2020
Little Doubt That CBT Works for Pediatric OCD
Storch EA, Peris TS, De Nadai A, Piacentini J, Bloch M, Cervin M, McGuire J, Farrell LJ, McCracken JT, McKay D, Riemann BC, Wagner AP, Franklin M, Schneider SC, Walkup JT, Williams L, Abramowitz JS, Stewart SE, Fitzgerald KD, Goodman WK. Little Doubt That CBT Works for Pediatric OCD. Journal Of The American Academy Of Child & Adolescent Psychiatry 2020, 59: 785-787. PMID: 32618273, DOI: 10.1016/j.jaac.2020.01.026.Peer-Reviewed Original ResearchChapter 39 Obsessive–compulsive disorder
Bloch M, Artukoglu B, Lennington J, Szuhay G, Lombroso P. Chapter 39 Obsessive–compulsive disorder. 2020, 663-674. DOI: 10.1016/b978-0-12-813866-3.00039-4.Peer-Reviewed Original ResearchObsessive-compulsive disorderEvidence-based treatmentsCognitive behavioral therapyTreatment-refractory obsessive-compulsive disorderSignificant hereditary componentRepetitive transcranial magnetic stimulationTranscranial magnetic stimulationBrain stimulantBehavioral therapyMagnetic stimulationCortico-striatoSelective serotonin reuptake inhibitorsPharmacological treatment strategiesFirst-line treatmentSerotonin reuptake inhibitorsAntipsychotic augmentationGenetic risk factorsReuptake inhibitorsDisordersRisk factorsTreatment strategiesAnimal studiesNeuroimagingModulating agentsHereditary component
2018
Chapter 17 Managing a Child With OCD Who Is Treatment Refractory
Bloch M. Chapter 17 Managing a Child With OCD Who Is Treatment Refractory. 2018, 329-356. DOI: 10.1016/b978-0-12-811427-8.00017-4.Peer-Reviewed Original ResearchObsessive-compulsive disorderTreatment-refractory obsessive-compulsive disorderCognitive behavioral therapyFirst-line treatmentOCD symptomsPediatric obsessive-compulsive disorderSelective serotonin reuptake inhibitor (SSRI) pharmacotherapyEffective first-line treatmentSelective serotonin reuptake inhibitorsIntensive treatment programSerotonin reuptake inhibitorsGlutamate-modulating agentsMajority of childrenTreatment programAntipsychotic augmentationReuptake inhibitorsTreatment refractoryPharmacological treatmentAvailable treatmentsChildrenSubstantial proportionPharmacotherapyTreatmentTherapySymptoms
2017
Monotherapy Insufficient in Severe Anxiety? Predictors and Moderators in the Child/Adolescent Anxiety Multimodal Study
Taylor JH, Lebowitz ER, Jakubovski E, Coughlin CG, Silverman WK, Bloch MH. Monotherapy Insufficient in Severe Anxiety? Predictors and Moderators in the Child/Adolescent Anxiety Multimodal Study. Journal Of Clinical Child & Adolescent Psychology 2017, 47: 266-281. PMID: 28956620, PMCID: PMC6191182, DOI: 10.1080/15374416.2017.1371028.Peer-Reviewed Original ResearchConceptsChild/Adolescent Anxiety Multimodal StudyCognitive behavioral therapyModerators of outcomeSevere anxietyCombination of CBTIndependent evaluator ratingsMultimodal studyParent-rated anxietySeparation anxiety disorderMain effect findingsObsessive-compulsive disorderAnxious youthSocial anxietyChild anxietyBehavioral therapyAnxiety severityPill placeboAnxiety disordersEvaluators' ratingsAnxietyModeratorSocioeconomic statusLow socioeconomic statusYouthEffect findingsObsessive-Compulsive Disorder: Advances in Diagnosis and Treatment
