2009
Mechanisms underlying age differences in dopaminergic drug sensitivity
Dwyer J, Buntrock L, Khalaj A, Martinez L, Leslie F. Mechanisms underlying age differences in dopaminergic drug sensitivity. The FASEB Journal 2009, 23: 745.3-745.3. DOI: 10.1096/fasebj.23.1_supplement.745.3.Peer-Reviewed Original ResearchNeural stress systemsCritical developmental periodAge differencesNeural circuitryAdolescenceDevelopmental periodBehavioral differencesBehavioral responsesStress systemDrug abuseIndirect dopamineStereotypic behaviorAdolescentsNeuropsychiatric disordersD2-like agonist quinpiroleImportant implicationsAdult male ratsImmediate early gene expressionAgonist quinpiroleReceptor changesAdulthoodMale ratsAbuseEarly gene expressionQuinpirole
2008
Nicotine and brain development
Dwyer JB, Broide RS, Leslie FM. Nicotine and brain development. Birth Defects Research Part C Embryo Today Reviews 2008, 84: 30-44. PMID: 18383130, DOI: 10.1002/bdrc.20118.Peer-Reviewed Original ResearchConceptsNicotine replacement therapyMaternal smokingPharmacologic propertiesBrain developmentSudden infant death syndromeFetal central nervous systemAuditory cognitive dysfunctionActivation of nAChRsInfant death syndromeCentral nervous systemNumerous brain regionsNicotinic acetylcholine receptorsCell survivalLigand-gated ion channelsLong-term alterationsSpecific neural circuitryCritical developmental periodPregnant womenReplacement therapyTobacco cessationCholinergic modulationFunctional statusNeonatal brainPreclinical studiesTransmitter release