2023
Can peripheral psychophysiological markers predict response to exposure-based cognitive behavioral therapy in youth with severely impairing irritability? A study protocol
Grasser L, Erjo T, Goodwin M, Naim R, German R, White J, Cullins L, Tseng W, Stoddard J, Brotman M. Can peripheral psychophysiological markers predict response to exposure-based cognitive behavioral therapy in youth with severely impairing irritability? A study protocol. BMC Psychiatry 2023, 23: 926. PMID: 38082431, PMCID: PMC10712194, DOI: 10.1186/s12888-023-05421-4.Peer-Reviewed Original ResearchConceptsExposure-based cognitive-behavioral therapyCognitive behavioral therapyPhysiological arousalBehavioral therapyAffective Reactivity IndexMultiple baseline trialClinical Global Impression ScaleAnger-inducing stimuliPeripheral physiological indicatorsIndividual differencesPsychophysiological markersPerson changesExposure sessionsMultilevel modelingPsychophysiological indicatorsHR/HRVInitial evidenceMental healthReasons youthReactivity indexYouthAppropriate Institutional Review BoardTreatment mechanismsGlobal Impression ScaleCourse of treatmentNetwork analysis of ecological momentary assessment identifies frustration as a central node in irritability
Tseng W, Naim R, Chue A, Shaughnessy S, Meigs J, Pine D, Leibenluft E, Kircanski K, Brotman M. Network analysis of ecological momentary assessment identifies frustration as a central node in irritability. Journal Of Child Psychology And Psychiatry 2023, 64: 1212-1221. PMID: 36977629, PMCID: PMC10615387, DOI: 10.1111/jcpp.13794.Peer-Reviewed Original Research
2022
Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability
Linke J, Haller S, Xu E, Nguyen L, Chue A, Botz-Zapp C, Revzina O, Perlstein S, Ross A, Tseng W, Shaw P, Brotman M, Pine D, Gotts S, Leibenluft E, Kircanski K. Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability. Journal Of The American Academy Of Child & Adolescent Psychiatry 2022, 62: 684-695. PMID: 36563874, PMCID: PMC11224120, DOI: 10.1016/j.jaac.2022.11.009.Peer-Reviewed Original ResearchConceptsResting-state scansPathophysiology of irritabilitySelf-reported irritabilityFunctional magnetic resonance imagingMagnetic resonance imagingParent-reported irritabilitySpecific intervention targetsRisk factorsMotor functionPsychiatric consultationCircuit reorganizationCommon reasonAffective disordersBrain network configurationIrritability symptomsResonance imagingBrain regionsIrritabilityCentral mechanismsAberrant responsesPilot studyIntervention targetsRecovery periodPediatric irritabilityBrain networksDifferences in white matter segments in autistic males, non-autistic siblings, and non-autistic participants: An intermediate phenotype approach
Chien YL, Chen YJ, Tseng WL, Hsu YC, Wu CS, Tseng WI, Gau SS. Differences in white matter segments in autistic males, non-autistic siblings, and non-autistic participants: An intermediate phenotype approach. Autism 2022, 27: 1036-1052. PMID: 36254873, DOI: 10.1177/13623613221125620.Peer-Reviewed Original ResearchConceptsNon-autistic siblingsNon-autistic peopleAutistic peopleAutistic traitsBrain regionsTheory of mindNon-autistic participantsHigher cognitive functionsAnterior brain regionsSocial cognitionNeurocognitive strengthsNeuropsychological characteristicsCognitive functionAutistic malesDifferent brain regionsAutismBrain adaptationIntermediate phenotype approachWhite matter differencesFuture researchNeural pathwaysBiological basisPeopleSiblingsCausal link
2021
Rates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish Population
