1989
Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys
Krystal J, Walker M, Heninger G. Intermittent naloxone attenuates the development of physical dependence on methadone in rhesus monkeys. European Journal Of Pharmacology 1989, 160: 331-338. PMID: 2540995, DOI: 10.1016/0014-2999(89)90088-5.Peer-Reviewed Original ResearchConceptsOpiate withdrawal syndromeInjection of naloxoneWithdrawal syndromeTreatment periodNaloxone injectionNaloxone administrationWithdrawal responsePhysical dependenceDays of methadoneAntagonist exposureMethadone treatmentDaily injectionsLack of incrementReceptor mechanismsDrug combinationsNaloxoneRhesus monkeysSyndromeDay 16MethadoneSame monkeysManagement of situationsInjectionAdministrationDays
1983
A preliminary description of acute physical dependence on morphine in the vervet monkey
Krystal JH, Redmond DE. A preliminary description of acute physical dependence on morphine in the vervet monkey. Pharmacology Biochemistry And Behavior 1983, 18: 289-291. PMID: 6682230, DOI: 10.1016/0091-3057(83)90379-9.Peer-Reviewed Original ResearchConceptsAcute physical dependencePhysical dependencePrevious animal studiesDevelopment of dependenceIntravenous morphineOpioid withdrawalOpiate dependencyNaloxone administrationNonhuman primate subjectsSyndrome characteristicsAnimal studiesMorphinePrimate subjectsVervet monkeysHoursMonkeysOpioidsPrimate speciesAdministration