2017
Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia
Logue MW, van Rooij SJH, Dennis EL, Davis SL, Hayes JP, Stevens JS, Densmore M, Haswell CC, Ipser J, Koch SBJ, Korgaonkar M, Lebois LAM, Peverill M, Baker JT, Boedhoe PSW, Frijling JL, Gruber SA, Harpaz-Rotem I, Jahanshad N, Koopowitz S, Levy I, Nawijn L, O’Connor L, Olff M, Salat DH, Sheridan MA, Spielberg JM, van Zuiden M, Winternitz SR, Wolff JD, Wolf EJ, Wang X, Wrocklage K, Abdallah CG, Bryant RA, Geuze E, Jovanovic T, Kaufman ML, King AP, Krystal JH, Lagopoulos J, Bennett M, Lanius R, Liberzon I, McGlinchey RE, McLaughlin KA, Milberg WP, Miller MW, Ressler KJ, Veltman DJ, Stein DJ, Thomaes K, Thompson PM, Morey RA. Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. Biological Psychiatry 2017, 83: 244-253. PMID: 29217296, PMCID: PMC5951719, DOI: 10.1016/j.biopsych.2017.09.006.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderTrauma-exposed control subjectsCurrent posttraumatic stress disorderSmaller hippocampal volumesControl subjectsSmaller hippocampiHippocampal volumeClinical dataAmygdala volumeAmygdala findingsSmaller amygdalaConsortium studySubcortical structuresNeuroimaging studiesLargest neuroimaging studyENIGMA consortiumBrain responsesNeurobiological underpinningsPsychiatric Genomics ConsortiumDisordersSubjectsWorking GroupSignificance levelHippocampus
2015
Significant association between rare IPO11‐HTR1A variants and attention deficit hyperactivity disorder in Caucasians
Zuo L, Saba L, Lin X, Tan Y, Wang K, Krystal JH, Tabakoff B, Luo X. Significant association between rare IPO11‐HTR1A variants and attention deficit hyperactivity disorder in Caucasians. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2015, 168: 544-556. PMID: 26079129, PMCID: PMC4851708, DOI: 10.1002/ajmg.b.32329.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttention Deficit Disorder with HyperactivityBeta KaryopherinsBlack or African AmericanFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationHumansMaleMiddle AgedPolymorphism, Single NucleotideQuantitative Trait LociReceptor, Serotonin, 5-HT1ARisk FactorsWhite PeopleConceptsAttention deficit hyperactivity disorderDeficit hyperactivity disorderNeuropsychiatric disordersRare variantsHyperactivity disorderDifferent neuropsychiatric disordersRNA expression changesIndependent cohortSignificant associationSignificant regulatory effectDisordersCaucasiansEuropean descentRegulatory effectsHuman brainDiseaseAssociationCis-eQTL analysisIPO11African descentExpression changesSubjectsCohortFalse discovery rateVariants
2013
Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence
Xie P, Kranzler HR, Krystal JH, Farrer LA, Zhao H, Gelernter J. Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence. Addiction Biology 2013, 19: 955-964. PMID: 23855403, PMCID: PMC3815683, DOI: 10.1111/adb.12072.Peer-Reviewed Original ResearchConceptsOpioid dependenceSubstance dependenceRare variantsN-methyl-D-aspartate (NMDA) glutamate receptorsCo-occurring alcohol dependenceHealthy control subjectsControl subjectsNMDA systemOpioid abuseGlutamate receptorsSchizophrenia risk genesSD riskAlcohol dependenceSignificant associationCocaine dependenceAdditional subjectsOD riskRisk genesDISC1African AmericansFirst demonstrationCommon variantsRiskSubjectsMinor allele frequency
2009
Population admixture modulates risk for alcohol dependence
Zuo L, Luo X, Listman JB, Kranzler HR, Wang S, Anton RF, Blumberg HP, Stein MB, Pearlson GD, Covault J, Charney DS, van Kammen DP, Price LH, Lappalainen J, Cramer J, Krystal JH, Gelernter J. Population admixture modulates risk for alcohol dependence. Human Genetics 2009, 125: 605-613. PMID: 19306106, PMCID: PMC2777998, DOI: 10.1007/s00439-009-0647-4.Peer-Reviewed Original Research
2005
Delta-9-tetrahydrocannabinol effects in schizophrenia: Implications for cognition, psychosis, and addiction