Xia Y, Xiao J, Yu Y, Tseng WL, Lebowitz E, DeWan AT, Pedersen LH, Olsen J, Li J, Liew Z. Rates of Neuropsychiatric Disorders and Gestational Age at Birth in a Danish Population. JAMA Network Open 2021, 4: e2114913. PMID: 34185070, PMCID: PMC8243234, DOI: 10.1001/jamanetworkopen.2021.14913.Peer-Reviewed Original ResearchConceptsIncidence rate ratiosLate pretermNeuropsychiatric disordersMajor neuropsychiatric disordersEarly termTerm birthsGestational agePostterm birthSingleton birthsAdult-onset neuropsychiatric disordersDanish Medical Birth RegisterLower incidence rate ratiosGestational age subgroupsMedical Birth RegisterGestational age groupsHigh ratePostterm groupGestational durationCohort studyNationwide registersPerinatal factorsPreterm birthBirth RegisterVery pretermAge subgroups
2020
Psychiatric comorbidity and social adjustment difficulties in children with disruptive mood dysregulation disorder: A national epidemiological study
Lin YJ, Tseng WL, Gau SS. Psychiatric comorbidity and social adjustment difficulties in children with disruptive mood dysregulation disorder: A national epidemiological study. Journal Of Affective Disorders 2020, 281: 485-492. PMID: 33383391, PMCID: PMC8142276, DOI: 10.1016/j.jad.2020.12.039.Peer-Reviewed Original ResearchConceptsDisruptive mood dysregulation disorderOppositional defiant disorderSocial adjustment difficultiesAdjustment difficultiesPsychiatric comorbiditySocial Adjustment InventoryKiddie epidemiologic versionParent-child interactionsChildhood mental disordersAdjustment InventoryDefiant disorderEpidemiologic VersionParental educational levelAcademic performanceMore difficultyDSM-5More problemsHigh psychiatric comorbiditySchool functionTaiwanese childrenMental disordersNational epidemiological studyChildrenAffective disordersSevere impairmentDevelopmental Course and Risk Factors of Physical Aggression in Late Adolescence
Henriksen M, Skrove M, Hoftun GB, Sund ER, Lydersen S, Tseng WL, Sukhodolsky DG. Developmental Course and Risk Factors of Physical Aggression in Late Adolescence. Child Psychiatry & Human Development 2020, 52: 628-639. PMID: 32852728, PMCID: PMC8238740, DOI: 10.1007/s10578-020-01049-7.Peer-Reviewed Original ResearchConceptsRisk factorsMale genderAggressive behaviorLate adolescenceHeavy drinkingEarly adolescenceStudy sampleLongitudinal studyPhysical aggressionAdolescencePhysical aggressive behaviorAdolescentsNorwegian adolescentsPhysical fightsAttention problemsYoung adolescentsDrinkingDevelopmental courseGenderSmokingFactorsStudyExecutive functions in youths with autism spectrum disorder and their unaffected siblings
Seng GJ, Tseng WL, Chiu YN, Tsai WC, Wu YY, Gau SS. Executive functions in youths with autism spectrum disorder and their unaffected siblings. Psychological Medicine 2020, 51: 2571-2580. PMID: 32349803, DOI: 10.1017/s0033291720001075.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpatial working memoryExecutive function tasksExecutive functionASD youthWorking memoryFunction tasksCognitive endophenotypesSpatial spanExecutive dysfunctionSpectrum disorderUnaffected siblingsCambridge Neuropsychological Test Automated BatteryAttention-deficit/hyperactivity disorderPotential cognitive endophenotypesExtra-dimensional shiftPlanning/problemVisuospatial working memoryBackward digit recallMain cognitive theoriesStockings of CambridgeDigit span testEvidence of deficitsCognitive theoryDigit recall
2019
Psychiatric comorbid patterns in adults with attention-deficit hyperactivity disorder: Treatment effect and subtypes
