2012
Altered Response to Neuroendocrine Challenge Linked to Indices of the Metabolic Syndrome in Healthy Adults
Tyrka A, Walters O, Price L, Anderson G, Carpenter L. Altered Response to Neuroendocrine Challenge Linked to Indices of the Metabolic Syndrome in Healthy Adults. Hormone And Metabolic Research 2012, 44: 543-549. PMID: 22549400, PMCID: PMC3580172, DOI: 10.1055/s-0032-1306342.Peer-Reviewed Original ResearchConceptsDEX/CRH testBody mass indexHealthy adultsCRH testBlood pressureACTH responseMetabolic syndromeAdrenocorticotropic hormoneDexamethasone/corticotropin-releasing hormone testCorticotropin-releasing hormone testIndices of MetSHPA axis functionNeuroendocrine challenge testsAdrenal axis activityPathogenesis of MetS.Significant medical problemEarly life stressHealthy community sampleCommunity sampleCentral obesityChronic medicationsMetS componentsHDL cholesterolCentral adiposityDevelopment of disease
2008
The potential role for emergence in autism
Anderson GM. The potential role for emergence in autism. Autism Research 2008, 1: 18-30. PMID: 19360647, DOI: 10.1002/aur.2.Peer-Reviewed Original Research
2006
Placental Trophoblast Inclusions in Autism Spectrum Disorder
Anderson GM, Jacobs-Stannard A, Chawarska K, Volkmar FR, Kliman HJ. Placental Trophoblast Inclusions in Autism Spectrum Disorder. Biological Psychiatry 2006, 61: 487-491. PMID: 16806106, DOI: 10.1016/j.biopsych.2006.03.068.Peer-Reviewed Original ResearchEffects of Short- and Long-Term Risperidone Treatment on Prolactin Levels in Children with Autism
Anderson GM, Scahill L, McCracken JT, McDougle CJ, Aman MG, Tierney E, Arnold LE, Martin A, Katsovich L, Posey DJ, Shah B, Vitiello B. Effects of Short- and Long-Term Risperidone Treatment on Prolactin Levels in Children with Autism. Biological Psychiatry 2006, 61: 545-550. PMID: 16730335, DOI: 10.1016/j.biopsych.2006.02.032.Peer-Reviewed Original ResearchConceptsRisperidone-induced increasesLong-term risperidone treatmentProlactin levelsRisperidone treatmentSerum prolactinOpen-label followWeeks of risperidoneBaseline prolactin levelsEffects of ShortPlacebo groupProlactin elevationReceptor polymorphismsWeek 8Baseline levelsMean increaseProlactinRisperidoneSerum samplesAdverse effectsPlaceboChildrenTreatmentMonthsDRD2 allelesAdolescents
2005
Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder
Tordjman S, Anderson GM, Pichard N, Charbuy H, Touitou Y. Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Biological Psychiatry 2005, 57: 134-138. PMID: 15652871, DOI: 10.1016/j.biopsych.2004.11.003.Peer-Reviewed Original ResearchConceptsAutistic disorderNocturnal urinary excretionPineal gland hormoneLow melatonin productionNormal control individualsMelatonin physiologyGroup of childrenUrinary excretionMelatonin administrationTanner stageSleep problemsNormal controlsReported alterationNocturnal excretionControl individualsExcretion rateDisordersGland hormoneMelatoninMelatonin productionAutistic impairmentsExcretionCircadian rhythmBehavioral expressionVerbal communication
2004
Effects of glucocorticoids on declarative memory function in major depression
