2024
Maternal Serotonin Levels and Neurodevelopmental Severity in Autistic Children: A Partial Replication and Extension
Jutla A, Shuffrey L, Guter S, Anderson G, O'Reilly K, Montgomery A, Sutcliffe J, Cook E, Veenstra-VanderWeele J. Maternal Serotonin Levels and Neurodevelopmental Severity in Autistic Children: A Partial Replication and Extension. JAACAP Open 2024 DOI: 10.1016/j.jaacop.2024.09.005.Peer-Reviewed Original ResearchLatent profile analysisSevere profileAdaptive functioningAssociated with social impairmentAutistic childrenAutism symptom severityAutism spectrum disorderNonverbal IQSerotonin systemSocial impairmentAutistic traitsRepetitive behaviorsSerotonin levelsSymptom severityHigh-severity groupSpectrum disorderPartial replicationGroup levelSevere groupExploratory modelProfile analysisChildrenStratified participantsSeveritySerotonin
1994
Enhanced stress responsivity of tourette syndrome patients undergoing lumbar puncture
Chappell P, Riddle M, Anderson G, Scahill L, Hardin M, Walker D, Cohen D, Leckman J. Enhanced stress responsivity of tourette syndrome patients undergoing lumbar puncture. Biological Psychiatry 1994, 36: 35-43. PMID: 8080901, DOI: 10.1016/0006-3223(94)90060-4.Peer-Reviewed Original ResearchConceptsTS patientsLumbar punctureNormal controlsTourette syndromeClinician ratingsEnhanced stress responsivityLumbar puncture stressUrinary norepinephrine excretionTourette syndrome patientsPeak ACTH levelsNorepinephrine excretionACTH levelsSympathetic systemAdrenal axisMedication responsivenessMore norepinephrinePhonic ticsSyndrome patientsUrinary catecholaminesMore ACTHPatientsTic severityNeuropsychiatric disordersSymptom severityStress responsivity
1992
Double-Blind, Crossover Trial of Fluoxetine and Placebo in Children and Adolescents with Obsessive-Compulsive Disorder
RIDDLE M, SCAHILL L, KING R, HARDIN M, ANDERSON G, ORT S, SMITH J, LECKMAN J, COHEN D. Double-Blind, Crossover Trial of Fluoxetine and Placebo in Children and Adolescents with Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 1992, 31: 1062-1069. PMID: 1429406, DOI: 10.1097/00004583-199211000-00011.Peer-Reviewed Original ResearchConceptsChildren's Yale-Brown Obsessive Compulsive ScaleObsessive-compulsive disorderYale-Brown Obsessive Compulsive ScaleEffective short-term treatmentSafety of fluoxetineFixed-dose trialCommon drug side effectsCY-BOCS total scoreMajor depressive disorderShort-term treatmentDrug side effectsMagnitude of improvementObsessive Compulsive ScaleFluoxetine groupPlacebo groupFluoxetine treatmentCrossover trialClinical trialsDepressive disorderObsessive-compulsive symptom severitySide effectsFluoxetineSymptom severityTotal scoreCompulsive Scale