2018
Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression
Zhou H, Cheng Z, Bass N, Krystal JH, Farrer LA, Kranzler HR, Gelernter J. Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression. Translational Psychiatry 2018, 8: 208. PMID: 30287806, PMCID: PMC6172277, DOI: 10.1038/s41398-018-0258-8.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide association study identifiesRisk genesTop risk genesCalcium ion bindingGenomes reference panelFast excitatory synaptic transmissionGenetic risk variantsGenetic basisEnrichment analysisAssociation studiesExome arrayCell adhesionRisk variantsGenesReference panelGenetic riskAMPA-sensitive glutamate receptorsIntronic variantsIon bindingBiological mechanismsConditional analysisGRIA4Excitatory synaptic transmissionSynaptic transmission
1989
Neurobiological aspects of PTSD: Review of clinical and preclinical studies
Krystal J, Kosten T, Southwick S, Mason J, Perry B, Giller E. Neurobiological aspects of PTSD: Review of clinical and preclinical studies. Behavior Therapy 1989, 20: 177-198. DOI: 10.1016/s0005-7894(89)80068-1.Peer-Reviewed Original Research
1988
Biological Mechanisms in Posttraumatic Stress Disorder Relevance for Substance Abuse
Kosten T, Krystal J. Biological Mechanisms in Posttraumatic Stress Disorder Relevance for Substance Abuse. Recent Developments In Alcoholism 1988, 6: 49-68. PMID: 3283864, DOI: 10.1007/978-1-4615-7718-8_3.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderSubstance abuseHuman studiesEndogenous opioid systemCentral catecholaminesOpioid systemBrain catecholaminesEmotional response modelsTherapeutic approachesAnimal studiesSignificant biological contributionStress disorderNonhuman primatesBehavioral correlatesCatecholaminesRelevant animalBiological mechanismsRecent studiesAbuseIndirect measureSyndromeIncidenceStudy