Bremner J, Vythilingam M, Vermetten E, Anderson G, Newcomer J, Charney D. Effects of glucocorticoids on declarative memory function in major depression. Biological Psychiatry 2004, 55: 811-815. PMID: 15050862, DOI: 10.1016/j.biopsych.2003.10.020.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDeclarative memory functionVerbal declarative memory functionDay 3Major depressionMemory functionParagraph recallUnipolar major depressive disorderSubset of patientsEffects of glucocorticoidsHealthy human subjectsDepressive disorderTransient impairmentHealthy subjectsRandomized fashionDeclarative memoryGlucocorticoid receptorBrain regionsExogenous cortisolGlucocorticoidsPlaceboDexamethasonePatientsBaselineDepression
2002
Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia
Anderson G, Gutknecht L, Cohen DJ, Brailly-Tabard S, Cohen JH, Ferrari P, Roubertoux PL, Tordjman S. Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia. Molecular Psychiatry 2002, 7: 831-836. PMID: 12232775, DOI: 10.1038/sj.mp.4001099.Peer-Reviewed Original ResearchAdolescentAutistic DisorderBlood PlateletsCarrier ProteinsChildCitalopramFemaleGenetic VariationGenotypeHumansLinear ModelsMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsPromoter Regions, GeneticSelective Serotonin Reuptake InhibitorsSerotoninSerotonin Plasma Membrane Transport Proteins
2000
Adrenomedullary Function During Cognitive Testing in Attention-Deficit/Hyperactivity Disorder
ANDERSON G, DOVER M, YANG B, HOLAHAN J, SHAYWITZ S, MARCHIONE K, HALL L, FLETCHER J, SHAYWITZ B. Adrenomedullary Function During Cognitive Testing in Attention-Deficit/Hyperactivity Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2000, 39: 635-643. PMID: 10802982, DOI: 10.1097/00004583-200005000-00018.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderEPI excretionHyperactivity disorderCognitive testingOppositional defiant/conduct disorderCognitive test batteryADHD inattentive subtypeTeacher-rated behaviorDiagnostic group differencesCognition-enhancing effectsInattentive behaviorCognitive challengesLearning disorderInattention factorTest batteryConduct disorderCorrelational analysisGroup differencesClassroom performanceContrast groupSympathoadrenomedullary functionDisordersBoysIndividualsFunctioningPharmacogenetics: Promise and Potential in Child and Adolescent Psychiatry
Anderson G, Cook E. Pharmacogenetics: Promise and Potential in Child and Adolescent Psychiatry. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 23-42. PMID: 10674189, DOI: 10.1016/s1056-4993(18)30134-2.Peer-Reviewed Original Research
1998
Cerebrospinal fluid levels of oxytocin in Prader–Willi syndrome: a preliminary report
Martin A, State M, Anderson G, Kaye W, Hanchett J, McConaha C, North W, Leckman J. Cerebrospinal fluid levels of oxytocin in Prader–Willi syndrome: a preliminary report. Biological Psychiatry 1998, 44: 1349-1352. PMID: 9861478, DOI: 10.1016/s0006-3223(98)00190-5.Peer-Reviewed Original ResearchEffects of Diagnosis, Race, and Puberty on Platelet Serotonin Levels in Autism and Mental Retardation
MCBRIDE P, ANDERSON G, HERTZIG M, SNOW M, THOMPSON S, KHAIT V, SHAPIRO T, COHEN D. Effects of Diagnosis, Race, and Puberty on Platelet Serotonin Levels in Autism and Mental Retardation. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 767-776. PMID: 9666633, DOI: 10.1097/00004583-199807000-00017.Peer-Reviewed Original Research
1997
Plasma β‐Endorphin, Adrenocorticotropin Hormone, and Cortisol in Autism
