2022
Systematic review of studies using platelet serotonin content to assess bioeffect of serotonin reuptake inhibitors at the serotonin transporter
Anderson G, Bruno-Pacella I. Systematic review of studies using platelet serotonin content to assess bioeffect of serotonin reuptake inhibitors at the serotonin transporter. Psychopharmacology 2022, 240: 1-13. PMID: 36399187, DOI: 10.1007/s00213-022-06276-5.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitorsSerotonin transporterPlatelet serotonin transporterSERT occupancyReuptake inhibitorsSystematic reviewClinical implicationsPlatelet serotonin contentMeasurement of plateletPlatelet serotonin uptakePractical clinical implicationsStudy of plateletsSerotonin uptakeHealthy controlsSerotonin contentDifferent SSRIsClinical practicePlateletsInhibitorsUptakeSNRIsSSRIsPatientsReviewTransporters
2010
Bioanalytical inaccuracy: a threat to the integrity and efficiency of research
Young S, Anderson G. Bioanalytical inaccuracy: a threat to the integrity and efficiency of research. Journal Of Psychiatry And Neuroscience 2010, 35: 3-6. PMID: 20040241, PMCID: PMC2799499, DOI: 10.1503/jpn.090171.Peer-Reviewed Original Research
2004
Time course of the effects of the serotonin-selective reuptake inhibitor sertraline on central and peripheral serotonin neurochemistry in the rhesus monkey
Anderson GM, Barr CS, Lindell S, Durham AC, Shifrovich I, Higley JD. Time course of the effects of the serotonin-selective reuptake inhibitor sertraline on central and peripheral serotonin neurochemistry in the rhesus monkey. Psychopharmacology 2004, 178: 339-346. PMID: 15452685, DOI: 10.1007/s00213-004-2011-7.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsCisternal cerebrospinal fluid (CSF) samplesPg/Young adult male rhesus monkeysRhesus monkeysSerotonin reuptake inhibitorsAdult male rhesus monkeysPlasma drug levelsCerebrospinal fluid samplesExtent of elevationMale rhesus monkeysTime courseNon-human primatesAutoreceptor desensitizationSerotonin neurochemistryReuptake inhibitorsNeurochemical effectsResponse latencyProlonged administrationDrug levelsDrug accumulationDay 0SertralineDiscontinuationBaseline
2002
Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia
Anderson G, Gutknecht L, Cohen DJ, Brailly-Tabard S, Cohen JH, Ferrari P, Roubertoux PL, Tordjman S. Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia. Molecular Psychiatry 2002, 7: 831-836. PMID: 12232775, DOI: 10.1038/sj.mp.4001099.Peer-Reviewed Original ResearchAdolescentAutistic DisorderBlood PlateletsCarrier ProteinsChildCitalopramFemaleGenetic VariationGenotypeHumansLinear ModelsMaleMembrane GlycoproteinsMembrane Transport ProteinsNerve Tissue ProteinsPromoter Regions, GeneticSelective Serotonin Reuptake InhibitorsSerotoninSerotonin Plasma Membrane Transport Proteins
2000
Pharmacogenetics and the serotonin system: initial studies and future directions
Veenstra-VanderWeele J, Anderson G, Cook E. Pharmacogenetics and the serotonin system: initial studies and future directions. European Journal Of Pharmacology 2000, 410: 165-181. PMID: 11134668, DOI: 10.1016/s0014-2999(00)00814-1.Peer-Reviewed Original Research
1998
Peripheral serotonin measures in prepubertal psychiatric inpatients and normal children: associations with suicidal behavior and its risk factors
Pfeffer C, McBride P, Anderson G, Kakuma T, Fensterheim L, Khait V. Peripheral serotonin measures in prepubertal psychiatric inpatients and normal children: associations with suicidal behavior and its risk factors. Biological Psychiatry 1998, 44: 568-577. PMID: 9787881, DOI: 10.1016/s0006-3223(98)00020-1.Peer-Reviewed Original ResearchConceptsPrepubertal psychiatric inpatientsBlood tryptophanRisk factorsSerotonin contentSuicidal behaviorMood disordersNormal controlsInpatient childrenSuicidal ideationSerotonin-amplified platelet aggregationPsychiatric inpatientsSuicide attemptsPlatelet serotonin contentEthnic differencesRecent suicide attemptSerotonin measuresPrepubertal controlsPlatelet serotoninPrepubertal childrenInpatientsPlatelet aggregationNormal childrenWhole bloodChildrenDisordersTryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects
Carpenter L, Anderson G, Pelton G, Gudin J, Kirwin P, Price L, Heninger G, McDougle C. Tryptophan Depletion During Continuous CSF Sampling in Healthy Human Subjects. Neuropsychopharmacology 1998, 19: 26-35. PMID: 9608574, DOI: 10.1016/s0893-133x(97)00198-x.Peer-Reviewed Original ResearchConceptsAmino acid drinkCerebrospinal fluidAcid drinkTRP levelsLow TRP dietTryptophan depletion paradigmBrain serotonin levelsPlasma TRP levelsHealthy adult subjectsHealthy human subjectsCSF TRP levelsPlasma TrpIndwelling catheterLumbar punctureSerotonin levelsTryptophan depletionContinuous cerebrospinal fluidSpecial dietAdult subjectsBehavioral effectsPlasma samplesHuman subjectsCorresponding fallCentral levelNadirEffects of Diagnosis, Race, and Puberty on Platelet Serotonin Levels in Autism and Mental Retardation
MCBRIDE P, ANDERSON G, HERTZIG M, SNOW M, THOMPSON S, KHAIT V, SHAPIRO T, COHEN D. Effects of Diagnosis, Race, and Puberty on Platelet Serotonin Levels in Autism and Mental Retardation. Journal Of The American Academy Of Child & Adolescent Psychiatry 1998, 37: 767-776. PMID: 9666633, DOI: 10.1097/00004583-199807000-00017.Peer-Reviewed Original ResearchSerotonin Transporter-Blocking Properties of Nefazodone Assessed by Measurement of Platelet Serotonin
Narayan M, Anderson G, Cellar J, Mallison R, Price L, Nelson J. Serotonin Transporter-Blocking Properties of Nefazodone Assessed by Measurement of Platelet Serotonin. Journal Of Clinical Psychopharmacology 1998, 18: 67-71.. PMID: 9472845, DOI: 10.1097/00004714-199802000-00011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntidepressive Agents, Second-GenerationBlood PlateletsCarrier ProteinsDepressive DisorderFemaleHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsMiddle AgedNerve Tissue ProteinsPiperazinesSelective Serotonin Reuptake InhibitorsSerotoninSerotonin Plasma Membrane Transport ProteinsTriazolesConceptsSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsHAM-D scoresHamilton Rating ScaleSerotonin type 2Nefazodone treatmentPretreatment plateletBaseline plateletSSRI treatmentReuptake inhibitorsUptake blockadeTherapeutic dosesPlatelet serotoninClinical dosesDepressed patientsMajor depressionTreatment groupsDepression scoresNefazodoneType 2Percent changeUptake inhibitionRating ScalePercent decreasePlatelets
1997
Sertraline and Breast-Feeding
Epperson C, Anderson G, McDougle C. Sertraline and Breast-Feeding. New England Journal Of Medicine 1997, 336: 1189-1190. PMID: 9102576, DOI: 10.1056/nejm199704173361615.Peer-Reviewed Original ResearchA preliminary study of tryptophan depletion on tics, obsessive-compulsive symptoms, and mood in Tourette's syndrome
Rasmusson A, Anderson G, Lynch K, McSwiggan-Hardin M, Scahill L, Mazure C, Goodman W, Price L, Cohen D, Leckman J. A preliminary study of tryptophan depletion on tics, obsessive-compulsive symptoms, and mood in Tourette's syndrome. Biological Psychiatry 1997, 41: 117-121. PMID: 8988803, DOI: 10.1016/s0006-3223(96)00380-0.Peer-Reviewed Original Research
1996
Adenosine diphosphate inhibits the serotonin transporter
Anderson G, Hall L, Horne W, Yang J. Adenosine diphosphate inhibits the serotonin transporter. Biochimica Et Biophysica Acta 1996, 1283: 14-20. PMID: 8765089, DOI: 10.1016/0005-2736(96)00073-9.Peer-Reviewed Original Research
1995
Plasma androgens in autism
Tordjman S, Anderson G, McBride P, Hertzig M, Snow M, Hall L, Ferrari P, Cohen D. Plasma androgens in autism. Journal Of Autism And Developmental Disorders 1995, 25: 295-304. PMID: 7559294, DOI: 10.1007/bf02179290.Peer-Reviewed Original ResearchConceptsCerebral palsyPlasma DHEA-S levelsNC individualsAdrenal androgen secretionDHEA-S levelsAdrenal androgen dehydroepiandrosterone sulfateBlood serotonin levelsNormal control subjectsWhole blood serotonin levelsEffect of pubertySignificant group differencesAndrogen secretionDehydroepiandrosterone sulfateControl subjectsPlasma levelsSerotonin levelsNC groupPlasma androgensPlasma testosteroneSignificant negative correlationTestosteroneImpaired subjectsWhole bloodMean levelsGroup differencesLinkage between brain serotonin concentration and the sex-specific part of the Y-chromosome in mice
Tordjman S, Roubertoux P, Carlier M, Moutier R, Anderson G, Launay M, Degrelle H. Linkage between brain serotonin concentration and the sex-specific part of the Y-chromosome in mice. Neuroscience Letters 1995, 183: 190-192. PMID: 7739791, DOI: 10.1016/0304-3940(94)11148-c.Peer-Reviewed Original Research
1993
Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder
Cook E, Arora R, Anderson G, Berry-Kravis E, Yan S, Yeoh HC, Sklena P, Charak D, Leventhal B. Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder. Life Sciences 1993, 52: 2005-2015. PMID: 7684805, DOI: 10.1016/0024-3205(93)90685-v.Peer-Reviewed Original ResearchConceptsLysergic acid diethylamideParoxetine bindingWhole bloodSubgroup of subjectsHyperserotonemia of autismProstaglandin E1Arginine vasopressinDensity of plateletsCAMP productionAcid diethylamideLSD bindingAutistic disorderSignificant differencesSignificant correlationBloodSubjectsBasalSubgroupsPlateletsChildrenAutistic probandsUptake VmaxAutistic children
1992
Activators of protein kinase C decrease serotonin transport in human platelets
Anderson G, Horne W. Activators of protein kinase C decrease serotonin transport in human platelets. Biochimica Et Biophysica Acta 1992, 1137: 331-337. PMID: 1445934, DOI: 10.1016/0167-4889(92)90154-4.Peer-Reviewed Original ResearchPlatelet dense granule release reaction monitored by high-performance liquid chromatography-fluorometric determination of endogenous serotonin
Anderson G, Hall L, Yang J, Cohen D. Platelet dense granule release reaction monitored by high-performance liquid chromatography-fluorometric determination of endogenous serotonin. Analytical Biochemistry 1992, 206: 64-67. PMID: 1456443, DOI: 10.1016/s0003-2697(05)80011-9.Peer-Reviewed Original ResearchPlatelet and whole blood serotonin content in depressed inpatients: Correlations with acute and life-time psychopathology
Mann J, McBride P, Anderson G, Mieczkowski T. Platelet and whole blood serotonin content in depressed inpatients: Correlations with acute and life-time psychopathology. Biological Psychiatry 1992, 32: 243-257. PMID: 1420642, DOI: 10.1016/0006-3223(92)90106-a.Peer-Reviewed Original ResearchConceptsPlatelet serotonin contentBorderline personality disorderBlood serotonin contentSerotonin contentWhole blood serotonin contentSerotonin levelsHealthy controlsPersonality disorderLower platelet serotonin contentComorbid borderline personality disorderHigher serotonin levelsLow serotonin levelsSeverity of depressionPlatelet serotonin levelsLife-time historyBPD attemptersPatient groupMajor depressionPatientsDepressed inpatientsSuicide attemptsSuicidal behaviorNonborderline patientsWhole bloodDisordersBrain Monoamines and Amino Acids in Gilles de la Tourette's Syndrome: A Preliminary Study of Subcortical Regions
Anderson G, Pollak E, CHATTERJEE D, Leckman J, Riddle M, Cohen D. Brain Monoamines and Amino Acids in Gilles de la Tourette's Syndrome: A Preliminary Study of Subcortical Regions. JAMA Psychiatry 1992, 49: 584-586. PMID: 1378261, DOI: 10.1001/archpsyc.1992.01820070078016.Peer-Reviewed Original ResearchConceptsGilles de la Tourette's syndromeLateral globus pallidusSubstantia nigra reticulataMedial globus pallidusLa Tourette's syndromeTourette syndromeGlobus pallidusSubthalamic nucleusSubcortical regionsTS groupMajor projection areaPossible pathophysiologic significanceLevels of monoaminesNeurotransmitter-related enzymesLow TS groupBrains of subjectsBrain monoaminesMonoamine metabolitesPathophysiologic significanceControl groupPostmortem tissueSyndromeBrainAvailable brainPallidusDifferentiation of Neuro-2a neuroblastoma cells by an antibody to GM3 ganglioside
Chatterjee D, Chakraborty M, Anderson G. Differentiation of Neuro-2a neuroblastoma cells by an antibody to GM3 ganglioside. Brain Research 1992, 583: 31-44. PMID: 1324094, DOI: 10.1016/s0006-8993(10)80007-1.Peer-Reviewed Original ResearchMeSH KeywordsAmino AcidsAnimalsAntibodies, MonoclonalBromodeoxyuridineBucladesineCatecholaminesCell DifferentiationCell DivisionCell LineDNA ReplicationElectrophoresis, Gel, Two-DimensionalElectrophoresis, Polyacrylamide GelFluorescent Antibody TechniqueG(M3) GangliosideGangliosidesKineticsMethionineMiceModels, BiologicalMolecular WeightNeoplasm ProteinsNeuroblastomaSerotoninThymidineConceptsNeuro-2a cellsTotal cellular proteinProtein kinase A (PKA) inhibitorProtein kinase C activityInhibitors of PKCKinase C activityNeuro-2a neuroblastoma cellsCellular proteinsCellular differentiationCell surface gangliosidesElevated intracellular cAMP levelsDifferentiated cellsIntracellular cAMP levelsCyclase activityMode of actionGi proteinsProteinPKCSurface gangliosidesC activityDifferentiationAdenylate cyclase activityNeuroblastoma cellsA inhibitorsGM2 ganglioside