Tsai FJ, Tseng WL, Yang LK, Gau SS. Psychiatric comorbid patterns in adults with attention-deficit hyperactivity disorder: Treatment effect and subtypes. PLOS ONE 2019, 14: e0211873. PMID: 30730956, PMCID: PMC6366698, DOI: 10.1371/journal.pone.0211873.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderDrug-naïve adultsChildhood attention-deficit/hyperactivity disorderPsychiatric comorbidityMedication treatmentHigh riskTreatment durationHyperactivity disorderSemi-structured psychiatric interviewCurrent medication treatmentHealthy adult controlsEffects of medicationLonger treatment durationShorter treatment durationAttention deficit hyperactivity disorderADHD inattentive subtypeMore comorbiditiesMedical recordsHealthy controlsMood disordersSleep disordersComorbiditiesPsychiatric interviewLower riskADHD subtypes
2018
Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths
Tseng WL, Deveney CM, Stoddard J, Kircanski K, Frackman AE, Yi JY, Hsu D, Moroney E, Machlin L, Donahue L, Roule A, Perhamus G, Reynolds RC, Roberson-Nay R, Hettema JM, Towbin KE, Stringaris A, Pine DS, Brotman MA, Leibenluft E. Brain Mechanisms of Attention Orienting Following Frustration: Associations With Irritability and Age in Youths. American Journal Of Psychiatry 2018, 176: 67-76. PMID: 30336704, PMCID: PMC6408218, DOI: 10.1176/appi.ajp.2018.18040491.Peer-Reviewed Original ResearchConceptsLevels of irritabilityWhole-brain activation analysesRegulation of emotionAffective Reactivity IndexInferior frontal gyrusFunctional MRI paradigmDorsolateral prefrontal cortexAnterior cingulate cortexAttention orientingNeural correlatesTransdiagnostic sampleBrain mechanismsFMRI paradigmChildhood irritabilityFrontal gyrusNeural activationChild reportsMotor executionPrefrontal cortexHigh irritabilityCingulate cortexNeural systemsYounger youthNeural activityOlder youthA Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth
Kircanski K, White LK, Tseng WL, Wiggins JL, Frank HR, Sequeira S, Zhang S, Abend R, Towbin KE, Stringaris A, Pine DS, Leibenluft E, Brotman MA. A Latent Variable Approach to Differentiating Neural Mechanisms of Irritability and Anxiety in Youth. JAMA Psychiatry 2018, 75: 631-639. PMID: 29625429, PMCID: PMC6137523, DOI: 10.1001/jamapsychiatry.2018.0468.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxietyAttention Deficit Disorder with HyperactivityBrainCase-Control StudiesCaudate NucleusCerebral CortexChildCross-Sectional StudiesFemaleFunctional NeuroimagingHumansIrritable MoodLatent Class AnalysisMagnetic Resonance ImagingMaleMood DisordersNeural PathwaysParietal LobePrefrontal CortexConceptsParent-reported irritabilityNeural mechanismsAnxiety symptomsLatent variable approachPediatric irritabilityNeural correlatesAmygdala connectivityShared varianceCross-sectional functional magnetic resonance imaging studyNeural activityFunctional magnetic resonance imaging studyDot-probe taskAffective Reactivity IndexVentrolateral prefrontal cortexCommon neural mechanismsAmygdala functional connectivityFunctional magnetic resonanceLevels of irritabilityWhole-brain analysisInferior parietal lobuleData-driven phenotypingMultiple diagnostic categoriesCo-occurring symptomsMagnetic resonance imaging studyNeutral faces
2017
Gender and Age Differences in Sleep Problems in Children: Person-Oriented Approach With Multigroup Analysis