Tordjman S, McBride P, Hertzig M, Snow M, Anderson G, Hall L, Thompson S, Ferrari P, Cohen D. Plasma β‐Endorphin, Adrenocorticotropin Hormone, and Cortisol in Autism. Journal Of Child Psychology And Psychiatry 1997, 38: 705-715. PMID: 9315980, DOI: 10.1111/j.1469-7610.1997.tb01697.x.Peer-Reviewed Original ResearchConceptsAdrenocorticotropin hormoneBeta-endorphinPlasma levelsHigher plasma levelsPlasma β-endorphinNormal control individualsAcute stress responseΒ-endorphinNormal controlsControl individualsAcute stressorChronic hyperarousalStress response systemSevere autismCortisolAutistic groupHormoneIndividualsGroupHighest meanAutistic individualsLevelsStress responseRisperidone Treatment of Children and Adolescents With Pervasive Developmental Disorders: A Prospective, Open-Label Study
MCDOUGLE C, HOLMES J, BRONSON M, ANDERSON G, VOLKMAR F, PRICE L, COHEN D. Risperidone Treatment of Children and Adolescents With Pervasive Developmental Disorders: A Prospective, Open-Label Study. Journal Of The American Academy Of Child & Adolescent Psychiatry 1997, 36: 685-693. PMID: 9136504, DOI: 10.1097/00004583-199705000-00020.Peer-Reviewed Original ResearchConceptsPervasive developmental disorderDevelopmental disordersRisperidone treatmentClinical Global Impression ScaleOpen-label studyOpen-label trialPlacebo-controlled studyCommon side effectsEfficacy of risperidoneShort-term safetyGlobal Impression ScaleGlobal improvement itemBehavioral ratingsChildhood disintegrative disorderSocial relatednessTreatment of childrenAsperger's disorderRepetitive behaviorsAutistic disorderBehavioral symptomsBaseline visitMean ageImpression ScaleAdolescentsOptimal dose
1996
Elevated cerebrospinal fluid corticotropin-releasing ractor in Tourette's syndrome: Comparison to obsessive compulsive disorder and normal controls
Chappell P, Leckman J, Goodman W, Bissette G, Pauls D, Anderson G, Riddle M, Scahill L, McDougle C, Cohen D. Elevated cerebrospinal fluid corticotropin-releasing ractor in Tourette's syndrome: Comparison to obsessive compulsive disorder and normal controls. Biological Psychiatry 1996, 39: 776-783. PMID: 8731518, DOI: 10.1016/0006-3223(95)00221-9.Peer-Reviewed Original ResearchConceptsCorticotropin-releasing factorCSF corticotropin-releasing factorTourette syndromeObsessive-compulsive disorderNormal controlsCerebrospinal fluidPathobiology of TSOCD patientsMedication-free outpatientsCompulsive disorderLumbar cerebrospinal fluidNoradrenergic mechanismsHealthy controlsTS patientsObsessive-compulsive behaviorTic severityCardinal featuresClinical ratingsPatientsSyndromeRelated conditionsStandardized fashionNeurobiological mechanismsGroup differencesDisorders
1995
Plasma androgens in autism
Tordjman S, Anderson G, McBride P, Hertzig M, Snow M, Hall L, Ferrari P, Cohen D. Plasma androgens in autism. Journal Of Autism And Developmental Disorders 1995, 25: 295-304. PMID: 7559294, DOI: 10.1007/bf02179290.Peer-Reviewed Original ResearchConceptsCerebral palsyPlasma DHEA-S levelsNC individualsAdrenal androgen secretionDHEA-S levelsAdrenal androgen dehydroepiandrosterone sulfateBlood serotonin levelsNormal control subjectsWhole blood serotonin levelsEffect of pubertySignificant group differencesAndrogen secretionDehydroepiandrosterone sulfateControl subjectsPlasma levelsSerotonin levelsNC groupPlasma androgensPlasma testosteroneSignificant negative correlationTestosteroneImpaired subjectsWhole bloodMean levelsGroup differencesCerebrospinal Fluid Biogenic Amines in Obsessive Compulsive Disorder, Tourette's Syndrome, and Healthy Controls