D’Souza D, Abi-Saab WM, Madonick S, Forselius-Bielen K, Doersch A, Braley G, Gueorguieva R, Cooper TB, Krystal JH. Delta-9-tetrahydrocannabinol effects in schizophrenia: Implications for cognition, psychosis, and addiction. Biological Psychiatry 2005, 57: 594-608. PMID: 15780846, DOI: 10.1016/j.biopsych.2004.12.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAkathisia, Drug-InducedArousalCognitionDose-Response Relationship, DrugDouble-Blind MethodDronabinolEndocrine SystemFemaleHumansInjections, IntravenousMaleMental RecallMiddle AgedMotor ActivityNeuropsychological TestsPerceptionPsychiatric Status Rating ScalesPsychotic DisordersPsychotropic DrugsSchizophreniaVerbal LearningConceptsSchizophrenia patientsAntipsychotic-treated schizophrenia patientsDelta-9-tetrahydrocannabinol effectsLong-term adverse eventsCognitive deficitsPlacebo-controlled studyDelta-9-THCTransient exacerbationAdverse eventsReceptor dysfunctionEndocrine effectsHealthy subjectsStudy participationPsychotic disordersPlasma prolactinSchizophrenia symptomsPatientsSchizophreniaCognitive effectsPerceptual alterationsDeficitsCannabisSubjectsAkathisiaExacerbationAbsence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine
Cho HS, D’Souza D, Gueorguieva R, Perry EB, Madonick S, Karper LP, Abi-Dargham A, Belger A, Abi-Saab W, Lipschitz D, Bennet A, Seibyl JP, Krystal JH. Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine. Psychopharmacology 2005, 179: 136-143. PMID: 15682309, DOI: 10.1007/s00213-004-2066-5.Peer-Reviewed Original ResearchConceptsHealthy human subjectsBehavioral sensitizationReceptor antagonistN-methyl-D-aspartate (NMDA) glutamate receptor antagonistBehavioral effectsHuman subjectsGlutamate receptor antagonistsNMDA receptor antagonistConclusionsThe current dataEvidence of sensitizationRetrospective studyKetamine administrationOutcome measuresNegative symptomsObjectivesThe purposePrevious exposureFirst exposureKetamineSensitizationAntagonistExposurePerceptual alterationsCurrent dataSeparate studiesSubjects
2002
Striking Differences in Glucose and Lactate Levels Between Brain Extracellular Fluid and Plasma in Conscious Human Subjects: Effects of Hyperglycemia and Hypoglycemia
Abi-Saab WM, Maggs DG, Jones T, Jacob R, Srihari V, Thompson J, Kerr D, Leone P, Krystal JH, Spencer DD, During MJ, Sherwin RS. Striking Differences in Glucose and Lactate Levels Between Brain Extracellular Fluid and Plasma in Conscious Human Subjects: Effects of Hyperglycemia and Hypoglycemia. Cerebrovascular And Brain Metabolism Reviews 2002, 22: 271-279. PMID: 11891432, DOI: 10.1097/00004647-200203000-00004.Peer-Reviewed Original ResearchConceptsConscious human subjectsBrain extracellular fluidLactate levelsECF levelsExtracellular fluidBasal conditionsGlucose-derived lactateEffects of hyperglycemiaHuman subjectsECF glucoseElectrophysiologic evaluationIntracerebral microdialysisIntractable epilepsyBrain levelsMetabolic milieuClamp studiesBrainAnaerobic glycolysisHuman dataLactateGlucoseLow levelsSubjectsHigh levelsLevels
2001
Quantitative Morphology of the Caudate and Putamen in Patients With Cocaine Dependence
Jacobsen LK, Giedd JN, Gottschalk C, Kosten TR, Krystal JH. Quantitative Morphology of the Caudate and Putamen in Patients With Cocaine Dependence. American Journal Of Psychiatry 2001, 158: 486-489. PMID: 11229995, DOI: 10.1176/appi.ajp.158.3.486.Peer-Reviewed Original ResearchConceptsCocaine dependenceDopaminergic functionStriatal dopaminergic depletionTypical neuroleptic treatmentTotal brain volumeChronic cocaine dependenceCocaine-dependent subjectsChronic cocaine useStriatal hypertrophyExtrapyramidal symptomsNeuroleptic treatmentDopaminergic depletionHealthy subjectsBrain volumePutamen volumeCocaine useStriatal structuresCaudatePatientsPutamenHypertrophyMagnetic resonanceDeficitsQuantitative morphologySubjects
2000
Cocaine use and the mid-latency auditory evoked responses
Boutros N, Campbell D, Petrakis I, Krystal J, Caporale M, Kosten T. Cocaine use and the mid-latency auditory evoked responses. Psychiatry Research 2000, 96: 117-126. PMID: 11063784, DOI: 10.1016/s0165-1781(00)00207-9.Peer-Reviewed Original ResearchConceptsCocaine-dependent subjectsInter-stimulus intervalMid-latency auditoryAge-matched healthy control subjectsCocaine useHealthy control subjectsDifferent inter-stimulus intervalsChronic cocaine useLong inter-stimulus intervalsPaired-click paradigmControl subjectsP50 componentN100 componentSignificant decreaseSubjectsAuditoryResponse paradigm
1999
Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report
