in Older Age Bipolar Disorder: Emerging Findings from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE –BD) Project
Sajatovic M, Lavin P, Blumberg H, Eyler L. Illness Chronology, Brain Morphology and Mixed Symptom Presentations in Older Age Bipolar Disorder: Emerging Findings from the Global Aging & Geriatric Experiments in Bipolar Disorder Database (GAGE –BD) Project. American Journal Of Geriatric Psychiatry 2022, 30: s8-s9. DOI: 10.1016/j.jagp.2022.01.263.Peer-Reviewed Original ResearchOlder age bipolar disorderBipolar disorderAge-related changesSymptom presentationEvolution of BDLate-onset bipolar disorderBrain structuresMajority of patientsOnset of illnessCourse of illnessGlobal AGEingWorse health outcomesGray matter volumeAge of onsetStructural magnetic resonance imaging (MRI) dataMixed featuresClinical factorsEarly mortalityMixed symptomsWhite matter microstructureClinical correlatesCorrelates of ageDepressive episodeFunctional statusRisk factors