Chen YL, Tseng WL, Yang LK, Gau SS. Gender and Age Differences in Sleep Problems in Children: Person-Oriented Approach With Multigroup Analysis. Behavioral Sleep Medicine 2017, 17: 302-313. PMID: 28753086, DOI: 10.1080/15402002.2017.1357117.Peer-Reviewed Original ResearchConceptsPerson-oriented approachSleep problemsAge groupsPrevalence ratesMultigroup analysisSleep-related breathing problemsVaried prevalence ratesAge-specific interventionsSleep Habits QuestionnaireHigh sleep problemsDifferent prevalence ratesAssociated FactorsParent reportAge differencesBreathing problemsHabits QuestionnaireEpidemiological sampleLatent class modelingSubtypesChildrenFuture studiesGenderGroupClass modelingParasomniasRelational‐Interdependent Self‐Construal and Gender Predicting Blood Pressure Reactivity and Recovery From Stress in Early Adolescence
Kawabata Y, Tseng W, Murray‐Close D. Relational‐Interdependent Self‐Construal and Gender Predicting Blood Pressure Reactivity and Recovery From Stress in Early Adolescence. Journal Of Research On Adolescence 2017, 27: 782-796. PMID: 29152862, DOI: 10.1111/jora.12314.Peer-Reviewed Original ResearchConceptsBlood pressure reactivityPressure reactivityGreater diastolic blood pressure reactivityDiastolic blood pressureDiastolic blood pressure reactivityGreater systolic blood pressure reactivitySystolic blood pressure reactivityLaboratory stress protocolBlood pressureImpaired recoveryStress protocolPeer stressorsTrend levelEarly adolescenceAssociationStressorsRecoveryTest-retest reliability and validity of a frustration paradigm and irritability measures
Tseng WL, Moroney E, Machlin L, Roberson-Nay R, Hettema JM, Carney D, Stoddard J, Towbin KA, Pine DS, Leibenluft E, Brotman MA. Test-retest reliability and validity of a frustration paradigm and irritability measures. Journal Of Affective Disorders 2017, 212: 38-45. PMID: 28135689, PMCID: PMC8049456, DOI: 10.1016/j.jad.2017.01.024.Peer-Reviewed Original ResearchConceptsTest-retest reliabilityParent-reported irritabilityIrritability measuresGood test-retest reliabilityNegative affectIrritability ScaleValidity of assessmentsBehavioral paradigmsChild irritabilityTreatment researchGeneral population sampleConvergent validityExcellent test-retest reliabilityModest supportConstruct validityTaskParticipantsIrritabilityParadigmIntraclass correlationAssociation of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology
Stoddard J, Tseng WL, Kim P, Chen G, Yi J, Donahue L, Brotman MA, Towbin KE, Pine DS, Leibenluft E. Association of Irritability and Anxiety With the Neural Mechanisms of Implicit Face Emotion Processing in Youths With Psychopathology. JAMA Psychiatry 2017, 74: 95-103. PMID: 27902832, PMCID: PMC6309540, DOI: 10.1001/jamapsychiatry.2016.3282.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAmygdalaAnxiety DisordersArousalAttention Deficit Disorder with HyperactivityBrainChildCross-Sectional StudiesDominance, CerebralEmotionsFacial RecognitionFemaleHumansIrritable MoodMagnetic Resonance ImagingMaleMental DisordersMood DisordersNerve NetPrefrontal CortexPsychopathologyConceptsFunctional magnetic resonance imagingPrefrontal cortex connectivityFace emotionsNeural responsesCortex connectivityMedial prefrontal cortex connectivityAttention-deficit/hyperactivity disorderChild Anxiety Related DisordersThreat-related facesDisruptive Mood DysregulationPathophysiology of irritabilityFace emotion processingAmygdala-medial prefrontal cortex connectivityCross-sectional functional magnetic resonanceAffective Reactivity IndexBrain-behavior relationshipsVentral visual areasAssociations of irritabilityUnique effectsAmygdala functional connectivityAnxiety Related DisordersFunctional magnetic resonanceYouth ages 8Angry facesFearful faces
2016