Hirschtritt ME, Bloch MH, Mathews CA. Obsessive-Compulsive Disorder: Advances in Diagnosis and Treatment. JAMA 2017, 317: 1358-1367. PMID: 28384832, DOI: 10.1001/jama.2017.2200.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsObsessive-compulsive disorderCognitive behavioral therapyTreatment of OCDReuptake inhibitorsBehavioral therapySystematic reviewFirst-line pharmacologic interventionPreferred initial treatment strategyTreatment-resistant obsessive-compulsive disorderInitial treatment strategyPrimary care settingTreatment-resistant casesDiagnosis of OCDFirst-line interventionEfficacy of neurolepticsDeep brain stimulationComputer-based cognitive behavioral therapyCase seriesPharmacologic interventionsAdjunctive useTreatment optionsTreatment advancesNeuromodulatory approachesIntranasal Ketamine and Cognitive-Behavioral Therapy for Treatment-Refractory Obsessive-Compulsive Disorder
Adams TG, Bloch MH, Pittenger C. Intranasal Ketamine and Cognitive-Behavioral Therapy for Treatment-Refractory Obsessive-Compulsive Disorder. Journal Of Clinical Psychopharmacology 2017, 37: 269-271. PMID: 28121735, PMCID: PMC5321820, DOI: 10.1097/jcp.0000000000000659.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyTreatment-Refractory ObsessiveCompulsive disorderObsessiveDisorders
2015
Predictors of anxiety recurrence in the Coordinated Anxiety Learning and Management (CALM) trial
Taylor JH, Jakubovski E, Bloch MH. Predictors of anxiety recurrence in the Coordinated Anxiety Learning and Management (CALM) trial. Journal Of Psychiatric Research 2015, 65: 154-165. PMID: 25896121, PMCID: PMC4492801, DOI: 10.1016/j.jpsychires.2015.03.020.Peer-Reviewed Original ResearchConceptsCoordinated Anxiety LearningAnxiety recurrenceAnxiety LearningAnxiety Sensitivity Index scoreUsual careCognitive behavioral therapyRelapse prevention programAnxiety remissionBehavioral therapyAnxiety disordersMultivariable logistic regression modelResidual anxietyCollaborative care interventionPrimary care clinicsPrimary care settingRisk of recurrenceComorbid depressionManagement trialsReceiver Operating CharacteristicLogistic regression modelsMonth 6Care clinicsPrevention programsPrognostic subgroupsCare interventionsAssessment and Management of Treatment-Refractory Obsessive-Compulsive Disorder in Children
Bloch MH, Storch EA. Assessment and Management of Treatment-Refractory Obsessive-Compulsive Disorder in Children. Journal Of The American Academy Of Child & Adolescent Psychiatry 2015, 54: 251-262. PMID: 25791142, PMCID: PMC4460245, DOI: 10.1016/j.jaac.2015.01.011.Peer-Reviewed Original ResearchConceptsTreatment-refractory obsessive-compulsive disorderPediatric obsessive-compulsive disorderSelective serotonin reuptake inhibitorsObsessive-compulsive disorderCognitive behavioral therapyTreatment-Refractory ObsessivePharmacological treatment optionsSide effect profileSerotonin reuptake inhibitorsTreatment of adultsGlutamate-modulating agentsLittle evidence-based dataEvidence of efficacyEvidence-based dataPediatric OCD patientsOCD symptomsAntipsychotic augmentationSSRI dosagesPediatric patientsReuptake inhibitorsEffect profilePediatric populationTreatment optionsPractice guidelinesEffective treatment
2014
Prognostic subgroups for remission and response in the Coordinated Anxiety Learning and Management (CALM) trial.