Boutros N, Belger A, Campbell D, D’Souza C, Krystal J. Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report. Psychiatry Research 1999, 88: 119-130. PMID: 10622348, DOI: 10.1016/s0165-1781(99)00074-8.Peer-Reviewed Original ResearchConceptsNormal control subjectsSchizophrenia patientsSensory gatingControl subjectsNormal subjectsSex-matched normal control subjectsPathophysiology of schizophreniaStimulus repetitionStable schizophrenia patientsSchizophrenia subjectsSimilar abnormalitiesPatientsPreliminary reportDysfunctionDegree of attenuationSchizophreniaLate phaseSubjectsDeviant stimuliStimulus changeIrrelevant stimuliPathophysiologyStimuliPotential paradigmAbnormalitiesPreliminary Evidence of Low Cortical GABA Levels in Localized 1H-MR Spectra of Alcohol-Dependent and Hepatic Encephalopathy Patients
Behar KL, Rothman DL, Petersen KF, Hooten M, Delaney R, Petroff OA, Shulman GI, Navarro V, Petrakis IL, Charney DS, Krystal JH. Preliminary Evidence of Low Cortical GABA Levels in Localized 1H-MR Spectra of Alcohol-Dependent and Hepatic Encephalopathy Patients. American Journal Of Psychiatry 1999, 156: 952-954. PMID: 10360140, DOI: 10.1176/ajp.156.6.952.Peer-Reviewed Original ResearchConceptsHepatic encephalopathy patientsEncephalopathy patientsGamma-aminobutyric acidHealthy subjectsCortical GABA levelsGABA-ergic systemDetoxified alcohol-dependent patientsAlcohol-dependent patientsNeuroactive amino acidsCerebral cortexGABA levelsOccipital cortexPatientsMetabolite levelsPreliminary evidenceCortexSubjectsLevelsDisease
1997
Lack of behavioral effects of monoamine depletion in healthy subjects
Salomon R, Miller H, Krystal J, Heninger G, Charney D. Lack of behavioral effects of monoamine depletion in healthy subjects. Biological Psychiatry 1997, 41: 58-64. PMID: 8988796, DOI: 10.1016/0006-3223(95)00670-2.Peer-Reviewed Original ResearchConceptsAmino acid drinkHealthy subjectsAcid drinkTryptophan-free amino acid drinkBehavioral effectsTyrosine hydroxylase inhibitorTest sessionsMonoamine depletionMonoamine hypothesisPara-tyrosineCombined administrationAlpha-methylHydroxylase inhibitorDrinksSubjectsSessionsAMPTCatecholaminesAdministration
1995
Effects of tryptophan depletion on responses to yohimbine in healthy human subjects
Goddard A, Charney D, Germine M, Woods S, Heninger G, Krystal J, Goodman W, Price L. Effects of tryptophan depletion on responses to yohimbine in healthy human subjects. Biological Psychiatry 1995, 38: 74-85. PMID: 7578653, DOI: 10.1016/0006-3223(94)00223-p.Peer-Reviewed Original ResearchConceptsHealthy human subjectsTryptophan depletionAlpha-2 adrenergic antagonist yohimbinePlacebo-controlled challenge testHuman subjectsAntagonist yohimbineNeurotransmitter systemsSerotonin systemChallenge testPossible functional interactionBiochemical variablesWhole groupFeelings of nervousnessNE functionMarked increaseNorepinephrineConsiderable evidenceFear responsesSubjectsHuman anxietyNervousnessCombination testControl testsFunctional interactionUnique changes
1991
Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects
Seibyl J, Krystal J, Price L, Woods S, D'Amico C, Heninger G, Charney D. Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects. Psychiatry Research 1991, 38: 227-236. PMID: 1754635, DOI: 10.1016/0165-1781(91)90013-f.Peer-Reviewed Original ResearchConceptsGrowth hormone responseEffects of ritanserinHealthy male subjectsHealthy human subjectsSelf-rated anxietyMCPP infusionAgonist mCPPCardiovascular effectsHT2 receptorCardiovascular responsesNeuroendocrine responsesRitanserinHormone responseMale subjectsCortisol elevationBehavioral responsesHuman subjectsMCPPSubjectsResponsePlaceboPremedicationChlorophenylpiperazineInfusionAntagonistSpect regional cerebral blood flow and neuropsychological testing in non-demented HIV-positive drug abusers: Preliminary results
Woods S, O'malley S, Martini B, Mcdougle C, Price L, Krystal J, Hoffer P, Kosten T. Spect regional cerebral blood flow and neuropsychological testing in non-demented HIV-positive drug abusers: Preliminary results. Progress In Neuro-Psychopharmacology And Biological Psychiatry 1991, 15: 649-662. PMID: 1956993, DOI: 10.1016/0278-5846(91)90055-6.Peer-Reviewed Original ResearchConceptsHIV-positive patientsPositive patientsHIV-positive drug abusersRegional cerebral blood flowHIV-positive groupCerebral blood flowInjection of TcBlood flow ratioStriatal ratioCNS involvementNeuropsychologic testingHealthy subjectsDementia symptomsHealthy volunteersPositive groupBlood flowNeuropsychological testingPatientsDrug abusersNP testingVerbal memoryHMPAOSustained attentionSubjectsHIV