Functional connectivity during masked and unmasked face emotion processing in bipolar disorder
Tseng WL, Thomas LA, Harkins E, Stoddard J, Zarate CA, Pine DS, Leibenluft E, Brotman MA. Functional connectivity during masked and unmasked face emotion processing in bipolar disorder. Psychiatry Research Neuroimaging 2016, 258: 1-9. PMID: 27814457, PMCID: PMC5135603, DOI: 10.1016/j.pscychresns.2016.10.006.Peer-Reviewed Original ResearchConceptsFace emotion processingEmotion processingHealthy volunteersBipolar disorderFunctional connectivityAffective priming taskAmygdala-vmPFC connectivityVentromedial prefrontal cortexExpression of emotionsBD patientsMedial frontal gyrusNeutral facesPriming taskEmotion typeEmotional processingFMRI scanningActivation differencesFrontal gyrusGreater activationLess activationPrefrontal cortexConnectivity findingsNeural connectivityPathophysiological correlatesNeural dysfunction
2015
Neural correlates of masked and unmasked face emotion processing in youth with severe mood dysregulation
Tseng WL, Thomas LA, Harkins E, Pine DS, Leibenluft E, Brotman MA. Neural correlates of masked and unmasked face emotion processing in youth with severe mood dysregulation. Social Cognitive And Affective Neuroscience 2015, 11: 78-88. PMID: 26137973, PMCID: PMC4692312, DOI: 10.1093/scan/nsv087.Peer-Reviewed Original ResearchConceptsSevere mood dysregulationFace emotion processingFunctional magnetic resonance imagingEmotion processingParahippocampal gyrusNeural correlatesMood dysregulationVentromedial prefrontal cortex activationAffective priming paradigmPrefrontal cortex activationSuperior temporal gyrusAngry facesFace processingHappy facesSMD patientsPositive emotionsPriming paradigmVmPFC dysfunctionNegative emotionsTemporal gyrusCortex activationEmotionsFMRI dataDecreased activationIndependent samplesBEHAVIOR AND EMOTION MODULATION DEFICITS IN PRESCHOOLERS AT RISK FOR BIPOLAR DISORDER
Tseng W, Guyer AE, Briggs‐Gowan M, Axelson D, Birmaher B, Egger HL, Helm J, Stowe Z, Towbin KA, Wakschlag LS, Leibenluft E, Brotman MA. BEHAVIOR AND EMOTION MODULATION DEFICITS IN PRESCHOOLERS AT RISK FOR BIPOLAR DISORDER. Depression And Anxiety 2015, 32: 325-334. PMID: 25691090, PMCID: PMC4409452, DOI: 10.1002/da.22342.Peer-Reviewed Original ResearchConceptsBipolar disorderAppropriate clinical assessment toolFamilial riskLow-risk groupFirst-degree relativesClinical assessment toolHigh familial riskStandardized laboratory observationsOppositional defiant disorderFamily historyMood disordersModulation deficitsLower riskProdromal indicatorsPsychiatric assessmentChild Behavior ChecklistEarly interventionAnger modulationDefiant disorderDisordersLarge longitudinal sampleHigh-risk preschoolersBehavior ChecklistRiskEmotional problemsAn fMRI study of emotional face encoding in youth at risk for bipolar disorder
Tseng W, Bones BL, Kayser RR, Olsavsky AK, Fromm SJ, Pine DS, Leibenluft E, Brotman MA. An fMRI study of emotional face encoding in youth at risk for bipolar disorder. European Psychiatry 2015, 30: 94-98. PMID: 25172156, PMCID: PMC10656053, DOI: 10.1016/j.eurpsy.2014.05.004.Peer-Reviewed Original Research
2014
Association between microstructural integrity of frontostriatal tracts and school functioning: ADHD symptoms and executive function as mediators
Gau SS, Tseng WL, Tseng WY, Wu YH, Lo YC. Association between microstructural integrity of frontostriatal tracts and school functioning: ADHD symptoms and executive function as mediators. Psychological Medicine 2014, 45: 529-543. PMID: 25075643, DOI: 10.1017/s0033291714001664.Peer-Reviewed Original Research