2013
Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism
DeVito EE, Meda SA, Jiantonio R, Potenza MN, Krystal JH, Pearlson GD. Neural Correlates of Impulsivity in Healthy Males and Females with Family Histories of Alcoholism. Neuropsychopharmacology 2013, 38: 1854-1863. PMID: 23584260, PMCID: PMC3746701, DOI: 10.1038/npp.2013.92.Peer-Reviewed Original ResearchConceptsAlcohol use measuresNeural correlatesFHP individualsImpulse controlHigher self-reported impulsivityGreater BOLD signalFHN groupSelf-reported impulsivityAlcohol useInferior frontal gyrusLeft anterior insulaUse measuresImpulsivity factorsAnterior insulaFrontal gyrusGreater activationImpulsivityAddictive disordersNeural systemsScanner measuresSuccessful inhibitionBOLD signalSex differencesBehavioral traitsAddiction
2010
Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors
Andrews MM, Meda SA, Thomas AD, Potenza MN, Krystal JH, Worhunsky P, Stevens MC, O'Malley S, Book GA, Reynolds B, Pearlson GD. Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors. Biological Psychiatry 2010, 69: 675-683. PMID: 21126735, PMCID: PMC3677031, DOI: 10.1016/j.biopsych.2010.09.049.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskIncentive delay taskNAcc activationReward anticipationDelay taskFamily history-positive individualsAbnormal reward processingRegional brain activationNucleus accumbens activationFunctional magnetic resonanceReward system activitySubstance-abusing individualsReward prospectReward sensitivityNeural correlatesImpulsivity constructsSubstance abuse historyImpulsivity factorsReward processingBehavioral impulsivityAtypical activationBrain activationOutcome phaseBiological predispositionTask phases