Kelly JM, Jakubovski E, Bloch MH. Prognostic subgroups for remission and response in the Coordinated Anxiety Learning and Management (CALM) trial. The Journal Of Clinical Psychiatry 2014, 76: 267-78. PMID: 25562579, PMCID: PMC4930076, DOI: 10.4088/jcp.13m08922.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic Uptake InhibitorsAdultAgedAnti-Anxiety AgentsAnxiety DisordersBenzodiazepinesCognitive Behavioral TherapyCombined Modality TherapyDepressive Disorder, MajorFemaleHumansMaleMiddle AgedOutcome Assessment, Health CarePanic DisorderPhobic DisordersPrognosisRemission InductionSelective Serotonin Reuptake InhibitorsSeverity of Illness IndexSex FactorsSocial ClassSocial SupportStress Disorders, Post-TraumaticYoung AdultConceptsLow socioeconomic statusCoordinated Anxiety LearningUsual careGeneralized anxiety disorderPosttraumatic stress disorderAnxiety disordersBaseline characteristicsPatient characteristicsPrognostic subgroupsAnxiety LearningSocioeconomic statusBaseline patient characteristicsCollaborative care interventionPrimary care settingPoor treatment outcomesCommunity treatment centersDSM-IV criteriaManagement trialsCognitive behavioral therapyLimited social supportExploratory moderator analysesMost patientsRemission criteriaComorbid depressionPrognostic outcomesA meta-analysis of computerized cognitive-behavioral therapy for the treatment of DSM-5 anxiety disorders.
Adelman CB, Panza KE, Bartley CA, Bontempo A, Bloch MH. A meta-analysis of computerized cognitive-behavioral therapy for the treatment of DSM-5 anxiety disorders. The Journal Of Clinical Psychiatry 2014, 75: e695-704. PMID: 25093485, DOI: 10.4088/jcp.13r08894.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyPerson cognitive-behavioural therapyComputerized cognitive behavioral therapyAnxiety disordersComputerized CBTNon-PTSD anxiety disordersCompletion of treatmentTreatment gainsStandardized mean differenceDSM-5 anxiety disordersGreater symptom reductionWait-list controlSpecific anxiety disordersFixed-effects modelClinical outcomesClinical comorbiditiesEfficacious interventionsSymptom reductionReal-world settingGreater efficacyMeta-AnalysisCBT treatmentMean differenceDisordersAnxiety symptoms
2013
Cognitive-Behavioral Therapy for Anxiety in Children With High-Functioning Autism: A Meta-analysis
Sukhodolsky DG, Bloch MH, Panza KE, Reichow B. Cognitive-Behavioral Therapy for Anxiety in Children With High-Functioning Autism: A Meta-analysis. Pediatrics 2013, 132: e1341-e1350. PMID: 24167175, PMCID: PMC3813396, DOI: 10.1542/peds.2013-1193.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyAutism spectrum disorderCo-occurring anxiety symptomsControl conditionSelf-reported anxietyAttention control conditionSample of childrenUsual control conditionFunctioning autismParent ratingsASD diagnosisBehavioral therapySpectrum disorderWaitlist controlAnxiety symptomsOverall effect sizeAnxietyClinician ratingsEffect sizeTreatment controlAdolescentsChildrenRatingsAutismTreatment changes
2005
Clinical treatment of obsessive compulsive disorder.
Pittenger C, Kelmendi B, Bloch M, Krystal JH, Coric V. Clinical treatment of obsessive compulsive disorder. Innov Clin Neurosci 2005, 2: 34-43. PMID: 21120095, PMCID: PMC2993523.Peer-Reviewed Original ResearchObsessive-compulsive disorderSRI-resistant obsessive compulsive disorderMainstay of treatmentSerotonin reuptake inhibitorsEffective treatment modalityUse of clomipramineCurrent treatment strategiesRecent epidemiological studiesCommon psychiatric disordersCompulsive disorderCognitive behavioral therapyInvasive neurosurgical proceduresPartial responseAvailable medicationsPharmacologic treatmentReuptake inhibitorsTreatment armamentariumSignificant morbidityTreatment modalitiesChronic disordersMedication managementTreatment strategiesEpidemiological studiesPsychiatric disordersClinical treatment