Leckman J, Goodman W, Anderson G, Riddle M, Chappell P, McSwiggan-Hardin M, McDougle C, Scahill L, Ort S, Pauls D, Cohen D, Price L. Cerebrospinal Fluid Biogenic Amines in Obsessive Compulsive Disorder, Tourette's Syndrome, and Healthy Controls. Neuropsychopharmacology 1995, 12: 73-86. PMID: 7766289, DOI: 10.1038/sj.npp.1380241.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTourette syndromeHealthy controlsOCD patientsTS patientsHomovanillic acidCerebrospinal fluidCerebrospinal fluid biogenic aminesMedication-free OCD patientsPathobiology of TSCSF HVA levelsCompulsive disorderLumbar cerebrospinal fluidConcentrations of tyrosineHVA levelsCSF norepinephrineNoradrenergic mechanismsSerotonergic mechanismsCSF MHPGSerotonergic systemHealthy subjectsHealthy volunteersNormal volunteersPatientsSyndrome
1994
Preliminary study of eating disorders among French female adolescents and young adults
Tordjman S, Zittoun C, Anderson G, Flament M, Jeammet P. Preliminary study of eating disorders among French female adolescents and young adults. International Journal Of Eating Disorders 1994, 16: 301-305. PMID: 7833965, DOI: 10.1002/1098-108x(199411)16:3<301::aid-eat2260160312>3.0.co;2-y.Peer-Reviewed Original ResearchElevated Cerebrospinal Fluid Levels of Oxytocin in Obsessive-compulsive Disorder: Comparison With Tourette's Syndrome and Healthy Controls
Leckman J, Goodman W, North W, Chappell P, Price L, Pauls D, Anderson G, Riddle M, McSwiggan-Hardin M, McDougle C, Barr L, Cohen D. Elevated Cerebrospinal Fluid Levels of Oxytocin in Obsessive-compulsive Disorder: Comparison With Tourette's Syndrome and Healthy Controls. JAMA Psychiatry 1994, 51: 782-792. PMID: 7524462, DOI: 10.1001/archpsyc.1994.03950100030003.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid levelsObsessive-compulsive disorderCSF oxytocin levelsTourette syndromeArginine vasopressinFamily historyFluid levelsElevated cerebrospinal fluid levelsTic-related obsessive-compulsive disorderOxytocin levelsSubgroup of patientsSubset of patientsElevated CSF levelsCentral arginine vasopressinSubtype of OCDCSF levelsFamily genetic dataHealthy controlsTic disordersForms of OCDPatientsRelated syndromesCurrent severitySyndromeFamily study dataNoradrenergic and adrenergic functioning in autism
Minderaa R, Anderson G, Volkmar F, Akkerhuis G, Cohen D. Noradrenergic and adrenergic functioning in autism. Biological Psychiatry 1994, 36: 237-241. PMID: 7986888, DOI: 10.1016/0006-3223(94)90605-x.Peer-Reviewed Original ResearchConceptsUrinary excretion rateNeurochemical assessmentVanillylmandelic acidAdrenergic functioningExcretion rateNormal control individualsUrinary excretionPlasma levelsNoradrenergic functioningMarked abnormalitiesNormal controlsGroup mean differencesControl groupControl individualsNorepinephrineMean differenceAutistic patientsAspartame, behavior, and cognitive function in children with attention deficit disorder.
Shaywitz B, Sullivan C, Anderson G, Gillespie S, Sullivan B, Shaywitz S. Aspartame, behavior, and cognitive function in children with attention deficit disorder. Pediatrics 1994, 93: 70-5. PMID: 7505423, DOI: 10.1542/peds.93.1.70.Peer-Reviewed Original ResearchConceptsAttention deficit disorderWisconsin Card Sorting TestDeficit disorderTreatment Emergent Symptom ScalePlacebo-controlled crossover studyComplete blood cell countStudy centersLiver function testsUrinary excretion rateBlood cell countAdministration of aspartameMental Disorders criteriaCognitive testsMeasurement of catecholaminesCrossover studyFunction testsMonoamine metabolismInpatient admissionsMetabolite excretionLarge dosesSymptom ScaleUsual consumptionCell countPlasma phenylalanineBiochemical measures